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The role of adhesion molecules in osteocalcin-induced effects on glucose and lipid metabolism in adipocytes BBA Mol. Cell Res. (IF 5.1) Pub Date : 2024-02-27 Takahito Otani, Akiko Mizokami, Hiroshi Takeuchi, Tetsuichiro Inai, Masato Hirata
Recent findings suggest that uncarboxylated osteocalcin (GluOC) promotes glucose and lipid metabolism via its putative receptor GPRC6A; however, its direct effect on adipocytes remains elusive. In this study, we elucidated the effects of GluOC on adipocytes, with an emphasis on the role of cell adhesion molecules. We determined that GluOC promoted the expression of adipocyte adhesion molecule (ACAM)
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Mycobacterium tuberculosis protein PPE15 (Rv1039c) possesses eukaryote-like SH3 domain that interferes with NADPH Oxidase assembly and Reactive Oxygen Species production BBA Mol. Cell Res. (IF 5.1) Pub Date : 2024-02-24 Sadhna Sharma, Hemant Joshi, Chanchal Kumar, Rashid Waseem, Monika Sharma
Inhibition of Reactive Oxygen Species (ROS) is one of the strategies that (Mtb) employs as its defence mechanism. In this study, the role of PPE15 (Rv1039c), a late-stage protein, has been investigated in modulating the cellular ROS. We discovered PPE15 to be a secretory protein that downregulates ROS generation in THP1 macrophages. Our in-silico analysis revealed the presence of a eukaryote-like SH3
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Missense variants in phospholamban and cardiac myosin binding protein identified in patients with a family history and clinical diagnosis of dilated cardiomyopathy BBA Mol. Cell Res. (IF 5.1) Pub Date : 2024-02-22 Gareth P. Armanious, M. Joanne Lemieux, L. Michel Espinoza-Fonseca, Howard S. Young
As the genetic landscape of cardiomyopathies continues to expand, the identification of missense variants in disease-associated genes frequently leads to a classification of variant of uncertain significance (VUS). For the proper reclassification of such variants, functional characterization is an important contributor to the proper assessment of pathogenic potential. Several missense variants in the
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Identification and validation of an immunotherapeutic signature for colon cancer based on the regulatory patterns of ferroptosis and their association with the tumor microenvironment BBA Mol. Cell Res. (IF 5.1) Pub Date : 2024-02-20 Yong Liu, Junzhang Zhao, Baoxiang Huang, Youcheng Liang, Guanming Jiang, Xinglin Zhou, Yilin Chen, Tao He, Mingbin Zheng, Zunnan Huang
The integrated landscape of ferroptosis regulatory patterns and their association with colon microenvironment have been demonstrated in recent studies. However, the ferroptosis-related immunotherapeutic signature for colon cancer (CC) remains unclear. We comprehensively evaluated 1623 CC samples, identified patterns of ferroptosis modification based on ferroptosis-associated genes, and systematically
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Flipping the script: Advances in understanding how and why P4-ATPases flip lipid across membranes BBA Mol. Cell Res. (IF 5.1) Pub Date : 2024-02-19 Adriana C. Norris, Alexander J. Mansueto, Mariana Jimenez, Eugenia M. Yazlovitskaya, Bhawik K. Jain, Todd R. Graham
Type IV P-type ATPases (P4-ATPases) are a family of transmembrane enzymes that translocate lipid substrates from the outer to the inner leaflet of biological membranes and thus create an asymmetrical distribution of lipids within membranes. On the cellular level, this asymmetry is essential for maintaining the integrity and functionality of biological membranes, creating platforms for signaling events
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The enzymes of serine synthesis pathway in cancer metastasis BBA Mol. Cell Res. (IF 5.1) Pub Date : 2024-02-19 Lei Li, Yuting Qin, Yuping Chen
Metastasis, the major cause of cancer mortality, requires cancer cells to reprogram their metabolism to adapt to and thrive in different environments, thereby leaving metastatic cells metabolic characteristics different from their parental cells. Mounting research has revealed that the serine synthesis pathway (SSP), a glycolytic branching pathway that consumes glucose carbons for serine makeup and
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TRAIL-induced apoptosis and proteasomal activity – Mechanisms, signalling and interplay BBA Mol. Cell Res. (IF 5.1) Pub Date : 2024-02-16 Chiara Boccellato, Markus Rehm
Programmed cell death, in particular apoptosis, is essential during development and tissue homeostasis, and also is the primary strategy to induce cancer cell death by cytotoxic therapies. Precision therapeutics targeting TRAIL death receptors are being evaluated as novel anti-cancer agents, while in parallel highly specific proteasome inhibitors have gained approval as drugs. TRAIL-dependent signalling
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FOSL1 regulates hyperproliferation and NLRP3-mediated inflammation of psoriatic keratinocytes through the NF-kB signaling via transcriptionally activating TRAF3 BBA Mol. Cell Res. (IF 5.1) Pub Date : 2024-02-16 Yan Liang, Dan Han, Shaojun Zhang, Liang Sun
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Plakoglobin regulates adipocyte differentiation independently of the Wnt/β-catenin signaling pathway BBA Mol. Cell Res. (IF 5.1) Pub Date : 2024-02-15 F. Abou Azar, Y. Mugabo, S. Yuen, S. Del Veliz, F. Paré, S.A. Rial, G. Lavoie, P.P. Roux, G.E. Lim
The scaffold protein 14-3-3ζ is an established regulator of adipogenesis and postnatal adiposity. We and others have demonstrated the 14-3-3ζ interactome to be diverse and dynamic, and it can be examined to identify novel regulators of physiological processes, including adipogenesis. In the present study, we sought to determine if factors that influence adipogenesis during the development of obesity
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Unconventional role of Rab4 in the secretory pathway in Leishmania BBA Mol. Cell Res. (IF 5.1) Pub Date : 2024-02-10 Irshad Ansari, Amir Kumar Singh, Anjali Kapoor, Amitabha Mukhopadhyay
is an auxotroph for heme. Parasite acquires heme by clathrin-mediated endocytosis of hemoglobin by specific receptor. However, the regulation of receptor recycling pathway is not known in . Here, we have cloned, expressed and characterized the Rab4 homologue from . We have found that LdRab4 localizes in both early endosomes and Golgi in . To understand the role of LdRab4 in , we have generated transgenic
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ZFP982 confers mouse embryonic stem cell characteristics by regulating expression of Nanog, Zfp42, and Dppa3 BBA Mol. Cell Res. (IF 5.1) Pub Date : 2024-02-10 Fariba Dehghanian, Patrick Piero Bovio, Fabian Gather, Simone Probst, Amirhosein Naghsh-Nilchi, Tanja Vogel
Understanding the genetic underpinnings of protein networks conferring stemness is of broad interest for basic and translational research. We used multi-omics analyses to identify and characterize stemness genes, and focused on the zinc finger protein 982 ( that regulates stemness through the expression of , and in mouse embryonic stem cells (mESC). is expressed in stem cells, and binds to chromatin
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Nucleocytoplasmic shuttling of the GPN-loop GTPase Gpn3 is regulated by serum and cell density in MCF-12A mammary cells BBA Mol. Cell Res. (IF 5.1) Pub Date : 2024-02-10 Sonia G. Peña-Gómez, Gema R. Cristóbal-Mondragón, Cristhian R. Vega-Palomo, Martín Mora-García, Tania Félix-Pérez, Yolanda Rebolloso-Gómez, Mónica R. Calera, Roberto Sánchez-Olea
The best-known function of the essential GPN-loop GTPase Gpn3 is to contribute to RNA polymerase II assembly, a prerequisite for its nuclear targeting. Although this process occurs in the cytoplasm, we have previously shown that Gpn3 enters the cell nucleus before being polyubiquitinated. Here, we show that inhibiting Crm1-mediated nuclear export with leptomycin B, or the proteasome with MG132, caused
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Raltitrexed induces apoptosis through activating ROS-mediated ER stress by impeding HSPA8 expression in prostate cancer cells BBA Mol. Cell Res. (IF 5.1) Pub Date : 2024-01-30 Yan Tao, Jianzhong Lu, Lanlan Li, Lanpeng Lu, Beitang Fu, Jing Zhang, Shuni Zhang, Ruicong Ma, Jialong Ma, Jiaping Sun, Shengjun Fu, Shanhui Liu, Zhiping Wang
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A reductionist perspective on HIF-1α's role in cell proliferation under non-hypoxic conditions BBA Mol. Cell Res. (IF 5.1) Pub Date : 2024-02-01 Jan Dreute, Maximilian Pfisterer, M. Lienhard Schmitz
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Mutation of conserved histidine residues of dengue virus envelope protein impairs viral like particle maturation and secretion BBA Mol. Cell Res. (IF 5.1) Pub Date : 2024-01-30 N. Veena Rani, Mirza Sarwar Baig, Bharti Pathak, Neera Kapoor, Anuja Krishnan
Dengue virus (DENV) envelope protein plays crucial role in virus entry and maturation of virus during infection. Maturation of DENV occurs in the trans Golgi network at slightly acidic pH which is close to pKa of histidine. When exposed to the acidic environment of the late secretory pathway, dengue virus particles go through a significant conformational change, whereby interactions of structural proteins
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Simulated microgravity induces DNA damage concurrent with impairment of DNA repair and activation of cell-type specific DNA damage response in microglial and glioblastoma cells BBA Mol. Cell Res. (IF 5.1) Pub Date : 2024-01-23 Ragini Singh, Aishwarya Jaiswal, Rana P. Singh
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12th Tuscany Retreat on Cancer Research and Apoptosis: Genetic profiling, resistance mechanisms and novel treatment concepts in cancer and neurodegeneration BBA Mol. Cell Res. (IF 5.1) Pub Date : 2024-01-23 Cristiano Ramos, Debora Bonasera, Julia Saggau, Julijan Kabiljo, Peter Lin, Sofya Tishina, María G. Rincón
The 12th Tuscany Retreat on Cancer Research and Apoptosis was held on August 19–26, 2023. The biennial retreat aims to bring together scientists who advance research in cancer, cell death, and neurodegenerative diseases. Topics covered ranged from drug resistance in cancer to insights into novel molecular cell signaling mechanisms and targets, all related to the pathways and molecules that regulate
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HSP90a promotes the resistance to oxaliplatin in HCC through regulating IDH1-induced cell competition BBA Mol. Cell Res. (IF 5.1) Pub Date : 2024-01-26 Sikai Wang, Hongxia Cheng, Yilan Huang, Miaomiao Li, Dongmei Gao, Huaping Chen, Ruxiong Su, Kun Guo
Though burgeoning research manifests that cell competition, an essential selection and quality control mechanism for maintaining tissue or organ growth and homeostasis in multicellular organisms, is closely related to tumorigenesis and development, the mechanism of cell competition associated with tumor drug resistance remains elusive. In the study, we uncovered that oxaliplatin-resistant hepatocellular
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Squalene monooxygenase facilitates bladder cancer development in part by regulating PCNA BBA Mol. Cell Res. (IF 5.1) Pub Date : 2024-01-26 Changyan Zhu, Xiao Fang, Xiangshen Liu, Chengxi Jiang, Wenjun Ren, Wenmao Huang, Yanyan Jiang, Dong Wang
Bladder cancer (BC) is one of the most common cancers worldwide. Although the treatment and survival rate of BC are being improved, the risk factors and the underlying mechanisms causing BC are incompletely understood. Squalene monooxygenase (SQLE) has been associated with the occurrence and development of multiple cancers but whether it contributes to BC development is unclear. In this study, we performed
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AKAP2-anchored extracellular signal-regulated kinase 1 (ERK1) regulates cardiac myofibroblast migration BBA Mol. Cell Res. (IF 5.1) Pub Date : 2024-01-18 Marion Delaunay, Aleksandra Paterek, Ivan Gautschi, Greta Scherler, Dario Diviani
Cardiac fibrosis is a major cause of dysfunctions and arrhythmias in failing hearts. At the cellular level fibrosis is mediated by cardiac myofibroblasts, which display an increased migratory capacity and secrete large amounts of extracellular matrix. These properties allow myofibroblasts to invade, remodel and stiffen the myocardium and eventually alter cardiac function. While the enhanced ability
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Baicalin ameliorates deficient decidualization in URSA by regulating mitochondrial fission induced necroptosis BBA Mol. Cell Res. (IF 5.1) Pub Date : 2024-01-18 Xiaoxuan Zhao, Ying Zhao, Qujia Yang, Jing Ma, Yang Zhao, Suxia Wang, Yuepeng Jiang, Qin Zhang
Unexplained recurrent spontaneous abortion (URSA) is a common complication of pregnancy that affects the health of pregnant women. Deficient endometrial decidualization has been associated with URSA. However, the underlying mechanism is poorly understood. This study aims to explore the mechanisms of mitochondrial fission induced necroptosis in deficient decidualization in URSA, and explore the regulation
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MGMT in TMZ-based glioma therapy: Multifaceted insights and clinical trial perspectives BBA Mol. Cell Res. (IF 5.1) Pub Date : 2024-01-18 Rajni Shaw, Malini Basu, Subhajit Karmakar, Mrinal K. Ghosh
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Unraveling the interplay between vital organelle stress and oxidative stress in idiopathic pulmonary fibrosis BBA Mol. Cell Res. (IF 5.1) Pub Date : 2024-01-17 Anushree Mohanan, Kaveri R. Washimkar, Madhav Nilakanth Mugale
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Loss of the epithelial marker CDX1 predicts poor prognosis in early-stage CRC patients BBA Mol. Cell Res. (IF 5.1) Pub Date : 2024-01-10 Laura Solé, Teresa Lobo-Jarne, Júlia-Jié Cabré-Romans, Antón González, Lierni Fernández, Laura Marruecos, Marta Guix, Miriam Cuatrecasas, Sandra López, Beatriz Bellosillo, Ferran Torres, Mar Iglesias, Anna Bigas, Lluís Espinosa
Background We have previously shown that non-curative chemotherapy imposes fetal conversion and high metastatic capacity to cancer cells. From the set of genes differentially expressed in Chemotherapy Resistant Cells, we obtained a characteristic fetal intestinal cell signature that is present in a group of untreated tumors and is sufficient to predict patient prognosis. A feature of this fetal signature
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EID3 inhibits the osteogenic differentiation of periodontal ligament stem cells and mediates the signal transduction of TAZ-EID3-AKT/MTOR/ERK BBA Mol. Cell Res. (IF 5.1) Pub Date : 2024-01-10 Linglu Jia, Hui Tian, Shaoqing Sun, Xingyao Hao, Yong Wen
Exploring the molecular mechanisms of cell behaviors is beneficial for promoting periodontal ligament stem cell (PDLSC)-mediated tissue regeneration. This study intends to explore the regulatory effects of EID3 on cell proliferation, apoptosis, and osteogenic differentiation and to preliminarily explore the regulatory mechanism of EID3. Here, EID3 was overexpressed or knocked down in PDLSCs by recombinant
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Moderating AKT signaling with baicalein protects against weight loss by preventing muscle atrophy in a cachexia model caused by CT26 colon cancer BBA Mol. Cell Res. (IF 5.1) Pub Date : 2024-01-12 Gahee Song, Woo Yong Park, Wenjun Jiao, Ja Yeon Park, Se Jin Jung, Sungwon Ma, Junhee Lee, Kil Yeon Lee, Seong-Kyu Choe, Jinbong Park, Hyun Jeong Kwak, Kwang Seok Ahn, Jea-Young Um
Cancer cachexia is a type of energy-wasting syndrome characterized by fatigue, anorexia, muscle weakness, fat loss, and systemic inflammation. Baicalein, a flavonoid with bioactive properties, has demonstrated the ability to mitigate cardiac and skeletal muscle atrophy in different experimental settings. This effect is achieved through the inhibition of muscle proteolysis, suggesting its potential
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EGCG-induced selective death of cancer cells through autophagy-dependent regulation of the p62-mediated antioxidant survival pathway BBA Mol. Cell Res. (IF 5.1) Pub Date : 2024-01-11 Ho Woon Lee, Jee-Hye Choi, Dongbeom Seo, Lkhagvasuren Gavaachimed, Jaesung Choi, Sehwan Park, Na Young Min, Dong Ho Lee, Hyo-Weon Bang, Seung Wook Ham, Jung-Woong Kim, Sung Chul Lee, Sangmyung Rhee, Sang-Beom Seo, Kwang-Ho Lee
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Murine double minute 2-mediated estrogen receptor 1 degradation activates macrophage migration inhibitory factor to promote vascular smooth muscle cell dedifferentiation and oxidative stress during thoracic aortic aneurysm progression BBA Mol. Cell Res. (IF 5.1) Pub Date : 2024-01-11 Tao Liu, Tian Zhang, Chenfan Guo, Xiangsen Liang, Pandeng Wang, Baoshi Zheng
Estrogen receptor 1 (ESR1) has been recently demonstrated as a potential diagnostic biomarker for thoracic aortic aneurysm (TAA). However, its precise role in the progression of TAA remains unclear. In this study, TAA models were established in ApoE-knockout mice and primary mouse vascular smooth muscle cells (VSMCs) through treatment with angiotensin (Ang) II. Our findings revealed a downregulation
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Identification of MCM4 and PRKDC as new regulators of osteosarcoma cell dormancy based on 3D cell cultures BBA Mol. Cell Res. (IF 5.1) Pub Date : 2024-01-10 Camille Jubelin, Javier Muñoz-Garcia, Emilie Ollivier, Denis Cochonneau, François Vallette, Marie-Françoise Heymann, Lisa Oliver, Dominique Heymann
Dormancy is a potential way for tumors to develop drug resistance and escape treatment. However, the mechanisms involved in cancer dormancy remain poorly understood. This is mainly because there is no in vitro culture model making it possible to spontaneously induce dormancy. In this context, the present work proposes the use of three-dimensional (3D) spheroids developed from osteosarcoma cell lines
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GDF11 mitigates high glucose-induced cardiomyocytes apoptosis by inhibiting the ALKBH5-FOXO3-CDR1as/Hippo signaling pathway BBA Mol. Cell Res. (IF 5.1) Pub Date : 2024-01-03 Yingchun Shao, Mengmeng Li, Yanying Wang, Yunmeng Qu, Manyu Gong, Qi Yu, Xuewen Yang, Dongping Liu, Haodong Li, Yaqi Wang, Han Sun, Yanwei Zhang, Xiyang Zhang, Tong Liu, Jie Liu, Tiantian Gong, Yuhong Sun, Zhiyuan Du, Lei Jiao, Ying Zhang
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Chrysin alleviates DNA damage to improve disturbed immune homeostasis and pro-angiogenic environment in laser-induced choroidal neovascularization BBA Mol. Cell Res. (IF 5.1) Pub Date : 2024-01-02 Jing Wang, Zilin Wang, Jingshu Liu, Minwen Zhou, Hong Wang, Hong Zhu, Mei Jiang, Qiyu Bo, Xiaodong Sun
Choroidal neovascularization (CNV) is a devastating pathology of numerous ocular diseases, such as wet age-related macular degeneration (wAMD), which causes irreversible vision loss. Although anti-vascular endothelial growth factor (VEGF) therapy has been widely used, poor response or no response still exists in some cases, suggesting that there are other components involved in the angiogenic process
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FXR controls insulin content by regulating Foxa2-mediated insulin transcription BBA Mol. Cell Res. (IF 5.1) Pub Date : 2023-12-20 Dan Yan, Moyang Lv, Xiangchen Kong, Linxian Feng, Ying Ying, Wenjuan Liu, Xin Wang, Xiaosong Ma
Farnesoid X receptor (FXR) is a nuclear ligand-activated receptor of bile acids that plays a role in the modulation of insulin content. However, the underlying molecular mechanisms remain unclear. Forkhead box a2 (Foxa2) is an important nuclear transcription factor in pancreatic β-cells and is involved in β-cell function. We aimed to explore the signaling mechanism downstream of FXR to regulate insulin
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Disordered regions mediate the interaction of p53 and MRE11 BBA Mol. Cell Res. (IF 5.1) Pub Date : 2023-12-19 Sinem Usluer, Markus Galhuber, Yukti Khanna, Benjamin Bourgeois, Emil Spreitzer, Helene Michenthaler, Andreas Prokesch, Tobias Madl
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Peripheral 5-HT/HTR6 axis is responsible for obesity-associated hypertension BBA Mol. Cell Res. (IF 5.1) Pub Date : 2023-12-11 Vadim I. Chechekhin, Anastasia M. Ivanova, Konstantin Y. Kulebyakin, Yulia G. Antropova, Maxim N. Karagyaur, Maria N. Skryabina, Elizaveta S. Chechekhina, Natalia A. Basalova, Olga A. Grigorieva, Veronika Yu Sysoeva, Natalia I. Kalinina, Vsevolod A. Tkachuk, Pyotr A. Tyurin-Kuzmin
Hypertension is one of the major life-threatening complications of obesity. Recently adipose multipotent mesenchymal stromal cells (MSCs) were implicated to the pathogenesis of obesity-associated hypertension. These cells amplify noradrenaline-induced vascular cell contraction via cAMP-mediated signaling pathway. In this study we tested the ability of several cAMP-mediated hormones to affect the adrenergic
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Tanc1/2 TPR domain interacts with Myo18a C-terminus and undergoes liquid-liquid phase separation BBA Mol. Cell Res. (IF 5.1) Pub Date : 2023-12-11 Qingqing Yang, Haiyang Liu, Dengqin Zhong, Zhiwei Li, Jianchao Li, Kang Xiao, Wei Liu
Tanc1 and its homologous protein Tanc2 are critical synaptic scaffold proteins which regulate synaptic spine densities and excitatory synapse strength. Recent studies indicated TANC1 and TANC2 are candidate genes of several neurodevelopmental disorders (NDDs). In this study, we identified and characterized a novel interaction between Tanc1/2 and Myo18a, mediated by the Tanc1/2 TPR domains and Myo18a
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Blockade of angiotensin II modulates insulin-like growth factor 1-mediated skeletal muscle homeostasis in experimental steatohepatitis BBA Mol. Cell Res. (IF 5.1) Pub Date : 2023-12-12 Misako Tanaka, Kosuke Kaji, Norihisa Nishimura, Shohei Asada, Aritoshi Koizumi, Takuya Matsuda, Nobuyuki Yorioka, Yuki Tsuji, Yukihisa Fujinaga, Shinya Sato, Tadashi Namisaki, Takemi Akahane, Hitoshi Yoshiji
Sarcopenia is associated with mortality in patients with nonalcoholic steatohepatitis (NASH). Angiotensin II receptor blocker (ARB) has been suggested to prevent sarcopenia, but reports on its effect on NASH-derived skeletal muscle atrophy in conjunction with insulin-like growth factor 1 (IGF-1)-mediated muscle homeostasis are few. Our aim was to examine the combined effect of the ARB losartan and
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Protein kinase D (PKD) on the crossroad of lipid absorption, synthesis and utilization BBA Mol. Cell Res. (IF 5.1) Pub Date : 2023-12-15 Magdalena Wit, Andrei Belykh, Grzegorz Sumara
Inappropriate lipid levels in the blood, as well as its content and composition in different organs, underlie multiple metabolic disorders including obesity, non-alcoholic fatty liver disease, type 2 diabetes, and atherosclerosis. Multiple processes contribute to the complex metabolism of triglycerides (TGs), fatty acids (FAs), and other lipid species. These consist of digestion and absorption of dietary
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The dynamics of the electrotactic reaction of mouse 3T3 fibroblasts BBA Mol. Cell Res. (IF 5.1) Pub Date : 2023-12-11 Slawomir Lasota, Eliza Zimolag, Sylwia Bobis-Wozowicz, Jagoda Pilipiuk, Zbigniew Madeja
The molecular mechanisms behind electrotaxis remain largely unknown, with no identified primary direct current electric field (dcEF) sensor. Two leading hypotheses propose mechanisms involving the redistribution of charged components in the cell membrane (driven by electrophoresis or electroosmosis) and the asymmetric activation of ion channels. To investigate these mechanisms, we studied the dynamics
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The lipid flippase ATP10B enables cellular lipid uptake under stress conditions BBA Mol. Cell Res. (IF 5.1) Pub Date : 2023-12-11 Rosanne Wouters, Igor Beletchi, Chris Van den Haute, Veerle Baekelandt, Shaun Martin, Jan Eggermont, Peter Vangheluwe
Pathogenic ATP10B variants have been described in patients with Parkinson's disease and dementia with Lewy body disease, and we previously established ATP10B as a late endo-/lysosomal lipid flippase transporting both phosphatidylcholine (PC) and glucosylceramide (GluCer) from the lysosomal exoplasmic to cytoplasmic membrane leaflet. Since several other lipid flippases regulate cellular lipid uptake
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The protease Lon prolongs insect lifespan by responding to reactive oxygen species and degrading mitochondrial transcription factor A BBA Mol. Cell Res. (IF 5.1) Pub Date : 2023-12-11 Xiao-Long Su, Zhi-Ren Su, Wei-Hua Xu
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Protein kinase D1 — A targetable mediator of pancreatic cancer development BBA Mol. Cell Res. (IF 5.1) Pub Date : 2023-12-05 Alicia K. Fleming Martinez, Peter Storz
Members of the Protein kinase D (PKD) kinase family each play important cell-specific roles in the regulation of normal pancreas functions. In pancreatic diseases PKD1 is the most widely characterized isoform with roles in pancreatitis and in induction of pancreatic cancer and its progression. PKD1 expression and activation increases in pancreatic acinar cells through macrophage secreted factors, Kirsten
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SPOP promotes CREB5 ubiquitination to inhibit MET signaling in liver cancer BBA Mol. Cell Res. (IF 5.1) Pub Date : 2023-11-22 De-ao Gong, Peng Zhou, Wen-yi Chang, Jia-yao Yang, Yan-lai Zhang, Ai-long Huang, Ni Tang, Kai Wang
Liver cancer is ranked as the sixth most prevalent from of malignancy globally and stands as the third primary contributor to cancer-related mortality. Metastasis is the main reason for liver cancer treatment failure and patient deaths. Speckle-type POZ protein (SPOP) serves as a crucial substrate junction protein within the cullin-RING E3 ligase complex, acting as a significant tumor suppressor in
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Unraveling the inhibitory mechanism of adenylyl cyclase 8E: New insights into regulatory pathways of cAMP signal integration BBA Mol. Cell Res. (IF 5.1) Pub Date : 2023-11-27 Yohan Legueux-Cajgfinger, Mahesh Velusamy, Samar Fathallah, Benjamin Vallin, Laurent Duca, Manuel Dauchez, Pierre Vincent, Isabelle Limon, Régis Blaise
Adenylyl Cyclase 8E (AC8E), which lacks part of M1 transmembrane domain, has been previously shown to dimerize with AC3 and down-regulate its activity, but the molecular mechanism of this inhibitory effect has remained elusive. Here, we first show that AC8E also inhibits AC2 and AC6, highlighting the functional importance of this novel regulatory mechanism in the cAMP signaling pathway across AC families
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High-throughput analysis of glycan sorting into extracellular vesicles BBA Mol. Cell Res. (IF 5.1) Pub Date : 2023-11-22 Jenifer Pendiuk Goncalves, Jorvani Cruz Villarreal, Sierra A. Walker, Xuan Ning Sharon Tan, Chad Borges, Joy Wolfram
Extracellular vesicles (EVs) are cell-released vesicles that mediate intercellular communication by transferring bioactive cargo. Protein and RNA sorting into EVs has been extensively assessed, while selective enrichment of glycans in EVs remains less explored. In this study, a mass spectrometry-based approach, glycan node analysis (GNA), was applied to broadly assess the sorting of glycan features
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Loss of Nrf1 rather than Nrf2 leads to inflammatory accumulation of lipids and reactive oxygen species in human hepatoma cells, which is alleviated by 2-bromopalmitate BBA Mol. Cell Res. (IF 5.1) Pub Date : 2023-11-22 Rongzhen Deng, Ze Zheng, Shaofan Hu, Meng Wang, Jing Feng, Peter Mattjus, Zhengwen Zhang, Yiguo Zhang
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Extracellular matrix stiffness controls cardiac fibroblast proliferation via the nuclear factor-Y (NF-Y) transcription factor BBA Mol. Cell Res. (IF 5.1) Pub Date : 2023-11-22 Reza Ebrahimighaei, Nathalie Tarassova, Samuel C. Bond, Madeleine C. McNeill, Tom Hathway, Hunaid Vohra, Andrew C. Newby, Mark Bond
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Comparative profiling of gut microbiota and metabolome in diet-induced obese and insulin-resistant C57BL/6J mice BBA Mol. Cell Res. (IF 5.1) Pub Date : 2023-11-22 Hobby Aggarwal, Jyoti Gautam, Deepika Kumari, Sonu Kumar Gupta, Sneh Bajpai, Kartikey Chaturvedi, Yashwant Kumar, Madhu Dikshit
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Proline and dihydroorotate dehydrogenase promote a hyper-proliferative state and dampen ferroptosis in cancer cells by rewiring mitochondrial redox metabolism BBA Mol. Cell Res. (IF 5.1) Pub Date : 2023-11-22 Ryan J. Mailloux
Redox realignment is integral to the initiation, progression, and metastasis of cancer. This requires considerable metabolic rewiring to induce aberrant shifts in redox homeostasis that favor high hydrogen peroxide (H2O2) generation for the induction of a hyper-proliferative state. The ability of tumor cells to thrive under the oxidative burden imposed by this high H2O2 is achieved by increasing antioxidant
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Acetylenic tricyclic bis-(cyano enone) interacts with Cys 374 of actin, a residue necessary for stress fiber formation and cell migration BBA Mol. Cell Res. (IF 5.1) Pub Date : 2023-11-20 Eddie Chan, Brennan S. Dirk, Tadashi Honda, Peter B. Stathopulos, Jimmy D. Dikeakos, Gianni M. Di Guglielmo
The migratory and invasive potential of tumour cells relies on the actin cytoskeleton. We previously demonstrated that the tricyclic compound, TBE-31, inhibits actin polymerization and here we further examine the precise interaction between TBE-31 and actin. We demonstrate that iodoacetamide, a cysteine (Cys) alkylating agent, interferes with the ability of TBE-31 to interact with actin. In addition
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SQSTM1/p62 inhibition impairs pro-survival signaling in hypoxic human dendritic cells BBA Mol. Cell Res. (IF 5.1) Pub Date : 2023-11-18 Federica Coppola, Sara Monaci, Alessandro Falsini, Carlo Aldinucci, Irene Filippi, Daniela Rossi, Fabio Carraro, Antonella Naldini
The sequestosome 1 (SQSTM1)/p62 is an adaptor protein which plays multiple roles in several cell functions, including cell survival and autophagy. Dendritic cells (DCs) are the most prominent antigen presenting cells and during their lifespan they are exposed to different oxygen tensions, including hypoxia. By using a siRNA approach we found out that p62 was implicated in the maintenance of Erk1/2
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Sulforaphane reduces adipose tissue fibrosis via promoting M2 macrophages polarization in HFD fed-mice BBA Mol. Cell Res. (IF 5.1) Pub Date : 2023-11-15 Zhenzhen Zhang, Huali Chen, Cheng Pan, Rui Li, Wangsheng Zhao, Tianzeng Song
Adipose tissue fibrosis has been identified as a novel contributor to the pathomechanism of obesity associated metabolic disorders. Sulforaphane (SFN) has been shown to have an anti-obesity effect. However, the impact of SFN on adipose tissue fibrosis is still not well understood. In this study, obese mice induced by high-fat diets (HFD) were used to examine the effects of SFN on adipose tissue fibrosis
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Lanosterol elevates cytoprotective response through induced-proteasomal degradation of aberrant proteins BBA Mol. Cell Res. (IF 5.1) Pub Date : 2023-11-13 Sumit Kinger, Yuvraj Anandrao Jagtap, Ankur Rakesh Dubey, Prashant Kumar, Akash Choudhary, Rohan Dhiman, Vijay Kumar Prajapati, Deepak Chitkara, Krishna Mohan Poluri, Amit Mishra
Efficient protein synthesis is a basic requirement of our cells to replace the old or defective proteins from the intrinsic crowded biomolecular environment. The interconnection among synthesis, folding, and degradation of proteins represents central paradigm to proteostasis. Failure of protein quality control (PQC) mechanisms results in the disturbance and inadequate functions of proteome. The consequent
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Akkermansia muciniphila-derived small extracellular vesicles attenuate intestinal ischemia-reperfusion-induced postoperative cognitive dysfunction by suppressing microglia activation via the TLR2/4 signaling BBA Mol. Cell Res. (IF 5.1) Pub Date : 2023-11-13 Xiang Gao, Chuantao Lin, Yebin Feng, Yi You, Zhe Jin, Mengyun Li, Yufeng Zhou, Kai Chen
Akkermansia muciniphila (AKK) bacteria improve the functions of theere intestinal and blood–brain barriers (BBB) via their extracellular vesicles (AmEvs). However, their role in postoperative cognitive dysfunction (POCD) and its underlying mechanisms remain unclear. To investigate, we used C57BL/6 J mice divided into five groups: Sham, POCD, POCD+Akk, POCD+Evs, and POCD+Evs + PLX5622. POCD was induced
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Inhibition of autophagy initiation: A novel strategy for oral squamous cell carcinomas BBA Mol. Cell Res. (IF 5.1) Pub Date : 2023-11-12 Yomna S. Abd El-Aziz, Matthew J. McKay, Mark P. Molloy, Betty McDowell, Elizabeth Moon, Loretta Sioson, Amy Sheen, Angela Chou, Anthony J. Gill, Patric J. Jansson, Sumit Sahni
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Open questions in the NF-κB field BBA Mol. Cell Res. (IF 5.1) Pub Date : 2023-11-09 Susanne Bacher, M. Lienhard Schmitz
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Paxillin/HDAC6 regulates microtubule acetylation to promote directional migration of keratinocytes driven by electric fields BBA Mol. Cell Res. (IF 5.1) Pub Date : 2023-11-10 Luojia Liu, Xiaoqiang Liu, Ying Chen, Meng Kong, Jinghong Zhang, Min Jiang, Hongling Zhou, Jinrui Yang, Xu Chen, Ze Zhang, Chao Wu, Xupin Jiang, Jiaping Zhang
Endogenous electric fields (EFs) have been demonstrated to facilitate wound healing by directing the migration of epidermal cells. Despite the identification of numerous molecules and signaling pathways that are crucial for the directional migration of keratinocytes under EFs, the underlying molecular mechanisms remain undefined. Previous studies have indicated that microtubule (MT) acetylation is
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Mitochondrial entry gate as regulatory hub BBA Mol. Cell Res. (IF 5.1) Pub Date : 2023-11-09 Fabian den Brave, Nikolaus Pfanner, Thomas Becker
Mitochondria import 1000–1300 different precursor proteins from the cytosol. The main mitochondrial entry gate is formed by the translocase of the outer membrane (TOM complex). Molecular coupling and modification of TOM subunits control and modulate protein import in response to cellular signaling. The TOM complex functions as regulatory hub to integrate mitochondrial protein biogenesis and quality
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Reactive oxygen species and cell signaling. Review BBA Mol. Cell Res. (IF 5.1) Pub Date : 2023-11-08 Diana Averill-Bates
Reactive oxygen species (ROS) is a term encompassing a group of highly reactive oxygen-derived molecules. In physiological systems, ROS production exists in concert with antioxidant defenses, which safeguard cells against higher, toxic levels of ROS. Oxidative stress, coined as “oxidative distress”, is “a serious imbalance between the generation of ROS and antioxidant defenses in favor of ROS, causing
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Fibroblast growth factor 21 alleviates unilateral ureteral obstruction-induced renal fibrosis by inhibiting Wnt/β-catenin signaling pathway BBA Mol. Cell Res. (IF 5.1) Pub Date : 2023-11-04 Wenhui Zhong, Yuheng Jiang, Huizhen Wang, Xiang Luo, Tao Zeng, Huimi Huang, Ling Xiao, Nan Jia, Aiqing Li
Fibroblast growth factor 21 (FGF21) is a key regulator of energy metabolism. Recent studies suggested that serum FGF21 levels increase with declining renal function. However, the link between FGF21 and kidney diseases and the direct effect of FGF21 in renal fibrosis remains unclear. In this study, FGF21 was upregulated in unilateral ureteral obstruction (UUO)-induced renal fibrosis and cellular fibrosis