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Exploring Retrograde Trafficking: Mechanisms and Consequences in Cancer and Disease Traffic (IF 4.5) Pub Date : 2024-02-28 Rachel Bingham, Helen McCarthy, Niamh Buckley
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Mechanisms regulating the intracellular trafficking and release of CLN5 and CTSD Traffic (IF 4.5) Pub Date : 2024-01-21 Robert J. Huber, William D. Kim, Morgan L. D. M. Wilson-Smillie
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Endoglin mutants retained in the endoplasmic reticulum exacerbate loss of function in hereditary hemorrhagic telangiectasia type 1 (HHT1) by exerting dominant negative effects on the wild type allele Traffic (IF 4.5) Pub Date : 2024-01-16 Nesrin Gariballa, Sally Badawi, Bassam R. Ali
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Rescue of secretion of rare-disease-associated misfolded mutant glycoproteins in UGGT1 knock-out mammalian cells Traffic (IF 4.5) Pub Date : 2024-01-14 Gabor Tax, Kevin P. Guay, Ludovica Pantalone, Martina Ceci, Tatiana Soldà, Charlie J. Hitchman, Johan C. Hill, Snežana Vasiljević, Andrea Lia, Carlos P. Modenutti, Kees R. Straatman, Angelo Santino, Maurizio Molinari, Nicole Zitzmann, Daniel N. Hebert, Pietro Roversi, Marco Trerotola
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Glucocorticoids rescue cell surface trafficking of R451C Neuroligin3 and enhance synapse formation Traffic (IF 4.5) Pub Date : 2024-01-14 Tamara Diamanti, Laura Trobiani, Lorenza Mautone, Federica Serafini, Roberta Gioia, Laura Ferrucci, Clotilde Lauro, Sara Bianchi, Camilla Perfetto, Stefano Guglielmo, Raimondo Sollazzo, Ezio Giorda, Andrea Setini, Davide Ragozzino, Elena Miranda, Davide Comoletti, Silvia Di Angelantonio, Emanuele Cacci, Antonella De Jaco
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The emerging functions of intraflagellar transport 52 in ciliary transport and ciliopathies Traffic (IF 4.5) Pub Date : 2024-01-11 Prajna Udupa, Debasish Kumar Ghosh
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A vesicular Warburg effect: Aerobic glycolysis occurs on axonal vesicles for local NAD+ recycling and transport Traffic (IF 4.5) Pub Date : 2023-12-12 Maximilian Mc Cluskey, Hervé Dubouchaud, Anne-Sophie Nicot, Frédéric Saudou
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Role of trafficking protein particle complex 2 in medaka development Traffic (IF 4.5) Pub Date : 2023-11-14 Francesca Zappa, Daniela Intartaglia, Andrea M. Guarino, Rossella De Cegli, Cathal Wilson, Francesco Giuseppe Salierno, Elena Polishchuk, Nicolina Cristina Sorrentino, Ivan Conte, Maria Antonietta De Matteis
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Peroxisome population control by phosphoinositide signaling at the endoplasmic reticulum-plasma membrane interface Traffic (IF 4.5) Pub Date : 2023-11-05 Barbara Knoblach, Richard A. Rachubinski
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Sequence elements within the PEXEL motif and its downstream region modulate PTEX-dependent protein export in Plasmodium falciparum Traffic (IF 4.5) Pub Date : 2023-11-05 Mikha Gabriela, Claudia B. G. Barnes, Dickson Leong, Brad E. Sleebs, Molly Parkyn Schneider, Dene R. Littler, Brendan S. Crabb, Tania F. de Koning-Ward, Paul R. Gilson
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IST1 regulates select recycling pathways Traffic (IF 4.5) Pub Date : 2023-11-05 Amy K. Clippinger, Teresa V. Naismith, Wonjin Yoo, Silvia Jansen, David J. Kast, Phyllis I. Hanson
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A new Caenorhabditis elegans model to study copper toxicity in Wilson disease Traffic (IF 4.5) Pub Date : 2023-10-27 Federico Catalano, Thomas J. O'Brien, Aleksandra A. Mekhova, Lucia Vittoria Sepe, Mariantonietta Elia, Rossella De Cegli, Ivan Gallotta, Pamela Santonicola, Giuseppina Zampi, Ekaterina Y. Ilyechova, Aleksei A. Romanov, Polina D. Samuseva, Josephine Salzano, Raffaella Petruzzelli, Elena V. Polishchuk, Alessia Indrieri, Byung-Eun Kim, André E. X. Brown, Ludmila V. Puchkova, Elia Di Schiavi, Roman S.
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Copper-independent lysosomal localisation of the Wilson disease protein ATP7B Traffic (IF 4.5) Pub Date : 2023-10-17 Saptarshi Maji, Marinella Pirozzi, Ruturaj, Raviranjan Pandey, Tamal Ghosh, Santanu Das, Arnab Gupta
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Interferon induction by STING requires its translocation to the late endosomes Traffic (IF 4.5) Pub Date : 2023-09-02 Chenyao Wang, Nikhil Sharma, Patricia M. Kessler, Ganes C. Sen
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Co-chaperone BAG3 enters autophagic pathway via its interaction with microtubule associated protein 1 light chain 3 beta Traffic (IF 4.5) Pub Date : 2023-09-01 Hagen Körschgen, Marius Baeken, Daniel Schmitt, Heike Nagel, Christian Behl
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Diamond controls epithelial polarity through the dynactin-dynein complex Traffic (IF 4.5) Pub Date : 2023-08-29 Hang Zhao, Lin Shi, Zhengran Li, Ruiyan Kong, Lemei Jia, Shan Lu, Jian-Hua Wang, Meng-qiu Dong, Xuan Guo, Zhouhua Li
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Dynamic tandem proximity-based proteomics—Protein trafficking at the proteome-scale Traffic (IF 4.5) Pub Date : 2023-08-15 Eric Chevet, Maria Antonietta De Matteis, Eeva-Liisa Eskelinen, Hesso Farhan
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Combination of hydrophobicity and codon usage bias determines sorting of model K+ channel protein to either mitochondria or endoplasmic reticulum Traffic (IF 4.5) Pub Date : 2023-08-14 Anja J. Engel, Steffen Paech, Markus Langhans, James L. van Etten, Anna Moroni, Gerhard Thiel, Oliver Rauh
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Statistical modeling of mRNP transport in dendrites: A comparative analysis of β-actin and Arc mRNP dynamics Traffic (IF 4.5) Pub Date : 2023-08-06 Hyerim Ahn, Xavier Durang, Jae Youn Shim, Gaeun Park, Jae-Hyung Jeon, Hye Yoon Park
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Anterograde trafficking of Toll-like receptors requires the cargo sorting adaptors TMED-2 and 7 Traffic (IF 4.5) Pub Date : 2023-07-26 Julia E. J. Holm, Sandro G. Soares, Martyn F. Symmons, Afiqah Saleh Huddin, Martin C. Moncrieffe, Nicholas J. Gay
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Restoration of β-GC trafficking improves the lysosome function in Gaucher disease Traffic (IF 4.5) Pub Date : 2023-07-25 Saloni Patel, Dhwani Radhakrishnan, Darpan Kumari, Priyanka Bhansali, Subba Rao Gangi Setty
Lysosomes function as a primary site for catabolism and cellular signaling. These organelles digest a variety of substrates received through endocytosis, secretion and autophagy with the help of resident acid hydrolases. Lysosomal enzymes are folded in the endoplasmic reticulum (ER) and trafficked to lysosomes via Golgi and endocytic routes. The inability of hydrolase trafficking due to mutations or
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Fast backward steps and detachment of single kinesin molecules measured under a wide range of loads Traffic (IF 4.5) Pub Date : 2023-07-18 Yuichi Kondo, Kazuo Sasaki, Hideo Higuchi
To understand force generation under a wide range of loads, the stepping of single kinesin molecules was measured at loads from −20 to 42 pN by optical tweezers with high temporal resolution. The optical trap has been improved to halve positional noise and increase bandwidth by using 200-nm beads. The step size of the forward and backward steps was 8.2 nm even over a wide range of loads. Histograms
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Distinct functional domains of the epsin-related Ent5p, a cargo adaptor for the SNARE Tlg2p in transport between endosomes and Golgi Traffic (IF 4.5) Pub Date : 2023-07-11 Lara Petersen, Rimma Bachmann, Sven Meinerz, Anne Tanz, Gabriele Fischer von Mollard
The epsin-related adaptor proteins Ent3p and Ent5p participate in budding of clathrin coated vesicles in transport between trans-Golgi network and endosomes in yeast. Transport of the arginine permease Can1p was analyzed, which recycles between plasma membrane and endosomes and can be targeted to the vacuole for degradation. ent3∆ cells accumulate Can1p-GFP in endosomes. Can1p-GFP is transported faster
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Real-time monitoring of cell surface protein arrival with split luciferases Traffic (IF 4.5) Pub Date : 2023-07-04 Alexandra A. M. Fischer, Larissa Schatz, Julia Baaske, Winfried Römer, Wilfried Weber, Roland Thuenauer
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Endocytic pathways of pathogenic protein aggregates in neurodegenerative diseases Traffic (IF 4.5) Pub Date : 2023-07-01 Pravin Hivare, Kratika Mujmer, Gitanjali Swarup, Sharad Gupta, Dhiraj Bhatia
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Cholangiocytes express an isoform of soluble adenylyl cyclase that is N-linked glycosylated and secreted in extracellular vesicles Traffic (IF 4.5) Pub Date : 2023-06-23 Simei Go, Hang Lam Li, Jung-Chin Chang, Arthur J. Verhoeven, Ronald P. J. Oude Elferink
Soluble adenylyl cyclase (sAC)-derived cAMP regulates various cellular processes; however, the regulatory landscape mediating sAC protein levels remains underexplored. We consistently observed a 85 kD (sAC85) or 75 kD (sAC75) sAC protein band under glucose-sufficient or glucose-deprived states, respectively, in H69 cholangiocytes by immunoblotting. Deglycosylation by PNGase-F demonstrated that both
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Syntaxin-5's flexibility in SNARE pairing supports Golgi functions Traffic (IF 4.5) Pub Date : 2023-06-21 Zinia D'Souza, Irina Pokrovskaya, Vladimir V. Lupashin
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The role of extracellular vesicles in iron homeostasis and ferroptosis: Focus on musculoskeletal diseases Traffic (IF 4.5) Pub Date : 2023-06-21 Zhiwei Liao, Bide Tong, Zixuan Ou, Junyu Wei, Ming Lei, Cao Yang
Iron homeostasis is crucial for maintaining proper cellular function, and its disruption is considered one of the pathogenic mechanisms underlying musculoskeletal diseases. Under conditions of oxidative stress, the accumulation of cellular iron overload and lipid peroxidation can lead to ferroptosis. Extracellular vesicles (EVs), serving as mediators in the cell-to-cell communication, play an important
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Crucial roles of Rab22a in endosomal cargo recycling Traffic (IF 4.5) Pub Date : 2023-06-21 Lingjie Kong, Shenghao Huang, Yuxuan Bao, Yingtong Chen, Chunyan Hua, Sheng Gao
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Deacidification of endolysosomes by neuronal aging drives synapse loss Traffic (IF 4.5) Pub Date : 2023-05-23 Tatiana Burrinha, César Cunha, Michael J. Hall, Mafalda Lopes-da-Silva, Miguel C. Seabra, Cláudia Guimas Almeida
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Pseudophosphatase STYXL1 depletion enhances glucocerebrosidase trafficking to lysosomes via ER stress Traffic (IF 4.5) Pub Date : 2023-05-17 Saloni Patel, Anshul Milap Bhatt, Priyanka Bhansali, Subba Rao Gangi Setty
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Genetic disruption of mammalian endoplasmic reticulum-associated protein degradation: Human phenotypes and animal and cellular disease models Traffic (IF 4.5) Pub Date : 2023-05-15 Sally Badawi, Feda E. Mohamed, Divya Saro Varghese, Bassam R. Ali
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Oxidized cholesteryl ester induces exocytosis of dysfunctional lysosomes in lipidotic macrophages Traffic (IF 4.5) Pub Date : 2023-05-02 Neuza Domingues, André R. A. Marques, Rita Diogo Almeida Calado, Inês S. Ferreira, Cristiano Ramos, José Ramalho, Maria I. L. Soares, Telmo Pereira, Luís Oliveira, José R. Vicente, Louise H. Wong, Inês C. M. Simões, Teresa M. V. D. Pinho e Melo, Andrew Peden, Cláudia Guimas Almeida, Clare E. Futter, Rosa Puertollano, Winchil L. C. Vaz, Otília V. Vieira
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Syntaxin 3 SPI-2 dependent crosstalk facilitates the division of Salmonella containing vacuole Traffic (IF 4.5) Pub Date : 2023-04-28 Ritika Chatterjee, Abhilash Vijay Nair, Anmol Singh, Nishi Mehta, Subba Rao Gangi Setty, Dipshikha Chakravortty
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Out of the ESCPE room: Emerging roles of endosomal SNX-BARs in receptor transport and host–pathogen interaction Traffic (IF 4.5) Pub Date : 2023-04-23 Boris Simonetti, James L. Daly, Peter J. Cullen
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SWIP mediates retromer-independent membrane recruitment of the WASH complex Traffic (IF 4.5) Pub Date : 2023-03-30 Vojtěch Dostál, Tereza Humhalová, Pavla Beránková, Ondřej Pácalt, Lenka Libusová
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A TRAFFIC themed series - Host membrane trafficking subversion by pathogens. Traffic (IF 4.5) Pub Date : 2023-03-01 Eric Chevet,Maria Antonietta De Matteis,Eeva-Liisa Eskelinen,Hesso Farhan
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N-BAR and F-BAR proteins—endophilin-A3 and PSTPIP1—control clathrin-independent endocytosis of L1CAM Traffic (IF 4.5) Pub Date : 2023-02-27 Camille Lemaigre, Apolline Ceuppens, Cesar Augusto Valades-Cruz, Benjamin Ledoux, Bastien Vanbeneden, Mujtaba Hassan, Fredrik R. Zetterberg, Ulf J. Nilsson, Ludger Johannes, Christian Wunder, Henri-François Renard, Pierre Morsomme
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Cysteinyl leukotriene receptor 1 is a potent regulator of the endosomal-lysosomal system in the ARPE-19 retinal pigment epithelial cell line Traffic (IF 4.5) Pub Date : 2023-01-27 Andreas Koller, Susanne Maria Brunner, Julia Preishuber-Pflügl, Christian Runge, Anja-Maria Ladek, Herbert Anton Reitsamer, Andrea Trost
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Golgi screen identifies the RhoGEF Solo as a novel regulator of RhoB and endocytic transport Traffic (IF 4.5) Pub Date : 2022-12-23 Cristiana Lungu, Florian Meyer, Marcel Hörning, Jasmin Steudle, Anja Braun, Bettina Noll, David Benz, Felix Fränkle, Simone Schmid, Stephan A. Eisler, Monilola A. Olayioye
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Metabolic depletion of sphingolipids inhibits agonist-induced endocytosis of the serotonin1A receptor Traffic (IF 4.5) Pub Date : 2022-12-19 Abhishek Kumar, Parijat Sarkar, Amitabha Chattopadhyay
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Inhibition of cholesterol transport impairs Cav-1 trafficking and small extracellular vesicles secretion, promoting amphisome formation in melanoma cells Traffic (IF 4.5) Pub Date : 2022-12-15 Daniela Peruzzu, Zaira Boussadia, Federica Fratini, Francesca Spadaro, Lucia Bertuccini, Massimo Sanchez, Maria Carollo, Paola Matarrese, Mario Falchi, Francesca Iosi, Carla Raggi, Isabella Parolini, Alessandra Carè, Massimo Sargiacomo, Maria Cristina Gagliardi, Katia Fecchi
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Henipaviruses and lyssaviruses target nucleolar treacle protein and regulate ribosomal RNA synthesis Traffic (IF 4.5) Pub Date : 2022-12-08 Stephen M. Rawlinson, Tianyue Zhao, Katie Ardipradja, Yilin Zhang, Patrick F. Veugelers, Jennifer A. Harper, Cassandra T. David, Vinod Sundaramoorthy, Gregory W. Moseley
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Acute COG complex inactivation unveiled its immediate impact on Golgi and illuminated the nature of intra-Golgi recycling vesicles Traffic (IF 4.5) Pub Date : 2022-12-05 Farhana Taher Sumya, Irina D. Pokrovskaya, Zinia D'Souza, Vladimir V. Lupashin
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GTP-stimulated membrane fission by the N-BAR protein AMPH-1 Traffic (IF 4.5) Pub Date : 2022-11-26 Lauren Kustigian, Xue Gong, Wei Gai, Jirapat Thongchol, Junjie Zhang, Jason Puchalla, Chavela M. Carr, Hays S. Rye
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AP2S1 regulates APP degradation through late endosome–lysosome fusion in cells and APP/PS1 mice Traffic (IF 4.5) Pub Date : 2022-11-22 Qi-Xin Wen, Biao Luo, Xiao-Yong Xie, Gui-Feng Zhou, Jian Chen, Li Song, Yue Liu, Shi-Qi Xie, Long Chen, Kun-Yi Li, Xiao-Jiao Xiang, Guo-Jun Chen
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Cab45 deficiency leads to the mistargeting of progranulin and prosaposin and aberrant lysosomal positioning Traffic (IF 4.5) Pub Date : 2022-11-18 Mai Ly Tran, Johanna Tüshaus, Yeongho Kim, Bulat R. Ramazanov, Swathi Devireddy, Stefan F. Lichtenthaler, Shawn M. Ferguson, Julia von Blume
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Multiplexed cellular profiling identifies an organoselenium compound as an inhibitor of CRM1-mediated nuclear export Traffic (IF 4.5) Pub Date : 2022-11-10 Lucia Jimenez, Victor Mayoral-Varo, Carlos Amenábar, Judit Ortega, João G. N. Sequeira, Miguel Machuqueiro, Cristiana Mourato, Romano Silvestri, Andrea Angeli, Fabrizio Carta, Claudiu T. Supuran, Diego Megías, Bibiana I. Ferreira, Wolfgang Link
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Developmental program-independent secretory granule degradation in larval salivary gland cells of Drosophila Traffic (IF 4.5) Pub Date : 2022-11-10 Tamás Csizmadia, Anna Dósa, Erika Farkas, Belián Valentin Csikos, Eszter Adél Kriska, Gábor Juhász, Péter Lőw
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An AP-3-dependent pathway directs phagosome fusion with Rab8 and Rab11 vesicles involved in TLR2 signaling Traffic (IF 4.5) Pub Date : 2022-10-12 Tanja Petnicki-Ocwieja, Bijaya Sharma, Urmila Powale, Devesh Pathak, Shumin Tan, Linden T. Hu
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Correction to: Evolution of factors shaping the endoplasmic reticulum Traffic (IF 4.5) Pub Date : 2022-09-18 Aspasia Kontou, Emily K. Herman, Mark C. Field, Joel B. Dacks, V. Lila Koumandou
The authors note an error in Figure 3 of the article “Evolution of factors shaping the endoplasmic reticulum”(1), which is corrected in Figure 3 below. The branches for M. brevicollis and T. adhaerens should be above the branching point from fungi, not below. FIGURE 3 Open in figure viewerPowerPoint Distribution of ER morphology proteins mapped onto eukaryotic phylogeny. The most likely point of origin
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Hox-driven conditional immortalization of myeloid and lymphoid progenitors: Uses, advantages, and future potential Traffic (IF 4.5) Pub Date : 2022-09-18 Shranjit S. Lail, Corey R. Arnold, Luiz G. N. de Almeida, Neil McKenna, Jose A. Chiriboga, Antoine Dufour, Amy L. Warren, Robin Michael Yates
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Roles of long noncoding RNAs and small extracellular vesicle-long noncoding RNAs in type 2 diabetes Traffic (IF 4.5) Pub Date : 2022-09-15 Wenguang Chang, Man Wang, Yuan Zhang, Fei Yu, Bin Hu, Katarzyna Goljanek-Whysall, Peifeng Li
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A LRRK2/dLRRK-mediated lysosomal pathway that contributes to glial cell death and DA neuron survival Traffic (IF 4.5) Pub Date : 2022-08-27 Linfang Wang, Honglei Wang, Shuanglong Yi, Shiping Zhang, Margaret S. Ho
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Dynamics of axonal β-actin mRNA in live hippocampal neurons Traffic (IF 4.5) Pub Date : 2022-08-18 Byung Hun Lee, Seokyoung Bang, Seung-Ryeol Lee, Noo Li Jeon, Hye Yoon Park
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Cdc42 GTPase activating proteins Rga4 and Rga6 coordinate septum synthesis and membrane trafficking at the division plane during cytokinesis Traffic (IF 4.5) Pub Date : 2022-08-17 Bethany F. Campbell, Brian S. Hercyk, Ashlei R. Williams, Ema San Miguel, Haylee G. Young, Maitreyi E. Das
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The Medicines for Malaria Venture Malaria Box contains inhibitors of protein secretion in Plasmodium falciparum blood stage parasites Traffic (IF 4.5) Pub Date : 2022-07-31 Oliver Looker, Madeline G. Dans, Hayley E. Bullen, Brad E. Sleebs, Brendan S. Crabb, Paul R. Gilson
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Defective axonal transport of endo-lysosomes and dense core vesicles in a Drosophila model of C9-ALS/FTD Traffic (IF 4.5) Pub Date : 2022-07-31 Hyun Sung, Thomas E. Lloyd
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Evolution of factors shaping the endoplasmic reticulum Traffic (IF 4.5) Pub Date : 2022-07-31 Aspasia Kontou, Emily K. Herman, Mark C. Field, Joel B. Dacks, V. Lila Koumandou