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Hsa_circ_0004872 alleviates meningioma progression by sponging miR-190a-3p/PTEN signaling BMC Cancer (IF 3.8) Pub Date : 2024-03-18 Yongkai Huang, Zhihui Wu, Zewei Peng, Anmin Liu, Wen Yuan, Deqing Han, Junmin Peng
Meningioma, the most prevalent intracranial tumor, possesses a significant propensity for malignant transformation. Circular RNAs (circ-RNAs), a class of non-coding RNAs, have emerged as crucial players in tumorigenesis. This study explores the functional relevance of hsa_circ_0004872, a specific circ-RNA, in the context of meningioma. Molecular structure and stability of hsa_circ_0004872 were elucidated
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Nomogram to predict overall survival of patients receiving radical gastrectomy and incomplete peri-operative adjuvant chemotherapy for stage II/III gastric cancer: a retrospective bi-center cohort study BMC Cancer (IF 3.8) Pub Date : 2024-03-18 Dian Liu, Hu Quan, Min Ma, Huijun Zhou, Xiaolin Yang, Zhengchun Wu, Jia Luo, Hua Xiao, Yanping Xiao
To establish a nomogram to predict the probability of survival of patients with stage II/III gastric cancer (GC) who received incomplete peri-operative adjuvant chemotherapy (PAC). The medical records of stage II/III GC patients who received curative resection and 1 to 5 cycles of PAC from two tertiary hospitals were retrospectively reviewed. Patients were randomly classified into either a training
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Correction: Impact of preoperative antiviral therapy on the prognosis of hepatitis B virus-related hepatocellular carcinoma BMC Cancer (IF 3.8) Pub Date : 2024-03-15 Yuxin Liang, Deyuan Zhong, Zilong Zhang, Yuhao Su, Su Yan, Chunyou Lai, Yutong Yao, Ying Shi, Xiaolun Huang, Jin Shang
Correction: BMC Cancer 24, 291 (2024) https://doi.org/10.1186/s12885-024-12031-0 Following publication of the original article [1], the author noticed a typesetting error. The equal contributions statement was erroneously omitted. The equal contributions statement is as follows: Yuxin Liang and Deyuan Zhong contributed equally to this manuscript. Further to this, affiliation 1 has been corrected. The
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Is low-dose computed tomography for lung cancer screening conveniently accessible in China? A spatial analysis based on cross-sectional survey BMC Cancer (IF 3.8) Pub Date : 2024-03-14 Jay Pan, Jianjian Wang, Wenjuan Tao, Chaohui Wang, Xiaojun Lin, Xiuli Wang, Ruicen Li
Regular Low-Dose Computed Tomography (LDCT) for lung cancer high-risk population has been proved to improve health outcomes and relieve disease burden efficiently for both individual and society. With geographical impedance becoming the major barrier preventing patients from getting timely healthcare service, this study incorporated health seeking behavior in estimating spatial accessibility of relative
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Establishment of a risk prediction model for bowel preparation failure prior to colonoscopy BMC Cancer (IF 3.8) Pub Date : 2024-03-14 Na Zhang, Miaomiao Xu, Xing Chen
This study aimed to determine the factors that contribute to the failure of bowel preparation in patients undergoing colonoscopy and to develop a risk prediction model. A total of 1115 outpatients were included. Patients were randomly divided into two groups: the modeling group (669 patients) and the validation group (446 patients). In the modeling group, patients were further divided into two groups
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Adult head and neck rhabdomyosarcoma: radiotherapy- based treatment, outcomes, and predictors of survival BMC Cancer (IF 3.8) Pub Date : 2024-03-14 Dan Zhao, Fang Zhou, Weixin Liu, Zhou Huang, Xiaolong Xu, Baomin Zheng, Changqing Liu, Chujie Bai, Jiayong Liu, Yan Sun, Weihu Wang, Shaowen Xiao
Adult head and neck rhabdomyosarcoma (HNRMS) is an exceptionally rare malignancy, and there is a paucity of data and research dedicated to understanding its characteristics and management in adult populations. This study aimed to assess the outcomes and identify survival predictors in adult HNRMS. We retrospectively evaluated 42 adult patients (> 16 years) with HNRMS who received radiotherapy (RT)-based
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Role of beta-(1→3)(1→6)-D-glucan derived from yeast on natural killer (NK) cells and breast cancer cell lines in 2D and 3D cultures BMC Cancer (IF 3.8) Pub Date : 2024-03-14 Abdelhadi Boulifa, Martin J. Raftery, Alexander Sebastian Franzén, Clarissa Radecke, Sebastian Stintzing, Jens-Uwe Blohmer, Gabriele Pecher
Beta-(1,3)(1,6)-D-glucan is a complex polysaccharide, which is found in the cell wall of various fungi, yeasts, bacteria, algae, barley, and oats and has immunomodulatory, anticancer and antiviral effects. In the present study, we investigated the effect of beta-(1,3)(1,6)-D-glucan derived from yeast on the proliferation of primary NK cells and breast cancer cell lines in 2D and 3D models, and on the
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Spectrum of malignant and premalignant skin lesions in 505 adult subjects at risk of skin cancers BMC Cancer (IF 3.8) Pub Date : 2024-03-14 Reetta Nevakivi, Hanna Siiskonen, Salla Haimakainen, Ilkka T. Harvima
Patients at risk of skin cancers can develop varying types of cutaneous malignancies. However, some subjects may develop only one type of lesion. In this cross-sectional study, the spectrum of premalignant (PM) and malignant skin lesions and their risk factors were studied. Therefore, 505 adult subjects (aged 21–79 years, 256 males and 249 females, 96 with immunosuppression) at risk of any type of
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Survival time prediction in patients with high-grade serous ovarian cancer based on 18F-FDG PET/CT- derived inter-tumor heterogeneity metrics BMC Cancer (IF 3.8) Pub Date : 2024-03-12 Dianning He, Xin Zhang, Zhihui Chang, Zhaoyu Liu, Beibei Li
The presence of heterogeneity is a significant attribute within the context of ovarian cancer. This study aimed to assess the predictive accuracy of models utilizing quantitative 18F-FDG PET/CT derived inter-tumor heterogeneity metrics in determining progression-free survival (PFS) and overall survival (OS) in patients diagnosed with high-grade serous ovarian cancer (HGSOC). Additionally, the study
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Impact of timing and format of patient decision aids for breast cancer patients on their involvement in and preparedness for decision making - the IMPACTT randomised controlled trial protocol BMC Cancer (IF 3.8) Pub Date : 2024-03-12 Bettina Mølri Knudsen, Stine Rauff Søndergaard, Dawn Stacey, Karina Dahl Steffensen
After curative surgery for early-stage breast cancer, patients face a decision on whether to undergo surgery alone or to receive one or more adjuvant treatments, which may lower the risk of recurrence. Variations in survival outcomes are often marginal but there are differences in the side effects and other features of the options that patients may value differently. Hence, the patient’s values and
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High-content analysis identified synergistic drug interactions between INK128, an mTOR inhibitor, and HDAC inhibitors in a non-small cell lung cancer cell line BMC Cancer (IF 3.8) Pub Date : 2024-03-12 Sijiao Wang, Juliano Oliveira-Silveira, Gang Fang, Jungseog Kang
The development of drug resistance is a major cause of cancer therapy failures. To inhibit drug resistance, multiple drugs are often treated together as a combinatorial therapy. In particular, synergistic drug combinations, which kill cancer cells at a lower concentration, guarantee a better prognosis and fewer side effects in cancer patients. Many studies have sought out synergistic combinations by
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Knockdown of ribosome RNA processing protein 15 suppresses migration of hepatocellular carcinoma through inhibiting PATZ1-associated LAMC2/FAK pathway BMC Cancer (IF 3.8) Pub Date : 2024-03-12 Tongtong Pan, Jinhai Li, Ouyang Zhang, Yuqin Zhu, Hongfei Zhou, Mengchen Ma, Yanwen Yu, Jiaojian Lyu, Yongping Chen, Liang Xu
Ribosomal RNA processing protein 15 (RRP15) has been found to regulate the progression of hepatocellular carcinoma (HCC). Nevertheless, the extent to which it contributes to the spread of HCC cells remains uncertain. Thus, the objective of this research was to assess the biological function of RRP15 in the migration of HCC. The expression of RRP15 in HCC tissue microarray (TMA), tumor tissues and cell
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A multicenter high-quality data registry for advanced proton therapy approaches: the POWER registry BMC Cancer (IF 3.8) Pub Date : 2024-03-12 Daniela Alterio, Maria Giulia Vincini, Stefania Volpe, Luca Bergamaschi, Mattia Zaffaroni, Sara Gandini, Giulia Peruzzotti, Federica Cattani, Cristina Garibaldi, Barbara Alicja Jereczek-Fossa, Roberto Orecchia
Paucity and low evidence-level data on proton therapy (PT) represent one of the main issues for the establishment of solid indications in the PT setting. Aim of the present registry, the POWER registry, is to provide a tool for systematic, prospective, harmonized, and multidimensional high-quality data collection to promote knowledge in the field of PT with a particular focus on the use of hypofractionation
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Pre-operative vs. post-operative stereotactic radiosurgery for operative metastatic brain tumors: study protocol for a phase III clinical trial BMC Cancer (IF 3.8) Pub Date : 2024-03-12 David M. Routman, Ignacio Jusue-Torres, Paul D. Brown, Daniel M. Trifiletti, Sujay A. Vora, Desmond A. Brown, Ian F. Parney, Terry C. Burns, Elizabeth Yan
Almost one third of cancer patients in the United States will develop brain metastases on an annual basis. Surgical resection is indicated in the setting of brain metastases for reasons, such as maximizing local control in select patients, decompression of mass effect, and/or tissue diagnosis. The current standard of care following resection of a brain metastasis has shifted from whole brain radiation
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Neuropilin-1 and placental growth factor as prognostic factors in metastatic breast cancer BMC Cancer (IF 3.8) Pub Date : 2024-03-11 Niina Mäenpää, Leena Tiainen, Mari Hämäläinen, Tiina Luukkaala, Minna Tanner, Outi Lahdenperä, Pia Vihinen, Peeter Karihtala, Pirkko-Liisa Kellokumpu-Lehtinen, Eeva Moilanen, Arja Jukkola
Angiogenesis is crucial for tumor development, progression, and metastasizing. The most important regulator of angiogenesis is the vascular endothelial growth factor (VEGF) family, which is involved in multiple pathways in tumor microenvironment. The objective of this study was to investigate the prognostic value of the VEGF family in patients treated for metastatic breast cancer. The emphasis was
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ST14 interacts with TMEFF1 and is a predictor of poor prognosis in ovarian cancer BMC Cancer (IF 3.8) Pub Date : 2024-03-11 Xin Nie, Lingling Gao, Mingjun Zheng, Shuang Wang, Caixia Wang, Xiao Li, Ouxuan Liu, Rui Gou, Juanjuan Liu, Bei Lin
TMEFF1 is a new protein involved in the physiological functions of the central nervous system, and we previously reported TMEFF1 can promote ovarian cancer. ST14 was determined to be involved in the processes of epidermal differentiation, epithelial cell integrity, and vascular endothelial cell migration, etc. The relationship between ST14 and TMEFF1 in the ovary remains unknown. In this study, we
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Validation of primary and outcome data quality in a Swedish population-based breast cancer quality registry BMC Cancer (IF 3.8) Pub Date : 2024-03-11 Sofia Palmér, Carl Blomqvist, Marit Holmqvist, Henrik Lindman, Mats Lambe, Johan Ahlgren
Population-based cancer quality registries are of great importance for the improvement of cancer care. However, little is known about the quality of recurrence data in cancer quality registries. The aim of this study was to evaluate data quality in the regional Breast Cancer Quality Registry of Central Sweden, with emphasis on the validity of recorded information on recurrence. Validation by re-abstraction
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Identification of BACH1-IT2-miR-4786-Siglec-15 immune suppressive axis in bladder cancer BMC Cancer (IF 3.8) Pub Date : 2024-03-11 Xingzhi Li, Ziji Liang, Jiexin Pan, Meng Zhang, Jinli Liu, Rong Hu, Caiyan Liao
The sialic acid binding Ig like lectin 15 (Siglec-15) was previously identified as tumor immune suppressor gene in some human cancers with elusive molecular mechanism to be elucidated. The continuous focus on both clinical and basic biology of bladder cancer leads us to characterize aberrant abundance of BACH1-IT2 associating with stabilization of Siglec-15, which eventually contributes to local immune
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The relationship between tumor-infiltrating neutrophils and clinical outcomes in patients with resectable hepatocellular carcinoma BMC Cancer (IF 3.8) Pub Date : 2024-03-11 Jung Hee Lee, Young Mi Hong
The impact of tumor-infiltrating neutrophils (TINs) on clinical outcomes has been reported in various cancer types, but their role in hepatocellular carcinoma (HCC) has not been fully evaluated. The aim of this study was to investigate the prognostic values for TINs in HCC patients undergoing curative resection. We assessed immune markers (CD3, CD4, CD8, CD66b) using immunohistochemistry in 115 patients
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FLI1 induces erythroleukemia through opposing effects on UBASH3A and UBASH3B expression BMC Cancer (IF 3.8) Pub Date : 2024-03-09 Jie Wang, Chunlin Wang, Anling Hu, Kunlin Yu, Yi Kuang, Babu Gajendran, Eldad Zacksenhaus, Klarke Michael Sample, Xiao Xiao, Wuling Liu, Yaacov Ben-David
FLI1 is an oncogenic transcription factor that promotes diverse malignancies through mechanisms that are not fully understood. Herein, FLI1 is shown to regulate the expression of Ubiquitin Associated and SH3 Domain Containing A/B (UBASH3A/B) genes. UBASH3B and UBASH3A are found to act as an oncogene and tumor suppressor, respectively, and their combined effect determines erythroleukemia progression
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Integrated analysis of transcriptome and genome variations in pediatric T cell acute lymphoblastic leukemia: data from north Indian tertiary care center BMC Cancer (IF 3.8) Pub Date : 2024-03-08 Minu Singh, Pankaj Sharma, Prateek Bhatia, Amita Trehan, Rozy Thakur, Sreejesh Sreedharanunni
T-cell acute lymphoblastic leukemia (T-ALL) is a genetically heterogeneous disease with poor prognosis and inferior outcome. Although multiple studies have been perform on genomics of T-ALL, data from Indian sub-continent is scarce. In the current study we aimed to identify the genetic variability of T-ALL in an Indian cohort of pediatric (age ≤ 12 years) T-ALL patients (n = 25) by whole transcriptome
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PErspective and current status of Radiotherapy Service in IRan (PERSIR)-1 study: assessment of current external beam radiotherapy facilities, staff and techniques compared to the international guidelines BMC Cancer (IF 3.8) Pub Date : 2024-03-08 Arefeh Saeedian, Fatemeh-sadat Tabatabaei, Amirali Azimi, Mohammad Babaei, Marzieh Lashkari, Ebrahim Esmati, Zeinab Abiar, Leila Moadabshoar, Saleh Sandoughdaran, Mitchell Kamrava, Arya Amini, Reza Ghalehtaki
Radiotherapy (RT) is an essential treatment modality against cancer and becoming even more in demand due to the anticipated increase in cancer incidence. Due to the rapid development of RT technologies amid financial challenges, we aimed to assess the available RT facilities and the issues with achieving health equity based on current equipment compared to the previous reports from Iran. A survey arranged
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Regulation of metastatic potential by drug repurposing and mitochondrial targeting in colorectal cancer cells BMC Cancer (IF 3.8) Pub Date : 2024-03-08 Shashank Mathur, Pransu Srivastava, Anubhav Srivastava, Neeraj Kumar Rai, Sabiya Abbas, Ashok kumar, Meenakshi Tiwari, Lokendra Kumar Sharma
Increased mitochondrial activities contributing to cancer cell proliferation, invasion, and metastasis have been reported in different cancers; however, studies on the therapeutic targeting of mitochondria in regulating cell proliferation and invasiveness are limited. Because mitochondria are believed to have evolved through bacterial invasion in mammalian cells, antibiotics could provide an alternative
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Diagnostic potential of exosomal extracellular vesicles in oncology BMC Cancer (IF 3.8) Pub Date : 2024-03-08 Mickensone Andre, Allen Caobi, Jana S. Miles, Arti Vashist, Marco A. Ruiz, Andrea D. Raymond
Liquid biopsy can detect circulating cancer cells or tumor cell-derived DNA at various stages of cancer. The fluid from these biopsies contains extracellular vesicles (EVs), such as apoptotic bodies, microvesicles, exomeres, and exosomes. Exosomes contain proteins and nucleic acids (DNA/RNA) that can modify the microenvironment and promote cancer progression, playing significant roles in cancer pathology
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Consolidation chemotherapy after definitive concurrent chemoradiotherapy in patients with inoperable esophageal squamous cell carcinoma: a multicenter non-inferiority phase III randomized clinical trial BMC Cancer (IF 3.8) Pub Date : 2024-03-07 Chengcheng Fan, Xu Wang, Xiaoli Zheng, Yanan Sun, Ke Ye, Yue Jiang, Xiao Liu, Wencai Xu, Yang Liu, Yuanyuan Yang, Jinsong Liu, Qiong Jiang, Chunyu He, Xiaoyuan Wu, Xin Nie, Jingwei Zhang, Bo Tan, Wen Wang, Yougai Zhang, Zhuo Feng, Chengliang Yang, Yufei Lu, Hailong Liu, Xijuan Chen, Jing Xu, Fang Liu, Xuefeng Zheng, Jianhua Wang, Shang Wu, Guofu Chen, Yaowen Zhang, Linzhi Jin, Hong Ge
Definitive concurrent chemoradiotherapy (dCCRT) is the gold standard for the treatment of locally advanced esophageal squamous cell carcinoma (ESCC). However, the potential benefits of consolidation chemotherapy after dCCRT in patients with esophageal cancer remain debatable. Prospective randomized controlled trials comparing the outcomes of dCCRT with or without consolidation chemotherapy in patients
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Apolipoprotein A-IV concentrations and cancer in a large cohort of chronic kidney disease patients: results from the GCKD study BMC Cancer (IF 3.8) Pub Date : 2024-03-07 Barbara Kollerits, Simon Gruber, Inga Steinbrenner, Johannes P. Schwaiger, Hansi Weissensteiner, Sebastian Schönherr, Lukas Forer, Fruzsina Kotsis, Ulla T. Schultheiss, Heike Meiselbach, Christoph Wanner, Kai-Uwe Eckardt, Florian Kronenberg
Chronic kidney disease (CKD) is highly connected to inflammation and oxidative stress. Both favour the development of cancer in CKD patients. Serum apolipoprotein A-IV (apoA-IV) concentrations are influenced by kidney function and are an early marker of kidney impairment. Besides others, it has antioxidant and anti-inflammatory properties. Proteomic studies and small case–control studies identified
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Regulation of cancer stem cells by CXCL1, a chemokine whose secretion is controlled by MCM2 BMC Cancer (IF 3.8) Pub Date : 2024-03-07 Yeon-Jee Kahm, In-Gyu Kim, Rae-Kwon Kim
A high expression pattern of minichromosome maintenance 2 (MCM2) has been observed in various cancers. MCM2 is a protein involved in the cell cycle and plays a role in cancer growth and differentiation by binding to six members of the MCM subfamily. The MCM protein family includes MCM2 through MCM7. MCM2 has shown high expression in both lung cancer stem cells (LCSCs) and glioma stem cells (GSCs).
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Exploration of the relationship between tumor-infiltrating lymphocyte score and histological grade in breast cancer BMC Cancer (IF 3.8) Pub Date : 2024-03-07 Deyong Kang, Chuan Wang, Zhonghua Han, Liqin Zheng, Wenhui Guo, Fangmeng Fu, Lida Qiu, Xiahui Han, Jiajia He, Lianhuang Li, Jianxin Chen
The histological grade is an important factor in the prognosis of invasive breast cancer and is vital to accurately identify the histological grade and reclassify of Grade2 status in breast cancer patients. In this study, data were collected from 556 invasive breast cancer patients, and then randomly divided into training cohort (n = 335) and validation cohort (n = 221). All patients were divided into
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p53/E2F7 axis promotes temozolomide chemoresistance in glioblastoma multiforme BMC Cancer (IF 3.8) Pub Date : 2024-03-07 Jiao Meng, Wei Qian, Zhenkun Yang, Lingli Gong, Daxing Xu, Hongbo Huang, Xinyi Jiang, Zhening Pu, Ying Yin, Jian Zou
Glioblastoma multiforme (GBM) is the most aggressive form of brain cancer, and chemoresistance poses a significant challenge to the survival and prognosis of GBM. Although numerous regulatory mechanisms that contribute to chemoresistance have been identified, many questions remain unanswered. This study aims to identify the mechanism of temozolomide (TMZ) resistance in GBM. Bioinformatics and antibody-based
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Economic evaluation of germline genetic testing for breast cancer in low- and middle-income countries: a systematic review BMC Cancer (IF 3.8) Pub Date : 2024-03-07 Sook Pin Goh, Siew Chin Ong, Jue Ern Chan
Breast cancer (BC) is the most common cancer affecting women globally. Genetic testing serves as a prevention and treatment strategy for managing BC. This study aims to systematically review economic evaluations and the quality of selected studies involving genetic screening strategies for BC in low and middle-income countries (LMICs). A search was performed to identify related articles that were published
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Fully semantic segmentation for rectal cancer based on post-nCRT MRl modality and deep learning framework BMC Cancer (IF 3.8) Pub Date : 2024-03-07 Shaojun Xia, Qingyang Li, Hai-Tao Zhu, Xiao-Yan Zhang, Yan-Jie Shi, Ding Yang, Jiaqi Wu, Zhen Guan, Qiaoyuan Lu, Xiao-Ting Li, Ying-Shi Sun
Rectal tumor segmentation on post neoadjuvant chemoradiotherapy (nCRT) magnetic resonance imaging (MRI) has great significance for tumor measurement, radiomics analysis, treatment planning, and operative strategy. In this study, we developed and evaluated segmentation potential exclusively on post-chemoradiation T2-weighted MRI using convolutional neural networks, with the aim of reducing the detection
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Correction: Oncological risk of proximal gastrectomy for proximal advanced gastric cancer after neoadjuvant chemotherapy BMC Cancer (IF 3.8) Pub Date : 2024-03-06 Yonghe Chen, Xiaojiang Chen, Yi Lin, Shenyan Zhang, Zhiwei Zhou, Junsheng Peng
Correction: BMC Cancer 24, 255 (2024) https://doi.org/10.1186/s12885-024-11993-5 Following publication of the original article [1], the authors reported an error in Fig. 1, specifically in colour spectrum within the heatmap located in the figure's lower right quadrant. The incorrect and the correct figures are supplied in this correction article. Incorrect Fig. 1 Corrected Fig. 1 Fig. 1 Q1 (a) This
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Transversal approach via a bladder neck and prostate combined longitudinal incision versus standard approach of robotic-assisted radical prostatectomy for localized prostate cancer: a retrospective analysis BMC Cancer (IF 3.8) Pub Date : 2024-03-06 Zefan Shen, CenChao Yao, YuChen Bai, YiFan Wang, Qi Zhang
Transversal approach for robotic-assisted radical prostatectomy via a bladder neck and prostate combined longitudinal incision (L-RALP) is a novel surgical method for patients with respectable prostate cancer. There were 669 patients with prostate cancer underwent L-RALP or S-RALP which identified from April 2016 to April 2020. The perioperative outcomes, Expanded Prostate Cancer Index Composite for
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Cost-effectiveness of immunotherapies for advanced squamous non-small cell lung cancer: a systematic review BMC Cancer (IF 3.8) Pub Date : 2024-03-06 Minyu Cheng, Yanfei Shao, Li Li, Menglao Jiang, Zhouye Song
There are differences in the pharmacoeconomics of Immune checkpoint blocking (ICB) therapies for the treatment of lung squamous cell carcinoma (LSCC). However, no corresponding review studies have fully discussed the cost-effectiveness of ICBs in treating LSCC. The aim of this paper is to systematically review and evaluate all available pharmacoeconomic studies of ICBs for LSCC. The inclusion criteria
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Analyses of quality of life in cancer drug trials - a review of measurements and analytical choices in post-reimbursement studies BMC Cancer (IF 3.8) Pub Date : 2024-03-06 Mikael Svensson, Gabriella Chauca Strand, Carl Bonander, Naimi Johansson, Niklas Jakobsson
For drugs reimbursed with limited evidence of patient benefits, confirmatory evidence of overall survival (OS) and quality of life (QoL) benefits is important. For QoL data to serve as valuable input to patients and decision-makers, it must be measured and analyzed using appropriate methods. We aimed to assess the measurement and analyses of post-reimbursement QoL data for cancer drugs introduced in
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Epidemiological, clinical, and pathological characteristics of invasive breast cancer in Bedouin and Jewish women in southern Israel: a retrospective comparative study BMC Cancer (IF 3.8) Pub Date : 2024-03-06 Itamar Ben Shitrit, Ao Wang, Karny Ilan, Ravit Agassi, Sofyan Abu Freih, Julie Vaynshtein
Invasive breast cancer (IBC) is a leading cause of cancer-related death among women in Israel, regardless of ethnicity. This study compared IBC epidemiological, clinical, and pathological characteristics in Bedouin and Jewish patients in southern Israel. Medical records of 1514 Jewish and 191 Bedouin women with IBC treated at Soroka University Medical Center between 2014 and 2021 were analyzed retrospectively
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A clinicopathological study about the epidemiology of granulosa cell tumors in Lebanon BMC Cancer (IF 3.8) Pub Date : 2024-03-06 Sana Yaacoub, Labib Hajj, Aya Khairallah
Granulosa Cell Tumors (GCT) are considered the most frequent type of sex-cord stromal tumors. These tumors constitute 3-6% of neoplasms of the ovaries. GCTs are divided into 2 types: Juvenile GCT (JGCT) and Adult GCT (AGCT). Most patients are diagnosed early in the course of the disease and tend to have a favorable prognosis. In the surgical treatment of GCT, two main factors play role in the determination
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Rural-urban disparity in cancer burden and care: findings from an Indian cancer registry BMC Cancer (IF 3.8) Pub Date : 2024-03-06 Divya Khanna, Priyanka Sharma, Atul Budukh, Rajesh Vishwakarma, Anand N. Sharma, Sonali Bagal, Varsha Tripathi, Vijay Kumar Maurya, Pankaj Chaturvedi, Satyajit Pradhan
Cancer incidence and mortality vary across the globe, with nearly two-thirds of cancer-related deaths occurring in low- and middle-income countries. The rural-urban disparity in socio-demographic, behavioural, and lifestyle-related factors, as well as in access to cancer care, is one of the contributing factors. Population-based cancer registries serve as a measure for understanding the burden of cancer
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Contrast-enhanced CT radiomics for preoperative prediction of stage in epithelial ovarian cancer: a multicenter study BMC Cancer (IF 3.8) Pub Date : 2024-03-06 Yinping Leng, Ao Kan, Xiwen Wang, Xiaofen Li, Xuan Xiao, Yu Wang, Lan Liu, Lianggeng Gong
Preoperative prediction of International Federation of Gynecology and Obstetrics (FIGO) stage in patients with epithelial ovarian cancer (EOC) is crucial for determining appropriate treatment strategy. This study aimed to explore the value of contrast-enhanced CT (CECT) radiomics in predicting preoperative FIGO staging of EOC, and to validate the stability of the model through an independent external
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Construction of a prognostic model for hepatocellular carcinoma patients receiving transarterial chemoembolization treatment based on the Tumor Burden Score BMC Cancer (IF 3.8) Pub Date : 2024-03-06 Jiawei Lin, Jie Li, Yifan Kong, Junhui Yang, Yunjie Zhang, Guoqing Zhu, Zhijie Yu, Jinglin Xia
Patients with hepatocellular carcinoma (HCC) who undergo transarterial chemoembolization (TACE) may have varied outcomes based on their liver function and tumor burden diversity. This study aims to assess the prognostic significance of the tumor burden score (TBS) in these patients and develop a prognostic model for their overall survival. The study involved a retrospective analysis of 644 newly diagnosed
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Pretreatment prostate-specific antigen density as a predictor of biochemical recurrence in patients with prostate cancer: a meta-analysis BMC Cancer (IF 3.8) Pub Date : 2024-03-06 Feilun Cui, Yue Qiu, Wei Xu, Chen Zou, Yu Fan
A consensus has not been reached on the value of prostate-specific antigen density (PSAD) as a predictor of biochemical recurrence of prostate cancer. This meta-analysis aimed to evaluate the association between PSAD and biochemical recurrence of prostate cancer after primary treatment. Two authors systematically searched PubMed, Web of Science, and Embase databases (up to August September 10, 2023)
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Stereotactic ablative brachytherapy versus percutaneous microwave ablation for early-stage non-small cell lung cancer: a multicenter retrospective study BMC Cancer (IF 3.8) Pub Date : 2024-03-06 Chuanwang Wu, Binglong Cao, Guanghui He, Yuliang Li, Wujie Wang
To analyze the efficacy of stereotactic ablative brachytherapy (SABT) and percutaneous microwave ablation (MWA) for the treatment of early-stage non-small cell lung cancer (NSCLC). Patients with early-stage (T1-T2aN0M0) NSCLC who underwent CT-guided SABT or MWA between October 2014 and March 2017 at four medical centers were retrospectively analyzed. Survival, treatment response, and procedure-related
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The Effect of chemo- and radiotherapy on tumor necrosis in soft tissue sarcoma– does it influence prognosis? BMC Cancer (IF 3.8) Pub Date : 2024-03-06 Julian Fromm, Alexander Klein, Maya Kirilova, Lars Hartwin Lindner, Silke Nachbichler, Boris Michael Holzapfel, Sophia Samira Goller, Thomas Knösel, Hans Roland Dürr
Soft tissue sarcomas (STSs) are a heterogeneous group of tumors. Wide surgical resection is standard, often combined with neoadjuvant chemotherapy, radiotherapy, or both. Studies have shown the predictive value of tumor necrosis in bone sarcoma (BS); however, the role of necrosis in STS after neoadjuvant therapies is still unclear. This study aimed to investigate the role of chemo- and radiotherapy
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Chemotherapy re-use versus anti-angiogenic monotherapy as the third-line treatment of patients with metastatic colorectal cancer: a real-world cohort study BMC Cancer (IF 3.8) Pub Date : 2024-03-05 Jingjing Duan, Lila Zhu, Yinghui Shi, Weixue Wang, Tongtong Wang, Tao Ning, Le Zhang, Ming Bai, Hongli Li, Rui Liu, Shaohua Ge, Xia Wang, Yuchong Yang, Zhi Ji, Feixue Wang, Yansha Sun, Yi Ba, Ting Deng
There are various recommendations for third-line treatment in mCRC, however, there is no consensus on who is more suitable for particular strategy. Chemotherapy re-use in third-line setting is a common option in clinical practice. This study aimed to investigate the efficacy of third-line chemotherapy re-use by the comparison with that of anti-angiogenic monotherapy, and further find the population
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Adherence to the evidence-based recommendations in managing bone health, pain, and mobility of patients with multiple myeloma: a mixed method in the Palestinian healthcare system BMC Cancer (IF 3.8) Pub Date : 2024-03-05 Ramzi Shawahna, Riad Amer, Husam Salameh, Abdul-Rahman Shawahna, Mohmmad Aljondy, Mohmmad Zain-Aldain
Consensus/evidence-based recommendations for assessing, managing, and monitoring bone health, pain, and mobility in patients with multiple myeloma were developed. This study was conducted to assess the adherence of the hematologists-oncologists to the consensus/evidence-based recommendations for assessing, managing, and monitoring bone health, pain, and mobility in patients with multiple myeloma who
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Comparison of sexual function after robot-assisted radical prostatectomy and carbon-ion radiotherapy for Japanese prostate cancer patients using propensity score matching BMC Cancer (IF 3.8) Pub Date : 2024-03-05 Yoshiyuki Miyazawa, Hidekazu Koike, Daisuke Oka, Hidemasa Kawamura, Nobuteru Kubo, Yuhei Miyasaka, Masahiro Onishi, Takahiro Syuto, Yoshitaka Sekine, Hiroshi Matsui, Tatsuya Ohno, Kazuhiro Suzuki
The quality of life of patients is an important consideration when selecting treatments for localized prostate cancer (PCa). We retrospectively compared sexual function after robot-assisted radical prostatectomy (RARP) and carbon-ion radiotherapy (CIRT) using propensity score matching. In total, 127 Japanese PCa patients treated with RARP and 190 treated with CIRT monotherapy were evaluated. We evaluated
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The insufficiency of CT examination in early detection of central lung squamous cell carcinoma and squamous epithelial precancerous lesions BMC Cancer (IF 3.8) Pub Date : 2024-03-05 Jiaming Zhou, Bijun Yu, Peng Guo, Shi Wang
CT examination for lung cancer has been carried out for more than 20 years and great achievements have been made in the early detection of lung cancer. However, in the clinical work, a large number of advanced central lung squamous cell carcinoma are still detected through bronchoscopy. Meanwhile, a part of CT-occult central lung squamous cell carcinoma and squamous epithelial precancerous lesions
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COVID-19 and cancer risk arising from ionizing radiation exposure through CT scans: a cross-sectional study BMC Cancer (IF 3.8) Pub Date : 2024-03-05 Golshan Mahmoudi, Heidar Toolee, Reza Maskani, Farzaneh Jokar, Milad Mokfi, Ali Hosseinzadeh
The surge in the utilization of CT scans for COVID-19 diagnosis and monitoring during the pandemic is undeniable. This increase has brought to the forefront concerns about the potential long-term health consequences, especially radiation-induced cancer risk. This study aimed to quantify the potential cancer risk associated with CT scans performed for COVID-19 detection. In this cross-sectional study
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Development and validation of a novel preoperative clinical model for predicting lymph node metastasis in perihilar cholangiocarcinoma BMC Cancer (IF 3.8) Pub Date : 2024-03-04 Shuqi Mao, Yuying Shan, Xi Yu, Yong Yang, Shengdong Wu, Caide Lu
We aimed to develop a novel preoperative nomogram to predict lymph node metastasis (LNM) in perihilar cholangiocarcinoma (pCCA) patients. 160 pCCA patients were enrolled at Lihuili Hospital from July 2006 to May 2022. A novel nomogram model was established to predict LNM in pCCA patients based on the independent predictive factors selected by the multivariate logistic regression model. The precision
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DOCK1 regulates the malignant biological behavior of endometrial cancer through c-Raf/ERK pathway BMC Cancer (IF 3.8) Pub Date : 2024-03-04 Shangdan Xie, Yanshan Jin, Jiakun Wang, Jingwei Li, Mengjia Peng, Xueqiong Zhu
The effect of DOCK1 gene on the biological behavior of endometrial carcinoma cells and its related pathway has not been reported. The immunohistochemical method and western blot were utilized to analyze DOCK1 protein expression in endometrial tissues and cells, respectively. CCK-8, BrdU, transwell and flow cytometry were performed to analyze the effect of DOCK1 expression changes on the viability,
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MMP-11 expression in early luminal breast cancer: associations with clinical, MRI, pathological characteristics, and disease-free survival BMC Cancer (IF 3.8) Pub Date : 2024-03-04 Sébastien Molière, Massimo Lodi, Suzanne Leblanc, Anne Gressel, Carole Mathelin, Fabien Alpy, Marie-Pierre Chenard, Catherine Tomasetto
Early hormone-positive breast cancers typically have favorable outcomes, yet long-term surveillance is crucial due to the risk of late recurrences. While many studies associate MMP-11 expression with poor prognosis in breast cancer, few focus on early-stage cases. This study explores MMP-11 as an early prognostic marker in hormone-positive breast cancers. In this retrospective study, 228 women with
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A preliminary study of IgG4 expression and its prognostic significance in oral squamous cell carcinoma BMC Cancer (IF 3.8) Pub Date : 2024-03-04 Hironobu Fukuda, Takeshi Uehara, Tomoyuki Nakajima, Mai Iwaya, Shiho Asaka, Hiroshi Kurita
IgG4, which plays a pivotal role in the progression of phenotypically diverse tumors, serves as a prognostic marker because of its influence on cancer immunity. Nevertheless, the functions of IgG4 in tongue squamous cell carcinoma (TSCC) remained to be identified. To evaluate the significance of IgG4 expression in TSCC, we performed immunohistochemical analysis of patients with TSCC (n = 50) to evaluate
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Comprehensive evaluation of serum hepatic proteins in predicting prognosis among cancer patients with cachexia: an observational cohort study BMC Cancer (IF 3.8) Pub Date : 2024-03-04 Jia-Xin Huang, Xi Zhang, Meng Tang, Qi Zhang, Li Deng, Chun-Hua Song, Wei Li, Han-Ping Shi, Ming-Hua Cong
Hepatic proteins, including albumin, prealbumin, and transferrin have been confirmed to be prognostic predictors in various cancers. This study aimed to comprehensively assess the prognostic value of these three serum markers in patients with cancer cachexia. This multicenter prospective cohort study included 1303 cancer cachexia patients, among whom 592 deaths occurred during a median follow-up of
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Identification of PANoptosis-related signature reveals immune infiltration characteristics and immunotherapy responses for renal cell carcinoma BMC Cancer (IF 3.8) Pub Date : 2024-03-04 Yan Xu, Jingqi Hua, Hongliang Que, Tengyue Zeng, Quan Li, Junpeng Deng, Jianjun Xie
PANoptosis is a specific type of inflammatory programmed cell death (PCD) modality that can be involved in three key modes of cellular programmed cell death-pyroptosis, apoptosis and necroptosis. We analyzed PANoptosis activity in three common renal cell carcinoma subtypes (Clear cell renal cell carcinoma, Papillary renal cell carcinoma, and Chromophobe renal cell carcinoma) separately and constructed
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Impact of preoperative antiviral therapy on the prognosis of hepatitis B virus-related hepatocellular carcinoma BMC Cancer (IF 3.8) Pub Date : 2024-03-04 Yuxin Liang, Deyuan Zhong, Zilong Zhang, Yuhao Su, Su Yan, Chunyou Lai, Yutong Yao, Ying Shi, Xiaolun Huang, Jin Shang
For chronic hepatitis B virus (HBV) infection patients, increasing evidence has demonstrated the effectiveness of expanding the indications and applicable population for antiviral therapy. However, the expanded indication of antiviral therapy for hepatocellular carcinoma (HCC) remains to be further explored. 196 HBV-related HCC patients who received radical hepatectomy and nucleos(t)ide analogues (NAs)
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Radiogenomic analysis of ultrasound phenotypic features coupled to proteomes predicts metastatic risk in primary prostate cancer BMC Cancer (IF 3.8) Pub Date : 2024-03-04 Qihuan Fu, Li Luo, Ruixia Hong, Hang Zhou, Xinzhi Xu, Yujie Feng, Kaifeng Huang, Yujie Wan, Ying Li, Jiaqi Gong, Xingyan Le, Xiu Liu, Na Wang, Jiangbei Yuan, Fang Li
Primary prostate cancer with metastasis has a poor prognosis, so assessing its risk of metastasis is essential. This study combined comprehensive ultrasound features with tissue proteomic analysis to obtain biomarkers and practical diagnostic image features that signify prostate cancer metastasis. In this study, 17 ultrasound image features of benign prostatic hyperplasia (BPH), primary prostate cancer
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Effect of health belief model-based educational intervention on prostate cancer prevention; knowledge, practices, and intentions BMC Cancer (IF 3.8) Pub Date : 2024-03-04 Marwa Ibrahim Mahfouz Khalil, Ayat Ashour, Reem Said Shaala, Rasha Mahmoud Allam, Thoraya Mohamed Abdelaziz, Enas Fouad Sayed Mousa
Prostate cancer screening is a crucial preventive element for improving the survival rates of prostate cancer. Therefore, our research objective was to investigate the effect of health belief model-based education on prostate cancer knowledge, health beliefs, and preventive health practices among adult and older adult males. A one-group pre-test/post-test quasi-experimental study design was carried
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Preimmunization with Listeria-vectored cervical cancer vaccine candidate strains can establish specific T-cell immune memory and prevent tumorigenesis BMC Cancer (IF 3.8) Pub Date : 2024-03-04 Yunwen Zhang, Sijing Liu, Mengdie Chen, Qian Ou, Sicheng Tian, Jing Tang, Zhiqun He, Zhaobin Chen, Chuan Wang
Although HPV prophylactic vaccines can provide effective immune protection against high-risk HPV infection, studies have shown that the protective effect provided by them would decrease with the increased age of vaccination, and they are not recommended for those who are not in the appropriate age range for vaccination. Therefore, in those people who are not suitable for HPV prophylactic vaccines,
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Characteristics of patients with recurrent retinoblastoma: a survival analysis BMC Cancer (IF 3.8) Pub Date : 2024-03-04 Nan Li, Yi-Zhuo Wang, Yi Zhang, Wei-Ling Zhang, Dong-Sheng Huang
Management guidelines and corresponding survival data for patients with recurrent retinoblastoma (RB) are lacking. This study aimed to summarize the clinical characteristics of patients with recurrent RB and analyze their survival outcomes. We retrospectively analyzed 68 patients with recurrent RB who underwent treatment in our institution from January 2016 to December 2020. Patients were grouped according
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Assessing the genomic feature of Chinese patients with ampullary adenocarcinoma: potential therapeutic targets BMC Cancer (IF 3.8) Pub Date : 2024-03-04 Zhang Dong, Wan Chong, Chen Chen, Li Qi, Li Mengke, Dou Minghui, Yuan Jiawei, Quan Longxi, Liu Hengchao, Jia Liu, Geng Zhimin
Ampullary adenocarcinoma (AMPAC) is a rare malignancy, treated as pancreatic or intestinal cancer based on its histologic subtype. Little is known about the genomic features of Chinese patients with AMPAC. We enrolled 145 Chinese AMPAC patients in our local cohort and performed a compressive somatic and germline genetic testing using a 156 gene panel. Expression of PD-L1 (clone 28 − 8) was also assessed