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Prognostic Significance of Iron Metabolism and Immune-Related Genes as Risk Markers in Hepatocellular Carcinoma J. Environ. Pathol. Toxicol. Oncol. (IF 2.4) Pub Date : 2024-03-01 Shijing Tang, Hao Chen
Hepatocellular carcinoma (HCC) is a highly lethal liver cancer with significant heterogeneity, which poses challenges in predicting prognosis and treatment outcomes. The impact of iron metabolism and immune-related genes (IMRGs) on HCC patient prognoses remains elusive. We utilized The Cancer Genome Atlas (TCGA) dataset to obtain mRNA expression data and clinical information from HCC patients. Through
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Molecular Pathogenesis, Organ Metastasis, and Targeted Therapy for Non-Small Cell Lung Cancer (NSCLC) J. Environ. Pathol. Toxicol. Oncol. (IF 2.4) Pub Date : 2024-03-01 Salik Abdullah, Ratul Chakraborty, Pratiksha Somnath Kumkar, Biplab Debnath, Asis Bala
Around 2 million people have been diagnosed with lung carcinoma every year, and 20,000 die from it. Amongst this around 80–85% of lung cancers belong to the category of non-small cell carcinomas. Throughout the last few decades, lung cancer's chromosomal makeup has been better understood, changing clinical care and treatment of advanced or metastatic non-small cell lung cancer patients. This has been
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A review on protease inhibitors of herbal origin to combat malignancy J. Environ. Pathol. Toxicol. Oncol. (IF 2.4) Pub Date : 2024-03-01 Sanjib Bhattacharya
Protease is the enzyme responsible for the breakdown of proteins. Proteases are involved in events of growth, development, progression and metastasis of cancers. If any agent could inhibit the protease i.e., protease inhibitor, it would arrest the cancer; thus indicating the search of protease inhibitors for newer anti-cancer drug discovery. Higher plants are the rich sources of different protease
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RNF20 reduced cell proliferation and Warburg effect of Liver cancer by the promotion of NLRP3 Ubiquitination in liver cancer J. Environ. Pathol. Toxicol. Oncol. (IF 2.4) Pub Date : 2024-03-01 Deqin Liu, Renyin Luo, Qian Zhou, Mei Li
Background: The present study explored that the effects and its possible mechanisms of ring finger protein 20 (RNF20) in Postoperative survival rate of Liver cancer in clinical. Methods: All the serum samples were collected from our hospital. Quantitative polymerase chain reaction (PCR) and Microarray analysis, and RNA pull down assay were used in this study. Results: We found that the serum RNF20
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Development of a Prognostic Model for Gastric Cancer Based on Apoptosis- and Hypoxia-Related Genes: Predictive Insights into Survival and Immune Landscape J. Environ. Pathol. Toxicol. Oncol. (IF 2.4) Pub Date : 2024-03-01 Jian Zhu, Yao Ma
Background: Gastric cancer (GC) stands as the fifth most prevalent malignancy worldwide and the fourth primary contributor to cancer-associated fatalities worldwide. The search for pivotal prognostic biomarkers and elucidation of underlying mechanisms driving GC progression necessitate innovative approaches. Apoptosis and hypoxia were intricately associated and interdependent in tumorigenesis. This
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Treatment strategy for breast benign intraductal papilloma: A Meta-Analysis J. Environ. Pathol. Toxicol. Oncol. (IF 2.4) Pub Date : 2024-03-01 Congkun Lou, Wenxin Wang, Binggang Zhou
Background: Currently, the optimal treatment approach for breast benign intraductal papilloma (IDP) diagnosed via biopsy remains uncertain. There is ongoing debate regarding the feasibility of clinical follow-up and the criteria for selective surgical excision. Objective: This study aims to conduct a meta-analysis to determine the rate of upgrade from breast benign IDP and identify predictive factors
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Probing the Potential: Exploring Probiotics as a Novel Frontier in Cancer Prevention and Therapeutics J. Environ. Pathol. Toxicol. Oncol. (IF 2.4) Pub Date : 2024-01-01 Akhil Nair, Kanchanlata Tungare, Ameyota De, Renitta Jobby
Cancer has emerged as one of the most prevalent diseases worldwide, with a consistent rise in the number of cases observed over the past few decades. The rising mortality rates associated with cancer have transformed it into a significant global challenge. Despite the presence of various anti-cancer drugs, the complete eradication of cancer remains an elusive goal. The numerous undesirable effects
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Role of Alpha-Fetoprotein in the Pathogenesis of Cancer J. Environ. Pathol. Toxicol. Oncol. (IF 2.4) Pub Date : 2024-01-01 Alok Ghosh Chaudhuri, Saptadip Samanta, Monalisha Dey, N. S. Raviraja, Souvik Dey
Alpha-fetoprotein (AFP) belongs to the albuminoid protein family and is considered as the fetal analog of serum albumin. This plasma protein is initially synthesized in the fetal liver and yolk sac and shows a maximum peak near the end of the first trimester. Later, concentrations begin to decline prenatally and drop precipitously after birth. This protein has three key ligand-binding pockets for interactions
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A Systems Biology Approach Unveils a Critical Role of DPP4 in Upper Gastrointestinal Cancer Patient Outcomes J. Environ. Pathol. Toxicol. Oncol. (IF 2.4) Pub Date : 2024-01-01 Sudhir Kotnala, Anupam Dhasmana, Swati Dhasmana, Shafiul Haque, Murali M. Yallapu, Manish K. Tripathi, Meena Jaggi, Subhash C. Chauhan
Gastrointestinal (GI) cancers comprise of cancers that affect the digestive system and its accessory organs. The late detection and poor prognosis of GI cancer emphasizes the importance of identifying reliable and precise biomarkers for early diagnosis and prediction of prognosis. The membrane-bound glycoprotein dipeptidyl-peptidase 4 (DPP4), also known as CD26, is ubiquitously expressed and has a
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Withaferin A-Encapsulated PEGylated Nanoliposomes Induce Apoptosis in B16F10 Melanoma Cells by Regulating Bcl2 and Bcl xl Genes and Mitigates Murine Solid Tumor Development J. Environ. Pathol. Toxicol. Oncol. (IF 2.4) Pub Date : 2024-01-01 Prathapan Abeesh, Chandrasekharan Guruvayoorappan
Withaferin A (WA) is a natural steroidal lactone with promising pharmacological activities, but its poor solubility and bioavailability hinder its clinical application. The liposomal drug delivery system has attracted considerable attention to overcome the delivery limitations of pharmacological agents. The present study investigated the effect of WA-loaded pegylated nanoliposomes (LWA) on in vitro
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Complex Genomic Rearrangement Patterns in Malignant Pleural Mesothelioma due to Environmental Asbestos Exposure J. Environ. Pathol. Toxicol. Oncol. (IF 2.4) Pub Date : 2024-01-01 Tunç Tuncel, Güntülü Ak, Hasan Veysi Güneş, Muzaffer Metintaş
Malignant pleural mesothelioma (MPM) is a rare type of cancer, and its main risk factor is exposure to asbestos. Accordingly, our knowledge of the genomic structure of an MPM tumor is limited when compared to other cancers. In this study, we aimed to characterize complex genomic rearrangement patterns and variations to better understand the genomics of MPM tumors. We comparatively scanned 3 MPM tumor
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TFR1-Mediated Iron Metabolism Orchestrates Tumor Ferroptosis and Immunity in Non-Small Cell Lung Cancer J. Environ. Pathol. Toxicol. Oncol. (IF 2.4) Pub Date : 2024-01-01 Zunqiao Wang, Xingkai Yao, Keping Wang, Bin Wang
This study aimed to investigate the underlying molecular mechanisms of transferrin receptor (TFR1) in non-small cell lung cancer (NSCLC). Histological analysis was performed using hematoxylin-eosin (HE) staining. The number of CD8+ T cell were determined by flow cytometry and immunofluorescence assays. mRNA levels were analyzed by qRT-PCR. Protein expression was detected by western blot. Ferroptosis
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Can the Toxic Heavy Metals Be Beneficial at Trace Levels? Understanding Their Outranged Biological Functions J. Environ. Pathol. Toxicol. Oncol. (IF 2.4) Pub Date : 2024-01-01 Sanjib Bhattacharya
Heavy metal toxicity poses a serious danger to the environment and its inhabitants on a global scale. The harmful heavy metals that are not necessary but are still dangerous, such as lead, arsenic, cadmium, and mercury are frequently linked to pollution and the resulting health problems. Despite several gross ill effects, toxic heavy metals have been found to show beneficial biological activity when
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Transcription Factor E2F1 Enhances Hepatocellular Carcinoma Cell Proliferation and Stemness by Activating GINS1 J. Environ. Pathol. Toxicol. Oncol. (IF 2.4) Pub Date : 2024-01-01 Xuefeng Ren, Lianqiang Shen, Shan Gao
Present studies report that high expression of GINS complex subunit 1 (GINS1) is notably pertinent to poor survival for hepatocellular carcinoma (HCC), but it remains unclear how GINS1 affects the progression of HCC. This study aims at investigating the mechanism by which GINS1 affects HCC cell proliferation and stemness. We performed bioinformatics analysis for determining GINS1 expression in HCC
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Frequency of Healthy Control Genotype of VDR Gene Polymorphisms in the Saudi Population of the Ha'il Region: A Comparative Study with Worldwide Population J. Environ. Pathol. Toxicol. Oncol. (IF 2.4) Pub Date : 2024-01-01 Mahvish Khan, Nashwa Z.A. Bushara, Manoj Kumar, Raju K. Mandal, Saheem Ahmad, Saif Khan
Genetic polymorphisms in the vitamin D receptor (VDR) may influence the biological effects of vitamin D and increase a person's susceptibility to cancer. Previous studies have shown that different ethnic groups exhibit varying frequencies of the VDR gene variants TaqI, ApaI, FokI, and BsmI. However, the allelic distribution of these VDR polymorphisms in the Saudi population of Ha'il region is not sufficiently
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Comprehensive Investigation of m6A Regulators for Prognosis in Head and Neck Squamous Cell Carcinoma J. Environ. Pathol. Toxicol. Oncol. (IF 2.4) Pub Date : 2023-09-01 Jingning Cheng, Yong Lyu, Ziyan Cheng
The early detection of head and neck squamous cell carcinoma (HNSCC) has an important impact on the clinical prognosis. N6-methyladenosine (m6A) is involved in the post-transcriptional regulation of tumorigenesis and development. In this study, the prognosis and biological functions of m6A regulator targets in HNSCC were explored. RNA-Seq expression data and clinical information from TCGA-HNSCC and
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Whole-Genome Comparative Copy Number Alteration Profiling between Malignant Pleural Mesothelioma and Asbestos-Induced Chronic Pleuritis J. Environ. Pathol. Toxicol. Oncol. (IF 2.4) Pub Date : 2024-01-01 Tunç Tuncel, Muzaffer Metintas, AK Güntülü, Hasan Veysi Güneş
Malignant pleural mesothelioma (MPM) is rare and aggressive cancer. The most important risk factor for MPM is exposure to asbestos. In this study, we scanned the genomes of individuals MPM and asbestos-induced chronic pleuritis (AICP) to compare and determine copy number alterations (CNAs) between two asbestos-related diseases. We used high-resolution SNP arrays to compare CNA profiles between MPM
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Chemotherapeutic drugs endow gastric cancer mesenchymal stem cell with stronger tumor-promoting ability J. Environ. Pathol. Toxicol. Oncol. (IF 2.4) Pub Date : 2024-01-01 Bo Shen
Gastric cancer (GC) is one of the most malignant tumors and has poor prognosis. Gastric cancer mesenchymal stem cells (GC-MSCs) are proved to promote GC progression, metastasis and chemoresistance through various mechanism. However, the effect of GC-MSCs on GC during chemotherapy remains unknown. Flow cytometry, CCK8 assay, migration assay, colony formation assay and western blot were performed in
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The mutational and transcriptional landscapes of speckle-type POZ protein (SPOP) and androgen receptor (AR) in a single center pT3 prostatectomy cohort J. Environ. Pathol. Toxicol. Oncol. (IF 2.4) Pub Date : 2024-01-01 Isil Ezgi Eryilmaz
Prostate cancer (PCa) is a heterogeneous disease both clinically and genetically. According to The Cancer Genome Atlas (TCGA), the speckle‑type POZ protein (SPOP) mutant form is one of the significant core subtypes of PCa. However, the prognostic value of SPOP variations remains unknown. As a critical PCa driver and an SPOP-targeted protein, androgen receptor (AR) also plays a role in PCa initiation
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The differences between urban and rural environment on cardiovascular health: a Systematic Review J. Environ. Pathol. Toxicol. Oncol. (IF 2.4) Pub Date : 2023-03-01 Venetia Notara, Stamatia Kokkou, Emanouil Bindakos, Evanthia Sakellari, Constantina Skanavis
Background: The effect of the urban vs. rural environment on cardiovascular health is an extremely significant issue, nowadays. Up to date, there is a number of studies revealing that there is environmental impact on the prevalence of cardiovascular disease (CVD). Objectives: The aim of the current systematic review was to investigate the relationship between the natural environment and cardiovascular
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Gene Variations of Chemokine and Chemokine Receptor CXCL12/CXCR4 in Lung Cancer J. Environ. Pathol. Toxicol. Oncol. (IF 2.4) Pub Date : 2023-01-01 Cansu Ozbayer, Emine Yagci, Guntulu Ak, Selma Metintas, Muzaffer Metintas, Hulyam Kurt
Lung cancer is the most common type of cancer in the world and about 1 million people die from lung cancer every year in the world. Inflammation is an important factor in the onset, progression and metastasis of lung cancer. The most important regulators of inflammation are chemokines and chemokine receptors. Chemokines induce the proliferation of cancer cells and prevent their apoptosis. Chemokines
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A Signature Constructed Based on the Integrin Family Predicts Prognosis and Correlates with the Tumor Microenvironment of Patients with Lung Adenocarcinoma J. Environ. Pathol. Toxicol. Oncol. (IF 2.4) Pub Date : 2023-01-01 Shusen Zhang, Dengxiang Liu, Xuecong Ning, Xiaochong Zhang, Yuanyuan Lu, Yang Zhang, Aimin Li, Zhiguo Gao, Zhihua Wang, Xiaoling Zhao, Shubo Chen, Zhigang Cai
As an important element in regulating the tumor microenvironment (TME), integrin plays a key role in tumor progression. This study aimed to establish prognostic signatures to predict the overall survival and identify the immune landscape of patients with lung adenocarcinoma based on integrins. The Cancer Genome Atlas-Lung Adenocarcinoma (TCGA-LUAD) and Gene Expression Omnibus datasets were used to
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Comprehensive Analysis of the Sorafenib-Associated Druggable Targets on Differential Gene Expression and ceRNA Network in Hepatocellular Carcinoma J. Environ. Pathol. Toxicol. Oncol. (IF 2.4) Pub Date : 2023-01-01 Zhi Fu, Guang Yang, Tiezheng Wang, Daming Gao, Dongdong Lin, Xiaoni Liu
Hepatocellular carcinoma (HCC) is the predominant pathological type of liver cancer. Several therapeutic treatments, including sorafenib and regorafenib, have only modestly improved survival in patients with HCC. The aim of this study was to investigate the expression profiles and the regulation of competitive endogenous RNAs (ceRNAs) of the sorafenib-related target genes in HCC. Based on clinical
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Identification of Potential Diagnostic and Prognostic Biomarkers for Gastric Cancer Based on Bioinformatic Analysis J. Environ. Pathol. Toxicol. Oncol. (IF 2.4) Pub Date : 2023-01-01 Yecheng Lin, Lei Zhang, Xiaoling Zhang, Xiaonan Wei, Xu Liu, Yanchao Xie, Guoda Han
Gastric cancer (GC) ranks third for cancer-related fatalities worldwide. It is still unclear what causes GC to progress. Using integrated bioinformatics analysis, COL5A2 has been proved to be related to GC development, which may identify the likely pathogenic mechanism. Data from GC patients were gathered using The Cancer Gene Atlas (TCGA) and the gene expression omnibus (GEO). The level of COL5A2
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Janus Kinase-Signal Transducer and Activator of Transcription Inhibitors for the Treatment and Management of Cancer J. Environ. Pathol. Toxicol. Oncol. (IF 2.4) Pub Date : 2023-01-01 Fahim Anwar Rizwi, Md. Abubakar, Eswara Rao Puppala, Ahsas Goyal, Ch. Veera Bhadrawamy, V. G. M. Naidu, S. Roshan, B. Tazneem, Waleed Hassan Almalki, Vetriselvan Subramaniyan, Sushama Rawat, Gaurav Gupta
According to the World Health Organization (WHO), cancer is the second-highest cause of mortality worldwide, killing nearly 9.6 million people annually. Despite the advances in diagnosis and treatment during the last couple of decades, it remains a serious concern due to the limitations of currently available cancer management strategies. Therefore, alternative strategies are highly required to overcome
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Clinicopathologic Features and Prognostic Significance of Immunohistochemistry and In Situ Hybridization Based Molecular Classification in Gastric Carcinoma J. Environ. Pathol. Toxicol. Oncol. (IF 2.4) Pub Date : 2023-01-01 Gizem Issin, İlyas Sayar, Fatih Demir, İrem Güvendir Bakkaloğlu, Mehmet Gamsizkan, Zeliha Yildiz, Ismail Yilmaz, Sevilay Akalp Özmen, Diren Vuslat Çağatay, Itır Ebru Zemheri, Murat Demiriz, Armağan Günal
Background/Aim: Gastric carcinoma (GC) is a highly heterogeneous disease with many subtypes that have different morphologic and molecular characteristics. In the current study, we analyzed immunohistochemical (IHC) and in situ hybridization (ISH) features of GCs and evaluated their association with prognosis and clinicopathological features. Materials and Methods: Three hundred cases analyzed by IHC
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An Insight into the Salutary Prospect of the Probiotic Microorganisms for the Remediation of Mercury Toxicity J. Environ. Pathol. Toxicol. Oncol. (IF 2.4) Pub Date : 2023-01-01 Sanjib Bhattacharya
Heavy metal toxicity imposes a potential worldwide threat to environment and humans. Mercury toxicity is regarded as a serious global community health risk, as there is no particular and proven treatment for chronic mercury toxicity. Probiotics include the live apathogenic microorganisms, which are administered orally to revamp the gut microbial equilibrium thus bestowing benefit to the host. Scientific
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Studies on the Therapeutic and Prognostic Biomarkers of Glioma Using a Novel Cuproptosis-Related IncRNA Signature and Validation in Glioma J. Environ. Pathol. Toxicol. Oncol. (IF 2.4) Pub Date : 2023-01-01 Ji Jin, Ren Li, Geng Guo, Yang Chen, Zi-Ao Li, Jianzhong Zheng
Glioma is the most common tumor of the central nervous system (CNS). Drug resistance, and lack of effective treatment methods make the treatment effect of glioma patients unsatisfactory. The recent discovery of cuproptosis has led to new thinking about the therapeutic and prognostic targets of glioma. The transcripts and clinical data of glioma samples were obtained from The cancer genome atlas (TCGA)
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Role of METTL3 in Aerobic Glycolysis of Glioma by Regulating m6A/miR-27b-3p/PDK1 J. Environ. Pathol. Toxicol. Oncol. (IF 2.4) Pub Date : 2023-01-01 Cijie Ruan, Yuanda Zhang, Jue Zhou, Haoyuan Tan, Yinghui Bao
Methyltransferase like 3 (METTL3) has been reported to be dysregulated in glioma. However, its role in aerobic glycolysis of glioma remains unknown. This study was conducted to explore the molecular mechanism by which METTL3 regulates aerobic glycolysis of glioma and provide novel targets for the treatment of glioma. The expression levels of METTL3, microRNA (miR)-27b-3p, and pyruvate dehydrogenase
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Expression Profiles, Prognosis, and ceRNA Regulation of SRY-Related HMG-Box Genes in Stomach Adenocarcinoma J. Environ. Pathol. Toxicol. Oncol. (IF 2.4) Pub Date : 2023-01-01 Chang Zhu, Yuxiang Fu, Ligang Xia, Fang Li, Kaibin Huang, Xiao Sun
Aberrant expression of the SRY-related HMG-box (SOX) genes contributes to tumor development and progression. This research aimed to identify the regulation of the SOX genes in stomach adenocarcinoma (STAD). Expression profiles downloaded from The Cancer Genome Atlas (TCGA) were conducted to analyze the expression and function of the SOX genes. A competing endogenous RNAs (ceRNA) network mediated by
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METTL14 Promotes Oral Squamous Cell Carcinoma Progression by Regulating the mRNA and m6A Levels of CALD1 J. Environ. Pathol. Toxicol. Oncol. (IF 2.4) Pub Date : 2023-01-01 Ruixue Chen, Suxin Zhang, Hexiang Li, Mengyuan Yang, Yiwen Lu, Xudong Zhang
Oral squamous cell carcinoma (OSCC) still threatens people's daily life. METTL14 is a newly discovered methyltransferase that catalyzes m6A methylation. Hence, this research was carried out to investigate the action mechanism of METTL14 in OSCC. The SCC-4 and UM2 cells, and tumorigenicity assay were utilized to investigate METTL14 roles in vitro and in vivo. Bioinformatic analysis was carried out with
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Benefits and Relevant Risk Factor Assessment of Neoadjuvant Chemotherapy in Combination with Surgery in Limited-Stage Small-Cell Lung Cancer J. Environ. Pathol. Toxicol. Oncol. (IF 2.4) Pub Date : 2023-01-01 Huiwen Miao, Shaohua Xu, Meihui Gao, Zhoumiao Chen
To illustrate the benefits of surgery in conjunction with neoadjuvant chemotherapy in patients with limited-stage small cell lung cancer (LS-SCLC), and to evaluate risk factors affecting patient's survival. Forty-six LS-SCLC patients who received surgery in our center from September 2012 to December 2018 were retrospectively analyzed. Twenty-five patients with LS-SCLC diagnosed after surgery who received
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Honey Can Obviate Heavy Metal Toxicity: A Review J. Environ. Pathol. Toxicol. Oncol. (IF 2.4) Pub Date : 2023-01-01 Sanjib Bhattacharya
Toxicity caused by heavy metals inflicts a grave global menace to the habitat and inhabitants. Arsenic (As), cadmium (Cd), lead (Pb), and mercury (Hg) are the non-essential yet harmful heavy metals commonly associated with pollution and resultant health complications. Typical chelating/complexing agents are not worthy of combating heavy metal-induced sub-chronic and chronic toxicities. It transpires
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Detection of Circulating Tumor Cells and Epithelial Progenitor Cells: A Comprehensive Study J. Environ. Pathol. Toxicol. Oncol. (IF 2.4) Pub Date : 2023-01-01 Shivkanya Fuloria, Vetriselvan Subramaniyan, Gaurav Gupta, Mahendran Sekar, Dhanalekshmi Unnikrishnan Meenakshi, Kathiresan Sathasivam, Kalvatala Sudhakar, Khalid Saad Alharbi, Sultan Saadi Almutairi, Waleed Hassan Almalki, Neeraj Kumar Fuloria
Technological advancement to enhance tumor cells (TC) has allowed discovery of various cellular bio-markers: cancer stem cells (CSC), circulating tumor cells (CTC), and endothelial progenitor cells (EPC). These are responsible for resistance, metastasis, and premetastatic conditions of cancer. Detection of CSC, CTC, and EPC assists in early diagnosis, recurrence prediction, and treatment efficacy.
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Circular RNA 0000311 Aggravates the Aggressiveness of Oral Squamous Cell Carcinoma via miR-876-5p/EZH2 Axis J. Environ. Pathol. Toxicol. Oncol. (IF 2.4) Pub Date : 2023-01-01 Jing Xu, Qing Lin, Xiqun Zhao
The purpose of the present study was to investigate the potentials of circ_0000311 in oral squamous cell carcinoma (OSCC). Quantitative real-time polymerase chain reaction (qRT-PCR) was applied for calculating the mRNA and miRNA level. Western blot was performed to determine protein expression. The binding sites between miR-876-5p and circ_0000311/Enhancer of zeste homolog-2 (EZH2) were predicted using
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Stromal Interaction Molecule 1 (STIM1) is a Potential Prognostic Biomarker and Correlates with Immune Infiltrates in Solid Tumors J. Environ. Pathol. Toxicol. Oncol. (IF 2.4) Pub Date : 2023-01-01 Zichao Zhang, Zhihui Wang, Yumeng Liu, Li Zhao, Weihua Fu
Increasing evidence has shown that stromal interaction molecule 1 (STIM1), a key subunit of store-operated Ca2+ entry (SOCE), is closely associated with tumor growth, development, and metastasis. However, there is no report of a comprehensive assessment of STIM1 in pan-cancer. This study aimed to perform a general analysis of STIM1 in human tumors, including its molecular characteristics, functional
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Dental Implants and Implant Coatings: A Focus on Their Toxicity and Safety J. Environ. Pathol. Toxicol. Oncol. (IF 2.4) Pub Date : 2023-01-01 Atakan Ozkan, Deniz Arca Çakır, Hülya Tezel, Sonia Sanajou, Anil Yirun, Terken Baydar, Pinar Erkekoglu
Dental implants are medical devices that are surgically inserted into the patient's jawbone by an orthodontist to act as roots of missing teeth. After the implantation, the maxilla or mandible integrates with the surface of the dental implant. This process, called "osseointegration," is an important period to ensure the long-term use of dental implants and prevent implant failures. Metal implants are
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Recent Developments and Challenges in Molecular-Targeted Therapy of Non-Small-Cell Lung Cancer J. Environ. Pathol. Toxicol. Oncol. (IF 2.4) Pub Date : 2023-01-01 Suman Rohilla, Mahaveer Singh, Sami I. Alzarea, Waleed Hassan Almalki, Fahad A. Al-Abbasi, Imran Kazmi, Obaid Afzal, Abdulmalik Saleh Alfawaz Altamimi, Sachin Kumar Singh, Dinesh Kumar Chellappan, Kamal Dua, Gaurav Gupta
Treatment of lung cancer with conventional therapies, which include radiation, surgery, and chemotherapy results in multiple undesirable adverse or side effects. The major clinical challenge in developing new drug therapies for lung cancer is resistance, which involves mutations and disturbance in various signaling pathways. Molecular abnormalities related to epidermal growth factor receptor (EGFR)
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Anticancer Phytochemical-Based Nanoformulations: Therapeutic Intervention in Cancer Cell Lines J. Environ. Pathol. Toxicol. Oncol. (IF 2.4) Pub Date : 2023-01-01 Debjyoti Talukdar, Parveen Kumar, Deepak Sharma, Vishal M. Balaramnavar, Obaid Afzal, Abdulmalik Saleh Alfawaz Altamimi, Imran Kazmi, Fahad A. Al-Abbasi, Sami I. Alzarea, Gaurav Gupta, Madan Mohan Gupta
Phytochemicals have the potential to treat resistant cancer. They are delivered to the target site via nano-based carriers. Promising results are seen in preclinical and in vitro models, as phytochemical-based nanoformulations have improved cell cytotoxicity compared to single agents. They can synergistically inhibit cancer cell growth through p53 apoptosis in MCF-7 breast cancer cell lines. Moreover
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A Review on Experimentally Proven Medicinal Plants and Their Constituents against Fluoride Toxicity J. Environ. Pathol. Toxicol. Oncol. (IF 2.4) Pub Date : 2023-01-01 Sanjib Bhattacharya
Fluoride toxicity, principally by polluted groundwater, is regarded as a momentous global public health risk, as there is no particular and proven treatment for chronic fluoride toxicity i.e., fluorosis which leads to several serious health complications. Scientific literature reveals several medicinal plants and natural products alleviate experimentally induced fluoride toxicity. The present review
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miR-125b-5p Suppresses Leukemia Cell Proliferation by Regulating MCL1 J. Environ. Pathol. Toxicol. Oncol. (IF 2.4) Pub Date : 2023-01-01 Yan Zhou, Huan Zhu, Jinan Han, Ying Xu, Dan Wang, Wen Jin, Ruyuan Zhu, Lixing Qiao
Leukemia threatens children's health, and leukemia cell proliferation and apoptosis participate in the regulation of leukemia. The current study aims to probe into the miR-125b-5p biological function in regulating leukemia cell proliferation and apoptosis by myeloid cell leukemia 1 (MCL1). Quantitative real-time polymerase chain reaction was conducted to quantify miR-125b-5p expression in leukemia
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Exploring the Mechanical Perspective of a New Anti-Tumor Agent: Melatonin J. Environ. Pathol. Toxicol. Oncol. (IF 2.4) Pub Date : 2023-01-01 Suman Rohilla, Mahaveer Singh, Sakshi Priya, Waleed Hassan Almalki, Shahril Mohamed Haniffa, Vetriselvan Subramaniyan, Shivkanya Fuloria, Neeraj Kumar Fuloria, Mahendran Sekar, Sachin Kumar Singh, Niraj Kumar Jha, Dinesh Kumar Chellappan, Poonam Negi, Kamal Dua, Gaurav Gupta
Melatonin is a serotonin-derived pineal gland hormone with many biological functions like regulating the sleep-wake cycle, circadian rhythm, menstrual cycle, aging, immunity, and antioxidants. Melatonin synthesis and release are more pronounced during the night, whereas exposure to light decreases it. Evidence is mounting in favor of the therapeutic effects of melatonin in cancer prevention, treatment
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RECEPTOR TYROSINE KINASE PATHWAY AND INFILTRATING UROTHELIAL CARCINOMA J. Environ. Pathol. Toxicol. Oncol. (IF 2.4) Pub Date : 2022-07-01 ?eyma Büyücek, Sinem Kantarcioglu Coskun, Binnur Önal, Mehmet Gamsizkan, Sengul Cangur, Onur Esbah
Receptor tyrosine kinase pathway is frequently searched for cancer causing mutations in tumors. Emerging targeted therapies are gleam of hope for them. Infiltrating urothelial carcinoma can have many morphological aspects according to their differentiation/variants. To evaluate KRAS, BRAF, PIK3CA mutations and HER2, EGFR, p16 expressions, we divided urothelial carcinomas into two groups: differentiated/variants
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Oncogenic role of HNRNPC in multiple cancer types, with a particular focus on LUAD, using a pan-cancer analysis and cell line experiments J. Environ. Pathol. Toxicol. Oncol. (IF 2.4) Pub Date : 2022-05-01 jiangl hong, libin zhang, hao peng, Jiang Lihong
Although some evidence has validated the connection between heterogeneous nuclear ribonucleoprotein C (HNRNPC) and the progression of tumors, a pan-cancer investigation is still required. Thus, we explored the oncogenic effect of HNRNPC across many tumors using The Cancer Genome Atlas datasets. Moreover, short hairpin RNAs (shRNAs) were found to repress HNRNPC in lung adenocarcinoma (LUAD) cells, and
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Sinigrin impedes the breast cancer cell growth through inhibition of PI3K/AKT/mTOR phosphorylation-mediated cell cycle arrest J. Environ. Pathol. Toxicol. Oncol. (IF 2.4) Pub Date : 2022-02-01 Shuqin Li, Jiawen Lin, Jiaofei Wei, Lingzhi Zhou, Peishun Wang, Shaohua Qu
Breast carcinoma, one of the most lethal variants of carcinogenesis, significantly diagnosed type of cancer amongst the female population. Sinigrin, also known as glucosinolate, is found in the seeds of Brassica nigra and shown to enhance various cancer cells potentially. Nevertheless, the mechanistic explanation of SGN-mediated breast cancer growth and augmentation is still to be investigated. Hence
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Comprehensive Analysis of Epigenetic Associated Genes on Differential Gene Expression and Prognosis in Hepatocellular Carcinoma J. Environ. Pathol. Toxicol. Oncol. (IF 2.4) Pub Date : 2022-01-01 Cong Li, Jing Ding, Jianmin Mei
Background: Early detection of hepatocellular carcinoma (HCC) is significantly effective in clinical management. This study aimed to identify potential HCC biomarkers. Methods: Analysis of expression profiles in HCC clinical samples downloaded from the cancer genome atlas (TCGA) and the gene expression omnibus (GEO) datasets was performed to identify differentially expressed genes (DEGs) using R packages
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Investigating in vitro and in vivo anti-tumor activity of Curvularia-based Platinum nanoparticles J. Environ. Pathol. Toxicol. Oncol. (IF 2.4) Pub Date : 2022-01-01 Sonali Bhattacharya, Madhusree Halder, Arnab Sarkar, Priyanka Pal, Arpan Das, Surekha Kundu, Deba Prasad Mandal, Shamee Bhattacharjee
The use of platinum (Pt) based anticancer drugs, although widespread in clinical practice, is severely limited due to toxic side-effects. One of the strategies for making Pt-based chemotherapy more effective is the synthesis and use of Pt nanoparticles (PtNPs). However, increasing evidences suggest that nanoplatinum also pose potential risk to human health. This study examined the toxicity and anticancer
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Adverse Effects of COVID-19 Treatments: A Special Focus on Susceptible Populations J. Environ. Pathol. Toxicol. Oncol. (IF 2.4) Pub Date : 2022-01-01 BEYZA NUR KÜÇÜK, RAHİME ŞİMŞEK, SELİNAY BAŞAK ERDEMLİ KÖSE, ANIL YİRÜN, Pinar Erkekoglu
On December 2019, world has faced a whole new pandemic caused by a novel type of coronavirus, namely “Severe Acute Respiratory Syndrome Coronovirus 2 (SARS-CoV-2)”. This disease is named as “Coronavirus Disease 2019 (COVID-19)”. This RNA virus infected millions of people around the world causing millions of deaths. It takes approximately 8-10 years to develop a new drug and it seems hard to have a
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PA2G4P4 Promotes Glioma Cell Migration and Tumorigenesis through the PTEN/AKT/mTOR Signaling Pathway J. Environ. Pathol. Toxicol. Oncol. (IF 2.4) Pub Date : 2022-01-01 Xiaofeng Hou, ZhengXiong Kou, Hengzhu Zhang
Dysregulation of pseudogene expression is closely related to the progression of various cancers, including glioma. Proliferation-associated 2G4 pseudogene 4 (PA2G4P4) could affect cell viability and apoptosis of glioma cells. However, the specific regulatory mechanism of PA2G4P4 is not clear. In this paper, we found that PA2G4P4 overexpres-sion promoted glioma cell proliferation, migration and cell
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miR-1246 promotes laryngeal squamous cell carcinoma progression by interacting with THBS1 J. Environ. Pathol. Toxicol. Oncol. (IF 2.4) Pub Date : 2022-01-01 Lifeng Wu,Na Zuo,Shuo Pan,Yue Wang,Qixue Wang,Jun Ma
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Effects of RNA Modification "Writers" of GALNT2 on the Tumor Microenvironment in Cervical Squamous Cell Carcinoma J. Environ. Pathol. Toxicol. Oncol. (IF 2.4) Pub Date : 2022-01-01 Shizhang Wang, Lin Chen
Cervical squamous cell carcinoma (CESC) is one of the most common causes of cancer-related deaths in women. RNA modification "writers" modulate and alter RNA molecular activity and have been implicated in the origin and development of cancer. We explored the effects of RNA modification writers on the tumor microenvironment in CESC and their prognostic value. RNA modification writers were altered at
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Promising Action of Cannabinoids on ER Stress-Mediated Neurodegeneration: An In Silico Investigation J. Environ. Pathol. Toxicol. Oncol. (IF 2.4) Pub Date : 2022-01-01 Fathima Hajee Basha, Mohammad Waseem, Hemalatha Srinivasan
Neurodegeneration has been recognized as a clinical episode characterized by neuronal death, including dementia, cognitive impairment and movement disorder. Most of the neurodegenerative deficits, via clinical symptoms, includes common pathogenic features as protein misfolding and aggregation. Therefore, the focus highlights the cellular organelle endoplasmic reticulum (ER) critically linked with the
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Melatonin: A Potential Antineoplastic Agent in Breast Cancer J. Environ. Pathol. Toxicol. Oncol. (IF 2.4) Pub Date : 2022-01-01 Saptadip Samanta
Melatonin is primarily synthesized in the pineal gland under the influence of noradrenergic stimulation at night. It regulates the sleep-wake cycle, gonadal activity, redox homeostasis, immune functions, and anticarcinogenic effects at the normal physiological state. The activity of melatonin is mediated by membrane-bound G protein-coupled receptors MT1 and MT2. Circadian deregulation, exposure to
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Exosomal circRNA_104948 Enhances the Progression of Glioma by Regulating miR-29b-3p and DNMT3B/MTSS1 Signaling J. Environ. Pathol. Toxicol. Oncol. (IF 2.4) Pub Date : 2022-01-01 Shoudan Zhang, Ning Guan, Xin Mao, Jingwen Cui, Xin Sui, Wenshi Guo
Glioma is a common type of malignancy in the central nervous system. The pathogenesis of glioma is complex and the underlying mechanisms remain largely unknown. In our study, exosomes were exacted from patient samples, and the isolated exosomes were confirmed by transmission electron microscope. The expression of circRNA_104948, miR-29b-3p and DNMT3B were determined using RT-qPCR. Proliferative activity
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PI3K/Akt/mTOR Pathways Inhibitors with Potential Prospects in Non-Small-Cell Lung Cancer J. Environ. Pathol. Toxicol. Oncol. (IF 2.4) Pub Date : 2022-01-01 Khalid Saad Alharbi, Mohammad Arshad Javed Shaikh, Waleed Hassan Almalki, Imran Kazmi, Fahad A. Al-Abbasi, Sami I. Alzarea, Syed Sarim Imam, Sultan Alshehri, Mohammed M. Ghoneim, Sachin K. Singh, Dinesh Kumar Chellappan, Brian G. Oliver, Kamal Dua, Gaurav Gupta
Lung cancer is the leading cause of cancer-related mortality across the globe. The most prevalent pathological form of lung cancer is non-small-cell lung cancer (NSCLC). Elevated stimulation of the PI3K/Akt/mTOR pathway causes a slew of cancer-related symptoms, making it a promising target for new anticancer drugs. The PI3K/Akt/mTOR path is involved extensively in carcinogenesis and disease advancement
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CircCHD2/miR-200b-3p/HLF Axis Promotes Liver Cirrhosis J. Environ. Pathol. Toxicol. Oncol. (IF 2.4) Pub Date : 2022-01-01 Peng Hu, Jinwei Guo, Benhuo Zhao, Zhixiang Zhang, Jincan Zhu, Feng Liu
Inactivation of hepatic stellate cells (HSCs) slows down liver cirrhosis (LC) advancement. The role of circular RNAs (circRNAs) in LC is largely undiscovered. Here, we clarified the effect of circCHD2 on HSCs. LX-2 cells were stimulated with TGF-β1 to establish a cell model. The circCHD2, miR-200b-3p, and HLF were inspected using quantitative real-time PCR (qPCR). Cell counting kit-8, 5-Ethynyl-2'-deoxyuridine
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miR-210-3p Impairs Pancreatic β-Cell Function by Targeting Dtx1 in Gestational Diabetes Mellitus J. Environ. Pathol. Toxicol. Oncol. (IF 2.4) Pub Date : 2022-01-01 Xiaohui Cao, Bin Lu, Ying Gu, Xiaodan Li, Danfeng Guo, Fei Xia
Gestational diabetes mellitus (GDM), a common complication in pregnancy, could threaten the health of both pregnancies and their offspring. miR-210-3p has been reported that play a crucial role in many diseases. Nevertheless, the molecular mechanism and clinical significance of miR-210-3p in the GDM is still unclear. miR-210-3p was overexpressed in the pancreas of the GDM mouse model. Meanwhile, miR-210-3p
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Comprehensive Investigation of Genes Associated Cell Cycle Pathways for Prognosis and Immunotherapy in Bladder Urothelial Carcinoma J. Environ. Pathol. Toxicol. Oncol. (IF 2.4) Pub Date : 2022-01-01 Yue Mi
Background: Bladder urothelial carcinoma (BLCA) is estimated to cause approximately 150,000 deaths per year in the world. The prognosis of BLCA remains dismal, so early detection can have a significant impact on clinical outcomes. Numerous studies have shown that genes can alter the progression of tumors by regulating cell cycle, thus achieving targeted therapy. Methods: A comprehensive comparison
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Structural Features of Coronavirus and the COVID-19 Pandemic's Impact in India J. Environ. Pathol. Toxicol. Oncol. (IF 2.4) Pub Date : 2022-01-01 Ankur Jaiswal, Vinay Babu, Muneesh Sethi, Basant Baishya, Pallavi Jaiswal, Raja Joshi, Sudhir Jugran, Bharti Ramola, Avnish Kumar
The rapid transmission of COVID-19 infection around the world in a brief timeframe has caused an exponential decline in street traffic and other industrial activities in various parts of the world. The confined human collaboration with the nature at the time of this emergency has shown up as an advantage for Mother Nature after COVID-19 flare because the air present in the atmosphere and water flowing
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Essential Trace Metals as Countermeasure for Lead Toxicity J. Environ. Pathol. Toxicol. Oncol. (IF 2.4) Pub Date : 2022-01-01 Sanjib Bhattacharya
Lead (Pb) is the most common toxic heavy metal that is physiologically non-essential and imposes health complications in animals and humans. Chelation therapy is considered as the definite therapy for acute lead toxicity; clinical uses of chelating agents are not recommended in long-term lead toxicity and in children. Research reveals that essential trace metals can counteract empirical Pb toxicity