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SHP1 Decreases Level of P-STAT3 (Ser727) and Inhibits Proliferation and Migration of Pancreatic Cancer Cells J. Environ. Pathol. Toxicol. Oncol. (IF 1.625) Pub Date : 2021-01-01 Mingming Zhang; Xiaoru Hu; Ye Kang; Zhe Wang; Wenyang Zhou; Chang Liu; Xianghong Yang
Purpose: To identify the direct effects and functional mechanisms of SHP1, plus its relationship with STAT3 in pancreatic cancer. Methods: Immunohistochemistry and Western blot assays were used to test SHP1 expression in pancreatic cancer. The functions of SHP1 in pancreatic cancer cells were analyzed by cell viability, colony formation, flow cytometric analysis of apoptosis, migration and invasion
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Betalain alleviates airway inflammation in an ovalbumin-induced mouse model of asthma via TGF-?1/Smad signalling pathway J. Environ. Pathol. Toxicol. Oncol. (IF 1.625) Pub Date : 2021-01-01 Ningling Wang
Betalain is one such phytochemical present in the plants of order Caryophyllales. These are water soluble nitrogen based pigments proven to possess antimicrobial, antioxidant, anti-inflammatory, hepatoprotective, antilipidemic, antidiabetic, anticancer properties. Hence in the current exploration we examined the curative potential of betalain against allergic asthma mice model. Young female BALB/c
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Protective effect of Mangiferin inhibits inflammation, cell proliferation and activates pro-apoptotic events via NF-?B inhibition in DMBA-induced mammary carcinogenesis J. Environ. Pathol. Toxicol. Oncol. (IF 1.625) Pub Date : 2021-01-01 Xin Wang; Tong Yuwen; Tianyan Qin
Mammary cancer is a second-most leading cancer among other cancer-related death of women worldwide. In recent years, the medical community has advanced chemotherapies for cancer treatment. However, the survival ratio has not yet been improved. Therefore, we try to identify a novel natural chemopreventive agent for the management of breast cancer. Mangiferin (MGN) is a polyphenol agent; it presents
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Tomentosin attenuates behavior deficits and neuroinflammatory response in MPTP-induced Parkinson’s disease in mice J. Environ. Pathol. Toxicol. Oncol. (IF 1.625) Pub Date : 2020-12-01 Yunhu Fan
Parkinson’s disease (PD) is the second most neurodegenerative disease, which affects many persons worldwide. Tomentosin is an active compound isolated from I.viscosa plant that has extensive therapeutic values. In this exploration, the neuroprotective actions of tomentosin were investigated against the MPTP-stimulated neuroinflammation in mice. The PD was stimulated to the C57/BL6 mice by injecting
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Phyllanthin exerts neuroprotective effect against ischaemic/reperfusion injury via alteration of NF kB and AMPK/Nrf2 pathway J. Environ. Pathol. Toxicol. Oncol. (IF 1.625) Pub Date : 2020-12-01 Jing Chen
Cerebral ischemia-reperfusion (CIR) is a common feature of ischemic stroke and is a major causative of disability and death among the patients, due to stroke worldwide. Phyllanthin, a lignin polyphenol is known for varied biological properties such as anti-inflammatory and anti-oxidative functions. Eventually, the protective effect against CIR has not been reported. Hence, the neuroprotective property
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Coronavirus disease 2019 (COVID-19): Research, clinical knowledge and preventive measures J. Environ. Pathol. Toxicol. Oncol. (IF 1.625) Pub Date : 2020-12-01 Richa Rathor; Geetha Suryakumar; Som Nath Singh; Bhuvnesh Kumar
In early December 2019, a novel coronavirus disease 2019 (COVID-19), the global pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) commenced in Wuhun, China and WHO declared the outbreak a pandemic and Public Health Emergency of International Concern. Ample numbers of clinical trials with multiple drugs are underway to overcome the current perilous condition. Still, the
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Whole Exome Sequencing identifies Cohesin component STAG1 mutation in de novo Acute Myeloid Leukemia (FAB M2): a pilot study with Cytogenetics, Clinical and Prognostic implica J. Environ. Pathol. Toxicol. Oncol. (IF 1.625) Pub Date : 2020-12-01 Kunnathur Murugesan Sakthivel; Narayanan Geetha; Thampirajan Vimaladevi Akhila Raj; Ramachandran Krishna Chandran; Kumarapillai Mohanan Nair Jagathnath Krishna; Hariharan Sreedharan
The clinical implications of cohesin gene complex mutation in acute myeloid leukemia (AML) are not well characterized. In the present study, all participants were thoroughly analyzed for chromosomal aberrations by conventional and molecular cytogenetic analysis in a cohort of 152 de novo unselected adult AML patients. Further, we examined the frequency and clinical implications of mutations in cohesin
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Perls' Prussian Blue Stains of Lung Tissue, Bronchoalveolar Lavage, and Sputum J. Environ. Pathol. Toxicol. Oncol. (IF 1.625) Pub Date : 2021-01-01 Andrew J. Ghio; Victor L. Roggli
Perls' Prussian blue (PPB) stain recognizes Fe3+ associated with hemosiderin. The employment of this stain in clinical medicine and research has been extensive and novel applications continue to evolve. Ferruginous bodies are intracellular structures in lung tissue, bronchoalveolar lavage (BAL), and sputum that stain with PPB. Inhaled, insoluble, biopersistent particles and fibers are phagocytosed
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TISSUE LEVELS OF ORGANOCHLORINE PESTICIDES IN BENIGN AND MALIGNANT BREAST DISEASE: A COMPARATIVE EXPLORATORY STUDY J. Environ. Pathol. Toxicol. Oncol. (IF 1.625) Pub Date : 2020-11-01 Pankaj Kumar Garg; Nilokali Chishi; Rahul Kumar; Thammineni Krishna Latha; Shreyash Rai; Basu Dev Banerjee; Sanjay Gupta
Exposure of organochlorine pesticides (OCPs) may be a potential risk factor for breast cancer. Their role may become more important in a developing country like India where they are used in abundance for agricultural purpose. The present study was planned to compare the tissue levels of OCPs in patients with breast cancer and fibroadenoma. The tissue levels of OCPs were compared in two groups of patients
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Hypoxia induces the overexpression of CCL28 to recruit Treg cells to enhance angiogenesis in lung adenocarcinoma J. Environ. Pathol. Toxicol. Oncol. (IF 1.625) Pub Date : 2020-11-01 Bingchun Liu; chuyan Wei
Lung cancer is the world-leading causative factor of disease-related death. CD4+CD25+ regulatory T cells (CD4+CD25+ Treg) are involved in immune escape of tumor cells and the recruitment of Tregs is highly related to tumor development and metastasis. Besides, Hypoxia induces the overexpression of chemokine (C-C motif) ligand 28 (CCL28) thus enhancing the angiogenesis and metastasis of lung adenocarcinoma
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Diosmin Regulates Oxidative Stress and Inflammatory Marker Levels in N-Methyl-N-Nitrosourea-Induced Gastric Carcinogenesis in Rats J. Environ. Pathol. Toxicol. Oncol. (IF 1.625) Pub Date : 2020-01-01 Yixiu Zhao; Jing Zhang; Weiwei Liu
Gastric cancer is the most typical oncological illness globally. Though the incidence of gastric cancer has dropped dramatically over the last few years, the survival rate is yet concerning due to poor diagnostic strategy. The etiology of gastric cancer is majorly associated with dietary factors. For this reason, application of nontoxic natural agents with anticancer effects for patients is needed
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Deciphering the Role of Human Gastrointestinal Microbiota in the Pathogenesis of Vaginal Infection and Cervical Cancer J. Environ. Pathol. Toxicol. Oncol. (IF 1.625) Pub Date : 2020-01-01 Jingyi Wang; Zhiling Yang; Wen Li
The human microbiota typically contains symbionts and supports the host, although it can be commensal or reciprocal and pathogenic in its host function, immunity, and diet. Modern studies indicate that perturbations in the microbiome may be present in quite a few diseases, including inflammation and cancer. To be more specific, changes in the microbiomes of the gut and vagina may be related to various
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Kirenol Exhibits the Protective Role against N-Methyl-N-Nitrosourea-Induced Gastric Cancer in Rats via Modulating the Oxidative Stress and Inflammatory Markers J. Environ. Pathol. Toxicol. Oncol. (IF 1.625) Pub Date : 2020-01-01 Weiwei Liu; Yuzhu Li; Chengzhen Li
Background: Gastric cancer (GC) may arise in any region of the stomach. Poorly diagnosed GC results in almost one million mortalities annually worldwide. Kirenol is a bioactive compound present in the Sieges beckia sps. Objective: In this current, we investigate the anticancer capacity of kirenol against the MNG-stimulated GC in rats via modulating the antioxidants status and inhibition of NF-κB cascade
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Biochemical Pathways Regulated by Algae to Mitigate Global Carbon Emissions: A Review J. Environ. Pathol. Toxicol. Oncol. (IF 1.625) Pub Date : 2020-01-01 Ankur Jaiswal; Vinay Babu; Basanta Baishya; Pallavi Jaiswal
Carbon dioxide (CO2), being an important greenhouse gas (GHG) significantly present in Earth's atmosphere, has been increasing because of several anthropogenic activities leading to global warming. Globally, various efforts have been made to confront climate change, and various CO2 capture and storage methods have been designed. This review aims at describing detailed studies about algae and the methods
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Role of Tilianin against Acute Lung Injury in In Vitro LPS-Induced Alveolar Macrophage Cells and an In Vivo C57BL/6 Mice Model J. Environ. Pathol. Toxicol. Oncol. (IF 1.625) Pub Date : 2020-01-01 Yonghong Zhang; Zhenshuai Fu
Acute lung injury (ALI) is a disorder of pulmonary tissue caused by prolonged inflammation and uncontrolled oxidative stress. Tilianin is a natural polyphenol, acknowledged for its anti-inflammatory and antioxidant activities. The goal of this work was to explore the effect of tilianin in an LPS-challenged ALI model. The mechanistic investigation was carried out using both in vitro and in vivo experiments
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Tomentosin Inhibits Lipopolysaccharide-Induced Acute Lung Injury and Inflammatory Response by Suppression of the NF-κB Pathway in a Mouse Model of Sepsis J. Environ. Pathol. Toxicol. Oncol. (IF 1.625) Pub Date : 2020-01-01 Haijun Zhu; Yongyi Wang; Jie Sun; Conghui Fan; Jian Wan
Acute lung injury (ALI) is a severe inflammatory disorder that causes respiratory failure. Cases of ALI are reported with increasing mortality rates each year. In this study, we investigated the anti-inflammatory role of tomentosin and its fundamental mechanisms against lipopolysaccharide (LPS)-induced ALI via the suppression of Toll-like receptor (TLR4)/nuclear factor-kappa beta (NF-κB) pathway in
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FAPP2 Accelerates the Proliferation and Invasion of Hepatocellular Carcinoma Cells via Wnt/β-Catenin Signaling J. Environ. Pathol. Toxicol. Oncol. (IF 1.625) Pub Date : 2020-01-01 Lianhua Kong; Li Dong
Four-phosphate adaptor-2 (FAPP2) has been recently identified as a tumor-associated regulator that is closely related to tumorigenesis. However, the precise role of FAPP2 in hepatocellular carcinoma (HCC) is still largely unknown. This study was designed to determine the function and molecular mechanisms of FAPP2 in HCC. Elevated expression of FAPP2 commonly occurred in the tumor tissue of HCC compared
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Vernolide-A and Vernodaline: Sesquiterpene Lactones with Cytotoxicity against Cancer J. Environ. Pathol. Toxicol. Oncol. (IF 1.625) Pub Date : 2020-01-01 Nguyen H. Nguyen; Minh Tan Nguyen; Peter J. Little; Anh Thu Do; Phuong Trinh Tran; Xuan Nam Vo; Bich Hang Do
Vernolide-A and vernodaline are sesquiterpene lactones isolated from genera of Vernonia. Vernolide-A and vernodaline have shown promising therapeutic properties, including antibacterial, antihelminth, and antioxidant activities. Recently, the anticancer properties of these sesquiterpene lactones have been investigated with the elucidation of effects on cell proliferation, metastasis, angiogenesis,
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Cystathionine β Synthase/Hydrogen Sulfide Signaling in Multiple Myeloma Regulates Cell Proliferation and Apoptosis. J. Environ. Pathol. Toxicol. Oncol. (IF 1.625) Pub Date : 2020-01-01 Minmin Zhang,Juan Li,Beihui Huang,Lifen Kuang,Fei Xiao,Dong Zheng
Objective-To investigate cystathionine β synthase (CBS)/hydrogen sulfide (H2S) signaling in multiple myeloma (MM) patients and to identify its effect on the proliferation of U266 cells. Methods-Bone marrow samples of 19 MM patients and 23 healthy donors were collected. qRT-PCR was performed to measure the mRNA expression levels of H2S synthases, cystathionine β synthase, and cystathionine γ lyase.
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Anti-Inflammatory Effect of Mangiferin on an Experimental Model of Allergic Rhinitis through the Inhibition of NF-κB Signaling Pathways J. Environ. Pathol. Toxicol. Oncol. (IF 1.625) Pub Date : 2020-01-01 Yanhui Wang; Chengchao Cui; Hongjun Sun
Allergic rhinitis (AR) is nasal inflammation caused by allergy and the prevalence of AR is rising globally. In this investigation, we used ovalbumin-provoked AR to examine the antiallergic, anti-inflammation activities of mangiferin. Mangiferin is a xanthone found in higher plants as well as mango and it has numerous health benefits including antitumor, antioxidant, antimutagenic, antidiabetic, antibacterial
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Malvidin Abrogates Oxidative Stress and Inflammatory Mediators to Inhibit Solid and Ascitic Tumor Development in Mice. J. Environ. Pathol. Toxicol. Oncol. (IF 1.625) Pub Date : 2020-01-01 Kunnathur Murugesan Sakthivel,Krishnamoorthy Kokilavani,Chinnadurai Kathirvelan,Durairaj Brindha
The anticancer activity of malvidin was studied in Dalton's lymphoma ascites (DLA)-induced solid and ascitic tumor mice models. Malvidin is a natural compound belonging to the family of O-methylated anthocyanidin and plays a predominant role in regulating both short- and long-term cellular activities. Animals were injected with DLA cells (1.5 × 106 cells/animal) to induce solid and ascitic tumors.
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Cross Talk between Mitochondria and Other Targets in Alzheimer's Disease. J. Environ. Pathol. Toxicol. Oncol. (IF 1.625) Pub Date : 2020-01-01 Rehana Khatoon,Monika Pahuja,Suhel Parvez
Among the neurodegenerative diseases, Alzheimer's disease (AD) is a predominant public health issue, affecting 16 million people around the world. It is clinically manifested by the presence of amyloid plaques (Aβ) and neurofibrillary tangles (NFT) within the brain. Due to intraneuronal processing, Aβ interacts with cellular targets such as mitochondria, ER, and Golgi apparatus and hampers their normal
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Protective Effect of D-Carvone against Dextran Sulfate Sodium Induced Ulcerative Colitis in Balb/c Mice and LPS Induced RAW Cells via the Inhibition of COX-2 and TNF-α. J. Environ. Pathol. Toxicol. Oncol. (IF 1.625) Pub Date : 2020-01-01 Xiaoyan Zhu,Guo Wang,Shuang Wu,Chengzhen Li
Ulcerative colitis (UC) is an intractable ailment, in which may chronic inflammations/ulcerations may develop in the mucosal lining of the colon with multiple recurrences. Various drugs such as steroids, immunosuppressants, and antibiotics are extensively used to treat UC. The patients suffer from adverse effects of these advanced drugs. So, they need a harmless therapeutic agent from natural sources
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Effects of Boldine on Antioxidants and Allied Inflammatory Markers in Mouse Models of Asthma. J. Environ. Pathol. Toxicol. Oncol. (IF 1.625) Pub Date : 2020-01-01 Wei Li,Vishnu Priya Veeraraghavan,Weining Ma
Asthma is marked by chronic irritation in the airway lumen of the lungs due to the accretion of inflammatory cells that influence the regular inhalation process. An extended buildup of inflammation leads to oxidative pressure and the repression of antioxidant functions. In the current study, a potential compound, boldine, was tested for the containment of provocative markers along the path of antiasthmatic
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Safety Concerns of Organic Ultraviolet Filters: Special Focus on Endocrine-Disrupting Properties. J. Environ. Pathol. Toxicol. Oncol. (IF 1.625) Pub Date : 2020-01-01 Didem Oral,Anil Yirun,Pinar Erkekoglu
Acute and chronic effects of ultraviolet radiation (UVR) on human health have long been a concern. It is well known that acute UVR causes epidermal hyperplasia, erythema, delayed tanning, pigment darkening, and free-radical formation. Apart from acute effects of UVR, its chronic effects involve immunosuppression, photoaging, exacerbation, photodermatoses, and photocarcinogenesis. To protect skin from
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Effect of Betulin on Inflammatory Biomarkers and Oxidative Status of Ova-Induced Murine Asthma. J. Environ. Pathol. Toxicol. Oncol. (IF 1.625) Pub Date : 2020-01-01 Lei Wang,Diansheng Zhong
Asthma is a chronic, serious allergic inflammatory disease in the airway. The inflammation in the airway is induced by the allergic T-helper 2 cells (Th2 cells), which leads to unfettered production of inflammatory cytokines. The accretion of inflammatory cells in the airway also speeds up the secretion of reactive oxygen species (ROS) and suppresses antioxidative processes. Hence, the present work
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Evaluation of Potential of Long Noncoding RNA NEAT1 in Colorectal Cancer. J. Environ. Pathol. Toxicol. Oncol. (IF 1.625) Pub Date : 2020-01-01 Hongping Cheng,Anshoo Malhotra
Long noncoding RNAs (lncRNAs) have been reported to be involved in cancer initiation and evolution, including colorectal cancer (CRC). Nuclear-enriched abundant transcript 1 (NEAT1) exerts important functions in multiple cancers; however, the specific modulatory mechanism in CRC demands in-depth exploration. The expression levels of NEAT1, microRNA-195-5p (miR-195-5p), and centrosomal protein 55 (CEP55)
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Vicenin-2 Treatment Attenuated the Diethylnitrosamine-Induced Liver Carcinoma and Oxidative Stress through Increased Apoptotic Protein Expression in Experimental Rats. J. Environ. Pathol. Toxicol. Oncol. (IF 1.625) Pub Date : 2020-01-01 Chunyang Zhang,Yuhui Chen,Ming Zhang,Chunni Xu,Guojin Gong,Vishnu Priya Veeraraghavan,Srinivasa Rao Bolla,Yandong Li
Liver cancer or hepatocellular carcinoma is considered to be the third leading cause of death among all other cancers. The rate of liver cancer occurrence is high, and the rate of recovery is low. In this study, we investigated the therapeutic efficacy of vicenin-2 against the diethylnitrosamine-induced liver carcinoma in experimental rats. Diethylnitrosamine was widely employed as a carcinogenic agent
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Going Beyond Antibiotics: Natural Plant Extracts as an Emergent Strategy to Combat Biofilm-Associated Infections. J. Environ. Pathol. Toxicol. Oncol. (IF 1.625) Pub Date : 2020-01-01 Janice Kou,Tan Yu Xin,Paul McCarron,Gaurav Gupta,Harish Dureja,Saurabh Satija,Meenu Mehta,Hamid A Bakshi,Murtaza M Tambuwala,Trudi Collet,Kamal Dua,Dinesh Kumar Chellappan
Biofilms are a collective of multiple types of bacteria that develop on a variety of surfaces. Biofilm development results in heightened resistance to antibiotics. Quorum sensing plays an important role in biofilm development as it is one of the common communication mechanisms within cells, which balances and stabilizes the environment, when the amount of bacteria increases. Because of the important
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Immunomodulatory Effect of Eriocitrin in Experimental Animals with Benzo(a)Pyrene-induced Lung Carcinogenesis. J. Environ. Pathol. Toxicol. Oncol. (IF 1.625) Pub Date : 2020-01-01 Qing Wang,Liqiong Zhang,Meifang Huang,Yuanyuan Zheng,Kai Zheng
Lung carcinogenesis is one of the main sources of cancer-related mortality globally and it is estimated that nearly 1 million people die from it every year. The 5-year survival rate of lung carcinogenesis is reported at just 15%. The aim of the current research was to investigate the immunomodulatory effect of eriocitrin against benzo(a)pyrene [B(a) P]-induced lung tumorigenesis in Swiss albino mice
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The Role of Spirulina (Arthrospira) in the Mitigation of Heavy-Metal Toxicity: An Appraisal. J. Environ. Pathol. Toxicol. Oncol. (IF 1.625) Pub Date : 2020-01-01 Sanjib Bhattacharya
Heavy-metal toxicity imposes a potential worldwide threat to the environment and humans. Cadmium, mercury, lead, and arsenic are nonessential toxic heavy metals that are most frequently involved in environmental and health hazards. Conventional chelating agents are unsuitable for subchronic and chronic heavy-metal toxicities. Scientific literature reveals that Spirulina (Arthrospira), a photosynthetic
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Therapeutic Role of Natural Agents in the Management of Coronary Artery Disease: A Review. J. Environ. Pathol. Toxicol. Oncol. (IF 1.625) Pub Date : 2020-01-01 Ketan Vinayakrao Hatware,Sanjay Sharma,Kiran Patil,Harpalsing Rajput,Gaurav Gupta
This review delineates the potential of naturally occurring substances for coronary artery disease (CAD), mainly coronary ischemia and its management, with their active constituents and probable mechanisms of action. As per the WHO, statistical incidence of CAD has increased in several countries. The number of coronary events worldwide has been increasing, and may increase even more in the near future
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Ginkgo biloba Extract Mechanism Inhibits Hepatocellular Carcinoma through the Nuclear Factor-κB/p53 Signaling Pathway. J. Environ. Pathol. Toxicol. Oncol. (IF 1.625) Pub Date : 2020-01-01 Ruike Wang,Xiaomei Shao,Jiping Yang,Zhenzhen Liu,Lisah Chew,Ying Shao
Ginkgo biloba extract EGb761 conveys an anticancer effect, but little is known regarding its role in hepatocellular carcinoma (HCC). Our study aims to determine the anticancer effect of EGb761 on HCC cell lines and clarify the underlying molecular mechanism. We explore biological functions of EGb761 in HCC using morphological observation, the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide
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Naringin, a Natural Flavonoid, Modulates UVB Radiation-Induced DNA Damage and Photoaging by Modulating NER Repair and MMPS Expression in Mouse Embryonic Fibroblast Cells. J. Environ. Pathol. Toxicol. Oncol. (IF 1.625) Pub Date : 2020-01-01 Roopa NilamberLal Das,Agilan Balupillai,Ernest David,Murali Santhoshkumar,Sridevi Muruhan
We have proven that naringin, a phytonutrient, diminishes oxidative damage and inflammatory responses by modulating PPAR-γ expressions in ultraviolet-B radiation (UVB)-induced NIH-3T3 cells. However, the role of naringin against DNA damage, photoaging, and apoptosis in NIH-3T3 cells has yet to be studied, necessitating investigation. We show that Naringin pretreatment significantly reduces UVB-induced
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Tilianin Protects Diabetic Retina through the Modulation of Nrf2/TXNIP/NLRP3 Inflammasome Pathways. J. Environ. Pathol. Toxicol. Oncol. (IF 1.625) Pub Date : 2020-01-01 Yunda Zhang,Zhao Gao,Xiaohong Gao,Zhigang Yuan,Tao Ma,Gaiyun Li,Ximei Zhang
Oxidative stress and inflammation are regarded as prime reasons for the progression and development of diabetic retinopathy. Currently, nuclear factor erythroid-2-related factor 2 (Nrf2), thioredoxin interacting protein (TXNIP) and NLRP3 inflammasome pathways are under increasing focus in research on oxidative stress and inflammation-related diseases. On the other hand, tilianin (TN) has received much
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Nobiletin Inhibits Helicobacterium pylori Infection-Induced Gastric Carcinogenic Signaling by Blocking Inflammation, Apoptosis, and Mitogen-Activated Protein Kinase Events in Gastric Epithelial-1 Cells. J. Environ. Pathol. Toxicol. Oncol. (IF 1.625) Pub Date : 2020-01-01 Yiming Ouyang,Linhai Li,Ping Ling
Helicobacter pylori causes a Gram-negative bacterial infection that can increase the risk of gastric cancer. Consequently, meticulous prevention of an H. pylori infection is significant for averting gastric cancer in humans. Nobiletin, an important dietary polymethoxylated flavonoid in citrus fruits, possesses multidimensional pharmaceutical properties, including its ability to act as an anticancer
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Antiatherosclerotic Activity of Eriocitrin in High-Fat-Diet-Induced Atherosclerosis Model Rats. J. Environ. Pathol. Toxicol. Oncol. (IF 1.625) Pub Date : 2020-01-01 Jia Wan,Yaoyu Feng,Lingjuan Du,Vishnu Priya Veeraraghavan,Surapaneni Krishna Mohan,Shikui Guo
Atherosclerosis is a multifactorial disease that develops and progresses in the arterial wall in response to a variety of stimuli. Among various other stimuli, hyperlipidemia is an extremely important factor that is correlated with the development of atherosclerosis. Lemon and citrus fruits contain various bioactive flavonoids, such as eriocitrin, that prevent obesity and related metabolic diseases
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Evaluation of Cytotoxicity of Different Part Extracts of Ipomoea turpethum against Breast Cancer Cell Lines. J. Environ. Pathol. Toxicol. Oncol. (IF 1.625) Pub Date : 2020-01-01 Mohd Mughees,Saima Wajid
The aim of the present study was to explore the anti-breast cancer activity of the plant I. turpethum together with the comparative analysis of the cytotoxicity of the extracts from different parts of the plant. The gas chromatography-mass spectrometry (GC-MS) analysis of the plant revealed the identification of 71 compounds. The cytotoxicity of the extracts from different parts (whole, aerial, and
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Identification of Potential Oncogenic Long Non-Coding RNA Set as a Biomarker Associated with Colon Cancer Prognosis. J. Environ. Pathol. Toxicol. Oncol. (IF 1.625) Pub Date : 2020-01-01 Meihua Chen,Ming Fan,Jialin Yang,Jinyi Lang
Colon cancer (CC) is the most common type of gastrointestinal cancer and is the third leading cause of cancer patient's death worldwide. Long non-coding RNAs (lncRNAs) are important regulatory molecules involved in various cellular processes, and many of them are shown as significant prognosis biomarkers of malignant tumors. In the present study, we identified differentially expressed lncRNAs between
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Effects of Tobacco on Biochemical Parameters in Healthy and Type 2 Diabetic Subjects. J. Environ. Pathol. Toxicol. Oncol. (IF 1.625) Pub Date : 2020-01-01 Bhumika Upadhyay,Shridhar Dwivedi,Saima Wajid,Swatantra Kumar Jain
Diabetes and tobacco use are two of the largest public health challenges of our time. We aim to investigate the association between the two by comparing biochemical profiles of diabetic tobacco users (TUs) and tobacco nonus-ers (TNUs) to provide insight into the joint effect of tobacco and diabetes on body systems. This case-controlled study included 265 subjects, aged 18-60 yr, from the suburban population
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Nobiletin Attenuates Cell Proliferation by Modulating the Activating Protein-1 Signaling Pathway in 7,12-Dimethylbenz[a]anthracene-Induced Mammary Carcinogenesis. J. Environ. Pathol. Toxicol. Oncol. (IF 1.625) Pub Date : 2020-01-01 Huazhi Zhang,Ping Lv,Zhanzhan Xiao,Elamaran Ananda Jothi,Jiangfei Yang
Breast cancer is a widespread disease that affects women globally. Diagnostic processes and remedial approaches to breast carcinogenesis have improved in recent decades, but continuous survival of patients with breast carcinogenesis is still lacking due to increased cell proliferation. The aim of the present work is to explore the anticell proliferative effects of nobiletin (NOB) against 7,12-dime
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Clozapine Improves Behavioral and Biochemical Outcomes in a MK-801-Induced Mouse Model of Schizophrenia. J. Environ. Pathol. Toxicol. Oncol. (IF 1.625) Pub Date : 2020-01-01 Syed Suhail Andrabi,Shruti Vishnoi,Riya Madan,Neha Bhardwaj,Heena Tabassum,Mohd Akram,Suhel Parvez
Glutamatergic N-methyl-D-aspartate (NMDA) receptors have critical roles in several neurological and psychiatric diseases. Dizocilpine (MK-801) is a ligand at phencyclidine recognition sites that is associated with NMDA receptor-coupled cation channels, where it acts as a potent noncompetitive antagonist of central glutamate receptors. In this study, we investigate the effect of clozapine on MK-801-induced
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D-Pinitol Ameliorates Imiquimod-Induced PsoriasisLike Skin Inflammation in a Mouse Model via the NF-κB Pathway. J. Environ. Pathol. Toxicol. Oncol. (IF 1.625) Pub Date : 2019-11-05 Jing Ma,Shijun Feng,Dongfang Ai,Yuan Liu,Xiufang Yang
Psoriasis is an autoregulated immune and inflammation-based skin disease affecting approximately 3-4% of the worldwide population. Pinitol, conservatively used in ayurvedic medicine, has been shown to disclose an antiinflammatory effect, hold back the T-helper cells, and postpone cardiovascular diseases. In the present study we aimed to reveal the effect of D-pinitol on imiquimod (IMQ)-induced psoriasis-like
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Low-Magnitude, High-Frequency Vibration Promotes Osteogenic Differentiation via Intensifying miRNA-335-5p Expression. J. Environ. Pathol. Toxicol. Oncol. (IF 1.625) Pub Date : 2019-11-05 Wei Zhao,Yi Tang,Yang Yang,Min Wang,Haiyang Yu
Certain mechanical stimuli-particularly low-magnitude, high-frequency vibration-could induce bone marrow stem cell osteogenic differentiation and promote bone formation via Wnt signaling pathway, although the molecular mechanism is still unclear. In this study, we found that miR-335-5p is significantly upregulated after low-magnitude, high-frequency vibration, which suppresses the expression of the
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Oxidative Stress Parameters, Selenium Levels, DNA Damage, and Phthalate Levels in Plastic Workers. J. Environ. Pathol. Toxicol. Oncol. (IF 1.625) Pub Date : 2019-11-05 Gulru Gurdemir,Pinar Erkekoglu,Aylin Balci,Unzile Sur,Gizem Ozkemahli,Engin Tutkun,Hinc Yilmaz,Ali Asci,Belma Kocer-Gumusel
Di(2-ethylhexyl)phthalate (DEHP) is the most widely used phthalate. DEHP is highly used in PVC floorings and PVC windows and carpeting. The objective of this study was to determine sex hormone levels, oxidative stress parameters, selenium levels, DNA damage, and phthalate levels in plastics workers (n = 24, age = 20-58 years) working in the production of rubber mechanical goods and exposed to DEHP
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Anti-Inflammatory and Apoptotic Signaling Effect of Fucoxanthin on Benzo(A)Pyrene-Induced Lung Cancer in Mice. J. Environ. Pathol. Toxicol. Oncol. (IF 1.625) Pub Date : 2019-11-05 Weiwei Chen,Hongjing Zhang,Yue Liu
Fucoxanthin, a potent carotenoid present in various natural sources especially from seaweeds; it exhibits several biological effects like anti-neoplastic, anti-mutagenic, anti-diabetic, anti-obesity and anti-inflammatory actions. Fucoxanthin role in chemoprevention of lung cancer in mouse model induced using benzo(a)pyrene [B(a)P] has been presented here. Oral administration of fucoxanthin with and
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Assessment of the Therapeutic Effects of Fucoxanthin by Attenuating Inflammation in Ovalbumin-Induced Asthma in an Experimental Animal Model. J. Environ. Pathol. Toxicol. Oncol. (IF 1.625) Pub Date : 2019-11-05 Xinjun Yang,Gang Guo,Minyan Dang,Lei Yan,Xin Kang,Kunjin Jia,Hong Ren
Asthma has affected more than 300 million people worldwide and is considered one of the most debilitating global public health problems based on a recent statistical report from the Global Initiative for Asthma. Inflammation of the airways leads to the various interrelated mechanisms of innate and adaptive immunity acting mutually with the epithelium of the respiratory organ. Fucoxanthin is an orange
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Atractylenolide III Enhances the Anti-Neoplastic Efficacy of Docetaxel in Gastric Cancer Cell by Inhibiting Fibroblast Growth Factor Receptors 1, -2, and -4 Expression. J. Environ. Pathol. Toxicol. Oncol. (IF 1.625) Pub Date : 2019-11-05 Yanxia Ji,Zhenqiao Kang,Ning Kang,Yanzheng Zhao,Qing Guo,Yongge Chen
BACKGROUND Natural active components have been reported to serve as adjuvant medications in the clinical practice of cancer therapeutics. However, the antineoplastic roles of atractylenolide III (ATL) are rarely reported. In the present study, we assessed the functions of ATL combined with docetaxel in gastric cancer cells. METHODS Cell viability and cytotoxic activity were evaluated using CCK-8 and
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Therapeutic potential of Artemisia vulgaris: An insight into underlying immunological mechanisms. J. Environ. Pathol. Toxicol. Oncol. (IF 1.625) Pub Date : 2019-11-05 Laura Soon,Phui Qi Ng,Jestin Chellian,Thiagarajan Madheswaran,Jithendra Panneerselvam,Gaurav Gupta,Srinivas Nammi,Nicole G Hansbro,Alan Hsu,Harish Dureja,Meenu Mehta,Saurabh Satija,Philip M Hansbro,Kamal Dua,Trudi Collet,Dinesh Kumar Chellappan
Artemisia vulgaris is a traditional Chinese herb believed to have a wide range of healing properties; it is traditionally used to treat numerous health ailments. The plant is commonly called mugwort or riverside wormwood. The plant is edible, and in addition to its medicinal properties, it is also used as a culinary herb in Asian cooking in the form of a vegetable or in soup. The plant has garnered
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Curcumin Modulates Hepatocellular Carcinoma by Reducing UNC119 Expression. J. Environ. Pathol. Toxicol. Oncol. (IF 1.625) Pub Date : 2019-11-05 Zhenjiang Zhao,Anshoo Malhotra,Wu Yuan Seng
UNCI 19 expression has been reported to be significantly higher in hepatic cancer cells (HCC). However, the clinical significance of modulating UNC119 expression in HCC is not well understood. The study described here aimed to explore the potential of curcumin in modulation of UNC119 expression in HCC by assessment with quantitative real-time PCR, western blot, and immune-histochemical analyses in
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AgNPs from Nigella sativa Control Breast Cancer: An In Vitro Study. J. Environ. Pathol. Toxicol. Oncol. (IF 1.625) Pub Date : 2019-11-05 Baradhan Rohini,Tahira Akther,Mohammad Waseem,Jasim Khan,Mohammad Kashif,Srinivasan Hemalatha
In our current study, we synthesized silver nanoparticles (AgNPs) from an aqueous seed extract of Nigella sativa. The seed extract contains phytochemical compounds including phenols, terpenoids, and flavonoids that may act as reducing agents and are able to convert metal ions to metal nanoparticles. The formation of synthesized AgNPs was characterized using UV-visible spectroscopy, Fourier transform
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Increased Expression of TGF-β and IFN-γ in Peripheral Blood Mononuclear Cells (PBMCs) Cultured in Conditioned Medium (CM) of K562 Cell Culture. J. Environ. Pathol. Toxicol. Oncol. (IF 1.625) Pub Date : 2019-11-05 A A Mohamed Adil,Lavanya Vallinayagam,K Chitra,Shazia Jamal,Ashok Kumar Pandurangan,Neesar Ahmed
In the present study, we investigated the effects of conditioned media (CM) collected from the cancer cell lines (K562, MCF-7, and HeLa) on peripheral blood mononuclear cells (PBMCs) isolated from the healthy human blood. The soluble factors in the CM are probably responsible for the differential mRNA expressions of Foxp3, Helios, Neuropilin- 1 (NRP-1), and glycoprotein A repetitions predominant (GARP)
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Analysis of Lead, Cadmium, and Nickel in Blood Donors in Relation to Smoking-A Comparative Study. J. Environ. Pathol. Toxicol. Oncol. (IF 1.625) Pub Date : 2019-11-05 Achummantakath Hashim,Haneena Fathima,Rashid C S Muhammed,D R Dsouzac Neevan
Donor blood is usually screened for some risk factors, such as hepatitis, HIV, and malarial parasites, but it is not routinely screened for heavy metals although their adverse effects on the human body have been proved by a number of studies. In this study, an attempt was made to determine the effect of smoking on concentration of cadmium, nickel, and lead in donor blood. A semistructured questionnaire
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Rutin Protects against Doxorubicin-Induced Cognitive Dysfunction While Retaining the Anticancer Potential of Dox in a Murine Model of N-Methyl-N-Nitrosourea - Induced Mammary Carcinoma. J. Environ. Pathol. Toxicol. Oncol. (IF 1.625) Pub Date : 2019-11-05 Grandhi Venkata Ramalingayya,Karthik Gourishetti,Pawan G Nayak,Chamallamudi Mallikarjuna Rao,Anoop Kishore,Sulaiman M Alnaseer,Shalam M Hussain,Krishnadas Nandakumar
Chemobrain is a significant post-chemotherapy complication for which no approved treatments are available. We had previously identified that rutin inhibits doxorubicin (Dox-) -induced cognitive decline in healthy rats. However, it was important to also establish that it does so in rats with mammary carcinoma without compromising Dox's antitumor potential. Mammary carcinoma was induced in female rats
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Nrf2/HO-1 Mediated Protective Activity of Genistein Against Doxorubicin-Induced Cardiac Toxicity. J. Environ. Pathol. Toxicol. Oncol. (IF 1.625) Pub Date : 2019-11-05 Miao Chen,Vijaya Paul Samuel,Yi Wu,Minyan Dang,Yukiat Lin,Raghava Sriramaneni,Sushil Kumar Sah,Gopala Krishna Chinnaboina,Guangping Zhang
The current study evaluated the cardioprotective activity of genistein in cases of doxorubicin-(Dox) induced cardiac toxicity and a probable mechanism underlying this protection, such as an antioxidant pathway in cardiac tissues. Animals used in this study were categorized into four groups. The first group was treated with sodium carboxymethylcellulose (0.3%; CMC-Na) solution. The second group received
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Metformin: A Salutary Candidate for Colorectal Cancer Treatment in Patients with Diabetes. J. Environ. Pathol. Toxicol. Oncol. (IF 1.625) Pub Date : 2019-11-05 Vijaya Paul Samuel,Rajiv Dahiya,Yogendra Singh,Gaurav Gupta,Sushil Kumar Sah,Shiva Kumar Gubbiyappa,Dinesh Kumar Chellappan,Kamal Dua
The current study is a review of the literature on patients with diabetes who are diagnosed with colorectal cancer (CRC), encompassing recent research on CRC and the molecular level changes occurring in these patients on the basis of varying environmental as well as non-environmental factors. It has been noted that nearly 50% of all patients undergo the systemic treatment module; however, most of them
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Evaluation of LncRNA ANRIL Potential in Hepatic Cancer Progression. J. Environ. Pathol. Toxicol. Oncol. (IF 1.625) Pub Date : 2019-11-05 Yongjian Ji,Hao Sun,Haiqing Liang,Yong Wang,Meili Lu,Zhaoyang Guo,Zhuozhen Lv,Wanhua Ren
BACKGROUND/AIMS LncRNAs are significant regulators in multiple cancers including hepatocellular carcinoma (HCC). Recently, lncRNA ANRIL has been reported to be elevated during multiple cancer types, exhibiting oncogenic roles. However, the exact biological mechanism of ANRIL is still poorly understood in HCC. METHODS Quantitative real-time polymerase chain reaction (qRT-PCR) assays were utilized to
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Role of Herbal Medicine in the Management of Urolithiasis- A Review for Future Perspectives. J. Environ. Pathol. Toxicol. Oncol. (IF 1.625) Pub Date : 2019-11-05 Ajay Patle,Ketan Vinayakrao Hatware,Kiran Patil,Sanjay Sharma,Gaurav Gupta
BACKGROUND Urolithiasis is the most common renal system pathology; it affects the health of a many people. Because urolithiasis leads to severe pain, it influences the patient in many aspects. The management of urolithiasis is essential. Herein, we discuss the limitations of the management of urolithiasis with conventional drugs and the possibilities of using natural or herbal pharmacologically active
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Reduction of Gamma Radiation-Induced Damage by Hydro-Alcoholic Extract of Nardostachys jatamansi. J. Environ. Pathol. Toxicol. Oncol. (IF 1.625) Pub Date : 2019-02-27 Aditya Menon,Tiju Chacko,Praseetha R Nair,Teeju Majeed,Cherupally Krishnan Krishnan Nair
The search for a nontoxic radioprotector has not yielded any promising results. Many antioxidant compounds, though effective under in vitro conditions as radioprotectors, have failed under in vivo settings due to their toxicity. The Indian medical system of Ayurveda uses a variety of plants with antioxidant potential, and these may be harboring molecules with radioprotective properties. In the present