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cGAS-STING and PD1/PDL-1 pathway in breast cancer: a window to new therapies J. Recept. Signal Transduct. (IF 2.8) Pub Date : 2024-03-12 Milad Khorasani, Maryam Alaei
Breast cancer is a complex malignancy with diverse molecular and cellular subtypes and clinical outcomes. Despite advances in treatment, breast cancer remains a significant health challenge. Howeve...
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New synthetic derivatives of isoindoline-dione: synthesis, neuroprotection assay and impact on the expression level of oxidative stress-related genes in neuronal-like cell line J. Recept. Signal Transduct. (IF 2.8) Pub Date : 2024-02-13 Abdolrahim Pourparizi, Mina Vazirinia, Fatemeh Pourrajab, Hamid Nadri, Asghar Davood
Oxidative stress can damage cells and cause age-related illnesses such as Alzheimer’s, Parkinson’s, and Huntington’s. This study looked at newly synthesized isoindole derivatives and their effects ...
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Exploring the composition of protein-ligand binding sites for cancerous inhibitor of PP2A (CIP2A) by inhibitor guided binding analysis: paving a new way for the Discovery of drug candidates against triple negative breast cancer (TNBC) J. Recept. Signal Transduct. (IF 2.8) Pub Date : 2024-02-13 Oluwayimika Ibitoye, Mahmoud A. A. Ibrahim, Mahmoud E. S. Soliman
Triple-negative breast cancer (TNBC) is associated with high-grade invasive carcinoma leading to a 10% to 15% death rate in younger premenopausal women. Targeting cancerous inhibitors of protein ph...
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The route of autophagy regulation by osteopontin: a review on the linking mechanisms J. Recept. Signal Transduct. (IF 2.8) Pub Date : 2024-01-18 Zohreh Abdolvahabi, Samira Ezzati-Mobaser, Zahra Hesari
Autophagy is a dynamic intracellular process of protein degradation, which is mostly triggered by nutrient deprivation. This process initiates with the formation of autophagosomes, which they captu...
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Molecular docking and toxicity studies of nerve agents against acetylcholinesterase (AChE) J. Recept. Signal Transduct. (IF 2.8) Pub Date : 2024-01-23 Mikael Ham Sembiring, Okta Nursanti, Tesia Aisyah Rahmania
Acetylcholinesterase (AChE) is a cholinergic enzyme that plays an essential role in the autonomic nervous system. This enzyme is often the target of many nerve agents. When this enzyme is inhibited...
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Cerebrolysin provides effective protection on high glucose-induced neuropathy in cultured rat dorsal root ganglion neurons J. Recept. Signal Transduct. (IF 2.8) Pub Date : 2024-01-23 Ugur Yazar, Ali Rıza Guvercin, Mahindokht Rouhikia, Mehmet Aktoklu, Mehmet Ali Demirci, Ibrahim Erbay, Ahmet Ayar
Cerebrolysin, an endogenous peptide with neuroprotective and neurotrophic properties, indicated to be beneficial on diabetic neuropathy by preliminary clinical and experimental studies but without ...
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Verapamil modulates NFAT2 to inhibit tumor growth and potentiates PD1ab immune checkpoint inhibitor therapy in cervical cancer treatment J. Recept. Signal Transduct. (IF 2.8) Pub Date : 2024-01-18 Yao-Qing Liao, Bin-Bo Fang, Qing-Xia Wu, Wei-Ying Dong, Guan-Ming Deng
Current evidence suggests a high co-prevalence of hypertension and cervical cancer. Accordingly, blood pressure control is indicated during anti-tumor drug therapy in this patient population. Over ...
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MicroRNA-124a regulates the differentiation of bone marrow mesenchymal stem cells into neurons J. Recept. Signal Transduct. (IF 2.8) Pub Date : 2024-01-16 Eryi Zhao, Daimei Wang, Lijun Jing, Zhongyan Zhao, Shixiong Huang, Ling Xie, Shijun Hu, Hui Liang, Yanquan Chen
This study investigated the effects of microRNA-124a on the differentiation of bone marrow mesenchymal stem cells (BMSCs) and its underlying mechanism.Flow cytometry was used for isolation and iden...
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Synthesis, in silico and in vitro anti-cancer studies of phosphorylated derivatives of didanosine targeting MDA-MB-231 breast cancer cell lines J. Recept. Signal Transduct. (IF 2.8) Pub Date : 2024-01-15 S. K. Thaslim Basha, S. Mahaboob Basha, D. Subba Rao, S. Rasheed, M. Varalakshmi, C. Naga Raju
A series of new phosphorylated derivatives of didanosine were designed, synthesized and evaluated their anticancer effects on human breast cancer cells. Their binding affinities were evaluated agai...
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Quantitative structure activity relationship (QSAR) modeling study of some novel thiazolidine 4-one derivatives as potent anti-tubercular agents J. Recept. Signal Transduct. (IF 2.8) Pub Date : 2024-01-11 Anguraj Moulishankar, Sundarrajan Thirugnanasambandam
This study aims to develop a QSAR model for Antitubercular activity. The quantitative structure-activity relationship (QSAR) approach predicted the thiazolidine-4-ones derivative’s Antitubercular a...
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Protective effects of salvianolic acid B on intestinal ischemia/reperfusion injury in rats by regulating the AhR/IL-22/STAT6 axis J. Recept. Signal Transduct. (IF 2.8) Pub Date : 2023-06-30 Jinyao Xu, Xiangjun Sun, Feng Qin, Xufeng Wang, Qian Chen, Ruicheng Yan
Intestinal ischemia/reperfusion (I/R) injury (IIRI) is associated with high morbidity and mortality. Salvianolic acid B (Sal-B) could exert neuroprotective effects on reperfusion injury after cereb...
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Rhein protects retinal Müller cells from high glucose-induced injury via activating the AMPK/Sirt1/PGC-1α pathway J. Recept. Signal Transduct. (IF 2.8) Pub Date : 2023-06-18 Cong Liu, Qian Cao, Yueqin Chen, Xi Chen, Yujie Zhu, Zhonghua Zhang, Wei Wei
Abstract Oxidative stress, inflammation and apoptosis are important pathogenic factors of diabetic retinopathy (DR). In the current study, we aimed to evaluate the potential role of Rhein, a natural anthraquinone compound found in rhubarb, in high glucose (HG)-induced Müller cells (MIO-M1). Cell Counting Kit‑8 assay, TUNEL assay, Western blot analysis, Reverse transcription quantitative polymerase
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An overview of the molecular and clinical significance of the angiopoietin system in leukemia J. Recept. Signal Transduct. (IF 2.8) Pub Date : 2023-05-15 Saeed Zaka Khosravi, Samira Molaei Ramshe, Mehdi Allahbakhshian Farsani, Mohammadreza Moonesi, Faroogh Marofi, Majid Farshdousti Hagh
Abstract The angiogenesis efficacy in solid tumors and hematological malignancies has been identified for more than twenty years. Although the exact role of angiogenesis in leukemia as a common hematological malignancy has not yet been extensively studied, its effect is demonstrated on the initiation and maintenance of a favorable microenvironment for leukemia cell proliferation. The angiopoietin family
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Sepsis modulates aortic AT1 and P2Y6 receptors to produce vascular hyporeactivity in mice J. Recept. Signal Transduct. (IF 2.8) Pub Date : 2023-04-26 T. Jagadeesh, Soumen Choudhury, Manju Gari, Vandana Singh, Amit Shukla, Satish K. Garg
Abstract Purpose Hyporeactivity to vasopressors leading to multiple organ failure is a serious clinical implication in sepsis. Though the regulatory role of purinoceptors in inflammation is reported, their involvement in sepsis-induced vasoplegia is still unknown. Thus we investigated the effect of sepsis on vascular AT1 and P2Y6 receptors. Materials and methods Polymicrobial sepsis was induced by
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Hypoxia and acidity regulate immune checkpoint molecule and IFN-β expression in non-small cell lung cancer cell lines J. Recept. Signal Transduct. (IF 2.8) Pub Date : 2023-04-26 Achilleas G. Mitrakas, Alexandra Giatromanolaki, Michael I. Koukourakis
Abstract Purpose Non-small cell lung cancer (NSCLC) is one of the most lethal tumors in humans. Immunotherapy with immune checkpoint inhibitors (ICIs) has revolutionized the treatment of patients with advanced diseases. Tumor microenvironment conditions like hypoxia and low pH may compromise the efficacy of ICIs. Materials and methods We report the effect of hypoxia and acidity on the expression levels
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Bone marrow mesenchymal stem cells inhibit ferroptosis via regulating the Nrf2-keap1/p53 pathway to ameliorate chronic kidney disease injury in the rats J. Recept. Signal Transduct. (IF 2.8) Pub Date : 2023-03-08 Lishi Shao, Qixiang Fang, Chen Shi, Ya Zhang, Chunjuan Xia, Yifan Zhang, Jiaping Wang, Fukun Chen
Abstract Purpose Although bone marrow mesenchymal stem cells (BMMSCs) have been reported to exhibit a protective effect on animal models of chronic kidney disease (CKD), the exact mechanisms involved require further investigation. This study aims to investigate the underlying molecular mechanisms of BMMSCs in inhibiting ferroptosis and preventing an Adriamycin (ADR)-induced CKD injury. Methods A rat
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Estrogen receptors as potential therapeutic target in endometrial cancer J. Recept. Signal Transduct. (IF 2.8) Pub Date : 2023-03-08 Payel Guha, Koushik Sen, Piyali Chowdhury, Dilip Mukherjee
Abstract Endometrial cancer (EC) is one of the most common gynecological carcinomas in both developed and developing countries. Majority of the gynecological malignancies are hormonally driven where estrogen signaling acts as an oncogenic signal. Estrogen’s effects are mediated via classical nuclear estrogen receptors; estrogen receptor alpha and beta (ERα and ERβ) and a trans-membrane G protein-coupled
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2-{N-[(2,4,5-trichlorophenoxy) acetyl]-N-methylamino}-3-pyrrolidinepropanamide analogs as potential antagonists of Urotensin II receptor J. Recept. Signal Transduct. (IF 2.8) Pub Date : 2023-01-18 Ajay Soni, Subham Saha, Aditi Agarwal, Abdul Rehman Abdul Rauf, Rakesh Kumar Singh, Mahesh Seth, Shashi Kant Singh, Sandeep Sinha, Raj Kumar Shirumalla, Shinji Marumoto, Ruchi Tandon
Abstract The purpose of the article To identify novel small molecule antagonists of Urotensin II receptor with acceptable pharmacological profile. Materials and methods Structure-activity-relationship (SAR) studies on 2-{N-[(2,4,5-trichlorophenoxy) acetyl]-N-methylamino}-3-pyrrolidinepropanamide series were conducted and shortlisted compounds were synthesized and evaluated in in vitro cell-based assays
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QSAR study of indole derivatives as active agents against Candida albicans: a DFT calculation J. Recept. Signal Transduct. (IF 2.8) Pub Date : 2022-11-03 Hanie Aminaee, Sharieh Hosseini, Asghar Davood, Elham Askarizadeh
Abstract Indole and its derivatives are common heterocyclic compounds in nature that have a wider range of medicinal activities such as antifungal, anti-inflammatory, and anti-seizure. Virtually all indole derivatives showed outstanding antifungal activity against Candida albicans. The aim of this study was to QSAR modeling of indole derivatives and the design of new drugs that have antifungal activity
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Crosstalk between kisspeptin and gonadotropin-inhibitory hormone in the silence of puberty: preclinical evidence from a calcium signaling study J. Recept. Signal Transduct. (IF 2.8) Pub Date : 2022-09-22 Ferah Bulut, Emine Kacar, Batuhan Bilgin, Munevver Gizem Hekim, Muhammed Mirac Keleştemur, Zafer Sahin, Ahmet Ayar, Mete Ozcan
Abstract Kisspeptin and gonadotropin-inhibitory hormone (GnIH) are among suggested neuroendocrine modulators of reproductive function. Intracellular calcium signaling is a critical component in the regulation of a variety of physiological and pathological processes including neurotransmitter release, and, therefore, can be used as signaling indicator for investigating the involvement of kisspeptin
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Identification of novel mycocompounds as inhibitors of PI3K/AKT/mTOR pathway against RCC J. Recept. Signal Transduct. (IF 2.8) Pub Date : 2022-09-20 Ravi Prakash Yadav, Srilagna Chatterjee, Arindam Chatterjee, Dilip Kumar Pal, Sudakshina Ghosh, Krishnendu Acharya, Madhusudan Das
Abstract PI3K/AKT/mTOR pathway is one of the frequently disrupted signaling pathways in renal cell carcinoma (RCC) that plays a significant role in tumor formation, disease progression and therapeutic resistance. Therefore, novel natural molecules targeting the critical proteins of this pathway will provide the best alternative to existing drugs, which are toxic and develops resistance. Recent studies
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CBLC inhibits the proliferation and metastasis of breast cancer cells via ubiquitination and degradation of CTTN J. Recept. Signal Transduct. (IF 2.8) Pub Date : 2022-08-31 Weiwei Li, Ting Lei, Xiaoyu Song, Chun Deng, Jingrun Lu, Wenwu Zhang, Zhenzhan Kuang, Yongyin He, Quan Zhou, Zhaoxun Luo, Fei Mo, Hanlin Yang, Jianfeng Hang, Bin Xiao, Linhai Li
Abstract The E3 ubiquitin ligase is an important regulator of cell signaling and proteostasis and is tightly controlled in many diseases, including cancer. Our study aimed to investigate the biological role of the E3 ubiquitin ligase CBLC in breast cancer and elucidate the specific mechanistic network underlying CBLC-mediated target substrate degradation, cell proliferation and metastasis. Here, we
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Pharmacological characterization of the α2A-adrenergic receptor inhibiting rat hippocampal CA3 epileptiform activity: comparison of ligand efficacy and potency J. Recept. Signal Transduct. (IF 2.8) Pub Date : 2022-08-19 Joseph P. Biggane, Ke Xu, Brianna L. Goldenstein, Kylie L. Davis, Elizabeth J. Luger, Bethany A. Davis, Chris W.D. Jurgens, Dianne M. Perez, James E. Porter, Van A. Doze
Abstract The mechanism underlying the antiepileptic actions of norepinephrine (NE) is unclear with conflicting results. Our objectives are to conclusively delineate the specific adrenergic receptor (AR) involved in attenuating hippocampal CA3 epileptiform activity and assess compounds for lead drug development. We utilized the picrotoxin model of seizure generation in rat brain slices using electrophysiological
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Gαs and Gαq/11 protein coupling bias of two AVPR2 mutants (R68W and V162A) that cause nephrogenic diabetes insipidus J. Recept. Signal Transduct. (IF 2.8) Pub Date : 2022-07-28 Beril Erdem Tuncdemir
Abstract Loss-of-function mutations of the arginine vasopressin receptor 2 gene (AVPR2) cause Nephrogenic diabetes insipidus (NDI). AVPR2 is a kind of G protein coupled receptor (GPCR) and mainly couples with Gαs protein leading to cAMP accumulation in the cell as a secondary messenger. Recent studies showed that some AVPR2 mutations could cause biased Gαq/11 protein coupling rather than Gαs. Investigation
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Can calcitonin gene-related peptide (CGRP) and pentraxin-3 (PTX-3) be useful in diagnosing acute migraine attack? J. Recept. Signal Transduct. (IF 2.8) Pub Date : 2022-07-27 Sevilay Vural, Levent Albayrak
Abstract Purpose Even if migraine is not fatal, it is a common and challenging disease with adverse effects on individuals' lives. The lack of objective diagnostic tools causes delays in diagnosis and treatment initiation. The primary aim of this study is to reveal the diagnostic value of Calcitonin Gene-Related Peptide (CGRP) and Pentraxin-3 (PTX-3) in acute migraine. To this aim, we compared the
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Target-based in-silico screening of basil polysaccharides against different epigenetic targets responsible for breast cancer J. Recept. Signal Transduct. (IF 2.8) Pub Date : 2022-07-21 Nancy Bhura, Pawan Gupta, Jeena Gupta
Abstract Purpose Breast cancer (BC) is one of the leading types of cancer found in women. One of the causes reported for BC is improper regulation of epigenetic modifications. Various epigenetic targets such as histone deacetylases (HDAC) and histone acetyltransferases (HAT) regulate many types of cancer, including BC. Basil is known to possess anti-cancer properties; however, the role of its polysaccharides
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Methylglyoxal enhances the proliferation of vascular smooth muscle cells via Akt phosphorylation J. Recept. Signal Transduct. (IF 2.8) Pub Date : 2022-07-11 Mustafa Kırça
Abstract Methylglyoxal (MGO) is predominantly produced as a by-product of the glycolysis pathway. The glyoxalase system effectively removes it in a healthy organism. However, this process is impaired, and MGO level is elevated in people with diabetes. MGO’s effects on proliferation were mostly studied in cancer cells, and the data in other cell types are limited. This study inspected the proliferative
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In silico screening of c-Met tyrosine kinase inhibitors targeting nucleotide and drug-substrate binding sites of ABCB1 as potential MDR reversal agents J. Recept. Signal Transduct. (IF 2.8) Pub Date : 2022-06-15 Fatemeh Moosavi, Tahereh Damghani, Somayeh Ghazi, Somayeh Pirhadi
Abstract Purpose Cancer is a significant public health problem and ranks as a leading cause of death globally. Multidrug resistance (MDR) affects the therapeutic potential of conventional chemotherapeutic agents in cancer chemotherapy. Receptor tyrosine kinases (RTKs) are enzymes whose aberrant activation contributes to the tumorigenesis of various types of cancers. The ability of several RTKs, such
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In silico screening of c-Met tyrosine kinase inhibitors targeting nucleotide and drug-substrate binding sites of ABCB1 as potential MDR reversal agents. J. Recept. Signal Transduct. (IF 2.8) Pub Date : 2022-06-15 Fatemeh Moosavi,Tahereh Damghani,Somayeh Ghazi,Somayeh Pirhadi
PURPOSE Cancer is a significant public health problem and ranks as a leading cause of death globally. Multidrug resistance (MDR) affects the therapeutic potential of conventional chemotherapeutic agents in cancer chemotherapy. Receptor tyrosine kinases (RTKs) are enzymes whose aberrant activation contributes to the tumorigenesis of various types of cancers. The ability of several RTKs, such as c-Met
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Ozone protects cardiomyocytes from myocardial ischemia–reperfusion injury through miR-200c/FOXO3 axis J. Recept. Signal Transduct. (IF 2.8) Pub Date : 2022-05-17 Lian Zhang, Xingping Men, Shenglong Yu, Huizhuang Guo, Yi Luo, Hanwei Chen, Shaohua Mi
Abstract Purpose Myocardial ischemia-reperfusion injury (I/R) is a detrimental process contributing to the pathological progression of coronary artery diseases. Studies indicate that miRNAs are implicated in ischemic heart disease, and ozone therapy could protect the heart from ischemic heart disease. In this study, we investigated the effect of ozone on miR-200c expression and the potential role of
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Anti-COVID-19 and antidiabetic activities of new oleanane and ursane-type triterpenoids from Salvia grossheimii: an in-silico approach J. Recept. Signal Transduct. (IF 2.8) Pub Date : 2022-05-11 Somayeh Zare, Somayeh Pirhadi, Hesham R. El Seedi, Amir Reza Jassbi
Abstract Salvia grossheimii is a perennial herb with antidiabetic and cytotoxic constituents. In continuation of our study on S. grosshiemii to identify the bioactive phytochemicals, we have reported the characterization of seven undescribed triterpenoids. The aerial parts of the plant were extracted in dichloromethane and its constituents were isolated using chromatography techniques. The structures
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Selective thyroid hormone receptor beta agonist, GC-1, is capable to reduce growth of colorectal tumor in syngeneic mouse models J. Recept. Signal Transduct. (IF 2.8) Pub Date : 2022-04-27 Katayoun Pourvali, Ghazaleh Shimi, Arman Ghorbani, Azam Shakery, Farshad Hosseini Shirazi, Hamid Zand
Abstract Objective The effect of thyroid hormone (TH) on cancers was proposed more than 100 years ago; however, conclusions are conflicting. THs are precisely regulated at tissue and cellular levels. It seems that this regulation is altered in cancers. Thyroid hormone receptor beta (TRβ) has anti-proliferative and tumor-suppressive effects in many cancer cells. Therefore, we decided to investigate
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MiR-370-5p inhibits the progression of breast cancer via targeting LUC7L3 J. Recept. Signal Transduct. (IF 2.8) Pub Date : 2022-03-30
(2022). MiR-370-5p inhibits the progression of breast cancer via targeting LUC7L3. Journal of Receptors and Signal Transduction: Vol. 42, No. 2, pp. 214-214.
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A review of protein-protein interaction and signaling pathway of Vimentin in cell regulation, morphology and cell differentiation in normal cells J. Recept. Signal Transduct. (IF 2.8) Pub Date : 2022-03-16 Danial Hashemi Karoii, Hossein Azizi
Abstract The Vimentin intermediate filament (VIF) is an essential cytoskeleton component. It shows dynamically changing expression patterns throughout various phases of the differentiation process, suggesting that the protein is physiologically important. Vimentin’s essential functions have recently been clear, so Vimentin-deficient of animals was described as a change of morphology and signaling pathway
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QSAR study of antituberculosis activity of oxadiazole derivatives using DFT calculations J. Recept. Signal Transduct. (IF 2.8) Pub Date : 2022-03-09 Sharieh Hosseini, Sepideh Ketabi, Golnar Hasheminasab
Abstract Mycobacterium tuberculosis (Mtb) is the causative agent of infectious diseases worldwide. Oxadiazole derivatives have many biological activities and can be a good alternative to antimicrobial drugs. In this study, the quantitative structure–activity relationship (QSAR) of fifty-one novel oxadiazoles derivatives has been studied using the density functional theory (DFT) and statistical methods
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GLP-1 agonist liraglutide improves ouabain-induced mania and depressive state via GSK-3β pathway J. Recept. Signal Transduct. (IF 2.8) Pub Date : 2022-02-08 Mustafa Nusret Çiçekli, Emre Soner Tiryaki, Ahmet Altun, Caner Günaydın
Abstract Bipolar disorder (BD) is a severe mental illness characterized by aberrant mood changes between hypomania and mania or mixed states and depression. Metabolic changes also accompany disease progression and cause significant morbidity. Symptomatic treatment options are available, but asymptomatic patients and poor drug responders are significant problems. Based on the most common pharmacological
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XIST/miR-34a-5p/PDL1 axis regulated the development of lung cancer cells and the immune function of CD8+ T cells J. Recept. Signal Transduct. (IF 2.8) Pub Date : 2022-01-23 Jing Li, Liyan Che, Chang Xu, Dongdong Lu, Yan Xu, Mengru Liu, Wenshu Chai
Abstract Purpose Long non-coding RNA (lncRNA) XIST has been shown to be involved in the immune escape of breast cancer, but it is unclear whether it is involved in the immune escape of lung cancer, so it will be discussed in this study. Methods XIST and miR-34a-5p expression in lung cancer tissues and cells were detected by quantitative reverse transcription-polymerase chain reaction (qRT-PCR). The
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Endothelial progenitor cells promote neural stem cell proliferation in hypoxic conditions through VEGF via the PI3K/AKT pathway J. Recept. Signal Transduct. (IF 2.8) Pub Date : 2022-01-18 Jingti Jing, Haoming Jiang, Lin Zhang
Abstract Neurons and vascular cells compose neurovascular niches in the central nervous system where endothelial cells can promote neurogenesis via direct and indirect effects. Neurocytes and vascular cells are gravely destroyed upon spinal cord injury, which severely affects spinal motor functions. Neurogenesis originates from neural stem cells (NSCs) and endothelial cells derived from endothelial
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Determination of cytokine profile and associated genes of the signaling pathway in HNSCC J. Recept. Signal Transduct. (IF 2.8) Pub Date : 2021-12-09 Aysel Kalayci Yigin, Ali Azzawri, Kayhan Ozturk, Tulin Cora, Mehmet Seven
Abstract Head and neck squamose cell carcinoma (HNSCC) is an aggressive group of tumors that are generally heterogeneous. Despite treatment advances, disease-free survival has not significantly improved. Therefore, it is of great importance to understand the molecular etiology of HNSCC and genetic alterations in the signal pathways in order to develop new therapeutic approaches. In this study, firstly
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Correction J. Recept. Signal Transduct. (IF 2.8) Pub Date : 2021-12-06
Published in Journal of Receptors and Signal Transduction (Vol. 43, No. 1, 2023)
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Integrated computational approach for in silico design of new purinyl pyridine derivatives as B-Raf kinase inhibitors J. Recept. Signal Transduct. (IF 2.8) Pub Date : 2021-11-29 Vinutha Kuchana, Vaeshnavi Kashetti, Sai Kiran Reddy Peddi, Sreekanth Sivan, Vijjulatha Manga
Abstract B-Raf is one among the most frequently mutating proto-oncogene which is associated with the serine/threonine Raf kinase family involved in the RAS-RAF-MEK-ERK pathway, which is the most deregulated pathway in human cancers. Mutant B-Raf V600E got an excellent scope for investigation in cancer as a potential therapeutic target. Formerly B-RafV600E is considered the molecular target for numerous
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Molecular docking study of britannin binding to PD-L1 and related anticancer pseudoguaianolide sesquiterpene lactones J. Recept. Signal Transduct. (IF 2.8) Pub Date : 2021-11-17 Gérard Vergoten, Christian Bailly
Abstract The pseudoguaianolide-type sesquiterpene lactone (SL) britannin (BRT), found in different Inula species, has been characterized as a potent anticancer agent acting via modulation of the transcription factor NFkB and the Nrf2-Keap1 signaling pathway. In addition, a BRT-induced down-regulation of the immune checkpoint PD-L1 (programmed cell death ligand 1) expressed on cancer cells has been
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DFT based QSAR study on quinolone-triazole derivatives as antibacterial agents J. Recept. Signal Transduct. (IF 2.8) Pub Date : 2021-10-24 Niloofar Ghasedi, Shahin Ahmadi, Sepideh Ketabi, Ali Almasirad
Abstract QSAR modeling was performed on 39 quinolone-triazole derivatives against gram-positive Staphylococcus aureus and gram-negative Pseudomonas aeruginosa bacteria. The molecular structures were optimized using the DFT/B3LYP method and 6–31 G basis set. Molecular descriptors were extracted using quantum mechanical calculations. The hierarchical cluster analysis was performed for a rational subset
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Zingerone suppresses proliferation, invasion, and migration of hepatocellular carcinoma cells by the inhibition of MTDH-mediated PI3K/Akt pathway J. Recept. Signal Transduct. (IF 2.8) Pub Date : 2021-10-13 Jian Fang, Huifen Zhu, Pengcheng Xu, Renya Jiang
Abstract Purpose Previous studies have proved that zingerone was a therapeutic agent for many tumors. Metadherin (MTDH) acts as an oncogene and is involved in tumorigenesis. The purpose of this study was to explore the underlying mechanism of zingerone that regulates MTDH to affect hepatocellular carcinoma (HCC) progression. Methods CCK-8 assay was performed to detect HCC cell proliferation. The invasion
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PPARγ activation by pioglitazone enhances the anti-proliferative effects of doxorubicin on pro-monocytic THP-1 leukemia cells via inducing apoptosis and G2/M cell cycle arrest J. Recept. Signal Transduct. (IF 2.8) Pub Date : 2021-10-13 Hassan Ghasemi, Ali Jamshidi, Mohammad Amin Ghatee, Komeil Mazhab-Jafari, Milad Khorasani, Mina Rahmati, Saeed Mohammadi
Abstract Purpose Doxorubicin (DOX) is a common chemotherapeutic agent, with toxic side effects, and chemoresistance. Combination chemotherapy is a successful approach to overcome these limitations. Here, we investigated the effects of pioglitazone (PGZ), a PPARγ agonist, and/or DOX on the viability, cell cycle, apoptosis on THP-1 cells and normal human monocytes (NHMs). Methods MTT assay was used to
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Statement of Retraction: β-Adrenergic receptor structure and function: molecular insights guiding the development of novel therapeutic strategies to treat malignancy J. Recept. Signal Transduct. (IF 2.8) Pub Date : 2021-08-19
(2021). Statement of Retraction: β-Adrenergic receptor structure and function: molecular insights guiding the development of novel therapeutic strategies to treat malignancy. Journal of Receptors and Signal Transduction: Vol. 41, No. 6, pp. 606-606.
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Protective role of selenium on MPP+ and homocysteine-induced TRPM2 channel activation in SH-SY5Y cells J. Recept. Signal Transduct. (IF 2.8) Pub Date : 2021-09-28 Kenan Yıldızhan, Mustafa Nazıroğlu
Abstract Homocysteine is an intermediate product of biochemical reactions occurring in living organisms. It is known that drugs that increase dopamine synthesis used in Parkinson's disease (PD) cause an increase in the plasma homocysteine level. As the plasma homocysteine level increases, the amount of intracellular free calcium ion ([Ca2+]i) and oxidative stress increase. As a result, it contributes
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In vivo and in vitro impact of miRNA-153 on the suppression of cell growth apoptosis through mTORC2 signaling pathway in breast cancer J. Recept. Signal Transduct. (IF 2.8) Pub Date : 2021-08-29 Haimei Liu, Hongyan Zang, Jilin Kong, Liguo Gong
Abstract Purpose To investigate the effects and mechanism of miRNA-153 on breast cancer cells in vitro and in vivo. Material and methods The cells and mice were divided into five groups: miRNA-153 mimic, miRNA-153 NC, miRNA-153 inhibitor, miRNA-153 inhibitor-NC, and blank control groups. The real-time PCR and western blot were used to detect the rictor expression regulated by miRNA-153. The western
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microRNA-199a downregulation alleviates hyperuricemic nephropathy via the PPARγ/β-catenin axis J. Recept. Signal Transduct. (IF 2.8) Pub Date : 2021-08-25 Peng Du, Ming Chen, Changcai Deng, Chonggui Zhu
Abstract Hyperuricemia always develops into hyperuricemic nephropathy (HN). The role of microRNA (miR) in HN is less studied. We aimed to discuss the role of miR-199a in HN. The expression of miR-199a and PPARγ in renal tissues of HN rats was detected. The targeting relation between miR-199a and PPARγ was verified. The contents of SCr, UA, BUN, and mALB, renal injury-relevant biomarkers were detected
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Long noncoding RNA LINC00858 promotes the progression of ovarian cancer via regulating the miR-134-5p/TRIM44 axis J. Recept. Signal Transduct. (IF 2.8) Pub Date : 2021-08-23 Pengbo Li, Gang Huang
Abstract Recent studies have shown that many long noncoding RNAs (lncRNAs) are abnormally expressed in ovarian cancer and involved in the pathological progress of ovarian cancer. In the present study, we aimed to investigate the role of lncRNA LINC00858 and the potential mechanism in ovarian cancer. The qRT-PCR was used to measure the expression levels of LINC00858 and miR-134-5p in ovarian cancer
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SMILES-based QSAR and molecular docking study of xanthone derivatives as α-glucosidase inhibitors J. Recept. Signal Transduct. (IF 2.8) Pub Date : 2021-08-12 Shahin Ahmadi, Zohreh Moradi, Ashwani Kumar, Ali Almasirad
Abstract Increasing diabetic population is one of the major health concerns all over the world. Inhibition of α-glucosidase is a clinically proved and attractive strategy to manage diabetes. In this study, robust and reliable QSAR models to predict α-glucosidase inhibitory potential of xanthone derivatives are developed by the Monte Carlo technique. The chemical structures are represented by SMILES
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Discovery of polymethoxyflavones as potential cyclooxygenase-2 (COX-2), 5-lipoxygenase (5-LOX) and phosphodiesterase 4B (PDE4B) inhibitors J. Recept. Signal Transduct. (IF 2.8) Pub Date : 2021-07-29 Muhd Hanis Md Idris, Siti Norhidayah Mohd Amin, Siti Norhidayu Mohd Amin, Agustono Wibowo, Zainul Amiruddin Zakaria, Zurina Shaameri, Ahmad Sazali Hamzah, Manikandan Selvaraj, Lay Kek Teh, Mohd Zaki Salleh
Abstract Non-steroidal anti-inflammatory drugs (NSAIDs) are widely prescribed to treat inflammatory-related diseases, pain and fever. However, the prolong use of traditional NSAIDs leads to undesirable side effects such as gastric, ulceration, and renal toxicity due to lack of selectivity toward respective targets for COX-2, 5-LOX, and PDE4B. Thus, targeting multiple sites can reduce these adverse
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Adrenergic receptor behaviors of mesenchymal stem cells obtained from different tissue sources and the effect of the receptor blockade on differentiation J. Recept. Signal Transduct. (IF 2.8) Pub Date : 2021-07-29 Erkan Maytalman, Arash Alizadeh Yegani, Ilknur Kozanoglu, Fazilet Aksu
Abstract In this study, it was aimed to analyze behavioral changes of adrenergic receptors (ARs) in first three passages and osteogenic/adipogenic differentiation of mesenchymal stem cells (MSCs) derived from placenta fetal membrane (FM) and bone marrow (BM). It was also aimed to evaluate effects of receptor blockade on differentiation. We obtained first three passages of MSCs from placenta and BM
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Statement of Retraction: Baicalin suppresses the progression of preeclampsia via regulating miR-155-5p/FOXO3 axis J. Recept. Signal Transduct. (IF 2.8) Pub Date : 2021-07-29
(2021). Statement of Retraction: Baicalin suppresses the progression of preeclampsia via regulating miR-155-5p/FOXO3 axis. Journal of Receptors and Signal Transduction: Vol. 41, No. 6, pp. 604-604.
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Statement of Retraction: Ultrasound microbubble-mediated miR-150-5p inhibits gastric cancer cell growth by targeting the expression of NR2F2 J. Recept. Signal Transduct. (IF 2.8) Pub Date : 2021-07-27
(2021). Statement of Retraction: Ultrasound microbubble-mediated miR-150-5p inhibits gastric cancer cell growth by targeting the expression of NR2F2. Journal of Receptors and Signal Transduction: Vol. 41, No. 6, pp. 605-605.
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Role of TRPV1 channels on glycogen synthase kinase-3β and oxidative stress in ouabain-induced bipolar disease J. Recept. Signal Transduct. (IF 2.8) Pub Date : 2021-07-26 Osman Kukula, Mustafa Nusret Çiçekli, Sinan Şafak, Caner Günaydın
Abstract Bipolar disorder (BD) is a multifactorial chronic and refractory disease characterized by manic, depressive, and mixed mood episodes. Although epidemiological, and pathophysiological studies demonstrated a strong correlation between bipolar disorder and oxidative stress, precise etiology is still missing. Recent studies suggested the possible role of transient receptor potential channels (TRP)
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Emodin alleviates high glucose-induced oxidative stress, inflammation and extracellular matrix accumulation of mesangial cells by the circ_0000064/miR-30c-5p/Lmp7 axis J. Recept. Signal Transduct. (IF 2.8) Pub Date : 2021-06-21 Li Sun, Yanquan Han, Chuqiao Shen, Huan Luo, Zhuo Wang
Abstract Emodin has been shown to exert a renoprotective effect in diabetic nephropathy (DN). In this paper, we investigated whether circular RNAs (circRNAs) might be involved in the renoprotective mechanism of emodin in DN. The levels of malondialdehyde (MDA), reactive oxygen species (ROS), superoxide dismutase (SOD), interleukin-1β (IL-1β), IL-6 and tumor necrosis factor-α (TNF-α) were measured using
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Curcumin restrains hepatocellular carcinoma progression depending on the regulation of the circ_0078710/miR-378b/PRIM2 axis J. Recept. Signal Transduct. (IF 2.8) Pub Date : 2021-06-18 Qian Chen, Hai Guo, Yan Zong, Xiaofeng Zhao
Abstract Purpose Curcumin has shown anti-tumor activity in multiple malignancies. The aim of our study was to explore the molecular mechanism behind the anti-tumor activity of curcumin in hepatocellular carcinoma (HCC). Methods The proliferation, migration, invasion, and apoptosis were analyzed by 5-ethynyl-2′-deoxyuridine (EDU) assay, transwell migration assay, transwell invasion assay, and flow cytometry
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MicroRNA-320a-containing exosomes from human umbilical cord mesenchymal stem cells curtail proliferation and metastasis in lung cancer by binding to SOX4 J. Recept. Signal Transduct. (IF 2.8) Pub Date : 2021-06-07 Huan Xie, Jie Wang
Abstract Exosomes from human umbilical cord mesenchymal stem cells (HUCMSCs) containing microRNAs (miRNAs) have been underscored as possible therapeutic options for cancers. Hence, our goal here was to investigate the relevance of miR-320a-containing exosomes from HUCMSCs to lung cancer. First, H1299 and H460 cells were co-cultured with the exosomes overexpressing miR-320a from HUCMSCs. The data displayed
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Uric acid can enhance MAPK pathway-mediated proliferation in rat primary vascular smooth muscle cells via controlling of mitochondria and caspase-dependent cell death J. Recept. Signal Transduct. (IF 2.8) Pub Date : 2021-05-30 Segün Doğru, Ekrem Yaşar, Akın Yeşilkaya
Abstract Hyperuricemia may be a risk factor for cardiovascular diseases such as hypertension and atherosclerosis, but the mechanisms underlying uric acid-induced pathological conditions remain unknown. In this study, we investigated the effect of short time and long-term administration of increasing uric acid concentrations on cell viability, proliferative and apoptotic pathways in vascular smooth