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USP28 promotes tumorigenesis and cisplatin resistance by deubiquitinating MAST1 protein in cancer cells Cell. Mol. Life Sci. (IF 8.0) Pub Date : 2024-03-18
Abstract Cisplatin is a chemotherapy drug that causes a plethora of DNA lesions and inhibits DNA transcription and replication, resulting in the induction of apoptosis in cancer cells. However, over time, patients develop resistance to cisplatin due to repeated treatment and thus the treatment efficacy is limited. Therefore, identifying an alternative therapeutic strategy combining cisplatin treatment
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Molecular engineering of a spheroid-penetrating phage nanovector for photodynamic treatment of colon cancer cells Cell. Mol. Life Sci. (IF 8.0) Pub Date : 2024-03-17 Eleonora Turrini, Luca Ulfo, Paolo Emidio Costantini, Roberto Saporetti, Matteo Di Giosia, Michela Nigro, Annapaola Petrosino, Lucia Pappagallo, Alena Kaltenbrunner, Andrea Cantelli, Valentina Pellicioni, Elena Catanzaro, Carmela Fimognari, Matteo Calvaresi, Alberto Danielli
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YAP1-CPNE3 positive feedback pathway promotes gastric cancer cell progression Cell. Mol. Life Sci. (IF 8.0) Pub Date : 2024-03-17
Abstract Hippo-Yes-associated protein 1 (YAP1) plays an important role in gastric cancer (GC) progression; however, its regulatory network remains unclear. In this study, we identified Copine III (CPNE3) was identified as a novel direct target gene regulated by the YAP1/TEADs transcription factor complex. The downregulation of CPNE3 inhibited proliferation and invasion, and increased the chemosensitivity
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Txnip regulates the Oct4-mediated pluripotency circuitry via metabolic changes upon differentiation Cell. Mol. Life Sci. (IF 8.0) Pub Date : 2024-03-15 Sojung Kwak, Cho Lok Song, Yee Sook Cho, Inpyo Choi, Jae-Eun Byun, Haiyoung Jung, Jungwoon Lee
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Lamin B1 curtails early human papillomavirus infection by safeguarding nuclear compartmentalization and autophagic capacity Cell. Mol. Life Sci. (IF 8.0) Pub Date : 2024-03-14
Abstract Human papillomavirus (HPV) infection is a primary cause of cervical and head-and-neck cancers. The HPV genome enters the nucleus during mitosis when the nuclear envelope disassembles. Given that lamins maintain nuclear integrity during interphase, we asked to what extent their loss would affect early HPV infection. To address this question, we infected human cervical cancer cells and keratinocytes
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High-content method for mechanosignaling studies using IsoStretcher technology and quantitative Ca2+ imaging applied to Piezo1 in cardiac HL-1 cells Cell. Mol. Life Sci. (IF 8.0) Pub Date : 2024-03-14 Anna-Lena Merten, Ulrike Schöler, Yang Guo, Fabian Linsenmeier, Boris Martinac, Oliver Friedrich, Sebastian Schürmann
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A novel mouse model for N-terminal truncated Aβ2-x generation through meprin β overexpression in astrocytes Cell. Mol. Life Sci. (IF 8.0) Pub Date : 2024-03-13
Abstract Neurotoxic amyloid-β (Aβ) peptides cause neurodegeneration in Alzheimer’s disease (AD) patients’ brains. They are released upon proteolytic processing of the amyloid precursor protein (APP) extracellularly at the β-secretase site and intramembranously at the γ-secretase site. Several AD mouse models were developed to conduct respective research in vivo. Most of these classical models overexpress
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The first A-to-I RNA editome of hemipteran species Coridius chinensis reveals overrepresented recoding and prevalent intron editing in early-diverging insects Cell. Mol. Life Sci. (IF 8.0) Pub Date : 2024-03-13
Abstract Background Metazoan adenosine-to-inosine (A-to-I) RNA editing resembles A-to-G mutation and increases proteomic diversity in a temporal-spatial manner, allowing organisms adapting to changeable environment. The RNA editomes in many major animal clades remain unexplored, hampering the understanding on the evolution and adaptation of this essential post-transcriptional modification. Methods
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The Janus-faced functions of Apolipoproteins L in membrane dynamics Cell. Mol. Life Sci. (IF 8.0) Pub Date : 2024-03-13 Etienne Pays
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Deubiquitinase UCHL1 promotes angiogenesis and blood–spinal cord barrier function recovery after spinal cord injury by stabilizing Sox17 Cell. Mol. Life Sci. (IF 8.0) Pub Date : 2024-03-13
Abstract Improving the function of the blood–spinal cord barrier (BSCB) benefits the functional recovery of mice following spinal cord injury (SCI). The death of endothelial cells and disruption of the BSCB at the injury site contribute to secondary damage, and the ubiquitin–proteasome system is involved in regulating protein function. However, little is known about the regulation of deubiquitinated
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Glymphatic-lymphatic coupling: assessment of the evidence from magnetic resonance imaging of humans Cell. Mol. Life Sci. (IF 8.0) Pub Date : 2024-03-13 Geir Ringstad, Per Kristian Eide
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Crosstalk between purinergic receptor P2Y11 and chemokine receptor CXCR7 is regulated by CXCR4 in human macrophages Cell. Mol. Life Sci. (IF 8.0) Pub Date : 2024-03-13
Abstract P2Y11 is a G protein-coupled ATP receptor that activates IL-1 receptor (IL-1R) in a cyclic AMP dependent manner. In human macrophages, P2Y11/IL-1R crosstalk with CCL20 as a prime target is controlled by phosphodiesterase 4 (PDE4), which mediates breakdown of cyclic AMP. Here, we used gene expression analysis to identify activation of CXCR4 and CXCR7 as a hallmark of P2Y11 signaling. We found
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Role of HCN channels in the functions of basal ganglia and Parkinson’s disease Cell. Mol. Life Sci. (IF 8.0) Pub Date : 2024-03-13 Zeng-Xin Qi, Qi Yan, Xiu-Juan Fan, Jian-Ya Peng, Hui-Xian Zhu, Yi-Miao Jiang, Liang Chen, Qian-Xing Zhuang
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PEBP4 deficiency aggravates LPS-induced acute lung injury and alveolar fluid clearance impairment via modulating PI3K/AKT signaling pathway Cell. Mol. Life Sci. (IF 8.0) Pub Date : 2024-03-13
Abstract Acute lung injury (ALI) is a common clinical syndrome, which often results in pulmonary edema and respiratory distress. It has been recently reported that phosphatidylethanolamine binding protein 4 (PEBP4), a basic cytoplasmic protein, has anti-inflammatory and hepatoprotective effects, but its relationship with ALI remains undefined so far. In this study, we generated PEBP4 knockout (KO)
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CircAKT3 alleviates postoperative cognitive dysfunction by stabilizing the feedback cycle of miR-106a-5p/HDAC4/MEF2C axis in hippocampi of aged mice Cell. Mol. Life Sci. (IF 8.0) Pub Date : 2024-03-13 Xuan Wang, Xiaole Tang, Pengfei Zhu, Dongyu Hua, Zheng Xie, Mingke Guo, Mengxin Que, Jing Yan, Xing Li, Qian Xia, Xiaoxiao Luo, Jiangjiang Bi, Yilin Zhao, Zhiqiang Zhou, Shiyong Li, Ailin Luo
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Lipid homeostasis is essential for oogenesis and embryogenesis in the silkworm, Bombyx mori Cell. Mol. Life Sci. (IF 8.0) Pub Date : 2024-03-12 Fangying Yang, Xiaoyan Xu, Bo Hu, Zhongjie Zhang, Kai Chen, Ye Yu, Hua Bai, Anjiang Tan
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ALKBH1 promotes HIF-1α-mediated glycolysis by inhibiting N-glycosylation of LAMP2A Cell. Mol. Life Sci. (IF 8.0) Pub Date : 2024-03-12 Yanyan Liu, Mengmeng Li, Miao Lin, Xinjie Liu, Haolin Guo, Junyang Tan, Liubing Hu, Jianshuang Li, Qinghua Zhou
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Inhibition of EHMT1/2 rescues synaptic damage and motor impairment in a PD mouse model Cell. Mol. Life Sci. (IF 8.0) Pub Date : 2024-03-12
Abstract Epigenetic dysregulation that leads to alterations in gene expression and is suggested to be one of the key pathophysiological factors of Parkinson’s disease (PD). Here, we found that α-synuclein preformed fibrils (PFFs) induced histone H3 dimethylation at lysine 9 (H3K9me2) and increased the euchromatic histone methyltransferases EHMT1 and EHMT2, which were accompanied by neuronal synaptic
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Role of the GLP2–Wnt1 axis in silicon-rich alkaline mineral water maintaining intestinal epithelium regeneration in piglets under early-life stress Cell. Mol. Life Sci. (IF 8.0) Pub Date : 2024-03-12 Jian Chen, Xue-Yan Dai, Bi-Chen Zhao, Xiang-Wen Xu, Jian-Xun Kang, Ya-Ru Xu, Jin-Long Li
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Vascular ATGL-dependent lipolysis and the activation of cPLA2–PGI2 pathway protect against postprandial endothelial dysfunction Cell. Mol. Life Sci. (IF 8.0) Pub Date : 2024-03-12
Abstract Adipose triglyceride lipase (ATGL) is involved in lipolysis and displays a detrimental pathophysiological role in cardio-metabolic diseases. However, the organo-protective effects of ATGL-induced lipolysis were also suggested. The aim of this work was to characterize the function of lipid droplets (LDs) and ATGL-induced lipolysis in the regulation of endothelial function. ATGL-dependent LDs
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Unraveling the molecular interactions between α7 nicotinic receptor and a RIC3 variant associated with backward speech Cell. Mol. Life Sci. (IF 8.0) Pub Date : 2024-03-12 Aditi Pradhan, Hayley Mounford, Jessica Peixinho, Edward Rea, Emmanouela Epeslidou, Julia S. Scott, Joanna Cull, Susan Maxwell, Richard Webster, David Beeson, Yin Yao Dong, Stefan Prekovic, Isabel Bermudez, Dianne F. Newbury
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MSCs alleviate LPS-induced acute lung injury by inhibiting the proinflammatory function of macrophages in mouse lung organoid–macrophage model Cell. Mol. Life Sci. (IF 8.0) Pub Date : 2024-03-11 Jiaqi Zhu, Jiahang Zhou, Bing Feng, Qiaoling Pan, Jinfeng Yang, Guanjing Lang, Dandan Shang, Jianya Zhou, Lanjuan Li, Jiong Yu, Hongcui Cao
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PRMT5-mediated homologous recombination repair is essential to maintain genomic integrity of neural progenitor cells Cell. Mol. Life Sci. (IF 8.0) Pub Date : 2024-03-08 Ya-Jun Wang, Jian-Bo Cao, Jing Yang, Tong Liu, Hua-Li Yu, Zi-Xuan He, Shi-Lai Bao, Xiao-Xiao He, Xiao-Juan Zhu
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Disrupting PIAS3-mediated SUMOylation of MLK3 ameliorates poststroke neuronal damage and deficits in cognitive and sensorimotor behaviors Cell. Mol. Life Sci. (IF 8.0) Pub Date : 2024-03-08 Yu Jiang, Lulu Hu, Baixue Wang, Bingge Zhang, Mengwen Shao, Li Meng, Yan Xu, Rourou Chen, Meng Li, Caiping Du
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Neutrophil extracellular traps mediate cardiomyocyte ferroptosis via the Hippo–Yap pathway to exacerbate doxorubicin-induced cardiotoxicity Cell. Mol. Life Sci. (IF 8.0) Pub Date : 2024-03-08 Peng Zhao, You Li, Xiangli Xu, Haobo Yang, Xintong Li, Shuai Fu, Zihong Guo, Jianing Zhang, Hairu Li, Jiawei Tian
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The role of fatty acid metabolism in acute lung injury: a special focus on immunometabolism Cell. Mol. Life Sci. (IF 8.0) Pub Date : 2024-03-08
Abstract Reputable evidence from multiple studies suggests that excessive and uncontrolled inflammation plays an indispensable role in mediating, amplifying, and protracting acute lung injury (ALI). Traditionally, immunity and energy metabolism are regarded as separate functions regulated by distinct mechanisms, but recently, more and more evidence show that immunity and energy metabolism exhibit a
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LncRNA LUESCC promotes esophageal squamous cell carcinoma by targeting the miR-6785-5p/NRSN2 axis Cell. Mol. Life Sci. (IF 8.0) Pub Date : 2024-03-08
Abstract Esophageal squamous cell carcinoma (ESCC) is one of the most prevalent gastrointestinal malignancies with high mortality worldwide. Emerging evidence indicates that long noncoding RNAs (lncRNAs) are involved in human cancers, including ESCC. However, the detailed mechanisms of lncRNAs in the regulation of ESCC progression remain incompletely understood. LUESCC was upregulated in ESCC tissues
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Tektin bundle interacting protein, TEKTIP1, functions to stabilize the tektin bundle and axoneme in mouse sperm flagella Cell. Mol. Life Sci. (IF 8.0) Pub Date : 2024-03-07 Xin-Yan Geng, Hui-Juan Jin, Lan Xia, Bin-Bin Wang, Su-Ren Chen
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The genome of Haberlea rhodopensis provides insights into the mechanisms for tolerance to multiple extreme environments Cell. Mol. Life Sci. (IF 8.0) Pub Date : 2024-03-05 Saurabh Gupta, Veselin Petrov, Vanika Garg, Bernd Mueller-Roeber, Alisdair R. Fernie, Zoran Nikoloski, Tsanko Gechev
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Cell-specific IL-1R1 regulates the regional heterogeneity of microglial displacement of GABAergic synapses and motor learning ability Cell. Mol. Life Sci. (IF 8.0) Pub Date : 2024-03-04 Yi You, Da-dao An, Yu-shan Wan, Bai-xiu Zheng, Hai-bin Dai, She-hong Zhang, Xiang-nan Zhang, Rong-rong Wang, Peng Shi, Mingjuan Jin, Yi Wang, Lei Jiang, Zhong Chen, Wei-Wei Hu
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Dynamic YAP expression in the non-parenchymal liver cell compartment controls heterologous cell communication Cell. Mol. Life Sci. (IF 8.0) Pub Date : 2024-03-04 Kaijing Liu, Lilija Wehling, Shan Wan, Sofia M. E. Weiler, Marcell Tóth, David Ibberson, Silke Marhenke, Adnan Ali, Macrina Lam, Te Guo, Federico Pinna, Fabiola Pedrini, Amruta Damle-Vartak, Anne Dropmann, Fabian Rose, Silvia Colucci, Wenxiang Cheng, Michaela Bissinger, Jennifer Schmitt, Patrizia Birner, Tanja Poth, Peter Angel, Steven Dooley, Martina U. Muckenthaler, Thomas Longerich, Arndt Vogel
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Apurinic/apyrimidinic endodeoxyribonuclease 1 (APE1) promotes stress granule formation via YBX1 phosphorylation in ovarian cancer Cell. Mol. Life Sci. (IF 8.0) Pub Date : 2024-03-04 Shuyu Mao, Chong Xie, Yufeng Liu, Ye Zhao, Mengxia Li, Han Gao, Yue Xiao, Yongkang Zou, Zhiguo Zheng, Ya Gao, Juan Xie, Bing Tian, Liangyan Wang, Yuejin Hua, Hong Xu
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Caspase-11/GSDMD contributes to the progression of hyperuricemic nephropathy by promoting NETs formation Cell. Mol. Life Sci. (IF 8.0) Pub Date : 2024-03-04 Fan Wu, Caiming Chen, Guo Lin, Chengkun Wu, Jingzhi Xie, Kongwen Lin, Xingchen Dai, Zhengyue Chen, Keng Ye, Ying Yuan, Zhimin Chen, Huabin Ma, Zishan Lin, Yanfang Xu
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Trisomy 21-driven metabolite alterations are linked to cellular injuries in Down syndrome Cell. Mol. Life Sci. (IF 8.0) Pub Date : 2024-03-03 Juli Liu, Shaoxian Chen, Guiping Huang, Pengju Wen, Xianwu Zhou, Yueheng Wu
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Molecular hallmarks of ageing in amyotrophic lateral sclerosis Cell. Mol. Life Sci. (IF 8.0) Pub Date : 2024-03-02 Cyril Jones Jagaraj, Sina Shadfar, Sara Assar Kashani, Sayanthooran Saravanabavan, Fabiha Farzana, Julie D. Atkin
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MDSC-derived S100A8/9 contributes to lupus pathogenesis by promoting TLR7-mediated activation of macrophages and dendritic cells Cell. Mol. Life Sci. (IF 8.0) Pub Date : 2024-03-01 Yonghong Yang, Xin Zhang, Lina Jing, Yucai Xiao, Yangzhe Gao, Yuxin Hu, Shujiao Jia, Guangxi Zhou, Huabao Xiong, Guanjun Dong
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Spem2, a novel testis-enriched gene, is required for spermiogenesis and fertilization in mice Cell. Mol. Life Sci. (IF 8.0) Pub Date : 2024-02-29
Abstract Spermiogenesis is considered to be crucial for the production of haploid spermatozoa with normal morphology, structure and function, but the mechanisms underlying this process remain largely unclear. Here, we demonstrate that SPEM family member 2 (Spem2), as a novel testis-enriched gene, is essential for spermiogenesis and male fertility. Spem2 is predominantly expressed in the haploid male
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FAM76B regulates PI3K/Akt/NF-κB-mediated M1 macrophage polarization by influencing the stability of PIK3CD mRNA Cell. Mol. Life Sci. (IF 8.0) Pub Date : 2024-02-29 Juan Wang, Xinyue Zhao, Qizhi Wang, Xiaojing Zheng, Dilihumaer Simayi, Junli Zhao, Peiyan Yang, Qinwen Mao, Haibin Xia
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Targeting the NF-κB pathway as a potential regulator of immune checkpoints in cancer immunotherapy Cell. Mol. Life Sci. (IF 8.0) Pub Date : 2024-02-29 Nasim Ebrahimi, Al-Hasnawi Rasool Riyadh Abdulwahid, Atena Mansouri, Nasrin Karimi, Rashid Jafardoust Bostani, Sheida Beiranvand, Samaneh Adelian, Roya Khorram, Reza Vafadar, Michael R. Hamblin, Amir Reza Aref
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Ketamine’s rapid and sustained antidepressant effects are driven by distinct mechanisms Cell. Mol. Life Sci. (IF 8.0) Pub Date : 2024-02-27 Radhika Rawat, Elif Tunc-Ozcan, Sara Dunlop, Yung-Hsu Tsai, Fangze Li, Ryan Bertossi, Chian-Yu Peng, John A. Kessler
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MicroRNA-9 promotes axon regeneration of mauthner-cell in zebrafish via her6/ calcium activity pathway Cell. Mol. Life Sci. (IF 8.0) Pub Date : 2024-02-27 Yueru Shen, Xinghan Chen, Zheng Song, Huaitong Yao, Along Han, Yawen Zhang, Yuan Cai, Bing Hu
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BOP1 contributes to the activation of autophagy in polycystic ovary syndrome via nucleolar stress response Cell. Mol. Life Sci. (IF 8.0) Pub Date : 2024-02-27 Rui Ji, Zhimo Zhang, Zhe Yang, Xin Chen, Tailang Yin, Jing Yang
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Pathological mutations reveal the key role of the cytosolic iRhom2 N-terminus for phosphorylation-independent 14-3-3 interaction and ADAM17 binding, stability, and activity Cell. Mol. Life Sci. (IF 8.0) Pub Date : 2024-02-27 Katharina Bläsius, Lena Ludwig, Sarah Knapp, Charlotte Flaßhove, Friederike Sonnabend, Diandra Keller, Nikola Tacken, Xintong Gao, Selcan Kahveci-Türköz, Caroline Grannemann, Aaron Babendreyer, Colin Adrain, Sebastian Huth, Jens Malte Baron, Andreas Ludwig, Stefan Düsterhöft
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The impact of VPS35 D620N mutation on alternative autophagy and its reversal by estrogen in Parkinson's disease Cell. Mol. Life Sci. (IF 8.0) Pub Date : 2024-02-27
Abstract VPS35 plays a key role in neurodegenerative processes in Alzheimer’s disease and Parkinson’s disease (PD). Many genetic studies have shown a close relationship between autophagy and PD pathophysiology, and specifically, the PD-causing D620N mutation in VPS35 has been shown to impair autophagy. However, the molecular mechanisms underlying neuronal cell death and impaired autophagy in PD are
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RFX4 is an intrinsic factor for neuronal differentiation through induction of proneural genes POU3F2 and NEUROD1 Cell. Mol. Life Sci. (IF 8.0) Pub Date : 2024-02-22 Wonyoung Choi, Mu Seog Choe, Su Min Kim, So Jin Kim, Jiyeon Lee, Yeongun Lee, Sun-Min Lee, So Hee Dho, Min-Young Lee, Lark Kyun Kim
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Role of chromosomal cohesion and separation in aneuploidy and tumorigenesis Cell. Mol. Life Sci. (IF 8.0) Pub Date : 2024-02-22 Debananda Pati
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A progesterone derivative linked to a stable phospholipid activates breast cancer cell response without leaving the cell membrane Cell. Mol. Life Sci. (IF 8.0) Pub Date : 2024-02-22 Jofre Font-Mateu, Pol Sanllehí, Jesús Sot, Beatriz Abad, Nicolas Mateos, Juan Andres Torreno-Pina, Roberto Ferrari, Roni H. G. Wright, Maria F. Garcia-Parajo, Jesús Joglar, Félix M. Goñi, Miguel Beato
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KIF18A inactivates hepatic stellate cells and alleviates liver fibrosis through the TTC3/Akt/mTOR pathway Cell. Mol. Life Sci. (IF 8.0) Pub Date : 2024-02-19 Hao Zhang, Tong Xia, Zhijia Xia, Huaxin Zhou, Zhipeng Li, Wei Wang, Xiangyu Zhai, Bin Jin
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Cellular forgetting, desensitisation, stress and ageing in signalling networks. When do cells refuse to learn more? Cell. Mol. Life Sci. (IF 8.0) Pub Date : 2024-02-19 Tamás Veres, Márk Kerestély, Borbála M. Kovács, Dávid Keresztes, Klára Schulc, Erik Seitz, Zsolt Vassy, Dániel V. Veres, Peter Csermely
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Targeted CRISPR activation is functional in engineered human pluripotent stem cells but undergoes silencing after differentiation into cardiomyocytes and endothelium Cell. Mol. Life Sci. (IF 8.0) Pub Date : 2024-02-19 Elaheh Karbassi, Ruby Padgett, Alessandro Bertero, Hans Reinecke, Jordan M. Klaiman, Xiulan Yang, Stephen D. Hauschka, Charles E. Murry
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Emerging role of complement in COVID-19 and other respiratory virus diseases Cell. Mol. Life Sci. (IF 8.0) Pub Date : 2024-02-18 Mark T. Xiao, Calder R. Ellsworth, Xuebin Qin
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WNT5A regulates the proliferation, apoptosis and stemness of human stem Leydig cells via the β-catenin signaling pathway Cell. Mol. Life Sci. (IF 8.0) Pub Date : 2024-02-17 Wei Liu, Li Du, Yinghong Cui, Caimei He, Zuping He
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RNA m6A modification regulates L1 retrotransposons in human spermatogonial stem cell differentiation in vitro and in vivo Cell. Mol. Life Sci. (IF 8.0) Pub Date : 2024-02-16 Zili Li, Fang Fang, Mohammad Ishraq Zafar, Xunwei Wu, Xinyu Liu, Xia Tan, Jingwen Luo, Zhen Ye, Chengliang Xiong, Honggang Li
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CircYthdc2 generates polypeptides through two translation strategies to facilitate virus escape Cell. Mol. Life Sci. (IF 8.0) Pub Date : 2024-02-15 Weiwei Zheng, Linchao Wang, Shang Geng, Tianjun Xu
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Role of Sam68 as an adaptor protein in inflammatory signaling Cell. Mol. Life Sci. (IF 8.0) Pub Date : 2024-02-14
Abstract Sam68 is a ubiquitously expressed KH-domain containing RNA-binding protein highly studied for its involvement in regulating multiple steps of RNA metabolism. Sam68 also contains multiple protein–protein interaction regions such as proline-rich regions, tyrosine phosphorylation sites, and arginine methylation sites, all of which facilitate its participation as an adaptor protein in multiple
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Size-exclusion chromatography combined with DIA-MS enables deep proteome profiling of extracellular vesicles from melanoma plasma and serum Cell. Mol. Life Sci. (IF 8.0) Pub Date : 2024-02-14 Evelyn Lattmann, Luca Räss, Marco Tognetti, Julia M. Martínez Gómez, Valérie Lapaire, Roland Bruderer, Lukas Reiter, Yuehan Feng, Lars M. Steinmetz, Mitchell P. Levesque
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FBP1 inhibits NSCLC stemness by promoting ubiquitination of Notch1 intracellular domain and accelerating degradation Cell. Mol. Life Sci. (IF 8.0) Pub Date : 2024-02-13 Tianyu He, Yanye Wang, Wang Lv, Yiqing Wang, Xinye Li, Qingyi Zhang, Han-Ming Shen, Jian Hu
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KCNH6 channel promotes insulin exocytosis via interaction with Munc18-1 independent of electrophysiological processes Cell. Mol. Life Sci. (IF 8.0) Pub Date : 2024-02-13
Abstract Glucose-stimulated insulin secretion (GSIS) in pancreatic islet β-cells primarily relies on electrophysiological processes. Previous research highlighted the regulatory role of KCNH6, a member of the Kv channel family, in governing GSIS through its influence on β-cell electrophysiology. In this study, we unveil a novel facet of KCNH6's function concerning insulin granule exocytosis, independent
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Zbtb16 increases susceptibility of atrial fibrillation in type 2 diabetic mice via Txnip-Trx2 signaling Cell. Mol. Life Sci. (IF 8.0) Pub Date : 2024-02-13 Zhi-Xing Wei, Xing-Xing Cai, Yu-Dong Fei, Qian Wang, Xiao-Liang Hu, Cheng Li, Jian-Wen Hou, Yu-Li Yang, Tai-Zhong Chen, Xiao-Lei Xu, Yue-Peng Wang, Yi-Gang Li
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Platelet C3G: a key player in vesicle exocytosis, spreading and clot retraction Cell. Mol. Life Sci. (IF 8.0) Pub Date : 2024-02-12 Cristina Fernández-Infante, Luis Hernández-Cano, Óscar Herranz, Pablo Berrocal, Carmen Sicilia-Navarro, José Ramón González-Porras, José María Bastida, Almudena Porras, Carmen Guerrero