We identified a new HLA‐C allele, HLA‐C*03:03:01:32 , with a splice site mutation in intron 5.

HLA‐DRB1*01:108 has a nucleotide polymorphism (c346.G > A) compared with HLA‐DRB1*01:01:01:01 , causing an amino acid substitution (p.Glu87Lys).

HLA‐DRB1*04:275 differs from HLA‐DRB1*04:04:01 by one nucleotide substitution in codon 41 in exon 2.

HLA‐DQA1*01:48 differs from HLA‐DQA1*01:02:01:04 by one nucleotide substitution in codon 160 in exon 3.

HLA‐A*26:199 differs from HLA‐A*26:01:01:01 by one nucleotide substitution in codon 261 in exon 4.

HLA‐DQA1*05:05:05 differs from HLA‐DQA1*05:05:01:07 by one nucleotide substitution in codon 111 in exon 3.

MICA*067 differs from MICA*004:01:01 by a single nucleotide change in exon 3, 374 A>G.

HLA‐C*03:517 differs from HLA‐C*03:03:01:01 by one nucleotide substitution in codon 319 in exon 6.

We report detailed peptide binding affinities between 438 HLA Class I and Class II proteins and complete proteomes of seven pandemic human viruses, including coronaviruses, influenza viruses and HIV‐1. We contrast these affinities with HLA allele frequencies across hundreds of human populations worldwide. Statistical modelling shows that peptide binding affinities classified into four distinct categories

HLA‐DQA1*03:01:06 differs from HLA‐DQA1*03:01:01:01 by one nucleotide substitution in codon 9 in exon 2.

HLA‐DPB1*1098:01N differs from HLA‐DPB1*03:01:01:01 by one nucleotide substitution in codon 128 in exon 3.

HLA‐B*46:74 shows a single nucleotide substitution at position 419 T>A when compared to HLA‐B*46:61.

HLA‐DRB3*02:02:25 differs from HLA‐DRB3*02:02:01:02 by one nucleotide substitution in codon 116 in exon 3.

HLA‐C*06:297 differs from C*06:02:01:01 by a single nucleotide change in codon ‐19 (CCC>TCC).

HLA‐A*11:361 differs from HLA‐A*11:01:01:01 by one nucleotide substitution in codon 138 in exon 3.

HLA‐DQA1*01:49 differs from HLA‐DQA1*01:01:01:06 by one nucleotide substitution in codon 9 in exon 2.

HLA‐DQA1*03:15 differs from HLA‐DQA1*03:01:01:01 by one nucleotide substitution in codon 79 in exon 2.

HLA‐DPB1*1089:01 differs from HLA‐DPB1*02:01:02:04 by two nucleotide substitutions in codon 43 in exon 2.

Pigs are especially useful large animal models, however, limited availability of commercially available antibodies for immunoblotting presents a significant obstacle facing preclinical xenotransplantation research. Major histocompatibility complex class I (MHC‐I) molecule expression enhancement by nucleotide‐binding oligomerization domain (NOD)‐like receptor family with a caspase recruitment domain

A non-sense mutation in either DPA1*01:03:01:02 or DPA1* 01:03:01:05/01:03:01:15 results in the novel allele, HLA-DPA1*01:35 N. This article is protected by copyright. All rights reserved.

HLA-B*15:437 shows one nucleotide difference with B*15:02 at position 814 G > A. This article is protected by copyright. All rights reserved.

COVID‐19 is a respiratory disease caused by a novel coronavirus and is currently a global pandemic. HLA variation is associated with COVID‐19 because HLA plays a pivotal role in the immune response to pathogens. Here, 82 individuals with COVID‐19 were genotyped for HLA‐A, ‐B, ‐C, ‐DRB1, ‐DRB3/4/5, ‐DQA1, ‐DQB1, ‐DPA1, and ‐DPB1 loci using next‐generation sequencing (NGS). Frequencies of the HLA‐C*07:29

Human leukocyte antigen (HLA) genes can exhibit extensive variations in frequency, especially in highly admixed populations, such as that of Brazil. In this study, we demonstrated NGS-based HLA typing in our laboratory using an Illumina HiSeq 2500 sequencing platform and downstream analysis. We herein describe and compare the allele and haplotype frequencies of the populations in Barra Mansa (BM) and

INTRODUCTION Accurate rapid genotyping of the genes within the HLA region presents many difficulties due to the complexity of this region. Here we present the results of our proof of concept Nanopore based long read PCR solution for HLA genotyping. METHODS For 15 HLA Anthropology based samples and 13 NHS Blood and Transplant derived samples 40 ng of genomic DNA underwent long range PCR for class I

Natural killer cells play important roles in innate and adaptive immunity, as well as in the reproduction of placental mammals. Ly49 (KLRA) molecules represent a lectin-like type of NK cell receptor encoded within a complex genomic region, the natural killer cell complex. In rodents and horses, an expansion of the genes encoding Ly49 receptors leading to the formation of a gene family was observed

HLA-B*48:50 differs from HLA-B*48:01:01 (467C->A, S132Y). This article is protected by copyright. All rights reserved.

Recent reports have identified that the presence of non-native conformation HLA to which antibody can bind upon Luminex HLA Class I single antigen beads, can vary in levels between different manufacturers kits and that the prozone effect may also be specific to particular products. We present a case in which both prozone and non-native HLA reactive antibodies were observed, which raises important questions

Four novel HLA-A alleles were detected using two next-generation sequencing technologies.

Japan is an island country, and the Japanese people have had minimal genetic exchange with other ethnolinguistic groups. Consequently, the population is highly uniform and has limited HLA diversity relative to people from other countries. However, Japan has three ethnolinguistic groups, and HLA distributions differ depending on geographic region. To collect an HLA-rich variety of bone marrow bank donor

Anti-"Mia " is the most frequent irregular RBC antibody in Taiwan due to high prevalence of Miltenberger antigens. Dialysis patients, a special patient group that needs frequent transfusions of RBCs, may have the greatest risk for developing anti-"Mia" antibodies. The aim of this study was to investigate the association between specific HLA-DRB1 alleles and Mi alloimmunization among dialysis patients

Routine HLA typing in clinical practice encompassing solid organ and hematopoietic stem cells transplantation programs, disease association typing, volunteer marrow donor typing and population studies, provided a large dataset for studying HLA allele polymorphism in the Croatian population which led to the identification of new, very rare and rare HLA alleles. Over the last 4 years we have identified

One nucleotide substitution in codon 85 of HLA-DPB1*04:01:01:01 results in a novel allele, HLA-DPB1*454:01.

HLA-A*31:01:34 differs from HLA-A*31:01:02:01 by one nucleotide substitution at position 123 C>G.

One nucleotide replacement in codon 233 of HLA-A*24:02:01:01 results in a novel allele, HLA-A*24:02:31.

One nucleotide substitution in codon 87 of HLA-DQB1*05:02:01:01 results in a novel allele, HLA-DQB1*05:116.

HLA-DQB1*03:01:46 differs from HLA-DQB1*03:01:01:01 by one nucleotide substitution at codon 142.3 in exon 3. This article is protected by copyright. All rights reserved.

The novel HLA-B*13:82 allele differs from the closest allele B*13:02:01:01 in exon 3. This article is protected by copyright. All rights reserved.

HLA-DQB1*05:236N differs from HLA-DQB1*05:03:01:01 by one nucleotide substitution at codon 34.1 in exon 2.

One nucleotide substitution in codon 84 of HLA-DPB1*02:01:02:01 results in a novel allele, HLA-DPB1*526:01.

HLA-C*06:284 differs from HLA-C*06:02:01:02 by two single nucleotide substitutions in codon 24 (Ser > Thr).

HLA-DPB1*10:01:05 differs from HLA-DPB1*10:01:01:01 by a single synonymous nucleotide substitution in exon 2, 38 G>A.

HLA-B*07:398 differs from HLA-B*07:02:01:01 by one nucleotide substitution at codon 98.3 in exon 3.

HLA-B*50:66 differs from HLA-B*50:01:01:01 by a single nucleotide substitution (C>A) in codon 153.

HLA-DPB1*14:01:11 differs from HLA-DPB1*14:01:01:01 by a single synonymous nucleotide substitution in codon 52.

Recent Genome Wide Association Studies have identified a number of HLA alleles that are associated with either increased or decreased risk in Follicular Lymphoma. We report a case-control pilot study that aims to validate these studies in a WA population of Follicular Lymphoma patients compared to a control population derived from the Busselton Healthy Ageing Study. We have corroborated the findings

One nucleotide substitution in codon 152 of HLA-A*33:03:01:01 results in a novel allele HLA-A*33:200. This article is protected by copyright. All rights reserved.

HLA-DRB1*15:170 differs from HLA-DRB1*15:01:01:03 by one nucleotide substitution at codon 85 in exon 2.

HLA eplet matching is a novel approach to define acceptable HLA mismatches for transplant recipients. We performed an eplet analysis of three different transplant case-series to determine if the available software programs gave accurate results. Eplet analysis was performed for three different transplant case-series typed by NGS for all HLA class I and II loci. The three different HLA datasets were

The new allele, HLA-DQB1*05:247 differs from HLA-DQB1*05:02:01:01 by one nucleotide substitution at codon 35.

Recently, HLA epitopes on donor HLA molecules have been shown to be important in the success of solid organ transplantation. However, these epitopes can only be defined using high-resolution typing results of which are often not available prior to deceased donor allocation. The ability to perform high-resolution typing at all HLA loci for deceased organ donor allocation prior to transplantation would

The new allele HLA-A*02:725 showed one nucleotide difference with A*02:06:01:01 at position 104(C>T).

The single nucleotide polymorphisms (SNPs) rs11188513, rs7071836, rs10748643, rs9450279, rs4458647, and rs6922 map in the genes of ectonucleoside triphosphate diphosphohydrolase 1 (ENTPD1) and 5'-nucleotidase ecto. We investigated whether these SNPs and haplotypes of these SNPs are associated with an acute cellular rejection after liver transplantation. A total of 69 recipients with an acute cellular

Identification of the first HLA-DQA1*01:01:02 variant, called HLA-DQA1*01:01:02:02.

HLA-B*40:01:45 differs from HLA-B*40:01:02 by a single nucleotide change in exon 1, 33 G > A (codon -14 CTG > CTA).

HLA-B*27:199 differs from HLA-B*27:05:02:01 by one nucleotide substitution (c.814G>T) with one amino acid change (p.V248L).

HLA-A*68:02:16 differs from A*68:02:01:01 by a single synonymous nucleotide change in codon 160 (CTG>CTA).

One nucleotide substitution in codon 38 of HLA-DQB1*06:01:01:01 results in a novel allele, HLA-DQB1*06:132.