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The novel HLA-DRB1*14:222 N allele was identified by next-generation sequencing HLA (IF 4.513) Pub Date : 2021-09-23 Jielin Wang, Xuan You, Sudan Tao, Ji He, Faming Zhu
HLA-DRB1*14:222 N differs from HLA-DRB1*14:03:01 by one single nucleotide substitution at position 262.
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The novel HLA-A*31:191 allele was identified in a Chinese platelet donor HLA (IF 4.513) Pub Date : 2021-09-21 Qiyue Yu, Jing Song, Yanke Zhang, Haoru Li, Faming Zhu
HLA-A*31:191 differs from HLA-A*31:01:02:01 by one single nucleotide substitution at nucleotide 74.
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Detection of the novel allele, A*01:380:01:02, in a Bahraini individual by next generation sequencing HLA (IF 4.513) Pub Date : 2021-09-12 Marion Alvares, Ayeda Al Mahri, Raysha Jannang, Zain Al Yafei, Gehad ElGhazali
HLA-A*01:380:01:02 is a variant of A*01:01:01:01, differing by five nucleotide substitutions.
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Characterization of the novel HLA-DPA1 allele, HLA-DPA1*01:86 HLA (IF 4.513) Pub Date : 2021-09-18 Francesco Ingrassia, Alice Pecoraro, Maria Blando, Valentina Cappuzzo
HLA-DPA1*01:86 differs from DPA1*01:03:01:05 by a single nucleotide change in codon 94 (AAG>GAG).
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Inside the pocket: Critical elements of HLA-mediated susceptibility to cervical precancerous lesions HLA (IF 4.513) Pub Date : 2021-09-10 Letícia Boslooper Gonçalves, Patrícia Pinho de França, Natália Angelica Petry, Marina Bárbara de Souza Xavier, Newton Sérgio de Carvalho, Maria da Graça Bicalho, Angelica Beate Winter Boldt, Patrícia Savio de Araujo-Souza
Human papillomavirus (HPV) infection is a necessary cause for cervical cancer (CC), but it also depends on genetic factors, such as HLA polymorphism. However, few reports addressed the role of amino acids residues at the HLA peptide-binding cleft in HPV-related cervical disease. Therefore, we aimed to investigate the association between HLA-B, HLA-C, and HLA-DRB1 polymorphism and amino acid residues
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The novel HLA-A*24 allele, HLA-A*24:487, identified in three unrelated bone marrow donors in Colombia HLA (IF 4.513) Pub Date : 2021-09-21 David Guillermo Hernández, Nathalie Camacho Ramírez, Melissa Mosquera Martínez, Paola Andrea Cendales, Bernardo Armando Camacho
Identification of the novel HLA-A*24:487 allele which differs from HLA-A*24:02:01:01 at one position.
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Report of 13 new HLA alleles found in Spanish individuals HLA (IF 4.513) Pub Date : 2021-09-13 Dolores Planelles, Antonio Balas, Manuel Rodriguez-Cebriá, José L. Vicario
Thirteen new HLA alleles were characterized in the Spanish population.
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Characterization of the novel HLA-C*04:438 allele by next generation sequencing HLA (IF 4.513) Pub Date : 2021-09-09 Valentine Jacob, Fabienne Farce, Rangolie Kaveri, Judith Desoutter, Nicolas Guillaume
HLA-C*04:438 differs from HLA-C*04:01:01 by one nucleotide substitution in codon 237 in exon 4.
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A new allele, HLA-C*08:228, identified by sequence-based typing in a Korean individual HLA (IF 4.513) Pub Date : 2021-09-05 Chris Gunwoo Kim, Oh-Joong Kwon, Yong Park, Yunjung Cho
The new allele C*08:228 showed one nucleotide difference from C*08:01:01 in codon 36 (TTC −> TTG).
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Analysis of de novo donor-specific HLA-DPB1 antibodies in kidney transplantation HLA (IF 4.513) Pub Date : 2021-09-03 Chen Tang, Christian Unterrainer, Annette Fink, Sofia Cinca, Andrea Ruhenstroth, Sabine Scherer, Christian Morath, Martin Zeier, Arianeb Mehrabi, Caner Süsal, Thuong Hien Tran
HLA matching and avoidance of unacceptable mismatches are important aspects in the selection of donors for solid organ transplantation. The impact of HLA-DPB1 incompatibility on the outcomes of kidney transplantation is not fully understood. We investigated a potential effect of mismatching for HLA-DPB1 at allele, eplet, or Terasaki epitope (TerEp) level on the formation of de novo donor-specific antibodies
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Characterization of the novel HLA-DQA1*01:80 allele by next generation sequencing HLA (IF 4.513) Pub Date : 2021-09-12 Valentine Jacob, Fabienne Farce, Rangolie Kaveri, Judith Desoutter, Nicolas Guillaume
HLA-DQA1*01:80 differs from HLA-DQA1*01:04:01 by one nucleotide substitution in codon −18 in exon 1.
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The genomic full-length sequence of the HLA-A*24:257 allele, identified by full-length group-specific sequencing HLA (IF 4.513) Pub Date : 2021-09-08 Bin Hu, Zhihui Feng, Shuxian Jiao, Shutao Pang
The genomic full-length sequence of HLA-A*24:257 was identified by a group-specific sequencing approach from China.
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Identification of the novel HLA-B*55:107 allele in a Chinese bone marrow donor HLA (IF 4.513) Pub Date : 2021-07-15 Yanmin He, Xuan You, Wei Zhang, Ji He, Faming Zhu
HLA-B*55:107 shows two nucleotides substitution when compared to HLA-B*55:02:01:01.
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Sequence-based typing identification of the novel HLA-B*27:226 variant allele in a Chinese family HLA (IF 4.513) Pub Date : 2021-09-04 Xiaojing Wang, Jiying Wang, Yan Zhang, Qinghua Li
HLA-B*27:226 differs from HLA-B*27:04:01 by a single nucleotide in exon 2 (91T→G, Y7D).
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Donor HLA genotyping of ex vivo expanded urine cells from kidney transplant recipients HLA (IF 4.513) Pub Date : 2021-09-10 Xirui Li, Yongcheng Wei, Jun Li, Ronghai Deng, Qian Fu, Weijian Nie, Huanxi Zhang, Chenglin Wu, Xiaojun Su, Jiali Wang, Dajiang Cao, Xiangjun Liu, Longshan Liu, Changxi Wang
Antibody-mediated rejection (AMR) induced by donor-specific anti-human leukocyte antigen (HLA) antibodies (DSA) remains a major cause of long-term graft loss after kidney transplantation. Currently, the presence of DSA cannot always be determined at a specific allele level, because existing donor HLA typing is low resolution and often incomplete, lacking HLA-DP, and occasionally HLA-C and HLA-DQ information
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“HLA-10-SNP”: A new qPCR-based system for rapid, effective, and accurate detection of 10 important SNPs in the HLA region HLA (IF 4.513) Pub Date : 2021-08-10 Zhong-Zheng Zheng, Dai-Yang Li, Ke-Ming Du, Xiang Xu, Ning-Juan Wang, Zhi-Yang Yuan, Bo-An Li
Mastering the SNP content in the HLA region can be based on it to judiciously select unrelated donor stem cells with preferable MHC matching to lower postoperative complications. Herein, quantitative PCR-based primers and probes were designed for 10 transplants outcome-associated SNP loci with two-allelic polymorphism, and then a new detection system (“HLA-10-SNP”) was established. Compared with Sanger
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Prognostic significance of high circulating sHLA-G in ovarian carcinoma HLA (IF 4.513) Pub Date : 2021-07-17 Wafa Babay, Nadia Boujelbene, Hamza Ben Yahia, Daria Bortolotti, Ines Zemni, Hadda-Imene Ouzari, Hanene Chelbi, Amel Mezlini, Roberta Rizzo, Inès Zidi
HLA-G is a non-classical major histocompatibility complex class Ib molecule. Its expression has been described in various cancer types, including ovarian cancer. HLA-G molecule has been implicated in immune escape and in progression of ovarian tumor cells. Our goal was to assess if total soluble (s)HLA-G molecules or HLA-G5 and sHLA-G1 isoforms could be considered as circulating ovarian tumor biomarkers
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HLA-B*27 typing using a triplex real time PCR in routine laboratory HLA (IF 4.513) Pub Date : 2021-08-03 Marte K. Viken, Alice L. Pedersen, Menaka Andersen, Tore Jensen, Benedicte A. Lie, Line M. L. Boulland
We have established an in-house HLA-B*27 multiplex typing assay by using a combination of previously published, newly designed and commercial primers and probes for use with real-time PCR instruments. Hence, facilitating quick and large-scale HLA-B*27 typing.
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HLA genetic polymorphism in patients with Coronavirus Disease 2019 in Midwestern United States HLA (IF 4.513) Pub Date : 2021-08-02 Emily Schindler, Marian Dribus, Brian F. Duffy, Karl Hock, Christopher W. Farnsworth, Loren Gragert, Chang Liu
The experience of individuals with Coronavirus Disease 2019 (COVID-19) ranges from asymptomatic to life threatening multi-organ dysfunction. Specific HLA alleles may affect the predisposition to severe COVID-19 because of their role in presenting viral peptides to launch the adaptive immune response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). In this population-based case–control
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Characterization of the novel HLA-A*03:01:102 allele by next-generation sequencing HLA (IF 4.513) Pub Date : 2021-07-06 Maria Loginova, Daria Smirnova, Svetlana Kutyavina, Igor Paramonov
HLA-A*03:01:102 differs from HLA-A*03:01:01:01 by one nucleotide substitution at position 72 in exon 1.
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Identification of a novel HLA-A allele, HLA-A*31:97, by sequence-based typing HLA (IF 4.513) Pub Date : 2021-07-28 Jian-Ping Li, Xu Zhang, Feng-Qiu Lin, Xiao-Feng Li
HLA-A*31:97 differs by three nucleotide and two amino acid changes from HLA-A*31:01:02:01.
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Recognition of the HLA-A*24:141 allele in a Taiwanese individual HLA (IF 4.513) Pub Date : 2021-07-17 Kuo-Liang Yang, Chi-Cheng Li, Py-Yu Lin
One nucleotide substitution in codon 178 of HLA-A*24:02:01:01 results in a novel allele, HLA-A*24:141.
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Characterization of the novel HLA-B*15:598 allele identified in a Korean individual by sequence-based typing HLA (IF 4.513) Pub Date : 2021-07-08 Oh Joo Kweon, Yong Kwan Lim, Mi-Kyung Lee, Hyue Mee Kim, Hye Ryoun Kim
One nucleotide substitution in codon 169 of B*15:01:01:01 results in a novel allele, HLA-B*15:598.
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Identification of the novel HLA-B*35:03:01:22 allele in an individual of Nepalese origin HLA (IF 4.513) Pub Date : 2021-07-01 Tenzin Phuntsok, Selma D'Silva, Manisha Tambe, Meenakshi Singh
The novel HLA-B*35:03:01:22 allele differs from HLA-B*35:03:01:01 by a nucleotide change at gDNA 125 C → T.
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Description of two new HLA alleles: HLA-B*46:80 and HLA-B*46:81 identified in Chinese individuals HLA (IF 4.513) Pub Date : 2021-07-08 Shuoxian Zhao, Yizhen He, Wei Zhang, Ji He, Faming Zhu
Compared with HLA-B*46:01:01:01, the alleles HLA-B*46:80 and HLA-B*46:81 each show one nucleotide substitution, respectively.
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Characterization of a novel HLA-C*04:01:01:102 allele in an individual from West Bengal HLA (IF 4.513) Pub Date : 2021-07-08 Manisha Tambe, Tenzin Phuntsok, Selma Z. D'Silva, Jyoti Rajak, Meenakshi Singh
The novel HLA-C*04:01:01:102 allele differs from HLA-C*04:01:01:01 by G → A nucleotide change at gDNA 2591.
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Recognition of the HLA-C*07:199:01 allele in a Singaporean unrelated hematopoietic stem cell donor HLA (IF 4.513) Pub Date : 2021-07-14 Louise Cho, Zi-Jing Seng, Py-Yu Lin, Kuo-Liang Yang
One nucleotide substitution in codon 95 of HLA-C*07:04:01:01 results in a novel allele, HLA-C*07:199:01.
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Characterization of the novel HLA-C*15:241 allele by sequencing-based typing HLA (IF 4.513) Pub Date : 2021-07-27 Marine Cargou, Vincent Elsermans, Isabelle Top, Elodie Wojciechowski, Jonathan Visentin
HLA-C*15:241 differs from HLA-C*15:02:01:01 by one nucleotide substitution in codon 48 in exon 2.
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Characterization of the novel HLA allele, HLA-DRB1*08:76 HLA (IF 4.513) Pub Date : 2021-07-16 Feng-Qiu Lin, Xu Zhang, Xiao-Feng Li, Jian-Ping Li
HLA-DRB1*08:76 is a novel allele differing by a single nucleotide from the HLA-DRB1*08:03:02 allele.
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Identification of the novel HLA-DRB1*11:271 allele by next-generation sequencing HLA (IF 4.513) Pub Date : 2021-07-19 Xuan You, Yanmin He, Sudan Tao, Ji He, Faming Zhu
HLA-DRB1*11:271 differs from HLA-DRB1*11:01:01:01 by a single nucleotide substitution at position 610G > A.
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The novel HLA-DQA1 allele, HLA-DQA1*03:03:05, first described in a Brazilian individual HLA (IF 4.513) Pub Date : 2021-07-01 Romulo Vianna, Giovanna Lopes, Danielle Secco, Angela Santos, Luís Cristóvão Porto
The novel HLA-DQA1*03:03:05 allele, first described in a potential bone marrow donor from Brazil.
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Corrigendum HLA (IF 4.513) Pub Date : 2021-09-08
In [1], after issue publication, the authors realized that the surname of the second author was incorrect. The correct author's name should be: Maria C. Artesani. This has also been corrected in the online version of the article. The authors apologize for the inconvenience caused.
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Identification of HLA-B*55:117N in an individual from Zhuang population of China HLA (IF 4.513) Pub Date : 2021-08-21 Yufen Tao, Lei Shi, Yufeng Yao, Li Shi, Shuyuan Liu
The novel HLA-B*55:117N allele identified in an individual of Zhuang ethnic population of China.
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Discovery of the HLA-C*03:561 allele, a variant of HLA-C*03, in a Chinese individual HLA (IF 4.513) Pub Date : 2021-09-02 Yan-Ping Zhong, Hong-Yan Zou
HLA-C*03:561 differs from HLA-C*03:02:02:01 by one nucleotide change in exon 4 at position 862 (G>A).
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Identification of the novel HLA-DQB1*06:386 allele by next-generation sequencing HLA (IF 4.513) Pub Date : 2021-07-22 Charlène Bouthemy, Mamy Ralazamahaleo, Marine Cargou, Marylise Fort, Nicolas Congy-Jolivet
HLA-DQB1*06:386 differs from DQB1*06:46 by one nucleotide substitution in Codon 130 in Exon 3.
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Identification of the novel HLA-DPA1, DPA1*01:56 by next-generation sequencing HLA (IF 4.513) Pub Date : 2021-07-28 Galluccio T., Giustiniani P., Guagnano A., Di Luzio A., Andreani M.
The novel HLA-DPA1*01:56 allele differs from HLA-DPA1*01:03:01:04 by one nucleotide substitution in Exon 3.
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HLA-DQA1*03:03:01:16Q, a novel allele with an acceptor splice site mutation HLA (IF 4.513) Pub Date : 2021-08-21 Heather Casey, Jennifer Tyler, Carolyn Fisher, Carrie Mowery, Hiroko Shike
DQA1*03:03:01:16Q differs from DQA1*03:03:01:01 by one nucleotide at the Intron 3 splicing acceptor site.
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Characterization of the novel HLA-B*57:02:01:03 allele by sequencing-based typing HLA (IF 4.513) Pub Date : 2021-08-21 Mohammed Alghamdi, Manar A. Aldosari, Abdulrhman Alkhaibari, Abdullah S. Matyuri, Ali H. Hajeer
Two-nucleotide changes in the 3′ UTR of HLA-B*57:02:01:01 result in the novel HLA-B*57:02:01:03 allele.
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Characterization of the novel HLA-DQA1*01:02:11 allele by sequencing-based typing HLA (IF 4.513) Pub Date : 2021-08-10 Marine Cargou, Marco Andreani, Mariarosa Battarra, Elodie Wojciechowski, Jonathan Visentin
HLA-DQA1*01:02:11 differs from HLA-DQA1*01:02:01:10 by one nucleotide substitution in codon 201 in exon 4.
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The novel HLA-DQB1*05:240 allele was likely generated by recombination between DQB1*05:01 and DQB1*03:02 HLA (IF 4.513) Pub Date : 2021-08-21 Vinícius N. Stelet, Rafael F. Cita, Maristela F. Mendes, Matilde Romero, Eliana Abdelhay
Identification of the novel HLA-DQB1*05:240 allele that differs from HLA-DQB1*05:01:09 at three positions in exon 2.
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Novel HLA-A, HLA-B, and HLA-DRB1 alleles identified in Brazilian individuals HLA (IF 4.513) Pub Date : 2021-08-21 Jessica Tavares, Natalia A. Petry, José Samuel da Silva, Maria da Graça Bicalho, Patricia Savio de Araujo-Souza
Identification of 12 novel HLA class I and II alleles in Brazilian bone marrow donors.
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Characterization of the novel HLA-A*68:277 allele by sequencing-based typing HLA (IF 4.513) Pub Date : 2021-08-20 Faisal Aloufi, Asma Alblaihed, Afnan Alqasem, Abdullah Al Rasheed, Ali H. Hajeer
A single nucleotide change in exon 1 of HLA-A*68:01:01:02 results in the novel HLA-A*68:277 allele.
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Characterization of the novel HLA-A*31:199 allele by sequencing-based typing HLA (IF 4.513) Pub Date : 2021-08-18 Hanan Alanazi, Abdullah Alshubaili, Aisha Alanazi, Mohammed Alburaq, Ali H. Hajeer
A single nucleotide change in exon 4 of HLA-A*31:01:02:31 results in the novel HLA-A*31:199 allele.
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MR1 encompasses at least six allele groups with coding region alterations HLA (IF 4.513) Pub Date : 2021-08-05 Erik Rozemuller, Sidonia Barbara Guiomar Eckle, Ian McLaughlin, Maarten Penning, Wietse Mulder, Helma de Bruin, Sake van Wageningen
Unlike classical HLA class I genes, MR1 is assumed to have limited polymorphic positions. We developed a MR1 specific PCR assay and sequenced 56 DNA samples from cells with a diverse set of HLA genotypes. In this relatively small panel we found six allele groups encoding for different MR1 proteins. The two most frequent allele groups found in this panel had a frequency of 71% (MR1*01) and 25% (MR1*02)
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Identification of three novel HLA-DRA alleles by next-generation sequencing HLA (IF 4.513) Pub Date : 2021-08-17 Shingo Suzuki, Atsuko Shigenari, Sayaka Ito, Jerzy K. Kulski, Takashi Shiina
Three novel HLA-DRA alleles, DRA*01:03, DRA*01:04, and DRA*01:05 alleles with unique amino acid sequences.
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Identification of the novel HLA-DRB3*02:02:19 allele HLA (IF 4.513) Pub Date : 2021-08-14 Da-Cheng Li, Yan-Ping Zhong, Zhan-Rou Quan, Hao Chen, Su-Qing Gao
The HLA-DRB3*02:02:19 allele differs from DRB3*02:02:01:02 by a single nucleotide change in exon 2.
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Full genomic sequence of the HLA-DQB1*04:51 allele identified by next-generation sequencing HLA (IF 4.513) Pub Date : 2021-08-10 Abdelhamid Liacini, Thomas Morris, Saber AlZahrani, Leena Mathew, Steven Geier
Full-length sequence of HLA-DQB1*04:51 covers the 5′-untranslated region (UTR), all introns and exons and the 3′-UTR.
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Detection of the novel HLA allele, HLA-B*46:64, in a Chinese platelet donor by sequence-based typing HLA (IF 4.513) Pub Date : 2021-08-12 Xiao-Feng Li, Li-Zhu Jiang, Xu Zhang, Feng-Qiu Lin, Jian-Ping Li
HLA-B*46:64 has one nucleotide change from HLA-B*46:01:01:01 where Histidine (113) is changed to Arginine.
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The novel HLA-B*40:489 allele identified in a Korean hematopoietic stem cell donor HLA (IF 4.513) Pub Date : 2021-08-13 Jung-Hyun Byun, Sooin Choi, Gyeong-Won Lee, Eun-Ha Koh, Younhee Park
Single nucleotide substitution in codon 140 of HLA-B*40:02:01:01 results in the novel HLA-B*40:489 allele.
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Identification of the novel HLA-DQB1*03:454 allele using next-generation sequencing HLA (IF 4.513) Pub Date : 2021-08-12 Kyunghee Yu, Jiung Kang, Sunmi Jung, Jina Lee, Younhee Park
The HLA-DQB1*03:454 allele differs from HLA-DQB1*03:01:01:01 allele by a single nucleotide at codon 227.
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Discovery of the novel HLA allele, HLA-DRB1*15:123, in a hematopoietic stem cell donor from China HLA (IF 4.513) Pub Date : 2021-08-10 Jian-Ping Li, Xu Zhang, Feng-Qiu Lin, Xiao-Feng Li
HLA-DRB1*15:123 has one nucleotide change from HLA-DRB1*15:01:01:01 where Threonine (90) is changed to Isoleucine.
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A novel HLA allele, HLA-A*32:74, detected by sequencing in a Chinese individual HLA (IF 4.513) Pub Date : 2021-08-10 Xiao-Feng Li, Ying Liu, Xu Zhang, Feng-Qiu Lin, Jian-Ping Li
HLA-A*32:74 has one nucleotide change from HLA-A*32:01:01:01 where alanine (211) is changed to glutamate.
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The novel HLA-DRB1*15:01:42 allele was identified by next-generation sequencing HLA (IF 4.513) Pub Date : 2021-08-14 Yanmin He, Xuan You, Sudan Tao, Ji He, Faming Zhu
HLA-DRB1*15:01:42 differs from HLA-DRB1*15:01:01:01 by one single nucleotide substitution at position 732 C>T.
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Characterization of the novel HLA-B*44:02:73 allele by sequencing-based typing HLA (IF 4.513) Pub Date : 2021-08-08 Marine Cargou, Vincent Elsermans, Isabelle Top, Elodie Wojciechowski, Jonathan Visentin
HLA-B*44:02:73 differs from HLA-B*44:02:01:01 by one nucleotide substitution in codon 89 in exon 2.
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A novel HLA-B allele, HLA-B*50:04:02, detected in a Russian hematopoietic stem cell donor HLA (IF 4.513) Pub Date : 2021-08-10 Maria Loginova, Daria Smirnova, Svetlana Kutyavina, Igor Paramonov, Maksim Zarubin
HLA-B*50:04:02 differs from HLA-B*50:04:01 by two silent mutations.
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Characterization of the novel HLA-C*07:01:101 allele by sequencing-based typing HLA (IF 4.513) Pub Date : 2021-08-09 Marine Cargou, Vincent Elsermans, Isabelle Top, Elodie Wojciechowski, Jonathan Visentin
HLA-C*07:01:101 differs from HLA-C*07:01:01:15 by one nucleotide substitution in codon 332 in exon 7.
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A novel HLA-C*15 allele, HLA-C*15:192, identified by next generation sequencing in a Chinese individual HLA (IF 4.513) Pub Date : 2021-08-04 Zhan-Rou Quan, Zhen Li, Hong-Yan Zou
Identification of the novel HLA-C*15:192 allele that differs from HLA-C*15:02:01:01 at one position in exon 2.
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Characterization of the novel HLA-A*24:538 allele by sequencing-based typing HLA (IF 4.513) Pub Date : 2021-08-08 Marine Cargou, Vincent Elsermans, Isabelle Top, Mamy Ralazamahaleo, Jonathan Visentin
HLA-A*24:538 differs from HLA-A*24:02:01:01 by one nucleotide substitution in codon −21 in exon 1.
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Comparison of different luminex single antigen bead kits for memory B cell-derived HLA antibody detection HLA (IF 4.513) Pub Date : 2021-07-03 Gonca E. Karahan, Yvonne de Vaal, Kim Bakker, Dave Roelen, Frans H. J. Claas, Sebastiaan Heidt
Detection of HLA-specific memory B cells can provide additional information on sensitization of alloantigen-exposed individuals and refine immunological risk assessment. We have recently developed an assay enabling profiling of memory B cell-derived HLA antibodies using luminex single antigen bead (SAB) assay. Here, we compared the performance of the SAB kits from two vendors for memory B cell-derived
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Two cases of acute lymphoid leukemia patients with loss of heterozygosity in HLA region before transplantation HLA (IF 4.513) Pub Date : 2021-07-19 Wenqiu Huang, Song Xue, Yongping Zhang, Fuhong Liu, Jingbo Wang
Leukemia is a complex disease in which mutations and other genomic and epigenomic abnormalities play a role in both its initiation and progression. Acute lymphoid leukemia (ALL) patients with loss of heterozygosity (LOH) in the HLA region before transplantation have been described rarely. In this report, we described two ALL cases with LOH encompassing the HLA, wholly or partly. HLA molecular typing
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