Severe acute pancreatitis (SAP) usually causes multiple-organ dysfunction syndrome and exhibits a high mortality rate. It has been previously reported that berberine, as a dominant alkaloid, can be effectively used against inflammation. However, there is limited data on the effects of berberine hydrochloride (BBRH) on inflammation in SAP rat models. Male Sprague–Dawley rats were given preliminary intraperitoneal

ABSTRACT This study was designed to evaluate the effects of alprostadil on patients with refractory heart failure receiving statin treatment. One hundred patients with refractory heart failure were categorized into two groups, control (n = 50) and intervention (n = 50). The control group was treated with statins only, while the intervention group received a combination treatment with alprostadil and

Abnormal long noncoding RNAs (lncRNAs) participate in the generation and progression of malignancies. We aimed to determine the expression and clinical importance of lncRNA ENST433110 in thyroid cancer (TC). We thus investigated the role of ENST433110 in TC cell invasion, migration, and proliferation. ENST433110 expression was assessed using RT-PCR, cell migration was evaluated using a Transwell assay

Whether electromagnetic radiation (EMR) emitted from mobile phones is hazardous to human health is largely unknown. We investigated the effects of mobile phone radiation on critical organs in a rabbit model by exposing the animals to mobile phone radiation with sub-thermal specific absorption rate (SAR) of 1.0 and 0.7 W/kg for the head and the body, respectively, for 16 weeks (6 h/day, 6 days/week)

Tumor necrosis factor-α induced protein 8 like 2 (TIPE2) is one of the newly discovered negative regulators for body’s immune balance. The present study aimed to investigate the effect of TIPE2 gene-modified human amniotic mesenchymal stem cells (hAD-MSCs) on immune tolerance. In this study, the TIPE2 over-expressed and the non-transfected hAD-MSCs were severally co-cultured with injured cardiomyocytes

N6-2-hydroxyethyl-adenosine (HEA) is one of the main bioactive components found in Cordyceps cicadae and it has been reported to display antioxidant and anti-inflammatory activities. Cisplatin (CP) is one of the most commonly used chemotherapeutic drug for treating various cancers and tumors, but the use is widely curtailed due to its toxicity of various organs including the kidney. This study was

Anhydrosafflor Yellow B (AHSYB), is an effective ingredient with a high content extracted from safflower. The effect of hydroxysafflor yellow A (HSYA), one of the main compounds in safflower, has been extensively investigated both in experimental study and in clinical practice. However, few studies of AHSYB on inflammation in rats with acute permanent cerebral ischemia was explored. In this study,

ABSTRACT In this study, endophytic fungi were isolated from Euphorbia larica Boiss. and their antagonistic potential against phytopathogenic fungi viz. Fusarium sp., Rosellinia sanctae-cruciana and Cladosporium sp. was evaluated using an in vitro confrontation assay. A total of four endophytic fungi were isolated from the roots of E. larica. Among them, two fungal isolates (SQUCC-F1-1 and SQUCC-F6-2)

ABSTRACT Hardy-Weinberg equilibrium is the study of the distribution of allelic and genotypic frequencies in a population. The objective of this study is to evaluate the allelic and genotypic frequency of different qualitative traits of men and women in Punjab, Pakistan. A total of 909 individuals were recruited for this study. In population, the frequency order of the blood group is B > O > A > AB

One of the primary purposes of pine cones is the protection and distant dispersal of pine seeds. Pine cones open and release their embedded seeds on dry and windy days for long-distance dispersal. In this study, how the pine seed attach to/ detach from the pine cone scale for efficient seed dispersal were experimentally investigated by using X-ray micro-imaging technique. The cone and seeds adhere

The primacy and power of RNA in governing many processes of life has begun to be more fully appreciated in both the discovery and inventive sciences. A variety of RNA interactions regulate gene expression, and structural self-assembly underlies many of these processes. The understanding sparked by these discoveries has inspired and informed the engineering of novel RNA structures, control elements

The variability of neuronal firing has been an intense topic of study for many years. From a modelling perspective it has often been studied in conductance based spiking models with the use of additive or multiplicative noise terms to represent channel fluctuations or the stochastic nature of neurotransmitter release. Here we propose an alternative approach using a simple leaky integrate-and-fire model