Data visualisation is an essential tool for effective communication and interpretation of information. Visualisation of information using images is easier compared to numerical values. Google Earth provides a platform for a practical monitoring site visualisation system. A real-time web-based water quality monitoring system was deployed on Google Earth based on National Water Quality Index of Malaysia

ABSTRACT This study aimed to investigate the expression of miR-223-3p in a rat model of myocardial infarction and the effects of miR-223-3p on cardiomyocytes. Forty rats were randomly divided into mock surgical, model (acute myocardial infarction (AMI) group (AMIG)), AMI + miR-223-3p adenovirus (intervention group (IG)), and AMI + scramble-NC (negative control group (NCG)) groups. Cardiac function

To our knowledge, no study to date has assessed the ability of baseline Acute Physiology and Chronic Health Evaluation (APACHE) II score plus uric acid (UA) concentration to predict short-term clinical outcomes in patients with sepsis. This single-center retrospective cohort study analyzed 432 patients with sepsis who were followed up for at least 30-days between January 2016 and December 2018. The

Endometriosis (EM) is an estrogen-dependent, frequent benign gynecological disease, which reduces the quality of life in EM patients. Propofol regulates the apoptosis of EM. miR-9-5p is decreased in early secretory endometrium, TGFBI is increased in EM, however, their functions in EM remain unclear. This study aimed to investigate the mechanisms underlying the effects of propofol on the proliferation

Long non-coding RNAs (lncRNAs) are involved in development of non-small cell lung cancer (NSCLC) by interacting with microRNAs (miRNAs) and/or mRNAs. However, the function of most lncRNAs in NSCLC remains unclear. Reverse transcription-quantitative PCR (RT-qPCR) and western blot were applied for detection of mRNA/miRNA and protein level. Interaction between LncRNA small nucleolar RNA host gene 14 (SNHG14)

Hyperlipidemia and oxidative stress are major risk factors for the development of atherosclerosis and cardiovascular disease. This study was designed to investigate the hypolipidemic and hepatic antioxidant potentials of the methanol Leek extract (LE) in a high-fat diet (HFD)-fed rat model. Wistar rats were divided into 6 groups (n = 6/groups) as 1) control fed standard diet, 2) HFD, 3) HFD + (Atorvastatin)

This study investigated the application of crude methanol extract (CME) of Zapoteca portoricensis root and its methanol (MF) and ethyl acetate (EAF) fractions in managing benign prostatic hyperplasia (BPH). Forty-five albino rats (180-200 g) were divided into nine groups of five rats each: Group 1 served as normal control. BPH was induced in groups 2–9 using dihydrotestosterone and estradiol. Group

Dendrobium officinale caulis is the dried mature stems (Mat) of D. officinale Kimura et Migo. D. officinale protocorms (DOPs) are the conical embryonic tissues formed after seed germination. Previous studies suggest that these different plant parts possess similar pharmacological activities. However, the metabolic profiles and gene expression across different growth stages of D. officinale remain unknown

We aimed to analyze the efficacy of cytarabine + aclarubicin + recombinant human granulocyte colony-stimulating factor (G-CSF, i.e. CAG) regimen combined with decitabine in the clinical treatment of adult acute myeloid leukemia (AML). In total, 68 patients with adult AML were randomized into observation and control groups by random sampling. The control group (n = 34) was treated with CAG regimen alone

Background: Obesity is associated with serious health risks, including premature mortality. This study investigated the anti-obesity effects of individual or combination treatment with Spirulina platensis and green coffee bean aqueous extracts in high-fat diet-induced (HFD) obese rats. Methods: Rats were fed on HFD to induce obesity. Corn oil in the HFD accounted for 50.98% of the calories. Fifty rats

Age-related osteoporosis affects people of both genders at any age especially postmenopausal women. The manifestation of reduced bone strength leads to increased risk of bone fracture. Currently, many have sought for plant-based supplements for the management of bone health. Red clover (Trifolium pratense) contains phytoestrogenic isoflavones which are known to limit osteoclastic activity and reduce

ABSTRACT Many traditional plants have been used to fight life-threatening diseases such as diabetes, atherosclerosis and cancer. These plants have been shown to possess antioxidant activities, decrease the diabetes nuisance. The effect of 250 mg/kg b.wt of polyherbal drug (PHD) was investigated on high-fat diet-induced diabetic rats and impact of PHD administration was observed. The blood biochemical

ABSTRACT Inflammation plays a major role in etiology of multiple diseases and it has become an imperative therapeutic target in pharmacological interventions. Over the years, natural products originating from plants have made great contributions in the drug discovery process. Belonging to the Asteraceae family, Stevia rebaudiana (S. rebaudiana) is exploited at a large scale for its purpose as a natural

Severe acute pancreatitis (SAP) usually causes multiple-organ dysfunction syndrome and exhibits a high mortality rate. It has been previously reported that berberine, as a dominant alkaloid, can be effectively used against inflammation. However, there is limited data on the effects of berberine hydrochloride (BBRH) on inflammation in SAP rat models. Male Sprague–Dawley rats were given preliminary intraperitoneal

ABSTRACT This study was designed to evaluate the effects of alprostadil on patients with refractory heart failure receiving statin treatment. One hundred patients with refractory heart failure were categorized into two groups, control (n = 50) and intervention (n = 50). The control group was treated with statins only, while the intervention group received a combination treatment with alprostadil and

Abnormal long noncoding RNAs (lncRNAs) participate in the generation and progression of malignancies. We aimed to determine the expression and clinical importance of lncRNA ENST433110 in thyroid cancer (TC). We thus investigated the role of ENST433110 in TC cell invasion, migration, and proliferation. ENST433110 expression was assessed using RT-PCR, cell migration was evaluated using a Transwell assay

Whether electromagnetic radiation (EMR) emitted from mobile phones is hazardous to human health is largely unknown. We investigated the effects of mobile phone radiation on critical organs in a rabbit model by exposing the animals to mobile phone radiation with sub-thermal specific absorption rate (SAR) of 1.0 and 0.7 W/kg for the head and the body, respectively, for 16 weeks (6 h/day, 6 days/week)

Tumor necrosis factor-α induced protein 8 like 2 (TIPE2) is one of the newly discovered negative regulators for body’s immune balance. The present study aimed to investigate the effect of TIPE2 gene-modified human amniotic mesenchymal stem cells (hAD-MSCs) on immune tolerance. In this study, the TIPE2 over-expressed and the non-transfected hAD-MSCs were severally co-cultured with injured cardiomyocytes

N6-2-hydroxyethyl-adenosine (HEA) is one of the main bioactive components found in Cordyceps cicadae and it has been reported to display antioxidant and anti-inflammatory activities. Cisplatin (CP) is one of the most commonly used chemotherapeutic drug for treating various cancers and tumors, but the use is widely curtailed due to its toxicity of various organs including the kidney. This study was

Anhydrosafflor Yellow B (AHSYB), is an effective ingredient with a high content extracted from safflower. The effect of hydroxysafflor yellow A (HSYA), one of the main compounds in safflower, has been extensively investigated both in experimental study and in clinical practice. However, few studies of AHSYB on inflammation in rats with acute permanent cerebral ischemia was explored. In this study,

ABSTRACT In this study, endophytic fungi were isolated from Euphorbia larica Boiss. and their antagonistic potential against phytopathogenic fungi viz. Fusarium sp., Rosellinia sanctae-cruciana and Cladosporium sp. was evaluated using an in vitro confrontation assay. A total of four endophytic fungi were isolated from the roots of E. larica. Among them, two fungal isolates (SQUCC-F1-1 and SQUCC-F6-2)

ABSTRACT Hardy-Weinberg equilibrium is the study of the distribution of allelic and genotypic frequencies in a population. The objective of this study is to evaluate the allelic and genotypic frequency of different qualitative traits of men and women in Punjab, Pakistan. A total of 909 individuals were recruited for this study. In population, the frequency order of the blood group is B > O > A > AB

One of the primary purposes of pine cones is the protection and distant dispersal of pine seeds. Pine cones open and release their embedded seeds on dry and windy days for long-distance dispersal. In this study, how the pine seed attach to/ detach from the pine cone scale for efficient seed dispersal were experimentally investigated by using X-ray micro-imaging technique. The cone and seeds adhere

The primacy and power of RNA in governing many processes of life has begun to be more fully appreciated in both the discovery and inventive sciences. A variety of RNA interactions regulate gene expression, and structural self-assembly underlies many of these processes. The understanding sparked by these discoveries has inspired and informed the engineering of novel RNA structures, control elements

The variability of neuronal firing has been an intense topic of study for many years. From a modelling perspective it has often been studied in conductance based spiking models with the use of additive or multiplicative noise terms to represent channel fluctuations or the stochastic nature of neurotransmitter release. Here we propose an alternative approach using a simple leaky integrate-and-fire model