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A narrative review of brain-derived neurotrophic factor (BDNF) on cognitive performance in Alzheimer’s disease Growth Factors (IF 1.543) Pub Date : 2021-01-11 Noor Azila Ismail; Mohammad Farris Iman Leong Abdullah; Rohayu Hami; Hazwani Ahmad Yusof
Abstract Brain-derived neurotrophic factor (BDNF) is a neurotrophin that is highly expressed in the brain. It influences neuronal survival, growth and acts as a control centre for neurotransmitters. It also plays a crucial role in learning and memory. Current evidence indicates that BDNF may be a possible neurotrophic factor that controls cognitive functions under normal and neuropathological conditions
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Quercetin accelerated cutaneous wound healing in rats by modulation of different cytokines and growth factors. Growth Factors (IF 1.543) Pub Date : 2020-09-22 Vinay Kant,Babu Lal Jangir,Vinod Kumar,Ankit Nigam,Vikash Sharma
Abstract Quercetin on wounds could be favorable for healing based on its variety of biological effects. Eighty wounded rats were divided into four groups i.e. dimethyl sulfoxide, 0.03% quercetin, 0.1% quercetin, and 0.3% quercetin-treated. Different treatments were topically applied for 20 days. Quercetin (0.3%) caused the fastest wound closure and markedly improved the oxidative stress. Quercetin
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Heparin-binding epidermal growth factor (EGF)-like growth factor in pediatric patients with type 1 diabetes mellitus Growth Factors (IF 1.543) Pub Date : 2020-10-30 Dragana Kacarevic; Natasa Bogavac-Stanojevic; Vesna Spasojevic-Kalimanovska; Dragana Bojanin; Tatjana Milenkovic; Aleksandra Stefanovic; Marija Mihajlovic; Sanja Vujcic; Rade Vukovic; Aleksandra Zeljkovic; Jelena Kotur-Stevuljevic; Ilijana Mazibrada; Jelena Vekic
Abstract Heparin-binding EGF-like growth factor (HB-EGF) is involved in atherosclerosis progression. We investigated association between plasma HB-EGF levels and lipid, oxidative stress and inflammatory biomarkers in pediatric patients with type 1 diabetes mellitus (T1DM). Levels of HB-EGF, high-sensitive C-reactive protein (hsCRP), prooxidant-antioxidant balance (PAB), total antioxidant status (TAS)
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Prospects for the application of growth factors in wound healing Growth Factors (IF 1.543) Pub Date : 2020-11-05 Sanam Dolati; Mehdi Yousefi; Alireza Pishgahi; Salman Nourbakhsh; Behzad Pourabbas; Seyed Kazem Shakouri
Abstract As the largest organ of the body, human skin is multifunctional and enjoys two layers, the epidermis and the dermis, the separation of which is performed by a basement membrane zone. Skin protects the body against mechanical forces and infections. Skin wounds represent large and growing challenges to the healthcare systems globally. Skin wound healing, as a protective shield for the body against
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Useful applications of growth factors for cardiovascular regenerative medicine Growth Factors (IF 1.543) Pub Date : 2020-10-07 Maria Rosaria De Pascale; Nunzia Della Mura; Michele Vacca; Claudio Napoli
Abstract Novel advances for cardiovascular diseases (CVDs) include regenerative approaches for fibrosis, hypertrophy, and neoangiogenesis. Studies indicate that growth factor (GF) signaling could promote heart repair since most of the evidence is derived from preclinical models. Observational studies have evaluated GF serum/plasma levels as feasible biomarkers for risk stratification of CVDs. Noteworthy
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SIRT1 attenuates endoplasmic reticulum stress and apoptosis in rat models of COPD. Growth Factors (IF 1.543) Pub Date : 2020-08-20 Li Zhang,Bailing Luo,Yuan Ting,Shengyang He,Lihua Xie,Shenghua Sun
Abstract The present study aimed to investigate the protective role of sirtuin 1 (SIRT1) and oxygen regulated protein 150 (ORP150) in a rat COPD model by inducing changes in ER stress and apoptosis. We separated 48 Sprague Dawley (SD) rats into four groups randomly: the control group, resveratrol group, COPD group and the resveratrol intervention group. Rats were challenged with cigarette smoke and
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Statement of retraction: Interferon-α2b (IFN-α2b)-induced apoptosis is mediated by p38 MAPK in hepatocytes from rat preneoplastic liver via activation of NADPH oxidase. Growth Factors (IF 1.543) Pub Date : 2020-07-23
(2020). Statement of retraction: Interferon-α2b (IFN-α2b)-induced apoptosis is mediated by p38 MAPK in hepatocytes from rat preneoplastic liver via activation of NADPH oxidase. Growth Factors: Vol. 38, No. 2, pp. 127-127.
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Cross talk of vascular endothelial growth factor and neurotrophins in mammary gland development. Growth Factors (IF 1.543) Pub Date : 2020-07-09 Kamini Dangat,Amrita Khaire,Sadhana Joshi
Abstract During the period of lactation, there is extensive growth and development of the mammary gland in order to fulfil the increased demands of milk for the growing infant. Angiogenesis plays a key role in alveolar development and facilitates optimal milk production. Vascular endothelial growth factor (VEGF) is one of the key growth factors regulating angiogenesis in mammary gland. Apart from VEGF
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Limb functional recovery is impaired in fibroblast growth factor-2 (FGF2) deficient mice despite chronic ischaemia-induced vascular growth. Growth Factors (IF 1.543) Pub Date : 2020-06-04 Adeola Adeyemo,Christopher Johnson,Andrew Stiene,Kathleen LaSance,Zhihua Qi,Lisa Lemen,Jo El J Schultz
Abstract FGF2 is a potent stimulator of vascular growth; however, even with a deficiency of FGF2 (Fgf2-/-), developmental vessel growth or ischaemia-induced revascularization still transpires. It remains to be elucidated as to what function, if any, FGF2 has during ischaemic injury. Wildtype (WT) or Fgf2-/- mice were subjected to hindlimb ischaemia for up to 42 days. Limb function, vascular growth
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Cyclosporin A suppresses Porphyromonas gingivalis lipopolysaccharide induced matrix metalloproteinases activities in the co-culture of human gingival fibroblasts and monocyte cell line THP-1. Growth Factors (IF 1.543) Pub Date : 2020-04-22 Lei Jiang,Min Ni Liu,Guo Dong Wang,Qun Wu,Yun Fu Zhao
Abstract Cyclosporine-A (CsA) is a widely used immunosuppressant. In this study, we explore the pathway through which CsA suppressed the Porphyromonas gingivalis lipopolysaccharide (P.g-LPS)-induced increase in matrix metalloproteinase (MMP) activities in co-cultured human gingival fibroblasts (HGFs) and THP-1 monocytes. In the co-culture, we found that CsA inhibited the expression of cyclophilin A
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Therapeutic approaches of trophic factors in animal models and in patients with spinal cord injury Growth Factors (IF 1.543) Pub Date : 2020-04-17 María del Carmen Díaz-Galindo; Denisse Calderón-Vallejo; Carlos Olvera-Sandoval; J. Luis Quintanar
Abstract Trophic factors are naturally produced by different tissues that participate in several functions such as the intercellular communication, in the development, stability, differentiation and regeneration at the cellular level. Specifically, in the case of spinal injuries, these factors can stimulate neuronal recovery. They are applied both in experimental models and in clinical trials in patients
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Effect of single bout downhill running on the serum irisin concentrations in rats. Growth Factors (IF 1.543) Pub Date : 2020-03-21 Masanobu Murao,Tetsuo Imano,Junichi Akiyama,Teruhiko Kawakami,Masaaki Nakajima
This study aimed to characterize the effect of different running modes on serum irisin concentrations in rats. A total of 18, 10-week-old rats were divided into three groups; control group, 16° uphill running group (concentric exercise; CON) and, −16° downhill running group (eccentric exercise; ECC). The running group’s rats ran on the inclined treadmill at 16 m/min, for a total of 90 min. Blood was
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Association between the serum concentrations of 12 cytokines and growth factors and metabolic syndrome in patients undergoing angiography. Growth Factors (IF 1.543) Pub Date : 2020-03-12 Seyed Reza Mirhafez,Mohamad Tajfard,Ahmadreza Zarifian,Ali Movahedi,Nazanin Amiri,Hamideh Ghazizadeh,Amir Avan,Gordon A Ferns,Majid Ghayour-Mobarhan
We aimed to compare the concentrations of serum cytokines in patients undergoing coronary angiography and finding their possible associations with metabolic syndrome. Twelve serum cytokines and growth factors (IL-1α, IL-1β, IL-2, IL-4, IL-6, IL-8, IL-10, TNF-α, MCP-1, IFN-γ, EGF, and VEGF) were measured by sandwich chemiluminescence assays, on the Evidence Investigator® system. There were significant
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IGF-1 regulate the expression of uncoupling protein 2 via FOXO1. Growth Factors (IF 1.543) Pub Date : 2020-03-10 Yukiko Watamoto,Kumi Futawaka,Misa Hayashi,Midori Matsushita,Mana Mitsutani,Zilin Song,Rie Koyama,Yuki Fukuda,Ayaka Nushida,Syoko Nezu,Akiko Kuwahara,Kazusaburo Kataoka,Tetsuya Tagami,Kenji Moriyama
Mitochondria uncoupling protein2 (UCP2) expressed ubiquitously is a key molecule of energy metabolism. Insulin-like growth factor-1 (IGF-1) is a hormone, a target molecule of growth hormone (GH) signal pathway, which is also known as the drug “mecasermin” for clinical usages. IGF-1 is seemed to be closely related to metabolic diseases, such as adult GH deficiency. However, there has not been reports
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Platelet-rich plasma improves impaired glucose hemostasis, disrupted insulin secretion, and pancreatic oxidative stress in streptozotocin-induced diabetic rat. Growth Factors (IF 1.543) Pub Date : 2020-03-10 Marzieh Zarin,Narges Karbalaei,Sara Keshtgar,Marzieh Nemati
Our study aimed to investigate the effects of platelet-rich plasma (PRP) on impaired glucose homeostasis, disrupted islet insulin secretion, and pancreatic oxidative status in streptozotocin (STZ)-diabetic rats. A total of 64 Sprague-Dawley male were randomized to four groups including controls, diabetes, control-PRP, and diabetes-PRP. The rats received the PRP (0.5 ml/kg, SC injection) twice weekly
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Epidermal growth factor receptor ligands: targets for optimizing treatment of metastatic colorectal cancer. Growth Factors (IF 1.543) Pub Date : 2019-12-26 Siavash Foroughi,Jeanne Tie,Peter Gibbs,Antony Wilks Burgess
The discovery of epidermal growth factor (EGF) and its receptor (EGFR) revealed the connection between EGF-like ligands, signaling from the EGFR family members and cancer. Over the next fifty years, analysis of EGFR expression and mutation led to the use of monoclonal antibodies to target EGFR in the treatment of metastatic colorectal cancer (mCRC) and this treatment has improved outcomes for patients
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Growth differentiation factor 15 and its role in carcinogenesis: an update. Growth Factors (IF 1.543) Pub Date : 2019-11-07 Anupama Modi,Shailender Dwivedi,Dipayan Roy,Manoj Khokhar,Purvi Purohit,Jeewanram Vishnoi,Puneet Pareek,Shailja Sharma,Praveen Sharma,Sanjeev Misra
Growth differentiation factor-15 (GDF-15) is a novel cytokine secreted by a variety of cells like macrophages, adipocytes, normally expressed in high amounts by placenta. It is also highly expressed in multiple carcinomas like Colon, Breast, Pancreas, Liver, and Ovarian. Several reports on serum GDF-15 as a potential biomarker for diagnosis and prognosis of cancer are hampered by the lack of robust
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Dose optimisation of PTEN inhibitor, bpV (HOpic), and SCF for the in-vitro activation of sheep primordial follicles. Growth Factors (IF 1.543) Pub Date : 2019-10-28 Samane Adib,Mojtaba Rezazadeh Valojerdi,Mehdi Alikhani
The in-vitro development of primordial follicles is critical for improving mammalian fertility and wildlife conservation. This study aimed to optimise the effective doses of bpV (HOpic) and stem cell factor (SCF) for the in-vitro activation of sheep primordial follicles. To do this, sheep ovarian cortex was treated with bpV (1.5, 15, and 150 μM) and SCF (50 and 100 ng/ml). Follicular count indicated
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Lowe syndrome with extremely short stature: growth hormone deficiency may be the pathogeny. Growth Factors (IF 1.543) Pub Date : 2019-10-03 Chengjun Dai,Liying Wang,Youli Li,Zhichao Zheng,Jieqi Qian,Chaoban Wang,Zishuo Liu,Xiaoou Shan
Lowe syndrome is an x-linked disorder characterized by congenital cataracts, nervous system abnormalities and renal tubular dysfunction. With the rising number of reported cases, more patients are found to suffer from endocrine abnormalities. Hereby, three Chinese patients with typical symptoms and extremely short stature were described. The OCRL gene was analyzed. A combination of blood biochemistry
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Plasma CCN2 is independently related to subsequent need for abdominal aorta aneurysm repair. Growth Factors (IF 1.543) Pub Date : 2019-09-29 Jannik Hjortshøj Larsen,Lars Melholt Rasmussen,Jes Sanddal Lindholt,Lasse Bach Steffensen
The objective of this study was to determine if plasma CCN2 is associated with abdominal aorta aneurysm (AAA), and future need for AAA repair, and further to assess the potential clinical value of CCN2 in predicting disease outcome. CCN2 was quantified in plasma samples obtained from a cohort of 679 men aged 65-74 at initial ultrasound screening for AAA in the Viborg Vascular (VIVA) screening trial
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An oncogenic activity of PDGF-C and its splice variant in human breast cancer. Growth Factors (IF 1.543) Pub Date : 2019-09-23 Alyssa Bottrell,Yong Hong Meng,Abdo J Najy,Newton Hurst,Seongho Kim,Chong Jai Kim,Eun-Sook Kim,Aree Moon,Eun Joo Kim,So Yeon Park,Hyeong-Reh Choi Kim
Despite strong evidence for the involvement of PDGF signaling in breast cancer, little is known about the PDGF ligand responsible for PDGFR activation during breast cancer progression. Here, we found PDGF-C to be highly expressed in breast carcinoma cell lines. Immunohistochemical analysis of invasive breast cancer revealed an association between increased PDGF-C expression and lymph node metastases
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Granulocyte colony-stimulating factor downregulates interferon-gamma receptor expression and stimulates interleukin-6 production in activated human macrophages. Growth Factors (IF 1.543) Pub Date : 2019-09-19 V I Seledtsov,V V Malashchenko,M E Meniailo,N D Gazatova,G V Seledtsova
We studied direct effects of human granulocyte colony-stimulating factor (G-CSF) on phenotypical properties of human macrophage cells in vitro. CD14+ monocyte/macrophages (Mc/Mphs) were isolated from blood of healthy donors by positive magnetic separation. G-CSF (0.01-1.0 ng/mL), when added to Mc/Mphs along with lipopolysaccharide (LPS, 1.0 μg/mL), was able to noticeably reduce proportions of CD119
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Association of growth performance and body conformational traits with BMP4 gene variation in Barki lambs. Growth Factors (IF 1.543) Pub Date : 2019-09-11 Adel H M Ibrahim
The objective of this study was to test the association of the variation in a 360 bp region in exon 2 of the ovine bone morphogenetic protein 4 (BMP4) gene with growth performance (birth weight, pre-weaning average daily gain, weaning weight, post-weaning average daily gain and marketing weight) and body conformational traits (height at withers, height at hips, body length, heart girth, thigh circumference
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Effects of hepatocyte growth factor gene-transfected mesenchymal stem cells on dimethylnitrosamine-induced liver fibrosis in rats. Growth Factors (IF 1.543) Pub Date : 2019-08-28 Soung Hoon Moon,Chang Min Lee,See-Hyoung Park,Myeong Jin Nam
Nowadays, transplantation of human mesenchymal stem cells (MSCs) has emerged as a potential cellular therapy for liver cirrhosis. Hepatocyte growth factor (HGF) plays an important role in the regeneration of the liver. The objective of the study was to investigate the therapeutic effect of HGF-transfected human umbilical cord blood-derived MSCs on dimethylnitrosamine (DMN)-induced liver fibrosis in
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Recombinant protein CCN5/WISP2 promotes islet cell proliferation and survival in vitro. Growth Factors (IF 1.543) Pub Date : 2019-08-23 Nancy Kaddour,Di Zhang,Zu-Hua Gao,Jun-Li Liu
Pancreatic ß cell proliferation, survival and function are key elements that need to be considered in developing novel antidiabetic therapies. We recently identified CCN5/WISP2 to have potential growth promoting properties when overexpressed in ß cells; however, further investigations are needed to validate those properties. In this study, we demonstrated that exogenous treatment of insulinoma cells
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Effects of subcutaneous injection of ozone during wound healing in rats. Growth Factors (IF 1.543) Pub Date : 2019-07-24 Ciro D Soares,Thayná M L Morais,Roberta M F G Araújo,Patrícia F Meyer,Eric A F Oliveira,Rodrigo M V Silva,Eneida M Carreiro,Edvaldo P Carreiro,Verônica G Belloco,Bruno A L A Mariz,Jacks Jorge-Junior
Fibroblast growth factor 2 (FGF2) regulates the wound repair process and it is secreted by inflammatory and endothelial cells, and by myofibroblasts. This study aimed to establish the expression patterns of FGF2 and myofibroblastic differentiation during wound healing in rats treated with subcutaneous ozone injection. We created full-thickness excisional wounds in rats, and the healing process was
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Growth factor signaling pathways in vascular development and disease. Growth Factors (IF 1.543) Pub Date : 2019-07-08 Zoe L Grant,Leigh Coultas
Angiogenic blood vessel growth is essential to ensure organs receive adequate blood supply to support normal organ function and homeostasis. Angiogenesis involves a complex series of cellular events through which new vessels grow out from existing vasculature. Growth factor signaling, layered over a range of other signaling inputs, orchestrates this process. The response of endothelial cells (ECs)
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Bone morphogenetic protein signaling in breast cancer progression. Growth Factors (IF 1.543) Pub Date : 2019-07-05 Lap Hing Chi,Allan D Burrows,Robin L Anderson
Breast cancer is the most prevalent type of cancer amongst women worldwide. The mortality rate for patients with early-stage breast cancer has been decreasing, however, the 5-year survival rate for patients with metastatic disease remains poor, currently at 27%. Here, we have reviewed the current understanding of the role of bone morphogenetic protein (BMP) signaling in breast cancer progression, and
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Vascular endothelial growth factor B inhibits lipid accumulation in C2C12 myotubes incubated with fatty acids. Growth Factors (IF 1.543) Pub Date : 2019-06-19 Ling-Jie Li,Jin Ma,Song-Bo Li,Xuefei Chen,Jing Zhang
To investigate (1) the effect of vascular endothelial growth factor B (VEGFB) on lipid accumulation and the alteration of fatty acids and fatty acid-related enzymes in C2C12 myotubes incubated with fatty acids and (2) the regulatory effect of VEGFB on skeletal muscle lipid metabolism. Mouse C2C12 myotubes were incubated with oleic acid (OA) and palmitic acid (PA), and differentiated mature C2C12 myotubes
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Structure, function and disease relevance of Wnt inhibitory factor 1, a secreted protein controlling the Wnt and hedgehog pathways. Growth Factors (IF 1.543) Pub Date : 2019-06-18 Krisztina Kerekes,László Bányai,Mária Trexler,László Patthy
Wnts and Hedgehogs (Hh) are large, lipid-modified extracellular morphogens that play key roles in embryonic development and stem cell proliferation of Metazoa. Both morphogens signal through heptahelical Frizzled-type receptors of the G-Protein Coupled Receptor family and there are several other similarities that suggest a common evolutionary origin of the Hh and Wnt pathways. There is evidence that
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Hepatocyte growth factor levels in livers and serum at Kasai-portoenterostomy are not predictive of clinical outcome in infants with biliary atresia. Growth Factors (IF 1.543) Pub Date : 2019-06-11 Omid Madadi-Sanjani,Joachim F Kuebler,Stephanie Dippel,Anna Gigina,Christine S Falk,Gertrud Vieten,Claus Petersen,Christian Klemann
Biliary atresia (BA) is characterized by progressive destruction of the biliary system leading to liver fibrosis and deterioration of liver function. Serum hepatocyte growth factor (HGF) has been shown to be increased in cirrhotic diseases including BA. The aim of this study was to investigate the prognostic value of HGF levels in sera and liver tissue for the further disease course. A total of 49
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Emerging roles for Interleukin-11 in disease. Growth Factors (IF 1.543) Pub Date : 2019-06-04 Paul M Nguyen,Suad M Abdirahman,Tracy L Putoczki
Interleukin (IL)-11 belongs to the IL-6 family of cytokines, discovered over 30 years ago. While early studies focused on the ability of IL-11 to stimulate megakaryocytopoiesis, the importance of this cytokine to inflammatory disease and cancers is only just beginning to be uncovered. This review outlines recent advances in our understanding of IL-11 biology, and highlights the development of novel
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Escherichia coli BMP-2 showed comparable osteoinductivity with Chinese hamster ovary derived BMP-2 with demineralized bone matrix as carrier. Growth Factors (IF 1.543) Pub Date : 2019-04-04 Yuan-Zhe Jin,Guang-Bin Zheng,Jae Hyup Lee
Escherichia coli bone morphogenetic protein-2 (ErhBMP-2) had a larger yield but less osteoinductivity than Chinese hamster ovary cell bone morphogenetic protein-2 (CrhBMP-2). Since the release profile of rhBMP-2 affects its osteoinductivity, an appropriate carrier could improve the effect of ErhBMP-2. Demineralized bone matrix (DBM) was one of the most widely used bone substitutes, but few studies
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The association of insulin-like growth factor-1 standard deviation score and height in Chinese children with type 1 diabetes mellitus. Growth Factors (IF 1.543) Pub Date : 2019-03-22 Wei Song,Yu Qiao,Jiang Xue,Fei Zhao,Xin Yang,Guimei Li
Assessing the relationship between IGF-1 and height in type 1 diabetes children. Seventy-two type 1 diabetes children and 190 controls were recruited. The height standard deviation score of type 1 diabetes children was significantly higher than controls. The height standard deviation score was higher than the target height standard deviation score in both type 1 diabetes and controls. Serum IGF-1 levels
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Regulation of hematopoietic cell signaling by SHIP-1 inositol phosphatase: growth factors and beyond. Growth Factors (IF 1.543) Pub Date : 2019-02-15 Margaret L Hibbs,April L Raftery,Evelyn Tsantikos
SHIP-1 is a hematopoietic-specific inositol phosphatase activated downstream of a multitude of receptors including those for growth factors, cytokines, antigen, immunoglobulin and toll-like receptor agonists where it exerts inhibitory control. While it is constitutively expressed in all immune cells, SHIP-1 expression is negatively regulated by the inflammatory and oncogenic micro-RNA miR-155. Knockout
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VEGF-A is associated with early degenerative changes in cartilage and subchondral bone. Growth Factors (IF 1.543) Pub Date : 2019-02-15 Janja Zupan,Peter Vrtačnik,Andrej Cör,Gregor Haring,Georges Weryha,Sophie Visvikis-Siest,Janja Marc
Paired cartilage and subchondral bone of subjects with no clinical history of joint disorders were analyzed to determine whether antioxidant enzymes, inflammatory cytokines and growth factors can be linked to a pre-osteoarthritis. Tissue explants were phenotyped according to Osteoarthritis Research Society International grading and micro-computed tomography, and also screened for the expression of
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Hematopoietic growth factors: the scenario in zebrafish. Growth Factors (IF 1.543) Pub Date : 2019-02-15 Vahid Pazhakh,Graham J Lieschke
Humoral regulation by ligand/receptor interactions is a fundamental feature of vertebrate hematopoiesis. Zebrafish are an established vertebrate animal model of hematopoiesis, sharing with mammals conserved genetic, molecular and cell biological regulatory mechanisms. This comprehensive review considers zebrafish hematopoiesis from the perspective of the hematopoietic growth factors (HGFs), their receptors
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The roles of vascular endothelial growth factor gene polymorphisms in congenital heart diseases: a meta-analysis. Growth Factors (IF 1.543) Pub Date : 2019-01-28 Weiping Wang,Aiping Xu,Hong Xu
We performed this study to better elucidate the correlations between vascular endothelial growth factor (VEGF) gene polymorphisms and congenital heart diseases (CHD). Eligible articles were searched in PubMed, Medline, Embase and CNKI. Eighteen studies were finally included in our meta-analysis. A significant association with the risk of CHD was detected for the rs1570360 polymorphism in additive comparison
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The effect of leukocyte-platelet-rich fibrin on bone morphogenetic protein-2 and insulin-like growth factor-1 levels in patients with chronic periodontitis: a randomized split mouth clinical trail. Growth Factors (IF 1.543) Pub Date : 2019-01-09 Alper Kizildağ,Yasin Çiçek,Taner Arabaci,Oğuz Köse
The present study evaluates the effects of leukocyte-platelet-rich fibrin (L-PRF) combined with open flap debridement (OFD) on clinical parameters and growth factors levels (GFL) in chronic periodontitis (CP) patients. This trial was registered at clinicaltrials.gov as NCT02594605. 16 patients (32 sites) with chronic periodontitis who had at least two areas of horizontal bone loss, were treated with
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Growth factor signalling in osteoarthritis. Growth Factors (IF 1.543) Pub Date : 2019-01-09 Jian Huang,Lan Zhao,Di Chen
Osteoarthritis (OA) is one of the most common diseases, affecting more than 10% of populations and thus creating immense socioeconomic burden. The pathological changes of OA involve the entire joint, which is composed of multiple types of tissues and cells, exemplified by cartilage degradation, subchondral bone thickening, osteophyte formation, synovium inflammation and hypertrophy, and ligament degeneration
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Heparin-binding EGF-like growth factor attenuates lung inflammation and injury in a murine model of pulmonary emphysema. Growth Factors (IF 1.543) Pub Date : 2019-01-02 Yanwei Su,Heng Luo,Jixin Yang
Pulmonary inflammation and progressive lung destruction are the major causes of chronic obstructive pulmonary disease (COPD), resulting in emphysema and irreversible pulmonary dysfunction. Heparin-binding EGF-like growth factor (HB-EGF), is known to play a protective role in the process of various inflammatory diseases. However, its effect on COPD is poorly understood. This study was designed to determine
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HMGB1 inhibits insulin signalling through TLR4 and RAGE in human retinal endothelial cells. Growth Factors (IF 1.543) Pub Date : 2018-12-11 Youde Jiang,Jena J Steinle
In the past decade, the role of inflammation has been shown in diabetes and its complications. Little is available on high mobility group box 1 (HMGB1) actions on the proteins involved in insulin signal transduction, which may be altered to result in insulin resistance in the retina. Retinal endothelial cells (REC) were grown in normal or high glucose and treated with recombinant human HMGB1, an Epac1
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Exploitation of receptor tyrosine kinases by viral-encoded growth factors. Growth Factors (IF 1.543) Pub Date : 2018-12-11 Zabeen Lateef,Lyn M Wise
Receptor tyrosine kinases (RTKs) are essential components of cell communication pathways utilized from the embryonic to adult stages of life. These transmembrane receptors bind polypeptide ligands, such as growth factors, inducing signalling cascades that control cellular processes such as proliferation, survival, differentiation, motility and inflammation. Many viruses have acquired homologs of growth
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Effect of serum fibroblast growth factor receptor 2 and CAPS proteins on calcium status in β-thalassaemia major patients who are free from overt inflammation. Growth Factors (IF 1.543) Pub Date : 2018-10-30 Hussein Kadhem Al-Hakeim,Zainab Hussein Alhillawi
Bone disorders and disturbed calcium (Ca) homeostasis are common disorders in β-thalassaemia major (β-TM). In the present study, two bone related markers are studied in β-TM patients with negative C-reactive protein for the first time; fibroblast growth factor receptor 2 (FGFR2) and CAPS protein. Another goal is to estimate the correlation between the recent parameters and bone biomaterials as a function
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Understanding SOCS protein specificity. Growth Factors (IF 1.543) Pub Date : 2018-10-15 Edmond M Linossi,Dale J Calleja,Sandra E Nicholson
The development and activity of our immune system are largely controlled by the action of pleiotropic cytokines and growth factors, small secreted proteins, which bind to receptors on the surface of immune cells to initiate an appropriate physiological response. Cytokine signalling is predominantly executed by intracellular proteins known as the Janus kinases (JAKs) and the signal transducers and activators
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Cytokine control of megakaryopoiesis. Growth Factors (IF 1.543) Pub Date : 2018-10-15 Kira Behrens,Warren S Alexander
Platelets are anuclear blood cells required for haemostasis and are implicated in other processes including inflammation and metastasis. Platelets are produced by megakaryocytes, specialized cells that are themselves generated by a process of controlled differentiation and maturation of bone-marrow stem and progenitor cells. This process of megakaryopoiesis involves the coordinated interplay of transcription
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Vascular endothelial growth factor gene polymorphisms and coronary heart disease: a systematic review and meta-analysis. Growth Factors (IF 1.543) Pub Date : 2018-10-15 Xiangwen Zhao,Liang Meng,Jimin Jiang,Xinglong Wu
We performed this study to better elucidate the relationship between vascular endothelial growth factor (VEGF) polymorphisms and coronary heart disease (CHD). Eligible articles were searched in PubMed, Medline, Embase, Scopus and CNKI. A total of 24 studies containing 6489 CHD patients and 5664 control subjects were analyzed. Our overall and subgroup analyses suggested that rs699947 polymorphism was
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Relationship of fibroblast growth factor 21, sirtuin 1, visfatin, and regulators in children with short stature. Growth Factors (IF 1.543) Pub Date : 2018-10-10 Davut Sinan Kaplan,Asuman Canak,Emregul Isık,Mustafa Orkmez,Burcu Kumru
Fibroblast growth factor 21 (FGF21) is mainly secreted by the liver. It is a factor that is not fully understood in relation to growth. Sirtuin 1 (SIRT1) is a deacetylase protein. It is thought that may have an effect on the release and function of GH and IGF-1. Visfatin is synthesized from adipose tissue as primary. It may be prognostic marker associated with growth factors. As a result of our work
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Heterodimeric BMP-2/7 exhibits different osteoinductive effects in human and murine cells. Growth Factors (IF 1.543) Pub Date : 2018-09-21 Xiao Zhang,Si Chen,Yunsong Liu,Ping Zhang,Yanjun Ge,Jing Guo,Gang Wu,Yongsheng Zhou
As robust osteoinductive cytokines, bone morphogenetic proteins (BMPs) play a significant role in bone tissue engineering. Constituted of two different polypeptides, heterodimeric BMPs are more effective than the homodimers in bone formation. While most studies focused on the murine cell lines, such as murine preosteoblasts MC3T3-E1, the role of heterodimeric BMPs in the osteogenic differentiation
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Effect of adipocyte-derived IGF-I on adipose tissue mass and glucose metabolism in the Berlin Fat Mouse. Growth Factors (IF 1.543) Pub Date : 2018-09-10 Deike Hesse,Jan Trost,Nadine Schäfer,Kristin Schwerbel,Andreas Hoeflich,Annette Schürmann,Gudrun A Brockmann
Besides liver, IGF-I is expressed in adipose tissue. However, the effects of this local IGF-I on adipose tissue and metabolism are unclear. We generated adipocyte-specific knock-out mice on the background of the Berlin Fat Mouse Inbred (BFMI) line to evaluate the contribution of adipocyte-IGF-I on glucose metabolism and adipose tissue development. BFMI mice are obese, non-diabetic with elevated plasma
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Cyclooxygenase-2 interacts with MMP and FGF pathways to promote epimorphic regeneration in lizard Hemidactylus flaviviridis. Growth Factors (IF 1.543) Pub Date : 2018-09-10 Pranav R Buch,Isha Ranadive,Isha Desai,Suresh Balarakrishnan
Cyclooxygenase-2 (COX-2) is an inducible enzyme known for its role in promoting inflammation, pain and cancer. It has more recently been attributed a function in epimorphic regeneration of vertebrate appendages. However, its position among the molecular regulators of regeneration remains unclear. This work was aimed at analyzing the influence of COX-2 on critical mediators of regenerative processes
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Deficiency of the Wnt receptor Ryk causes multiple cardiac and outflow tract defects. Growth Factors (IF 1.543) Pub Date : 2018-07-23 Kumudhini Kugathasan,Michael M Halford,Peter G Farlie,Damien Bates,Darrin P Smith,You Fang Zhang,James P Roy,Maria L Macheda,Dong Zhang,James L Wilkinson,Margaret L Kirby,Donald F Newgreen,Steven A Stacker
Ryk is a member of the receptor tyrosine kinase (RTK) family of proteins that control and regulate cellular processes. It is distinguished by binding Wnt ligands and having no detectable intrinsic protein tyrosine kinase activity suggesting Ryk is a pseudokinase. Here, we show an essential role for Ryk in directing morphogenetic events required for normal cardiac development through the examination
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Evaluation of the growth factors VEGF-a and VEGF-B in the vitreous and serum of patients with macular and retinal vascular diseases. Growth Factors (IF 1.543) Pub Date : 2018-07-03 Joana Mesquita,João Paulo Castro-de-Sousa,Sara Vaz-Pereira,Arminda Neves,Luís A Passarinha,Cândida T Tomaz
VEGF-A and VEGF-B are proangiogenic and key regulating factors for blood vessel growth. This study aims to compare VEGF-A and VEGF-B levels in the serum and vitreous of patients with neovascular pathology versus non-neovascular pathology. Our findings showed vitreous VEGF-A and VEGF-B levels increased in patients with neovascular disease, with higher levels of VEGF-A compared to VEGF-B (p ≤ .05). In
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STAT3: a multifaceted oncoprotein. Growth Factors (IF 1.543) Pub Date : 2018-06-06 Aleks C Guanizo,Chamira Dilanka Fernando,Daniel J Garama,Daniel J Gough
Signal transducer and activator of transcription (STAT) 3 is a key signalling protein engaged by a multitude of growth factors and cytokines to elicit diverse biological outcomes including cellular growth, differentiation, and survival. The complete loss of STAT3 is not compatible with life and even partial loss of function mutations lead to debilitating pathologies like hyper IgE syndrome. Conversely
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Role of granulosa cell mitogen-activated protein kinase 3/1 in gonadotropin-mediated meiotic resumption from diplotene arrest of mammalian oocytes. Growth Factors (IF 1.543) Pub Date : 2018-05-29 Kankshi Sahu,Anumegha Gupta,Alka Sharma,Meenakshi Tiwari,Ashutosh N Pandey,Shilpa Prasad,Pramod K Yadav,Ajai K Pandey,Tulsidas G Shrivastav,Shail K Chaube
In mammals, preovulatory oocytes are encircled by several layers of granulosa cells (GCs) in follicular microenvironment. These follicular oocytes are arrested at diplotene arrest due to high level of cyclic nucleotides from encircling GCs. Pituitary gonadotropin acts at the level of encircling GCs and increases adenosine 3′,5′-cyclic monophosphate (cAMP) and guanosine 3′,5′-cyclic monophosphate (cGMP)
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The biochemistry, signalling and disease relevance of RYK and other WNT-binding receptor tyrosine kinases. Growth Factors (IF 1.543) Pub Date : 2018-05-28 James P Roy,Michael M Halford,Steven A Stacker
The receptor tyrosine kinases (RTKs) are a well-characterized family of growth factor receptors that have central roles in human disease and are frequently therapeutically targeted. The RYK, ROR, PTK7 and MuSK subfamilies make up an understudied subset of WNT-binding RTKs. Numerous developmental, stem cell and pathological roles of WNTs, in particular WNT5A, involve signalling via these WNT receptors
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In vitro and in vivo evaluation of osteoinductivity and bone fusion ability of an activin a/BMP2 chimera (AB204): a comparison study between AB204 and rhBMP-2. Growth Factors (IF 1.543) Pub Date : 2018-04-13 Guang Bin Zheng,Jae Hyup Lee,Yuan-Zhe Jin
This study compared osteoinductivity and osteogenic capacity between AB204 and rhBMP-2 using hMSCs in vitro and a beagle’s posterolateral spinal fusion model. Cultured hMSCs were treated with AB204 or rhBMP-2 with low to high doses. Three male beagles were performed posterolateral spinal fusion with biphasic calcium phosphate (2 ml) + AB204 or rhBMP-2 (20, 50 or 200 µg). They were euthanized after
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Differential effects of epidermal growth factor (EGF) receptor ligands on receptor binding, downstream signalling pathways and DNA synthesis in hepatocytes. Growth Factors (IF 1.543) Pub Date : 2018-03-27 J Ødegård,J E Sondresen,M Aasrum,I H Tveteraas,T K Guren,T Christoffersen,G H Thoresen
Hepatocytes are responsive to mitogenic effects of several ligands acting via EGFR. Studying primary cultures of rat hepatocytes, we found that, as compared to EGF, HB-EGF had a markedly higher affinity of the EGFR, while AR and TGFα had lower affinity. HB-EGF was also more potent compared to the other growth factors regarding phosphorylation of EGFR, Shc, ERK1/2 and Akt. All ligands induced phosphorylation
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Toll-like receptor 4 regulates insulin signal transduction in retinal Müller cells. Growth Factors (IF 1.543) Pub Date : 2018-02-28 Li Liu,Jena J Steinle
Dysfunctional insulin signalling is a causative factor in type-2 diabetes. While insulin signal transduction has been well investigated in many tissues, less is known in retinal tissues. We have previously reported that toll-like receptor 4 (TLR4) is involved in retinal damage in diabetes. We used TLR4 retinal Müller cell-specific knockout mice and Müller cells in culture to investigate the effects
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Systemic inhibition of BMP1-3 decreases progression of CCl4-induced liver fibrosis in rats. Growth Factors (IF 1.543) Pub Date : 2018-02-27 Lovorka Grgurevic,Igor Erjavec,Ivica Grgurevic,Ivo Dumic-Cule,Jelena Brkljacic,Donatella Verbanac,Mario Matijasic,Hana Cipcic Paljetak,Rudjer Novak,Mihovil Plecko,Jadranka Bubic-Spoljar,Dunja Rogic,Vera Kufner,Martina Pauk,Tatjana Bordukalo-Niksic,Slobodan Vukicevic
Liver fibrosis is a progressive pathological process resulting in an accumulation of excess extracellular matrix proteins. We discovered that bone morphogenetic protein 1-3 (BMP1-3), an isoform of the metalloproteinase Bmp1 gene, circulates in the plasma of healthy volunteers and its neutralization decreases the progression of chronic kidney disease in 5/6 nephrectomized rats. Here, we investigated