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FOXN2, identified as a novel biomarker in serum, modulates the transforming growth factor-beta signaling pathway through its interaction with partitioning defective 6 homolog alpha, contributing to the pathogenesis of gastric cancer Growth Factors (IF 1.8) Pub Date : 2024-03-04 Liang Li, XueFeng Sun, Mei Zhang, BangShuo Zhang, Yi Yang, Sheng Wang
Dysregulated expression of Forkhead Box N2 (FOXN2) has been detected in various cancer types. However, the underlying mechanisms by which FOXN2 contributes to the onset and progression of gastric c...
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Interleukin-3 production by basal-like breast cancer cells is associated with poor prognosis Growth Factors (IF 1.8) Pub Date : 2024-02-01 Emma J. Thompson, Samantha Escarbe, Denis Tvorogov, Gelareh Farshid, Philip A. Gregory, Yeesim Khew-Goodall, Stephen Madden, Wendy V. Ingman, Geoffrey J. Lindeman, Elgene Lim, Angel F. Lopez, Claudine S. Bonder
Breast cancer represents a collection of pathologies with different molecular subtypes, histopathology, risk factors, clinical behavior, and responses to treatment. “Basal-like” breast cancers pred...
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Evaluation of the effect of injectable platelet-rich fibrin (i-PRF) in wound healing and growth factor release in rats: a split-mouth study Growth Factors (IF 1.8) Pub Date : 2024-01-31 Aysan Lektemur Alpan, Gizem Torumtay Cin, Alper Kızıldağ, Necati Zavrak, Özlem Özmen, Şevki Arslan, Doğukan Mutlu
This experimental study aimed to evaluate the effects of injectable platelet-rich fibrin (i-PRF) on mucosal healing and the release of growth factors in rats. 40 rats were used; i-PRF was administe...
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The effects of 12 weeks of high-intensity interval training and moderate-intensity continuous training on FGF21, irisin, and myostatin in men with type 2 diabetes mellitus Growth Factors (IF 1.8) Pub Date : 2024-01-31 Simin Riahy
This study investigated the influence of a 12-week high-intensity interval training (HIIT) and moderate-intensity continuous training (MICT) on irisin, fibroblast growth factor 21 (FGF21), and myos...
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Network pharmacology-and molecular docking-based investigation of Danggui blood-supplementing decoction in ischaemic stroke Growth Factors (IF 1.8) Pub Date : 2024-01-31 Jinling Zhang, Ruiqing Li, Yang Yu, Weijia Sun, Chengshi Zhang, Haijun Wang
Danggui blood-supplementing decoction (DBsD) is an herbal preparation treating several diseases including stroke. The present study sought to investigate the potential mechanism of DBsD in ischaemi...
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PLA2G2D fosters angiogenesis in non-small cell lung cancer through aerobic glycolysis Growth Factors (IF 1.8) Pub Date : 2024-01-01 Huaizhong Zhang, Keng Chen, Yongqing Zhou, Zhuo Cao, Cunlai Xu, Lin Zhou, Gongzhi Wu, Congxiong Peng, Songqing Lai, Xuhui Wu
Non-small cell lung cancer (NSCLC) stands prominent among the prevailing and formidable oncological entities. The immune and metabolic-related molecule Phospholipase A2, group IID (PLA2G2D) exerts ...
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Fibroblast growth factor 23 and its role in bone diseases Growth Factors (IF 1.8) Pub Date : 2023-10-31 Andrija Jurina, Dino Kasumović, Valentina Delimar, Tajana Filipec Kanižaj, Mladen Japjec, Tomislav Dujmović, Marijana Vučić Lovrenčić, Mario Starešinić
Fibroblast growth factor 23 (FGF23) has been casually linked to numerous hypophosphatemic bone diseases, however connection with bone loss or fragility fractures is still a matter of debate. The pu...
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Knock-down of IGFBP2 ameliorates lung fibrosis and inflammation in rats with severe pneumonia through STAT3 pathway Growth Factors (IF 1.8) Pub Date : 2023-10-19 Yuyu Wang, Jianjiang Huang, Fang Zhang, Keli Shen, Bin Qiu
To observe the mechanism of IGFBP2 knock-down in improving lung fibrosis and inflammation through STAT3 pathway in rats with severe pneumonia.First, SP rat model was established. Then rats were div...
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Role of transforming growth factor-β in airway remodelling in bronchiolitis obliterans Growth Factors (IF 1.8) Pub Date : 2023-07-24 Ziwei Wang
Airway remodelling is the main pathological mechanism of bronchiolitis obliterans (BO). Several studies have found that transforming growth factor-β (TGF-β) expression is increased in BO during air...
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Transcription factor ETV1-induced lncRNA MAFG-AS1 promotes migration, invasion, and epithelial–mesenchymal transition of pancreatic cancer cells by recruiting IGF2BP2 to stabilize ETV1 expression Growth Factors (IF 1.8) Pub Date : 2023-07-10 Hanqin Weng, Weijian Feng, Fengling Li, Dong Huang, Liangyi Lin, Zaiguo Wang
Abstract We investigated the mechanism of ETS-translocation variant 1 (ETV1)/lncRNA-MAFG-AS1 in pancreatic cancer (PC). MAFG-AS1 and ETV1 levels in PC cell lines and HPNE cells were determined using reverse transcription quantitative polymerase chain reaction (RT-qPCR) and Western blotting (WB). After transfection with sh-MAFG-AS1, PC cell invasion, migration, proliferation, and epithelial–mesenchymal
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Microfracture technique combined with mesenchymal stem cells inducer represses miR-708-5p to target special at-rich sequence-binding protein 2 to drive cartilage repair and regeneration in rabbit knee osteoarthritis Growth Factors (IF 1.8) Pub Date : 2023-07-05 YongChao Wang, Qin Su, HaiRong Tang, Qiang Tian, Xin Lin, MeiChun Fu, RenMing Zhang, ZhangFeng Luo, KeYun Zhang
Abstract Knee osteoarthritis (KOA) is a degenerative joint illness which leads to knee pain and functional limitation. In this study, we combined microfracture surgery with kartogenin (KGN), a small bioactive molecule used to promote the differentiation of mesenchymal stem cells (MSCs), and explored its impact on cartilage repair and possible latent mechanisms of action. The research offers a brand-new
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Effects of hepatocyte growth factor-transfected mesenchymal stem cell transplantation in canine injured vocal folds Growth Factors (IF 1.8) Pub Date : 2023-07-03 Xingqiao Xie, Xumao Li, Xinsheng Lin, Xiangyu Chen, Chenshan Zhang, Guangbin Sun
Abstract This study aimed to assess the efficacy of hepatocyte growth factor (HGF)-transfected adipose-derived mesenchymal stem cell (ADSC) transplantation in the injured vocal folds (VFs) of canines. A lentiviral vector encoding HGF was successfully produced via Gateway cloning, which was used to infect ADSCs. Four weeks after transoral laser microsurgery (type II) with CO2 laser, the beagles of each
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Production of a biosimilar version of aflibercept to improve VEGF blocker cytotoxicity on endothelial cells Growth Factors (IF 1.8) Pub Date : 2023-06-28 Amin Ramezani, Mohammadrasul Zareinejad, Elham Mahmoudi Maymand, Elina Kaviani, Abbas Ghaderi
This project aimed to produce a biosimilar version of aflibercept (AFL) and evaluate the effect of the co-treatment of AFL with other vascular endothelial growth factor (VEGF) blocker drugs. For th...
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Technological advances define shifting pathway signaling from normal to primary and metastatic colorectal cancer Growth Factors (IF 1.8) Pub Date : 2023-06-23 Robert G. Ramsay, Vicki Whitehall, Michael P. Flood
Adoption of organoid/tumoroid propagation of normal and malignant intestinal epithelia has provided unparalleled opportunities to compare cell growth factor and signaling dependencies. These 3D str...
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Comparative evaluation of autologous platelet-rich plasma and platelet lysate in patients with knee osteoarthritis Growth Factors (IF 1.8) Pub Date : 2023-06-23 Sareh Hosseini, Mohammad Sadegh Soltani-Zangbar, Majid Zamani, Yoda Yaghoubi, Reza Rikhtegar Ghiasi, Roza Motavalli, Ali Ghassabi, Rahim Iranzad, Amir Mehdizadeh, Seyed Kazem Shakouri, Alireza Pishgahi, Mehdi Yousefi
Abstract Autologous platelet-rich plasma (PRP) and platelet lysate (PL) are nowadays promising candidates in the treatment of articular cartilage lesions. We aimed to compare PRP and PL injection effectiveness in patients with knee osteoarthritis (KOA). A total of fifty women with KOA were included in the study. Patients were treated with intra-articular injections of PRP and PL. Clinical outcomes
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A review about the role of additives in nerve tissue engineering: growth factors, vitamins, and drugs Growth Factors (IF 1.8) Pub Date : 2023-06-21 Mehrsa Nasiri, Javad Esmaeili, Amir Tebyani, Hojat Basati
Abstract Notably the integration of additives such as growth factors, vitamins, and drugs with scaffolds promoted nerve tissue engineering. This study tried to provide a concise review of all these additives that facilitates nerve regeneration. An attempt was first made to provide information on the main principle of nerve tissue engineering, and then to shed light on the effectiveness of these additives
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Dynamics of transforming growth factor β signaling and therapeutic efficacy Growth Factors (IF 1.8) Pub Date : 2023-05-25 Siqi Wu, Rodney Brian Luwor, Hong-Jian Zhu
Abstract Transforming growth factor β (TGFβ) is a multifunctional cytokine, and its signalling responses are exerted via integrated intracellular pathways and complex regulatory mechanisms. Due to its high potency, TGFβ signalling is tightly controlled under normal circumstances, while its dysregulation in cancer favours metastasis. The recognised potential of TGFβ as a therapeutic target led to emerging
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Transcription factors TP63 facilitates malignant progression of thyroid cancer by upregulating KRT17 expression and inducing epithelial-mesenchymal transition Growth Factors (IF 1.8) Pub Date : 2023-03-15 Fanbo Meng, Liting Dai
Thyroid cancer (TC) is a relatively prevalent endocrine tumor among women, the incidence of which is rapidly rising. In this present study, we aimed to provide new therapeutic targets from the aspe...
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Characterisation of mesenchymal stem cells conditioned media obtained at different conditioning times: their effect on glial cells in in vitro scratch model Growth Factors (IF 1.8) Pub Date : 2023-02-24 Eva Székiová, Zuzana Michalová, Juraj Blaško, Rastislav Mucha, Lucia Slovinská, Martin Kello, Ivo Vanický
Abstract In this study, the bone marrow mesenchymal stem cells conditioned media (BMMSC-CM) obtained by conditioning for 24(CM24), 48(CM48) and 72(CM72) hours was characterised. In vitro, the impact of BMMSC-CM on the astrocyte migratory response and oligodendrocyte density was evaluated using the scratch model. The proteomic profiles of individual secretomes were analysed by mass spectrometry and
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HIVEP3 as a potential prognostic factor promotes the development of acute myeloid leukemia Growth Factors (IF 1.8) Pub Date : 2022-12-26 Yanfei Tang, Guangtao Xu, Bo Hu, Yuzhang Zhu
Abstract Acute myeloid leukemia (AML) is a common malignancy worldwide. Human immune deficiency virus type 1 enhancer-binding protein 3 (HIVEP3) was verified to play a vital role in types of cancers. However, the functional role of HIVEP3 in AML was rarely reported. In this study, CCK-8, colony formation assay, flow cytometry, and Trans-well chamber experiments were applied for detecting cell proliferation
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Successful production of human epidermal growth factor in tobacco chloroplasts in a biologically active conformation Growth Factors (IF 1.8) Pub Date : 2022-12-01 Yunpeng Wang, Jieying Fan, Niaz Ahmad, Wen Xin, Zhengyi Wei, Shaochen Xing
Abstract Human epidermal growth factor (hEGF) is an important therapeutic compound with multiple applications particularly in pharmaceutical industry. Human EGF has already been expressed in different expression systems, however, the production of hEGF with bioactivity in chloroplasts has not been successful so far. In this study, we expressed a 6 × His-tagged hEGF in tobacco chloroplasts in its native
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Effects of propofol on IGF-1 activity and cell behaviour in the GES 1 mucosal cell model Growth Factors (IF 1.8) Pub Date : 2022-11-28 Chai Hua, Peng Wenyong, Zhu Zhongquan, Xiong Chang, Jin Xiayun
Abstract Propofol is an important and widely used anaesthetic drug in the clinic. Many works have shown that propofol has important biological functions except as an anaesthetic. In the current study, we mainly explored the effect of propofol on the biological activity of IGF-1, which is an important growth factor involved in regulating the growth and development of the stomach. Here, we explored the
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Retinoic acid signaling is critical for generation of pancreatic progenitors from human embryonic stem cells Growth Factors (IF 1.8) Pub Date : 2022-11-14 Niloufer P. Dumasia, Aparna P. Khanna, Prasad S. Pethe
Abstract Retinoic acid (RA) is essential for gut endoderm development and has been extensively used for in vitro pancreatic differentiation from human pluripotent stem cells. However, the gene regulatory network triggered by RA signaling remains poorly addressed. Also, whether RA signals control histone modifiers such as the Polycomb group proteins during pancreatic specification remains to be explored
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The polymethoxylated flavone hexamethylquercetagetin suppresses NF-κB signaling and inhibits cell survival in cervical carcinoma Growth Factors (IF 1.8) Pub Date : 2022-11-13 Yanan Sun, Nan Li, Yuru Cai, Xingnan Zhao, Hongyu Yang
Abstract Nuclear factor-κB (NF-κB) contributes to the development and progression of cervical carcinoma. To construct a xenograft model, Ca Ski cells were subcutaneously inoculated into BALB/c nude mice. The relative protein expression of NF-κB p65, p-p65, IκBα, and p-IκBα were detected in hexamethylquercetagetin (HTQC) treated cervical carcinoma cells with or without tumor necrosis factor (TNF)α stimulation
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Matrine induces hepatocellular carcinoma apoptosis and represses EMT and stemness through microRNA-299-3p/PGAM1 axis Growth Factors (IF 1.8) Pub Date : 2022-10-19 BaoLin Wang, HuiHai Wang, Qin Zhao, Fei Lu, ZhenZhuang Yan, Fang Zhou, QingLun Su
Abstract This study explored the impacts of matrine on hepatocellular carcinoma (HCC) cell growth, metastasis, epithelial-mesenchymal transition (EMT), and stemness through regulating the microRNA (miR)-299-3p/phosphoglycerate mutase 1 (PGAM1) axis. The association between miR-299-3p expression with the prognosis of HCC patients was studied. miR-299-3p and PGAM1 sequences were transfected into matrine-treated
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Embryonic growth retardation and altered expression of IGF-II is reciprocal induced by phytocompounds during early gestation in mice Growth Factors (IF 1.8) Pub Date : 2022-10-07 Khamhee Wangsa, Krishnakshi Misra, Upasa Gowala, Indira Sarma, Purba Jyoti Saikia, Hirendra Nath Sarma
Abstract Methanolic crude extract of Scoparia dulcis (CESD) was orally administered to female mice during the early gestation (day 4–day 8) at a dose of 500 mg/kg/day. It induces embryo resorption and morphological changes of fetal maternal tissue. Histomorphology was studied by routine hematoxylin eosin stain. In situ immunofluorescence localization of IGF-II using Texas red showed an ordered expression
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High mobility group box 1 and Dickkopf-related protein 1 as biomarkers of glucose toxicity, atherogenicity, and lower β cell function in patients with type 2 diabetes mellitus Growth Factors (IF 1.8) Pub Date : 2022-09-27 Hussein Kadhem Al-Hakeim, Qasim Jasim Al-Kaabi, Michael Maes
Abstract Type 2 diabetes mellitus (T2DM) is associated with increased atherogenicity and inflammatory responses, which may be related to high mobility group box 1 (HMGB1) and Dickkopf-related protein 1 (DKK1). The role of HMGB1 and DKK1 in T2DM is examined in association with lipid and insulin profiles. Serum HMGB1 and DKK1 were measured in T2DM with and without hypertension and compared with controls
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Increased circulating TGF-β1 is associated with impairment in NK cell effector functions in metastatic melanoma patients Growth Factors (IF 1.8) Pub Date : 2022-09-21 Katarina Mirjačić Martinović, Ana Vuletić, Emina Mališić, Tatjana Srdić-Rajić, Nevena Tišma Miletić, Nada Babović, Vladimir Jurišić
Abstract Transforming growth factor beta (TGF-β) plays a complex role in carcinogenesis. In 30 melanoma patients and 20 healthy controls (HC) we analysed functional and phenotypic characteristics of NK cells by Flow cytometry, gene expression of TGF-β1 in peripheral blood mononuclear cells by qPCR and serum and supernatant level of free TGF-β1 by ELISA. Melanoma patients had significantly higher serum
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Effects of dual-gene modification on biological characteristics of vascular endothelial cells and their significance as reserving cells for chronic wound repair Growth Factors (IF 1.8) Pub Date : 2022-09-09 Lingli Guo, Baohua Wei, Feng Pan, Hasi Wulan, Mi Cai
Abstract bFGF is a commonly used and reliable factor for improving chronic wound healing, and hSulf-1 expression is abundant in surrounding cells of chronic wound tissue and vascular endothelial cells, which can reverse the effect of bFGF and inhibit the signalling activity of cell proliferation. In this study, an adenovirus, Ad5F35ET1-bFGF-shSulf1, was designed for establishing the dual-gene modified
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MiR-200c regulates invasion, proliferation and EMT of anaplastic thyroid cancer cells by targeting parathyroid hormone like hormone Growth Factors (IF 1.8) Pub Date : 2022-09-06 Yan Zhang, Yuanyuan Duan, Chenguang Wu, Wen Peng, Wenyu Chen, Li Wang, Zhaoqun Deng
Abstract This study aimed to explore the specific effect of miR-200c in anaplastic thyroid cancer (ATC). Hth74 and ARO cell lines were used. Proliferation, invasion, and colony formation activities of Hth74 and ARO cell lines affected by miR-200c were studied. Expression of epithelial-to-mesenchymal transition (EMT) markers (E-cadherin, N-cadherin, Slug, and Snail) in the Hth74 and ARO cell lines were
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Platelet lysate and tendon healing: comparative analysis of autologous frozen-thawed PRP and ketorolac tromethamine in the treatment of patients with rotator cuff tendinopathy Growth Factors (IF 1.8) Pub Date : 2022-08-26 Raha Markazi, Mohammad Sadegh Soltani-Zangbar, Majid Zamani, Shadi Eghbal-Fard, Roza Motavalli, Amin Kamrani, Sanam Dolati, Majid Ahmadi, Leili Aghebati-Maleki, Amir Mehdizadeh, Fariba Eslamian, Alireza Pishgahi, Mehdi Yousefi
Abstract Platelet-rich blood derivatives are being nowadays increasingly used in the treatment of tendon-related pathologies as a rich source of growth factors. We sought to ascertain if local application of platelet lysate (PL) to augment rotator cuff repair ameliorates patient outcomes compared to ketorolac tromethamine treated group. A total of forty patients, with clinical diagnosis of Rotator
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Halofuginone inhibits cell proliferation and AKT/mTORC1 signaling in uterine leiomyoma cells Growth Factors (IF 1.8) Pub Date : 2022-08-24 Jing Lin, Xiaochun Wu
Abstract The present study aimed to explore the effects of antifibrotic agent halofuginone on uterine leiomyomas (ULs) cells. The survival of the uterine smooth muscle (UtSMC) cells and UL ELT3 cells were measured. Flow cytometry was used to assess the cell cycle distribution and apoptosis. Effects of halofuginone on the state of AKT/mTOR pathway were evaluated. Xenograft animal model was applied to
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Effects of penehyclidine hydrochloride on myocardial ischaemia-reperfusion injury in rats by inhibiting TLR4/MyD88/NF-κB pathway via miR-199a-3p Growth Factors (IF 1.8) Pub Date : 2022-08-19 Ling Qiang Bai, Bin Zhe Wang, Qi Wei Liu, Wen Qiang Li, Hang Zhou, Xiao Yan Yang
Abstract This study was to probe the role of penehyclidine hydrochloride (PHC) mediating the impact of toll-like receptor 4 (TLR4)/myeloid differentiation factor 88 (MyD88)/nuclear factor-kappa B (NF-κB) signalling pathway on myocardial ischaemia-reperfusion injury (MI/RI) in rats through miR-199a-3p. The rat MI/RI model was established through ligating left anterior descending (LAD) coronary artery
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The expression of BMP, integrin, ZEB2 in ovarian high-grade serous carcinoma in relation with lymph node metastasis Growth Factors (IF 1.8) Pub Date : 2022-07-22 Elham Bahador Zırh, Elif Taşar Kapaklı, Anıl Dolgun, Alp Usubütün, Naciye Dilara Zeybek
Abstract Ovarian cancer (OC) is clinically important because it is diagnosed late and has metastasis when it is diagnosed. Mortality risk increases 2.75 times in the presence of lymph node (LN) metastasis. During metastasis, many molecules including BMPs originated from stroma, and tumor cells participate through transcription factors and integrins for cytoskeleton regulation during cell migration
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The cellular and molecular mediators of metastasis to the lung Growth Factors (IF 1.8) Pub Date : 2022-07-21 Oliver Cucanic, Rae H. Farnsworth, Steven A. Stacker
Abstract Organ-specific metastasis to secondary organs is dependent on the formation of a supportive pre-metastatic niche. This tissue-specific microenvironmental response is thought to be mediated by mutational and epigenetic changes to primary tumour cells resulting in altered cross-talk between cell types. This response is augmented through the release of tumour and stromal signalling mediators
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Transforming growth factor-β signalling pathway in tendon healing Growth Factors (IF 1.8) Pub Date : 2022-06-16 Yujie Li, Xinyue Liu, Xueli Liu, Yuanqiu Peng, Bin Zhu, Sheng Guo, Chenglong Wang, Dingxuan Wang, Sen Li
Abstract Transforming growth factor-β(TGF-β) plays an important but diverse role in tendon injuries, such as collagen synthesis, cell proliferation, cell differentiation, and cell adhesion, leading to tendon healing and tendon fibrosis. In the well-known canonical TGF-β signalling pathway, TGF-β activates Smad signalling through its two cell surface receptors, which leads to Smad-mediated transcriptional
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Impact of methionine restriction on muscle aerobic metabolism and hypertrophy in young and old mice on an obesogenic diet Growth Factors (IF 1.8) Pub Date : 2022-06-05 Anandini Swaminathan, Leonardo Cesanelli, Tomas Venckunas, Hans Degens
Abstract Methionine restriction (MR) reduces inflammation and increases longevity. We studied the effects of MR (0.17% kCal methionine, 10% kCal fat) and MR + high-fat diet (HFD) (0.17% methionine, 45% kCal fat) and overload-induced hypertrophy on inflammation, angiogenesis and mitochondrial activity in the hind-limb muscle in 10- and 26-month-old male C57BL/6J mice. Plasma IL-6 concentrations were
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miR-146a suppresses the expression of vascular endothelial growth factor and inflammatory responses in diabetic retinopathy Growth Factors (IF 1.8) Pub Date : 2022-05-23 Shichao Sun, Fujun Wang, Yao Sun, Lei Bai
Abstract This study was designed to explore the role of miR-146a in diabetic retinopathy (DR). 30 healthy control (HC), 50 patients with type 2 diabetes mellitus, and 48 DR patients were enrolled. Blood was collected and levels of miR-146a expression, vascular endothelial growth factor (VEGF), and three inflammatory cytokines (NF-κB, IL-1β, and TNF-α) were detected. Moreover, ARPE-19 cells were treated
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An appraisal of vascular endothelial growth factor (VEGF): the dynamic molecule of wound healing and its current clinical applications Growth Factors (IF 1.8) Pub Date : 2022-05-18 Aakansha Giri Goswami, Somprakas Basu, Farhanul Huda, Jayanti Pant, Amrita Ghosh Kar, Tuhina Banerjee, Vijay Kumar Shukla
Abstract Angiogenesis is a critical step of wound healing, and its failure leads to chronic wounds. The idea of restoring blood flow to the damaged tissues by promoting neo-angiogenesis is lucrative and has been researched extensively. Vascular endothelial growth factor (VEGF), a key dynamic molecule of angiogenesis has been investigated for its functions. In this review, we aim to appraise its biology
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The effects of CHF6467, a new mutated form of NGF, on cell models of human glioblastoma. A comparison with wild-type NGF Growth Factors (IF 1.8) Pub Date : 2022-04-20 Lucia Lisi, Gabriella Maria Pia Ciotti, Marta Chiavari, Maria Martire, Pierluigi Navarra
Abstract CHF6467 is a mutated form of human recombinant nerve growth factor (NGF). The mutation selectively disrupts the binding of NGF to its p75NTR receptor while maintaining the affinity toward TrkA receptor. Because of such different profile of receptor interaction, CHF6467 maintains unaltered the neurotrophic and neuroprotective properties of wild-type NGF but shows reduced algogenic activity
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The roles of epidermal growth factor receptor in viral infections Growth Factors (IF 1.8) Pub Date : 2022-04-19 Kah Man Lai, Wai Leng Lee
Abstract Viruses are intracellular pathogen that exploit host cellular machinery for their propagation. Extensive research on virus-host interaction have shed light on an alternative antiviral strategy that targets host cell factors. Epidermal growth factor receptor (EGFR) is a versatile signal transducer that is involved in a range of cellular processes. Numerous studies have revealed how viruses
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Icariin attenuates renal fibrosis in vivo and in vitro by inhibiting the Notch2/Hes-1 pathway Growth Factors (IF 1.8) Pub Date : 2022-04-15 Qiaoqi Zhang, Lei Xie, Lin Jiang, Jiaqing Ni, Wenke Han, Xiuhua Mi, Ping Wang
Abstract Chinese herbs were widely proposed as a novel approach for renal fibrosis. Icariin has been reported to be involved in a variety of diseases. Unilateral ureteral obstruction (UUO) is a popular experimental model of renal injury, which is often used in the study of renal fibrosis. A UUO mouse model was successfully constructed, and tubular injury and renal fibrosis were observed. Icariin treatment
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Systematic training in master swimmer athletes increases serum insulin growth factor-1 and decreases myostatin and irisin levels Growth Factors (IF 1.8) Pub Date : 2022-03-27 V. Curiel-Cervantes, J. C. Solis-Sainz, M. Camacho-Barrón, A. Aguilar-Galarza, M. E. Valencia, M. A. Anaya-Loyola
Abstract During ageing, anabolic status is essential to prevent the decrease in quantity and quality of skeletal muscle mass (SMM). Exercise modulates endocrine markers of muscle status. We studied the differences of endocrine markers for muscle status in 62 non-sarcopenic Mexican swimmer adults aged 30–70 y/o, allocated into two groups: the systematic training (ST) group including master athletes
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The pheromone affects reproductive physiology and behavior by regulating hormone in juvenile mice Growth Factors (IF 1.8) Pub Date : 2022-03-23 Bing Hu, Zhongxiang Mo, Jianlin Jiang, Jinning Liang, Minlin Wei, Xiujuan Zhu, Yuan Liang, Yunhao Liu, Qiaojuan Huang, Yiqiang Ouyang, Junming Sun
Abstract Pheromones could promote hormone secretions and regulate sexual behavior. It was unclear whether multiparous pheromone could induce variations in puberty. The aim was to ascertain whether pheromone in urine of multiparous females induced central precocious puberty (CPP) in juvenile C57BL/6J females. The precocious puberty was examined by vaginal smear, lordosis reaction, HE stain, and ELISA
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Quantile-specific heritability of serum growth factor concentrations Growth Factors (IF 1.8) Pub Date : 2022-03-21 Paul T. Williams
Abstract Background “Quantile-dependent expressivity” occurs when the effect size of a genetic variant depends upon whether the phenotype (e.g. growth factor concentration) is high or low relative to its distribution. Methods Quantile-regression analysis was applied to family sets from the Framingham Heart Study to determine whether the heritability (h2) of vascular endothelial growth factor (VEGF)
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Production of active human FGF21 using tobacco mosaic virus-based transient expression system Growth Factors (IF 1.8) Pub Date : 2022-02-20 Jieying Fan, Yunpeng Wang, Shuang Huang, Shaochen Xing, Zhengyi Wei
Abstract Fibroblast growth factor (FGF) family has a wide range of metabolic processes. FGF21 exerts critical physiological functions in clinical application. This study aimed to explore a convenient and highly efficient approach for rhFGF21 expression using TMV-TES. Firstly, the vector pTTEV-GFP was constructed, followed by optimisation of the expression parameters in Nicotiana benthamiana. Then,
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Myokine-mediated exercise effects: the role of myokine meteorin-like hormone (Metrnl) Growth Factors (IF 1.8) Pub Date : 2022-02-08 Hamid Alizadeh
Abstract Meterorin-like hormone (Metrnl), as a novel secreted factor, has been shown to be involved in physiological and pathophysiological processes. The behaviour of Metrnl in metabolic conditions like type 2 diabetes is conflicting. Metrnl-mediated (treatment with Metrnl) auto/paracrine actions in skeletal muscle are glucose uptake, fat oxidation and muscle regeneration. Exercise-induced Metrnl
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Vasomotor tone-associated factors and pregnancy outcomes of women who undergo in vitro fertilization Growth Factors (IF 1.8) Pub Date : 2021-12-31 Yonglian Lan, Xiaokui Yang, Yu Liang, Lingling Lei, Ying Li, Shuyu Wang
Abstract Vasomotor tone-associated factors play important roles in normal pregnancy, but their roles in the pregnancy outcome of women who undergo in vitro fertilization and embryo transfer (IVF-ET) remain unclear. A total of 82 infertile women who underwent successful IVF-ET were enrolled, including 18 pregnancy losses, 11 complications, and 53 normal deliveries. The serum NO and iNOS levels were
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Autologous conditioned serum for degenerative diseases and prospects Growth Factors (IF 1.8) Pub Date : 2021-12-09 Seyed Kazem Shakouri, Sanam Dolati, Jessica Santhakumar, Avnesh S. Thakor, Reza Yarani
Abstract Autologous conditioned serum (ACS) is a blood-derived product that is prepared by the incubation of whole blood with medical-grade glass beads, resulting in serum enrichment in interleukin-1 receptor antagonist (IL-1Ra), anti-inflammatory cytokines (IL-4, IL-10, and IL-13), and high concentrations of growth factors. ACS has shown qualitatively and quantitatively better therapeutic effects
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Regenerative responses of rabbit corneal endothelial cells to stimulation by fibroblast growth factor 1 (FGF1) derivatives, TTHX1001 and TTHX1114 Growth Factors (IF 1.8) Pub Date : 2021-12-09 Jessica Weant, David D. Eveleth, Amuthakannan Subramaniam, Jennifer Jenkins-Eveleth, Michael Blaber, Ling Li, David M. Ornitz, Asaf Alimardanov, Trevor Broadt, Hui Dong, Vinay Vyas, Xiaoyi Yang, Ralph A. Bradshaw
Abstract Utilising rabbit corneal endothelial cells (CEC) in three different paradigms, two human FGF1 derivatives (TTHX1001 and TTHX1114), engineered to exhibit greater stability, were tested as proliferative agents. Primary CECs and mouse NIH 3T3 cells treated with the two FGF1 derivatives showed equivalent EC50 ranges (3.3–24 vs.1.9–16. ng/mL) and, in organ culture, chemically lesioned corneas regained
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Role of the BMP6 protein in breast cancer and other types of cancer Growth Factors (IF 1.8) Pub Date : 2021-10-28 Andrea Marlene García Muro, Azaria García Ruvalcaba, Lourdes del Carmen Rizo de la Torre, Josefina Yoaly Sánchez López
Abstract The BMP6 protein (Bone Morphogenetic Protein 6) is part of the superfamily of transforming growth factor-beta (TGF-β) ligands, participates in iron homeostasis, inhibits invasion by increasing adhesions and cell-cell type interactions and induces angiogenesis directly on vascular endothelial cells. BMP6 is coded by a tumor suppressor gene whose subexpression is related to the development and
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Effect of fasting on body composition and proteolysis gene expression in skeletal muscles and liver of BEH+/+ and BEL mice Growth Factors (IF 1.8) Pub Date : 2021-08-06 Edgaras Lapinskas, Raulas Krusnauskas, Agne Cekanauskaite, Aivaras Ratkevicius
Abstract Fasting improves health, but can cause muscle weakness. We assessed body composition in 21-week old males of Berlin high (BEH+/+) and Berlin low (BEL) strains after two bouts of 48-h or 40-h of fasting with 5-day refeeding in between, respectively. BEH+/+ mice tended to loose less weight than BEL in bout 1 and 2 (16.0 ± 2.7 versus 23.5 ± 2.9%, p < 0.001 and 17.1 ± 3.4 versus 20.4 ± 3.4%, p = 0
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Insulin and IGF-2 support rat corneal endothelial cell growth and wound repair in the organ cultured tissue Growth Factors (IF 1.8) Pub Date : 2021-08-13 Sheldon R. Gordon, Darryl R. Reaume, Thomas R. Perkins
Abstract The ability of insulin and IGF-2 to support wound repair in the organ-cultured rat corneal endothelium was investigated. Corneas given a circular transcorneal freeze injury, were explanted into organ cultures containing either insulin or IGF-2 and cultured up to72 h. Both factors increased [3H]-thymidine incorporation and mitotic levels compared to controls. Insulin’s ability to mediate wound
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Third-degree burn mouse treatment using recombinant human fibroblast growth factor 2 Growth Factors (IF 1.8) Pub Date : 2021-08-20 Thu-Minh Tran-Nguyen, Khanh-Thien Le, Le-Giang Thi Nguyen, Thanh-Loan Thi Tran, Phuong-Cac Hoang-Thai, Thuoc Linh Tran, Sik-Loo Tan, Hieu Tran-Van
Abstract Fibroblast growth factor 2 (FGF-2) is a multifunctional protein that has major roles in wound healing, tissue repair, and regeneration. This therapeutic protein is widely used for burn treatment because it can stimulate cell proliferation and differentiation, angiogenesis, and extracellular matrix remodeling. In this study, we developed a simple method using a controlled heated brass rod to
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miRNA-26-5p inhibits cyclosporine A-induced overgrowth of gingival fibroblasts by regulating PTEN/PI3K/AKT pathway Growth Factors (IF 1.8) Pub Date : 2021-08-24 Qiyong Hu, Nadan Guo, Yuting Zhao, Yi Chen, Peng Zhang, Wei Shen, Ziya Gu
Abstract We evaluated the effect of cyclosporine A (CsA) administration on the level of miR-26-5p in rat gingival tissues and human gingival fibroblasts (HGFs) by qRT-PCR assay. Further, we conducted Western blotting and immunohistochemical analysis to assess the expressions of PTEN, PI3K, and p-AKT, and evaluated cell proliferation of HGFs by MTT assay. CsA treatment significantly downregulated the
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Insulin and IGF-2 support rat corneal endothelial cell growth and wound repair in the organ cultured tissue. Growth Factors (IF 1.8) Pub Date : 2021-08-13 Sheldon R Gordon,Darryl R Reaume,Thomas R Perkins
The ability of insulin and IGF-2 to support wound repair in the organ-cultured rat corneal endothelium was investigated. Corneas given a circular transcorneal freeze injury, were explanted into organ cultures containing either insulin or IGF-2 and cultured up to72 h. Both factors increased [3H]-thymidine incorporation and mitotic levels compared to controls. Insulin's ability to mediate wound closure
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Effect of fasting on body composition and proteolysis gene expression in skeletal muscles and liver of BEH+/+ and BEL mice. Growth Factors (IF 1.8) Pub Date : 2021-08-06 Edgaras Lapinskas,Raulas Krusnauskas,Agne Cekanauskaite,Aivaras Ratkevicius
Fasting improves health, but can cause muscle weakness. We assessed body composition in 21-week old males of Berlin high (BEH+/+) and Berlin low (BEL) strains after two bouts of 48-h or 40-h of fasting with 5-day refeeding in between, respectively. BEH+/+ mice tended to loose less weight than BEL in bout 1 and 2 (16.0 ± 2.7 versus 23.5 ± 2.9%, p < 0.001 and 17.1 ± 3.4 versus 20.4 ± 3.4%, p = 0.17,
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Effect of autologous growth factors on apoptosis and thickness of the outer nuclear layer in an experimental retinal degeneration model Growth Factors (IF 1.8) Pub Date : 2021-07-08 Emin Ozmert, Sibel Demirel, Umut Arslan, Özlem Biçer, Ozan Ahlat, Figen Şermet
Abstract Retinal pigment epithelium and photoreceptor cells are a microenvironment where 90 different peptides are synthesized for transduction, visual cycle, intracellular electron transport chain, and removal of metabolic wastes. Depending on the inheritance pattern, either mutant proteins accumulate inside the cells or the energy cycle is disrupted. Disruption of homeostasis causes the cells to
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Effects of galectin-1 on immunomodulatory properties of human monocyte-derived dendritic cells Growth Factors (IF 1.8) Pub Date : 2021-07-05 Tanja Džopalić, Miloš Kostić, Milena Kostić, Goran Marjanović, Jelena Guzina, Vladimir Jurišić, Biljana Božić Nedeljković
Abstract Our study aimed to evaluate the effects of Gal-1 in dose depending manner on maturation and immunomodulatory properties of monocyte-derived (Mo) DCs in-vitro. The effects were analyzed by monitoring their phenotypic characteristics, cytokine profile, and the ability to direct the immune response in the co-culture with allogeneic CD4+T cells. Gal-1 reduced the expression of CD80 and CD86 molecules
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Interactions between thymic endothelial cells and thymocytes are influenced by growth hormone Growth Factors (IF 1.8) Pub Date : 2021-05-24 Marvin Paulo Lins, Iana Mayane Mendes Nicácio Viana, Salete Smaniotto, Maria Danielma dos Santos Reis
Abstract Growth hormone (GH), in addition to its classic actions on growth and metabolism in the body, exerts pleiotropic effects on the immune system, particularly on the thymus. The aim of this study was to evaluate the influence of GH on the interactions between mature thymocytes and the thymic endothelium involved in the migratory process. To this end, fresh thymocytes (C57BL/6 mice) and the thymic