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CD151 promotes Colorectal Cancer progression by a crosstalk involving CEACAM6, LGR5 and Wnt signaling via TGFβ1 Int. J. Biol. Sci. (IF 4.858) Pub Date : 2021-2-17 Tao Yang; Huibing Wang; Meng Li; Linqi Yang; Yu Han; Chao Liu; Baowen Zhang; Mingfa Wu; Gang Wang; Zhenya Zhang; Wenqi Zhang; Jianming Huang; Huaxing Zhang; Ting Cao; Pingping Chen; Wei Zhang
CD151 impacts various signaling pathways in different cancers, and promotes colorectal cancer (CRC) cell malignancy by yet undefined mechanisms. This study aimed to comprehensively assess CD151's function in CRC. CD151 levels were significantly higher in CRC tissues and cells compared with controls in the tissue microarray. Cell viability, migration and invasion were suppressed by CD151 downregulation
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PTEN-mediated AKT/β-catenin signaling enhances the proliferation and expansion of Lgr5+ hepatocytes Int. J. Biol. Sci. (IF 4.858) Pub Date : 2021-2-17 Jimin Han; Kaijun Lin; Xuezheng Zhang; Lingchen Yan; Yu Chen; Haiyan Chen; Jianjun Liu; Jia Liu; Yaojiong Wu
Rationale: Compelling evidence suggests that Lgr5+ hepatocytes repair liver damage by promoting the regeneration of hepatocytes and ductal cells in the case of liver injury. The PTEN-mediated AKT/β-catenin signaling plays a key role in the regulation of innate immune regulation in the liver. However, the signaling pathways that control Lgr5+ hepatocyte proliferation in the liver remain unclear./nMethods:
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MLKL inhibits intestinal tumorigenesis by suppressing STAT3 signaling pathway Int. J. Biol. Sci. (IF 4.858) Pub Date : 2021-2-17 Qun Zhao; Xinran Cheng; Jian Guo; Yun Bi; Li Kuang; Jianhua Ren; Jing Zhong; Longrui Pan; Xudong Zhang; Yang Guo; Yongqiang Liu; Shu Jin; Yan Tan; Xianjun Yu
Mixed lineage kinase domain-like protein (MLKL) plays an important role in necroptosis, but the role and mechanism of MLKL in intestinal tumorigenesis remain unclear. Here, we found that hematopoietic- and nonhematopoietic-derived MLKL affected intestinal inflammation, but nonhematopoietic-derived MLKL primarily inhibited intestinal tumorigenesis. Loss of MLKL enhanced intestinal regeneration and the
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Novel biomarkers for post-contrast acute kidney injury identified from long non-coding RNA expression profiles Int. J. Biol. Sci. (IF 4.858) Pub Date : 2021-2-17 Guanzhong Chen; Bowen Liu; Shiqun Chen; Huanqiang Li; Jin Liu; Ziling Mai; Enzhao Chen; Chunyun Zhou; Guoli Sun; Zhaodong Guo; Li Lei; Shanyi Huang; Liyao Zhang; Min Li; Ning Tan; Hong Li; Yulin Liao; Jia Liu; Jiyan Chen; Yong Liu
Background: Post-contrast acute kidney injury (PC-AKI) is a severe complication of cardiac catheterization. Emerging evidence indicated that long non-coding RNAs (lncRNAs) could serve as biomarkers for various diseases. However, the lncRNA expression profile and potential biomarkers in PC-AKI remain unclear. This study aimed to investigate novel lncRNA biomarkers for the early detection of PC-AKI./nMethods:
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Evaluation and characterization of HSPA5 (GRP78) expression profiles in normal individuals and cancer patients with COVID-19 Int. J. Biol. Sci. (IF 4.858) Pub Date : 2021-2-18 Jiewen Fu; Chunli Wei; Jiayue He; Lianmei Zhang; Ju Zhou; Kyathegowdanadoddi Srinivasa Balaji; Shiyi Shen; Jiangzhou Peng; Amrish Sharma; Junjiang Fu
HSPA5 (BiP, GRP78) has been reported as a potential host-cell receptor for SARS-Cov-2, but its expression profiles on different tissues including tumors, its susceptibility to SARS-Cov-2 virus and severity of its adverse effects on malignant patients are unclear. In the current study, HSPA5 has been found to be expressed ubiquitously in normal tissues and significantly increased in 14 of 31 types of
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Basal-like breast cancer with low TGFβ and high TNFα pathway activity is rich in activated memory CD4 T cells and has a good prognosis Int. J. Biol. Sci. (IF 4.858) Pub Date : 2021-1-30 Dingxie Liu; Jaydutt Vadgama; Yong Wu
Basal-like breast cancer (BLBC) is a type of high-grade invasive breast cancer with high risk of recurrence, metastases, and poor survival. Immune activation in BLBC is a key factor that influences both cancer progression and therapeutic response, although its molecular mechanisms are not well clarified. In this study, we examined five cancer immunity-related pathways (IFNα, IFNγ, STAT3, TGFβ and TNFα)
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Preclinical evaluation of radiation therapy of BRCA1-associated mammary tumors using a mouse model Int. J. Biol. Sci. (IF 4.858) Pub Date : 2021-1-31 Eun Ju Cho; Jong Kwang Kim; Hye Jung Baek; Sun Eui Kim; Eun Jung Park; Bum Kyu Choi; Tae Hyun Kim; Dong Hoon Shin; Young Kyung Lim; Chu-Xia Deng; Sang Soo Kim
Although germline mutations in BRCA1 highly predispose women towards breast and ovarian cancer, few substantial improvements in preventing or treating such cancers have been made. Importantly, BRCA1 function is closely associated with DNA damage repair, which is required for genetic stability. Here, we examined the efficacy of radiotherapy, assessing the accumulation of genetic instabilities, in the
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Depression and its relationship with quality of life in frontline psychiatric clinicians during the COVID-19 pandemic in China: a national survey Int. J. Biol. Sci. (IF 4.858) Pub Date : 2021-1-30 Hong-He Zhang; MD; Yan-Jie Zhao; PHD; Chun Wang; PhD; Qinge Zhang; MD; Hai-Yang Yu; MD; Teris Cheung; PhD; Brian J. Hall; PhD; Feng-Rong An; MSc; Yu-Tao Xiang; MD; PhD
This was a national survey that determined the prevalence of depressive symptoms (depression thereafter) and its relationship with quality of life (QOL) in frontline clinicians working in psychiatric hospitals in China during the COVID-19 pandemic. Depression and QOL were assessed using the Patient Health Questionnaire nine items (PHQ-9) and the World Health Organization Quality of Life Questionnaire-brief
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Ferroptosis-Related Long Non-Coding RNA signature predicts the prognosis of Head and neck squamous cell carcinoma Int. J. Biol. Sci. (IF 4.858) Pub Date : 2021-1-31 Yun Tang; MD; Cheng Li; MD; You-Jing Zhang; MD; Zeng-Hong Wu; MD
Background: Head and neck squamous cell carcinoma (HNSCC) are head and neck cancers. On the other hand, ferroptosis is a novel iron-dependent and ROS reliant type of cell death observed various disease conditions./nMethod: We constructed a prognostic multilncRNA signature based on ferroptosis-related differentially expressed lncRNAs in HNSCC./nResults: We identified 25 differently expressed lncRNAs
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The G1 phase optical reporter serves as a sensor of CDK4/6 inhibition in vivo Int. J. Biol. Sci. (IF 4.858) Pub Date : 2021-1-31 Cuiping Guo; Yuxian Guo; Jingjing Liu; Yiyang Gao; Min Wei; Ruijun Zhao; Min Chen; Guojun Zhang
Visualization of cell-cycle G1 phase for monitoring the early response of cell cycle specific drug remains challenging. In this study, we developed genetically engineered bioluminescent reporters by fusing full-length cyclin E to the C-terminal luciferase (named as CycE-Luc and CycE-Luc2). Next, HeLa cell line or an ER-positive breast cancer cell line MCF-7 was transfected with these reporters. In
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Bovine serum albumin aggravates macrophage M1 activation and kidney injury in heterozygous Klotho-deficient mice via the gut microbiota-immune axis Int. J. Biol. Sci. (IF 4.858) Pub Date : 2021-2-2 Lingyun Lai; Yi Li; Jianjun Liu; Lei Luo; Jianguo Tang; Jun Xue; Te Liu
Klotho expression abnormalities induces kidney injury and chronic kidney disease, however, the underlying mechanism remains unclear. Here, Klotho+/- mice and wild-type mice were treated with low-dose bovine serum albumin (BSA). Pathological examination demonstrated that the area of glomerular collagen deposition and fibrosis in BSA-Kl-/+ mice was significantly larger than that in BSA-WT mice. The serum
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Linc-KILH potentiates Notch1 signaling through inhibiting KRT19 phosphorylation and promotes the malignancy of hepatocellular carcinoma Int. J. Biol. Sci. (IF 4.858) Pub Date : 2021-2-8 Xudong Zhang; Xiaoliang Xu; Zechuan Zhang; Cailin Xue; Zhijun Kong; Siyuan Wu; Xiao Yun; Yue Fu; Chunfu Zhu; Xihu Qin
Long noncoding RNAs (LncRNAs) are emerging as crucial regulators in the pathophysiological process of various tumors, including HCC. Here, we identify a novel lncRNA Linc-KILH (KRT19 interacting long noncoding RNA in hepatocellular carcinoma), which is significantly up-regulated in HCC tissues and positively correlated with larger tumor size, severer microvascular invasion, more intrahepatic metastasis
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AKR1B10 confers resistance to radiotherapy via FFA/TLR4/NF-κB axis in nasopharyngeal carcinoma Int. J. Biol. Sci. (IF 4.858) Pub Date : 2021-2-3 Xiangting Liu; Zheng Hu; Jiayao Qu; Jia Li; Ke Gong; Li Wang; Jing Jiang; Xiangning Li; Rongzhang He; Lili Duan; Weihao Luo; Chenglai Xia; Dixian Luo
Nasopharyngeal carcinoma (NPC) is one kind of human head and neck cancers with high incidence in Southern China, Southeast Asia and North Africa. In spite of great innovations in radiation and chemotherapy treatments, the 5-year survival rate is not satisfactory. One of the main reasons is resistance to radiotherapy which leads to therapy failure and recurrence of NPC. The mechanism underlying remains
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miR-26b enhances the sensitivity of hepatocellular carcinoma to Doxorubicin via USP9X-dependent degradation of p53 and regulation of autophagy Int. J. Biol. Sci. (IF 4.858) Pub Date : 2021-2-8 Enjiang Chen; Enliang Li; Hao Liu; Yue Zhou; Liang Wen; Jianxin Wang; Yi Wang; Longyun Ye; Tingbo Liang
Multi-drug resistance is a major challenge to hepatocellular carcinoma (HCC) treatment, and the over-expression or deletion of microRNA (miRNA) expression is closely related to the drug-resistant properties of various cell lines. However, the underlying molecular mechanisms remain unclear. CCK-8, EdU, flow cytometry, and transmission electron microscopy were performed to determine cell viability, proliferation
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LncRNA-NONHSAT024778 promote the proliferation and invasion of chordoma cell by regulating miR-1290/Robo1 axis Int. J. Biol. Sci. (IF 4.858) Pub Date : 2021-2-8 Bin Wang; MD; Kai Zhang; MD; Sen Meng; MD; PhD; Xiaofeng Shao; MD; Zhangzhe Zhou; MD; Haiqing Mao; MD; PhD; Ziqiang Zhu; MD; PhD; Hao Chen; MD; PhD; Huilin Yang; MD; PhD; Kangwu Chen; MD; PhD
Chordoma is a malignant bone tumor originating from the embryonic remnants of the notochord. lncRNAs act as competing endogenous RNAs (ceRNAs) and play a critical role in tumor pathology. However, the biological role of lncRNA-NONHSAT024778 and the underlying molecular mechanism in chordoma remains unknown. qRT-PCR was used to analyze the expression changes of NONHSAT024778 and miR-1290 in chordoma
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Anterior gradient 2 increases long-chain fatty acid uptake via stabilizing FABP1 and facilitates lipid accumulation Int. J. Biol. Sci. (IF 4.858) Pub Date : 2021-2-8 Yunqiu Wang; Mengqi Jia; Chuanjie Liang; Nan Sheng; Xiaodan Wang; Fang Wang; Yanhai Luo; Jin Jiang; Liangyu Cai; Huanmin Niu; Deyu Zhu; Effat Un Nesa; Charles YF Young; Huiqing Yuan
Anterior gradient 2 (AGR2), a protein disulfide isomerase (PDI), is a well-established oncogene. Here, we found that Agr2-/- mice had a decreased fat mass and hepatic and serum lipid levels compared with their wild-type littermates after fasting, and exhibited reduced high-fat diet (HFD)-induced fat accumulation. Transgenic mice overexpressing AGR2 (Agr2/Tg) readily gained fat weight on a HFD but not
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Tight junctions and their regulation by non-coding RNAs Int. J. Biol. Sci. (IF 4.858) Pub Date : 2021-1-31 Xiaojiao Zhao; Hongliang Zeng; Li Lei; Xiaoliang Tong; Lun Yang; Yan Yang; Si Li; Ying Zhou; Liping Luo; Jinhua Huang; Rong Xiao; Jing Chen; Qinghai Zeng
Tight junction (TJ) is a “zippering up” junction structure located at the uppermost portion of adjacent epithelial/endothelial cells in organs and tissues. TJs maintain the relative stability of intracellular substances and functions by closing or opening intercellular pathways, coordinating the entry and exit of molecules of different sizes and charges, and regulating the permeability of paracellular
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Crucial roles of different RNA-binding hnRNP proteins in Stem Cells Int. J. Biol. Sci. (IF 4.858) Pub Date : 2021-2-8 Wen Xie; Hecheng Zhu; Ming Zhao; Lei Wang; Shasha Li; Cong Zhao; Yao Zhou; Bin Zhu; Xingjun Jiang; Weidong Liu; Caiping Ren
The self-renewal, pluripotency and differentiation of stem cells are regulated by various genetic and epigenetic factors. As a kind of RNA binding protein (RBP), the heterogeneous nuclear ribonucleoproteins (hnRNPs) can act as “RNA scaffold” and recruit mRNA, lncRNA, microRNA and circRNA to affect mRNA splicing and processing, regulate gene transcription and post-transcriptional translation, change
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Understanding the Effects of Gut Microbiota Dysbiosis on Nonalcoholic Fatty Liver Disease and the Possible Probiotics Role: Recent Updates Int. J. Biol. Sci. (IF 4.858) Pub Date : 2021-2-8 Ashiq Khan; Zitong Ding; Muhammad Ishaq; Ali Sher Bacha; Israr Khan; Anum Hanif; Wenyuan Li; Xusheng Guo
Nonalcoholic fatty liver disease (NAFLD) is leading chronic liver syndrome worldwide. Gut microbiota dysbiosis significantly contributes to the pathogenesis and severity of NAFLD. However, its role is complex and even unclear. Treatment of NAFLD through chemotherapeutic agents have been questioned because of their side effects on health. In this review, we highlighted and discussed the current understanding
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Spreading of pathological TDP-43 along corticospinal tract axons induces ALS-like phenotypes in Atg5+/- mice Int. J. Biol. Sci. (IF 4.858) Pub Date : 2021-1-1 Rui Zhang; Yongkang Chen; Xinxin Wang; Haiyan Tian; Han Liu; Zhi Xiang; Dan Qi; Jason H. Huang; Erxi Wu; Xuebing Ding; Xuejing Wang
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease, characterized by phosphorylated TDP-43 (pTDP-43)-positive inclusions in neurons and glial cells. However, the pathogenic mechanism that underlies ALS remains largely unknown. To investigate the effects of autophagy deficiency in the formation and spreading of pathological TDP-43 along corticospinal tract axons, TDP-43 preformed
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SOX13/TRIM11/YAP axis promotes the proliferation, migration and chemoresistance of anaplastic thyroid cancer Int. J. Biol. Sci. (IF 4.858) Pub Date : 2021-1-1 Jianing Tang; Zelin Tian; Xing Liao; Gaosong Wu
Anaplastic thyroid cancer (ATC) is one of the most aggressive and virulent solid tumors. The ubiquitin proteasome system presents in all eukaryotic cells and is essential for cellular homeostasis. While its underlying role in ATC remains largely unclear. TRIM11 is an E3 ubiquitin ligase and has been reported to act as an oncogene in several human cancers. The present study aims to reveal the oncogenic
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Involvement of miR-619-5p in resistance to cisplatin by regulating ATXN3 in oral squamous cell carcinoma Int. J. Biol. Sci. (IF 4.858) Pub Date : 2021-1-1 An Song; Yuanyuan Wu; Weiming Chu; Xueming Yang; Zaiou Zhu; Enshi Yan; Wei Zhang; Junbo Zhou; Xu Ding; Jie Liu; Hongxia Zhu; Jinhai Ye; Yunong Wu; Yang Zheng; Xiaomeng Song
MicroRNAs are major post-transcriptional regulators responsible for the development of human cancers, including OSCC. The specific role of miR-619-5p in OSCC, however, is rarely reported. Cisplatin is one of the mostly applied chemotherapy drugs of OSCC. Nevertheless, drug resistance of cisplatin following the initial chemotherapy largely restricts its clinical benefits, and the mechanism of cisplatin
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Development of a novel immune-related lncRNA signature as a prognostic classifier for endometrial carcinoma Int. J. Biol. Sci. (IF 4.858) Pub Date : 2021-1-1 Jinhui Liu; Jie Mei; Yichun Wang; Xucheng Chen; Jiadong Pan; Laigen Tong; Yan Zhang
Endometrial carcinoma (EnCa) is one of the deadliest gynecological malignancies. The purpose of the current study was to develop an immune-related lncRNA prognostic signature for EnCa. In the current research, a series of systematic bioinformatics analyses were conducted to develop a novel immune-related lncRNA prognostic signature to predict disease-free survival (DFS) and response to immunotherapy
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17β-Estradiol promotes LC3B-associated phagocytosis in trained immunity of female mice against sepsis Int. J. Biol. Sci. (IF 4.858) Pub Date : 2021-1-1 Zhiheng Sun; Junxing Qu; Xiaoyu Xia; Yuchen Pan; Xinghan Liu; Huaping Liang; Huan Dou; Yayi Hou
Sepsis is a common serious clinical infectious disease accompanied by more severe injuries and higher mortality rates in men than women. The much higher level of 17β-estradiol (E2) in female is one of the significant reasons for better sepsis resistance ability. Trained immunity is a novel way to fight against infection by improving innate immunity. However, whether β-glucan-induced trained immunity
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The association of Metabolic Syndrome and its Components with the Incidence and Survival of Colorectal Cancer: A Systematic Review and Meta-analysis Int. J. Biol. Sci. (IF 4.858) Pub Date : 2021-1-1 Fei Han; Guanghai Wu; Shuai Zhang; Judong Zhang; Yongjie Zhao; Jing Xu
Background: This meta-analysis was aimed to quantitatively assess the associations of metabolic syndrome (MetS) and its components with colorectal cancer (CRC)./nMethods: PubMed, EMBASE and Web of Science databases were systematically searched for eligible studies. A total of 18 studies for CRC incidence and 12 studies for CRC mortality were identified./nResults: MetS was associated with an increased
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DGCR5 is activated by PAX5 and promotes pancreatic cancer via targeting miR-3163/TOP2A and activating Wnt/β-catenin pathway Int. J. Biol. Sci. (IF 4.858) Pub Date : 2021-1-1 Shi-lei Liu; Chen Cai; Zi-yi Yang; Zi-you Wu; Xiang-song Wu; Xue-feng Wang; Ping Dong; Wei Gong
Long noncoding RNA DiGeorge syndrome critical region gene 5 (DGCR5) has been shown to be highly associated with cancer development. However, the biological role and molecular mechanism of DGCR5 in pancreatic cancer (PC) remains largely unknown. This study aimed to explore the role of DGCR5 in PC. It was revealed that DGCR5 was highly expressed in PC tissues compared with adjacent normal tissues and
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KIF11 promotes cell proliferation via ERBB2/PI3K/AKT signaling pathway in gallbladder cancer Int. J. Biol. Sci. (IF 4.858) Pub Date : 2021-1-1 Dang Wei; Bian Rui; Fan Qingquan; Cai Chen; Hu Yun ping; Song Xiaoling; Weng Hao; Gu Jun
Proliferation is one of the significant hallmarks of gallbladder cancer, which is a relatively rare but fatal malignance. Aim of this study was to examine the biological impact and molecular mechanism of the candidate hub-gene on the proliferation and tumorigenesis of gallbladder cancer. We analyzed the differentially expressed genes and the correlation between these genes with MKI67, and showed that
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The histone demethylase KDM2B regulates human primordial germ cell-like cells specification Int. J. Biol. Sci. (IF 4.858) Pub Date : 2021-1-1 Weiyan Yuan; Zhaokai Yao; Veeramohan Veerapandian; Xinyan Yang; Xiaoman Wang; Dingyao Chen; Linzi Ma; Chaohui Li; Yi Zheng; Fang Luo; Xiao-yang Zhao
Germline specification is a fundamental step for human reproduction and this biological phenomenon possesses technical challenges to study in vivo as it occurs immediately after blastocyst implantation. The establishment of in vitro human primordial germ cell-like cells (hPGCLCs) induction system allows sophisticated characterization of human primordial germ cells (hPGCs) development. However, the
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A rapid screening classifier for diagnosing COVID-19 Int. J. Biol. Sci. (IF 4.858) Pub Date : 2021-1-9 Yang Xia; Weixiang Chen; Hongyi Ren; Jianping Zhao; Lihua Wang; Rui Jin; Jiesen Zhou; Qiyuan Wang; Fugui Yan; Bin Zhang; Jian Lou; Shaobin Wang; Xiaomeng Li; Jie Zhou; Liming Xia; Cheng Jin; Jianjiang Feng; Wen Li; Huahao Shen
Rationale: Coronavirus disease 2019 (COVID-19) has caused a global pandemic. A classifier combining chest X-ray (CXR) with clinical features may serve as a rapid screening approach./nMethods: The study included 512 patients with COVID-19 and 106 with influenza A/B pneumonia. A deep neural network (DNN) was applied, and deep features derived from CXR and clinical findings formed fused features for diagnosis
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Free CA125 promotes ovarian cancer cell migration and tumor metastasis by binding Mesothelin to reduce DKK1 expression and activate the SGK3/FOXO3 pathway Int. J. Biol. Sci. (IF 4.858) Pub Date : 2021-1-14 Qianyu Huo; Chen Xu; Yanhong Shao; Qin Yu; Lunhui Huang; Yunde Liu; Huijing Bao
Objective: CA125/MUC16 is an O-glycosylated protein that is expressed on the surfaces of ovarian epithelial cells. This molecule is a widely used tumor-associated marker for diagnosis of ovarian cancer. Recently, CA125 was shown to be involved in ovarian cancer metastasis. The purpose of this study was to investigate the mechanism of CA125 during ovarian cancer metastasis./nMethods: We analyzed the
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MEF2A-mediated lncRNA HCP5 Inhibits Gastric Cancer Progression via MiR-106b-5p/p21 Axis Int. J. Biol. Sci. (IF 4.858) Pub Date : 2021-1-16 Weiwei Chen; Kundong Zhang; Yuhan Yang; Zengya Guo; Xiaofeng Wang; Buwei Teng; Qian Zhao; Chen Huang; Zhengjun Qiu
Background: Long non-coding RNAs (lncRNAs) are deemed to be relevant to the tumorigenesis and development of a variety of tumors, containing gastric cancer (GC). The purpose of our investigations is to explore the character of HCP5 in GC./nMethods: HCP5 expression was detected by quantitative real-time polymerase chain reaction (qRT-PCR) in 62 matched GC tissues and corresponding para-carcinoma tissues
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Inhibition of PI3K/AKT signaling via ROS regulation is involved in Rhein-induced apoptosis and enhancement of oxaliplatin sensitivity in pancreatic cancer cells Int. J. Biol. Sci. (IF 4.858) Pub Date : 2021-1-15 Yuhui Liu; Chengjian Shi; Zheng He; Feng Zhu; Min Wang; Ruizhi He; Chunle Zhao; Xiuhui Shi; Min Zhou; Shutao Pan; Yang Gao; Xu Li; Renyi Qin
Several natural products have been demonstrated to both enhance the anti-tumor efficacy and alleviate the side effects of conventional chemotherapy drugs. Rhein, a main constituent of the Chinese herb rhubarb, has been shown to induce apoptosis in various cancer types. However, the exact pharmacological mechanisms controlling the influence of Rhein on chemotherapy drug effects in pancreatic cancer
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ITGB1 enhances the Radioresistance of human Non-small Cell Lung Cancer Cells by modulating the DNA damage response and YAP1-induced Epithelial-mesenchymal Transition Int. J. Biol. Sci. (IF 4.858) Pub Date : 2021-1-18 Yuexian Li; Cheng Sun; Yonggang Tan; Heying Zhang; Yuchao Li; Huawei Zou
Objectives: Radiotherapy has played a limited role in the treatment of non-small cell lung cancer (NSCLC) due to the risk of tumour radioresistance. We previously established the radioresistant non-small cell lung cancer (NSCLC) cell line H460R. In this study, we identified differentially expressed genes between these radioresistant H460R cells and their radiosensitive parent line. We further evaluated
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The role of miR-320 in glucose and lipid metabolism disorder-associated diseases Int. J. Biol. Sci. (IF 4.858) Pub Date : 2021-1-1 Hengzhi Du; Yanru Zhao; Zhongwei Yin; Dao Wen Wang; Chen Chen
Glucose and lipids are important nutrients that provide the majority of energy for each organ to maintain homeostasis of the body. With the continuous improvement in living standards, the incidence of metabolic disorder-associated diseases, such as diabetes, hyperlipidemia, and atherosclerosis, is increasing worldwide. Among them, diabetes, which could be induced by both glucose and lipid metabolic
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Application of radiomics and machine learning in head and neck cancers Int. J. Biol. Sci. (IF 4.858) Pub Date : 2021-1-1 Zhouying Peng; Yumin Wang; Yaxuan Wang; Sijie Jiang; Ruohao Fan; Hua Zhang; Weihong Jiang
With the continuous development of medical image informatics technology, more and more high-throughput quantitative data could be extracted from digital medical images, which has resulted in a new kind of omics-Radiomics. In recent years, in addition to genomics, proteomics and metabolomics, radiomic has attracted the interest of more and more researchers. Compared to other omics, radiomics can be
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Extracellular vesicles and pancreatitis: mechanisms, status and perspectives Int. J. Biol. Sci. (IF 4.858) Pub Date : 2021-1-11 Yu-Chen Jia; Yi-Xuan Ding; Wen-Tong Mei; Yu-Ting Wang; Zhi Zheng; Yuan-Xu Qu; Kuo Liang; Jia Li; Feng Cao; Fei Li
Comprehensive reviews and large population-based cohort studies have played an important role in the diagnosis and treatment of pancreatitis and its sequelae. The incidence and mortality of pancreatitis have been reduced significantly due to substantial advancements in the pathophysiological mechanisms and clinically effective treatments. The study of extracellular vesicles (EVs) has the potential
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Exosomal circRNAs as novel cancer biomarkers: Challenges and opportunities Int. J. Biol. Sci. (IF 4.858) Pub Date : 2021-1-14 Shuai Wang; Yanhan Dong; Anjing Gong; Huimin Kong; Jinning Gao; Xiaodan Hao; Yongmei Liu; Zibo Wang; Yuqiao Fan; Chengyu Liu; Wenhua Xu
Identifying high specificity and sensitivity biomarkers has always been the focus of research in the field of non-invasive cancer diagnosis. Exosomes are extracellular vesicles with a lipid bilayer membrane that can be released by all types of cells, which contain a variety of proteins, lipids, and a variety of non-coding RNAs. Increasing research has shown that the lipid bilayer can effectively protect
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Dihydroartemisinin: A Potential Natural Anticancer Drug Int. J. Biol. Sci. (IF 4.858) Pub Date : 2021-1-16 Xiaoshuo Dai; Xiaoyan Zhang; Wei Chen; Yihuan Chen; Qiushuang Zhang; Saijun Mo; Jing Lu
Dihydroartemisinin (DHA) is an active metabolite of artemisinin and its derivatives (ARTs), and it is an effective clinical drug widely used to treat malaria. Recently, the anticancer activity of DHA has attracted increasing attention. Nevertheless, there is no systematic summary on the anticancer effects of DHA. Notably, studies have shown that DHA exerts anticancer effects through various molecular
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Advancement and properties of circular RNAs in prostate cancer: An emerging and compelling frontier for discovering Int. J. Biol. Sci. (IF 4.858) Pub Date : 2021-1-19 Hong Zhou; Xu-dong Zheng; Chang-ming Lin; Jie Min; Shuang Hu; Ying Hu; Liang-yun Li; Jia-si Chen; Yu-min Liu; Hao-dong Li; Xiao-ming Meng; Jun Li; Ya-ru Yang; Tao Xu
Prostate cancer (PC) is the most common carcinoma among men worldwide which results in 26% of leading causes of cancer-related death. However, the ideal and effective molecular marker remains elusive. CircRNA, initially observed in plant-infected viruses and Sendai virus in 1979, is generated from pre-mRNA back-splicing and comes in to play by adequate expression. The differential expression in prostate
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Clinical characteristics and analysis of risk factors for disease progression of COVID-19: A retrospective Cohort Study Int. J. Biol. Sci. (IF 4.858) Pub Date : 2021-1-1 Zhengtong Lv; Shubin Lv
Objective: Since December 2019, an outbreak of coronavirus disease 2019 (COVID 19) has been experienced from Wuhan, China to the world. A retrospective cohort study was conducted to summarize the clinical characteristics of patients with COVID-19 and to explore the risk factors affecting the disease duration in Jiangan Fangcang shelter hospital, Wuhan, China./nMethods: Clinical characteristics of 409
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ACE2 Correlated With Immune Infiltration Serves As A Novel Prognostic Biomarker In Clear Cell Renal Cell Carcinoma: Implication For COVID-19 Int. J. Biol. Sci. (IF 4.858) Pub Date : 2021-1-1 Wuping Yang; Lei Li; Kenan Zhang; Kaifang Ma; Haibiao Xie; Yanqing Gong; Jingcheng Zhou; Kan Gong
The current severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a global infection, and is seriously threatening human life, especially cancer patients. Thus, we sought to determine the clinical roles of ACE2 (the cell entry receptor of SARS-CoV-2) in ccRCC (clear cell renal cell carcinoma). TCGA, GEO and TIP datasets, and immunohistochemistry and western blot results were used
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Eomesodermin in CD4+T cells is essential for Ginkgolide K ameliorating disease progression in experimental autoimmune encephalomyelitis Int. J. Biol. Sci. (IF 4.858) Pub Date : 2021-1-1 Sheng Chen; Juan Zhang; Wen-Bo Yu; Jing-Cong Zhuang; Wei Xiao; Zhi-Ying Wu; Bao-Guo Xiao
Eomesodermin (Eomes), a transcription factor, could suppress the Th17 cell differentiation and proliferation through directly binding to the promoter zone of the Rorc and Il17a gene, meanwhile the expression of Eomes is suppressed when c-Jun directly binds to its promoter zone. Ginkgolide K (1,10-dihydroxy-3,14-didehydroginkgolide, GK) is a diterpene lactone isolated from the leaves of Ginkgo biloba
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Deciphering the genomic and lncRNA landscapes of aerobic glycolysis identifies potential therapeutic targets in pancreatic cancer Int. J. Biol. Sci. (IF 4.858) Pub Date : 2021-1-1 Li-Li Zhu; Zheng Wu; Rong-Kun Li; Xin Xing; Yong-Sheng Jiang; Jun Li; Ya-Hui Wang; Li-Peng Hu; Xu Wang; Wei-Ting Qin; Yong-Wei Sun; Zhi-Gang Zhang; Qin Yang; Shu-Heng Jiang
Aerobic glycolysis, also known as the Warburg effect, is emerged as a hallmark of most cancer cells. Increased aerobic glycolysis is closely associated with tumor aggressiveness and predicts a poor prognosis. Pancreatic ductal adenocarcinoma (PDAC) is characterized by prominent genomic aberrations and increased glycolytic phenotype. However, the detailed molecular events implicated in aerobic glycolysis
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Ferroptosis in a sarcopenia model of senescence accelerated mouse prone 8 (SAMP8) Int. J. Biol. Sci. (IF 4.858) Pub Date : 2021-1-1 Yan Huang; Beiling Wu; Dingzhu Shen; Jiulin Chen; Zhihua Yu; Chuan Chen
As a systemic syndrome characterized by age-associated degenerative skeletal muscle atrophy, sarcopenia leads to a risk of adverse outcomes in the elderly. Age-related iron accumulation is found in the muscles of sarcopenia animal models and patients, but the role of iron in sarcopenia remains poorly understood. It has been recently found that iron overload in several diseases is involved in ferroptosis
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MYC dysfunction modulates stemness and tumorigenesis in breast cancer Int. J. Biol. Sci. (IF 4.858) Pub Date : 2021-1-1 Yiqiu Liu; Chengjun Zhu; Lin Tang; Qin Chen; Nan Guan; Kun Xu; Xiaoxiang Guan
As a transcription factor and proto-oncogene, MYC is known to be deregulated in a variety of tumors, including breast cancer. However, no consistent conclusion on the role and mechanism of MYC deregulation during breast cancer carcinogenesis has been formed. Here, we used the UALCAN, bc-GenExMiner, TCGA, cBioportal, STRING and Kaplan-Meier Plotter databases to explore the mRNA expression, prognosis
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PRPF6 promotes androgen receptor/androgen receptor-variant 7 actions in castration-resistant prostate cancer cells Int. J. Biol. Sci. (IF 4.858) Pub Date : 2021-1-1 Wei Liu; Chunyu Wang; Shengli Wang; Kai Zeng; Shan Wei; Ning Sun; Ge Sun; Manlin Wang; Renlong Zou; Wensu Liu; Lin Lin; Huijuan Song; Zining Jin; Yue Zhao
Androgen receptor (AR) and its variants play vital roles in development and progression of prostate cancer. To clarify the mechanisms involved in the enhancement of their actions would be crucial for understanding the process in prostate cancer and castration-resistant prostate cancer transformation. Here, we provided the evidence to show that pre-mRNA processing factor 6 (PRPF6) acts as a key regulator
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HES1 promotes breast cancer stem cells by elevating Slug in triple-negative breast cancer Int. J. Biol. Sci. (IF 4.858) Pub Date : 2021-1-1 Xiaoying Li; Yang Li; Xianqiang Du; Xu Wang; Shu Guan; Yu Cao; Feng Jin; Feng Li
Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer. TNBC is enriched with breast cancer stem cells (BCSCs), which are responsible for cancer initiation, cancer progression and worse prognosis. Our previous study found that HES1 was overexpressed and promoted invasion in TNBC. However, the role of HES1 in modulating BCSC stemness of TNBC remains unclear. Here, we found
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NETO2 promotes esophageal cancer progression by inducing proliferation and metastasis via PI3K/AKT and ERK pathway Int. J. Biol. Sci. (IF 4.858) Pub Date : 2021-1-1 Jia-cheng Xu; Tian-yin Chen; Le-tai Liao; Tao Chen; Quan-lin Li; Jia-xin Xu; Jian-wei Hu; Ping-hong Zhou; Yi-qun Zhang
Esophageal squamous cell carcinoma (ESCC) causes aggressive and lethal malignancies with extremely poor prognoses, and accounts for about 90% of cases of esophageal cancer. Neuropilin and tolloid-like 2 (NETO2) protein coding genes have been associated with various human cancers. Nevertheless, little information is reported about the phenotypic expression and its clinical significance in ESCC progression
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Novel Functions of CD147 in the Mitochondria Exacerbates Melanoma Metastasis Int. J. Biol. Sci. (IF 4.858) Pub Date : 2021-1-1 Lixia Lu; Jianglin Zhang; Pingping Gan; Lisha Wu; Xu Zhang; Cong peng; Jianda Zhou; Xiang Chen; Juan Su
Melanoma is an aggressive form of skin cancer characterized by rapid invasion and metastasis. CD147 is known to be functioning in cell invasion. In this study, we showed that CD147 was translocated from the cell membrane to the mitochondria in advanced melanoma. Melanoma patients with CD147 localized to the mitochondria confer a worse prognosis. The mitochondrial CD147 levels are correlated with the
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The IFN-γ-IDO1-kynureine pathway-induced autophagy in cervical cancer cell promotes phagocytosis of macrophage Int. J. Biol. Sci. (IF 4.858) Pub Date : 2021-1-1 Shao-Liang Yang; Hai-Xia Tan; Tian-Tian Niu; Yu-Kai Liu; Chun-Jie Gu; Da-Jin Li; Ming-Qing Li; Hai-Yan Wang
Background: Cervical cancer is a common malignant disease in female patients accompanied by activation of autophagy in tumor cells. However, the exact regulatory factors of autophagy and its effects on the immune response remain unknown./nMethods: The induction of autophagy in HeLa and SiHa cells treated with IFN-γ, tryptophan depletion, kynurenine and epacadostat was detected by western blot analysis
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CDH1 is Identified as A Therapeutic Target for Skin Regeneration after Mechanical Loading Int. J. Biol. Sci. (IF 4.858) Pub Date : 2021-1-1 Xiaolu Huang; Xiao Liang; Yiwen Zhou; Haizhou Li; Hengyu Du; Yinjun Suo; Wenhui Liu; Rui Jin; Bangda Chai; Ran Duan; Haizhou Li; Qingfeng Li
Rationale: Mechanical stimuli in the microenvironment are considered key regulators of cell function. Clinically, mechanical force (tissue expander) is widely used to regenerate skin for post-burn or trauma repair, implying that mechanical stretching can promote skin cell regeneration and proliferation. However, the underlying mechanism remains unknown./nMethods: Microarray analysis was utilized to
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Current advances in the development of SARS-CoV-2 vaccines Int. J. Biol. Sci. (IF 4.858) Pub Date : 2021-1-1 Annoor Awadasseid; Yanling Wu; Yoshimasa Tanaka; Wen Zhang
Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is now a global pandemic that has wreaked havoc globally, which has put a heavy toll on public health, lives, and the world economy. Vaccination is considered as one of the greatest successes in medical history. Based on prior experience with the development of SARS-CoV vaccines, all COVID-19
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βII spectrin (SPTBN1): biological function and clinical potential in cancer and other diseases Int. J. Biol. Sci. (IF 4.858) Pub Date : 2021-1-1 Panyu Yang; Yanyan Yang; Pin Sun; Yu Tian; Fang Gao; Chen Wang; Tingyu Zong; Min Li; Ying Zhang; Tao Yu; Zhirong Jiang
βII spectrin, the most common isoform of non-erythrocyte spectrin, is a cytoskeleton protein present in all nucleated cells. Interestingly, βII spectrin is essential for the development of various organs such as nerve, epithelium, inner ear, liver and heart. The functions of βII spectrin include not only establishing and maintaining the cell structure but also regulating a variety of cellular functions
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A Multiple-Hit Hypothesis Involving Reactive Oxygen Species and Myeloperoxidase Explains Clinical Deterioration and Fatality in COVID-19 Int. J. Biol. Sci. (IF 4.858) Pub Date : 2021-1-1 Pravin T Goud; David Bai; Husam M Abu-Soud
Multi-system involvement and rapid clinical deterioration are hallmarks of coronavirus disease 2019 (COVID-19) related mortality. The unique clinical phenomena in severe COVID-19 can be perplexing, and they include disproportionately severe hypoxemia relative to lung alveolar-parenchymal pathology and rapid clinical deterioration, with poor response to O2 supplementation, despite preserved lung mechanics
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Role of hydrogen sulfide donors in cancer development and progression Int. J. Biol. Sci. (IF 4.858) Pub Date : 2021-1-1 Ebenezeri Erasto Ngowi; Attia Afzal; Muhammad Sarfraz; Saadullah Khattak; Shams Uz Zaman; Nazeer Hussain Khan; Tao Li; Qi-Ying Jiang; Xin Zhang; Shao-Feng Duan; Xin-Ying Ji; Dong-Dong Wu
In recent years, a vast number of potential cancer therapeutic targets have emerged. However, developing efficient and effective drugs for the targets is of major concern. Hydrogen sulfide (H2S), one of the three known gasotransmitters, is involved in the regulation of various cellular activities such as autophagy, apoptosis, migration, and proliferation. Low production of H2S has been identified in
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The Regulatory Effect of SIRT1 on Extracellular Microenvironment Remodeling Int. J. Biol. Sci. (IF 4.858) Pub Date : 2021-1-1 Zhuo Wang; Wendong Guo; Fei Yi; Tingting Zhou; Xiaoman Li; Yanling Feng; Qiqiang Guo; Hongde Xu; Xiaoyu Song; Liu Cao
The sirtuins family is well known by its unique nicotinamide adenine dinucleotide (NAD+)-dependent deacetylase function. The most-investigated member of the family, Sirtuin 1 (SIRT1), accounts for deacetylating a broad range of transcription factors and coregulators, such as p53, the Forkhead box O (FOXO), and so on. It serves as a pivotal regulator in various intracellular biological processes, including
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SARS-CoV-2 variants evolved during the early stage of the pandemic and effects of mutations on adaptation in Wuhan populations Int. J. Biol. Sci. (IF 4.858) Pub Date : 2021-1-1 Annoor Awadasseid; Yanling Wu; Yoshimasa Tanaka; Wen Zhang
The outbreak of the coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The pandemic apparently started in December 2019 in Wuhan, China, and has since affected many countries worldwide, turning into a major global threat. Chinese researchers reported that SARS-CoV-2 could be classified into two major variants. They suggest that investigating