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Duration-specific association between plasma IGFBP7 levels and diabetic complications in patients with type 2 diabetes mellitus Growth Horm. IGF Res. (IF 1.4) Pub Date : 2024-02-21 Xiaoyan Zhu, Fei Liang, Jieyun Yin, Xiaoliang Li, Lai Jiang, Yan Gao, Yan Lu, Yihe Hu, Ningbin Dai, Jian Su, Zhuoqiao Yang, Mengxin Yao, Yue Xiao, Wenxin Ge, Yue Zhang, Yi Zhong, Jun Zhang, Ming Wu
Insulin-like growth factor binding protein 7 (IGFBP7) has a strong affinity to insulin. This study aimed to evaluate the relationship between IGFBP7 and complications among type 2 diabetes mellitus (T2DM) patients. A total of 1449 T2DM patients were selected from a cross-sectional study for disease management registered in the National Basic Public Health Service in Changshu, China, and further tested
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Insights from an advisory board: Facilitating transition of care into adulthood in brain cancer survivors with acquired pediatric growth hormone deficiency Growth Horm. IGF Res. (IF 1.4) Pub Date : 2024-02-15 Craig Alter, Margaret Boguszewski, David Clemmons, Georgiana A. Dobri, Mitchell E. Geffner, Nicky Kelepouris, Bradley S. Miller, Richard Oh, Heidi Shea, Kevin C.J. Yuen
Children with growth hormone deficiency (GHD) face multiple challenges that can negatively impact the transition from pediatric to adult endocrinology care. For children with GHD resulting from brain cancer or its treatment, the involvement of oncology care providers and possible disease-related comorbidities add further complexity to this transition. An advisory board of pediatric and adult endocrinologists
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Evaluation of growth hormone deficiency in women with unexplained infertility Growth Horm. IGF Res. (IF 1.4) Pub Date : 2024-01-23 Mehmet Serif Ortac, Aysa Hacioglu, Semih Zeki Uludag, Zuleyha Karaca, Kursad Unluhizarci, Fahrettin Kelestimur, Fatih Tanriverdi
Purpose Growth hormone (GH) has been recognized to play a regulatory role in female reproduction. It has been reported that infertile GH deficient patients regained fertility after GH replacement. The frequency of GH deficiency is not established in patients diagnosed with unexplained infertility. Here, we aim to present the prevalence of GH deficieny in this patient group. Methods We included patients
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Growth hormone directly stimulates GATA2 expression Growth Horm. IGF Res. (IF 1.4) Pub Date : 2024-01-24 Mana Mitsutani, Midori Matsushita, Mei Yokoyama, Ayumu Morita, Hiromi Hano, Tomomi Fujikawa, Tetsuya Tagami, Kenji Moriyama
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Insulin-like growth factor (IGF) performance in ovarian function and applications in reproductive biotechnologies Growth Horm. IGF Res. (IF 1.4) Pub Date : 2023-12-05 Tathyana Benetis Piau, Aline de Queiroz Rodrigues, Fernanda Paulini
The role of the insulin-like growth factor (IGF) system has attracted close attention. The activity of IGF binding proteins (IGFBPs) within the ovary has not been fully elucidated to date. These proteins bind to IGF with an equal, or greater, affinity than to the IGF1 receptor, thus being in the main position to regulate IGF signalling, in addition to extending the half-life of IGFs within the bloodstream
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A combined top-down and bottom-up LC-HRMS/MS method for the quantification of human growth hormone in plasma and serum Growth Horm. IGF Res. (IF 1.4) Pub Date : 2023-11-21 Sophia Krombholz, Andreas Thomas, Philippe Delahaut, Martin Bidlingmaier, Katharina Schilbach, Geoffrey Miller, Mario Thevis
Objective The precise and accurate quantification of human growth hormone (GH) in plasma/ serum is crucial for the diagnosis and treatment of diseases like GH deficiency or acromegaly. However, the ligand-binding assays (LBAs) currently used for routine testing show considerable methodological variability. Here, we present a complementary, combined top-down and bottom-up LC-MS-based method to quantify
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Comparison of hyperoxia or normoxia resolution of intermittent hypoxia and intermittent hyperoxia episodes on liver histopathology, IGF-1, IGFBP-3, and GHBP in neonatal rats Growth Horm. IGF Res. (IF 1.4) Pub Date : 2023-09-09 Charles L. Cai, Matthew Marcelino, Jacob V. Aranda, Kay D. Beharry
Objective Extremely low gestational age neonates requiring oxygen therapy for chronic lung disease experience repeated fluctuations in arterial oxygen saturation, or intermittent hypoxia (IH), during the first few weeks of life. These events are associated with a high risk for reduced growth, hypertension, and insulin resistance in later life. This study tested the hypothesis that IH, or intermittent
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Growth hormone therapy for children with Duchenne muscular dystrophy and glucocorticoid induced short stature Growth Horm. IGF Res. (IF 1.4) Pub Date : 2023-08-30 Eran Lavi, Amitay Cohen, Abdulsalam Abu Libdeh, Reuven Tsabari, David Zangen, Talya Dor
Objective To evaluate the outcome of recombinant human Growth Hormone (rhGH) therapy in patients with Duchene Muscular Dystrophy (DMD) and glucocorticoid treatment with compromised growth. Design Four DMD patients on Deflzacort 0.6–0.85 mg/kg/day or prednisolone 0.625 mg/kg/day recieved rhGH (0.24 mg/kg/week) for 6–18 months. Primary outcomes were Growth velocity and Height for age Z-scores (Height
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Response to growth hormone therapy in ring chromosome 15: Review and evidence from a new case on possible beneficial effect in neurodevelopment Growth Horm. IGF Res. (IF 1.4) Pub Date : 2023-07-25 Selmen Wannes, Ikram El Ahmer, Khouloud Rjiba, Nessrine Jemmali, Hamza Haj Abdallah, Rania Bel Haj, Asma Achour, Hassan Bouzidi, Ali Saad, Soumaya Mougou, Bahri Mahjoub
Type 1 Insulin-like Growth Factor Receptor(IGF1R) plays a fundamental role in normal growth and development. Its disruption is usually characterized by severe intrauterine and postnatal growth retardation, microcephaly and neurodevelopmental delay.The efficacy of recombinant human growth hormone treatment remains a challenge for children with IGF1 resistance and pathogenic mutations of IGF1R, with
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Prevalence of refractoriness when testing growth hormone levels in children Growth Horm. IGF Res. (IF 1.4) Pub Date : 2023-07-24 Camilla Borghammar, Victoria Boije, Charlotte Becker, Bengt Lindberg, Maria Elfving
Objective Late night spontaneous growth hormone (GH) pulses may influence the pituitary GH response to provocation tests. We evaluated GH response during arginine-insulin-tolerance test (AITT) after a GH peak during a short spontaneous nocturnal profile (SSNP) in children with short stature or low growth velocity. Design Using SSNP and subsequent AITT, we examined 257 children 4–18 years old (138 (53
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Administration of insulin like growth factor I (IGFI) lowers serum lipoprotein(a)-impact on atherosclerotic cardiovascular disease Growth Horm. IGF Res. (IF 1.4) Pub Date : 2023-07-22 Zvi Laron, Haim Werner
Insulin like growth factor I (IGFI) secreted by the liver upon stimulation by pituitary growth hormone (GH) acts as the most important growth stimulating hormone in children. The present review presents evidence that among its additional metabolic effects, IGF-I suppresses the synthesis of lipoprotein(a) [Lp(a)], an independent risk factor for atherosclerotic cardiovascular disease. In view of this
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Assessment of anterior pituitary reserve capacity based on growth hormone response to growth hormone-releasing peptide-2 test in the elderly Growth Horm. IGF Res. (IF 1.4) Pub Date : 2023-06-02 Shinichiro Teramoto, Shigeyuki Tahara, Yujiro Hattori, Akihide Kondo, Akio Morita
Objective The growth hormone (GH)-releasing peptide-2 (GHRP-2) test is relatively safe among endocrine stimulation tests for the elderly. We investigated whether anterior pituitary function in elderly patients could be assessed on the basis of GH response to the GHRP-2 test. Design Sixty-five elderly patients aged 65 years and older with non-functioning pituitary neuroendocrine tumor (PitNET) who underwent
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Metabolic and quality of life effects of growth hormone replacement in patients with TBI and AGHD: A pilot study Growth Horm. IGF Res. (IF 1.4) Pub Date : 2023-06-01 Megan Herodes, Nancy Le, Lindsey J. Anderson, Dorota Migula, Gary Miranda, Lauren Paulsen, Jose M. Garcia
Objective Traumatic brain injury (TBI), a common cause of adult growth hormone deficiency (AGHD), affects 20% of Veterans returning from Iraq and Afghanistan (OEF/OIF/OND). Growth hormone replacement therapy (GHRT) improves quality of life (QoL) in AGHD but remains unexplored in this population. This pilot, observational study investigates the feasibility and efficacy of GHRT in AGHD following TBI
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Decreased insulin-like growth factor-1 expression in response to mechanical loading is associated with skeletal muscle anabolic resistance in cancer cachexia Growth Horm. IGF Res. (IF 1.4) Pub Date : 2023-05-18 Mitsunori Miyazaki, Atsushi Sawada, Daisuke Sawamura, Susumu Yoshida
Objective Cachexia is a systemic metabolic syndrome characterized by loss of body weight and skeletal muscle mass during chronic wasting diseases, such as cancer. Skeletal muscle in cancer cachexia is less responsive to anabolic factors including mechanical loading; however, the precise molecular mechanism is largely unknown. In this study, we examined the underlying mechanism of anabolic resistance
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Growth hormone-releasing hormone antagonists counteract hydrogen peroxide – induced paracellular hyperpermeability in endothelial cells Growth Horm. IGF Res. (IF 1.4) Pub Date : 2023-05-18 Nektarios Barabutis, Agnieszka Siejka, Mohammad S. Akhter
Growth Hormone-Releasing Hormone (GHRH) is a hypothalamic peptide which regulates the release of Growth Hormone from the anterior pituitary gland, and has been involved in inflammatory processes. On the other hand, GHRH antagonists (GHRHAnt) were developed to counteract those effects. Herein we demonstrate for the first time that GHRHAnt can suppress hydrogen peroxide (H2O2) - induced paracellular
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Exercise combined with lysine-inositol vitamin B12 promotes height growth in children with idiopathic short stature Growth Horm. IGF Res. (IF 1.4) Pub Date : 2023-05-16 Fengping Sun, Liqin Chao, Junxia Zhang, Xiaoli Pan
Objective This study was aimed to systematically determine the effect of exercise combined with lysine-inositol vitamin B12 (VB12) therapy on the height of children with idiopathic short stature (ISS). Methods Sixty children with ISS were randomly divided into observation and control groups (N = 30). Each group was given lysine-inositol VB12 oral solution (10 mL bid). Simultaneously, the observation
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Associations of CTCF and FOXA1 with androgen and IGF pathways in men with localized prostate cancer Growth Horm. IGF Res. (IF 1.4) Pub Date : 2023-04-14 Rachel Barker, Kalina Biernacka, Georgina Kingshott, Alex Sewell, Paida Gwiti, Richard M. Martin, J. Athene Lane, Lucy McGeagh, Anthony Koupparis, Edward Rowe, Jon Oxley, Claire M. Perks, Jeff M.P. Holly
Aims To examine associations between the transcription factors CCCTC-binding factor (CTCF) and forkhead box protein A1 (FOXA1) and the androgen receptor (AR) and their association with components of the insulin-like growth factor (IGF)-pathway in a cohort of men with localized prostate cancer. Methods Using prostate tissue samples collected during the Prostate cancer: Evidence of Exercise and Nutrition
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Efficacy and safety of growth hormone therapy in children with Noonan syndrome Growth Horm. IGF Res. (IF 1.4) Pub Date : 2023-04-09 Giorgio Sodero, Clelia Cipolla, Lucia Celeste Pane, Linda Sessa, Elena Malavolta, Federica Arzilli, Chiara Leoni, Giuseppe Zampino, Donato Rigante
Patients with Noonan syndrome typically have a target height <2 standard deviations compared to the general population, and half of the affected adults remain permanently below the 3rd centile for height, though their short stature might result from a multifactorial etiology, not-yet fully understood. The secretion of growth hormone (GH) following the classic GH stimulation tests is often normal, with
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Comparison of growth response and adverse reaction according to growth hormone dosing strategy for children with short stature: LG Growth Study Growth Horm. IGF Res. (IF 1.4) Pub Date : 2023-02-24 Kyungchul Song, Mo Kyung Jung, Jun Suk Oh, Su Jin Kim, Han Saem Choi, Myeongseob Lee, Junghwan Suh, Ahreum Kwon, Hyun Wook Chae, Ho-Seong Kim
Objective Growth hormone (GH) dosage in children is conventionally determined either by body weight (BW) or body surface area (BSA). However, there is no consensus on the calculation method for proper GH treatment dose. We aimed to compare growth response and adverse reactions between BW- and BSA-based GH treatment doses for children with short statures. Design Data from 2284 GH-treated children were
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Comparison of two prediction models in a clinical setting to predict growth in prepubertal children on recombinant growth hormone Growth Horm. IGF Res. (IF 1.4) Pub Date : 2023-01-07 Helena-Jamin Ly, Anders Lindberg, Hans Fors, Jovanna Dahlgren
Objective Prediction models that calculate the growth response in children on recombinant growth hormone (GH) have shown to be helpful tools in deciding who should start treatment, as identifying GH deficiency can be a challenge. The aim of the study is to compare two prediction models; the KIGS (Pfizer International Growth Study) prediction models which are more accessible and the Gothenburg model
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Growth hormone responses during arginine and clonidine stimulation test: Correlations with patients' auxological and metabolic parameters in a single centre study Growth Horm. IGF Res. (IF 1.4) Pub Date : 2022-12-05 Sodero Giorgio, Mariani Francesco, Caprarelli Michela, Agazzi Cristiana, Quarta Ludovica, Benacquista Luca, Rigante Donato, Cipolla Clelia
Background Children with auxological parameters defining a ‘short stature’ is routinely subjected to various blood tests and, if necessary, to growth hormone stimulation test (GHST) for differentiating GH deficiency (GHD) and other causes of stunted growth. Aim This retrospective monocentric study aimed to evaluate any correlations between GH peaks during GHST in children assessed for short stature
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The coexistence of newly diagnosed acromegaly with primary empty sella: More frequent than expected? Growth Horm. IGF Res. (IF 1.4) Pub Date : 2022-11-11 Emre Urhan, Aysa Hacioglu, Izzet Okcesiz, Zuleyha Karaca, Canan Sehit Kara, Kursad Unluhizarci
Objective We investigated the coexistence of newly diagnosed acromegaly with primary empty sella (ES), which is considered to be a rare association, and the impact of ES on the laboratory, radiological and prognostic status of acromegaly. Design Acromegaly patients diagnosed and followed-up between 2012 and 2021 were included. Empty sella was defined as the pituitary gland and adenoma filling <50%
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Biomarkers of growth and carbohydrate metabolism in neonatal rats supplemented with fish oil and/or antioxidants during intermittent hypoxia Growth Horm. IGF Res. (IF 1.4) Pub Date : 2022-11-05 Despoina Myrsini Galetaki, Charles L. Cai, Kulsajan S. Bhatia, Vivian Chin, Jacob V. Aranda, Kay D. Beharry
Objective Extremely low gestational age neonates (ELGANs) experience frequent intermittent hypoxia (IH) episodes during therapeutic oxygen. ELGANs exhibit poor postnatal growth requiring lipid supplementation. Lipids are targets of reactive oxygen species resulting in lipid peroxidation and cell death, particularly in preterm infants with compromised antioxidant systems. We tested the hypothesis that
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Corrigendum to “Insulin-like growth Factors I and II receptors in the breast cancer disparity” among African-American women [Growth Hormone & IGF Research 20 (2010) 245–254] Growth Horm. IGF Res. (IF 1.4) Pub Date : 2022-10-21 S. Kalla Singh, Q.W. Tan, C. Brito, M. De León, D. De León
Abstract not available
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Association between gestational diabetes mellitus and bioavailability of insulin-like growth factors and role of their binding proteins Growth Horm. IGF Res. (IF 1.4) Pub Date : 2022-10-03 Kateřina Anderlová, Anna Cinkajzlová, Patrik Šimják, Jana Kloučková, Helena Kratochvílová, Zdeňka Lacinová, Věra Toušková, Hana Krejčí, Miloš Mráz, Antonín Pařízek, Martin Haluzík, Michal Kršek
Objective Insulin-like growth factors (IGFs) are involved in regulating growth and metabolism and increase insulin sensitivity, improve glucose metabolism, and are potentially related to gestational diabetes mellitus (GDM) and its complications for mothers and fetuses. Design This study aimed to assess serum levels and cord blood levels of IGF system components in pregnant women with (39 participants)
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Effects of 18 months of GH replacement on cardiovascular risk factors and quality of life in GH deficient adults; a randomized controlled trial using a fixed very low and a standard dose of GH Growth Horm. IGF Res. (IF 1.4) Pub Date : 2022-09-28 Galina Götherström, Gudmundur Johannsson, Johan Svensson
Objective Little is known of the effects of a fixed very low dose of growth hormone (GH) replacement on cardiovascular risk factors, bone mass, muscle strength and quality of life (QoL) in hypopituitary patients. Design/patients/methods This was an open-label randomized study performed at a single center. Consecutive hypopituitary patients with adult onset GH deficiency (GHD) and BMI ≥ 27 kg/m2 were
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Increase of serum lipoprotein (a), an adverse effect of growth hormone treatment Growth Horm. IGF Res. (IF 1.4) Pub Date : 2022-09-09 Zvi Laron
A number of reports show that high endogenous, or therapeutic administration of human growth hormone (hGH) cause an increase of serum lipoprotein a, Lp(a). Being thrombogenic Lp(a) is an independent risk factor of atherosclerotic cardiovascular disease (ASCVD). Hence, it is hypothesized that the recently reported association between childhood hGH treatment and cardiovascular morbidity is probably due
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Pharmacokinetics and pharmacodynamics of once-weekly administration of JR-142, a long-acting albumin-fused human growth hormone: A rondemized, placebo-controlled phase 1 study Growth Horm. IGF Res. (IF 1.4) Pub Date : 2022-09-08 Yasuko Owada, Mika Okazaki, Toshiaki Ikeda, Ryuji Yamamoto, Kohtaro Minami, Kenichi Takahashi, Tohru Hirato, Yoko Mita, Tatsuyoshi Yamamoto, Kazunori Tanizawa, Hiroyuki Sonoda, Yuji Sato
Objective Under clinical development for patients with growth hormone deficiency, JR-142 is a long-acting growth hormone with a half-life extended by fusion with modified serum albumin. We conducted a Phase 1 study to investigate the safety, tolerability, and pharmacokinetic (PK) and pharmacodynamic (PD) profiles of once-weekly subcutaneous administrations of JR-142. The study consisted of two parts:
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Age, GH/IGF-1 levels, tumor volume, T2 hypointensity, and tumor subtype rather than proliferation and invasion are all reliable predictors of biochemical response to somatostatin analogue therapy in patients with acromegaly: A clinicopathological study Growth Horm. IGF Res. (IF 1.4) Pub Date : 2022-09-09 Elif Tutku Durmuş, Ayşegül Atmaca, Mehmet Kefeli, Sultan Çalışkan, Ozgur Mete, Kerim Aslan, Murat Fidan, Ramis Çolak, Buğra Durmuş
Purpose To determine whether biochemical responses to long-acting forms of first-generation somatostatin analogue (SSA) therapy in patients with acromegaly could be predicted from baseline and postoperative hormone concentrations, and tumor radiological and histopathological characteristics. Methods A total of 68 patients with acromegaly for whom postoperative SSA therapy was started were categorized
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Paradoxical GH increase during oral glucose load may predict overall remission in acromegalic patients Growth Horm. IGF Res. (IF 1.4) Pub Date : 2022-09-08 Hakan Düğer, Hayri Bostan, Hilal Yıldırım Deryol, Narin Nasıroğlu İmga, Bekir Uçan, Murat Çalapkulu, Sema Hepşen, Pınar Akhanlı, Ümran Gül, Muhammed Erkam Sencar, Erman Çakal, Şeyda Özdemir, Muhammed Kızılgül
Background The nadir growth hormone (nGH) during the oral glucose tolerance test (OGTT) is the gold standard method for diagnosing acromegaly. A paradoxical growth hormone (GH) response to oral glucose (OG) in acromegaly can be observed. The role of the paradoxical GH response on how the patients with acromegaly respond to the treatment has been addressed in few studies. The aim of this study was to
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The regulation of proliferation and apoptosis in hepatocellular carcinoma via insulin-like growth factor 1 receptor Growth Horm. IGF Res. (IF 1.4) Pub Date : 2022-08-27 Guanjun Xu, Jiesheng Chu, Yu Shi, Longzhang Huang, Jingzhong Fu
Objectives Insulin-like growth factor 1 receptor (IGF-1R) is a transmembrane tyrosine kinase receptor of the insulin receptor family. Its expression is consistently increased in hepatocellular carcinoma (HCC) tissue, and it participates in hepatic carcinogenesis. Targeting IGF-1R may be a potential therapeutic approach against hepatocellular carcinoma. This study therefore aimed to explore the effect
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Growth hormone inhibits adipogenic differentiation and induces browning in bovine subcutaneous adipocytes Growth Horm. IGF Res. (IF 1.4) Pub Date : 2022-08-18 Tingting Li, Hui Bai, Haoyuan Fang, Liang Yang, Peishi Yan
Objective It is well established that growth hormone (GH) has the ability to stimulate lipolysis. The effects of GH on adipocyte differentiation and browning have not been clearly described. Therefore, the present study aimed to elucidate the role of GH in the differentiation and browning of bovine subcutaneous adipocytes as well as its underlying molecular mechanisms. Methods We first treated bovine
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Acromegaly-related cutis verticis gyrata Growth Horm. IGF Res. (IF 1.4) Pub Date : 2022-07-28 João Roque, Pedro Marques
Objective Acromegaly is a disorder caused by hypersecretion of growth hormone (GH), resulting in excessive levels of insulin-like growth factor 1 (IGF-1), and almost always due to a pituitary tumor. It is classically associated with acral enlargement, prominent facial features and soft tissue overgrowth. Skin manifestations include hirsutism, acne, skin tags, oily skin and acanthosis nigricans. However
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Do neurosteroids have impact on depression and cognitive functions in cases with acromegaly? Growth Horm. IGF Res. (IF 1.4) Pub Date : 2022-07-27 Esra Hatipoglu, Yalcin Hacioglu, Yeliz Polat, Hilmi Furkan Arslan, Sena Oner, Ozlem Balci Ekmekci, Mutlu Niyazoglu
Objective Neurosteroids (NSs) are a distinct hormone group and, they are known for their contribution into the status of mood and cognitive functions. Whether they are also involved in the mood disturbances and cognition in acromegaly is not known. Herein we aimed to evaluate the relation of mood status and cognitive functions with the NS levels in cases with acromegaly. Design A total of 33 cases
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A consensus on optimization of care in patients with growth hormone deficiency and mild traumatic brain injury Growth Horm. IGF Res. (IF 1.4) Pub Date : 2022-07-25 Kevin C.J. Yuen, Brent Masel, Michael S. Jaffee, Gregory O'Shanick, Tamara L. Wexler, Kent Reifschneider, Randall J. Urban, Sophie Hoang, Nicky Kelepouris, Andrew R. Hoffman
Objective/design Approximately 2.9 million children and adults in the US experience traumatic brain injuries (TBIs) annually, most of which are considered mild. TBI can induce varying consequences on pituitary function, with growth hormone deficiency (GHD) among the more commonly reported conditions. Panels of pediatric and adult endocrinologists, neurologists, physical medicine and rehabilitation
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Effect of long-acting growth hormone treatment on endogenous growth hormone secretion in prepubertal patients with idiopathic short stature: A preliminary study Growth Horm. IGF Res. (IF 1.4) Pub Date : 2022-07-08 Han Saem Choi, Ahreum Kwon, Junghwan Suh, Kyungchul Song, Hyun Wook Chae, Ho-Seong Kim
Long-acting growth hormone (LAGH) is emerging to be a new preparation for treatment of short stature. We aimed to determine whether 12-month treatment with LAGH in patients with idiopathic short stature has an effect on the nocturnal endogenous growth hormone (GH) secretion and metabolic consequences and efficacy. Participants included 10 GH-naïve prepubertal children with idiopathic short stature
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Effect of metformin on thyroid cancer risk in patients with acromegaly: A preliminary observational study Growth Horm. IGF Res. (IF 1.4) Pub Date : 2022-06-30 Cem Sulu, Ayyuce Begum Bektas, Suleyman Sami Guzel, Kubilay Tay, Serdar Sahin, Emre Durcan, Hande Mefkure Ozkaya, Pinar Kadioglu
Purpose To evaluate the role of metformin on thyroid cancer risk in patients with acromegaly. Methods Medical charts of 534 patients with acromegaly that were followed-up between 1983 and 2019 were reviewed. Patients with follow-up duration at least 6 months were included. Cohort entry was defined as first visit date. The date of each case's thyroid cancer diagnosis was defined as index date. Patients
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Reduced exercise-induced growth hormone secretion among children with attention-deficit hyperactivity disorder Growth Horm. IGF Res. (IF 1.4) Pub Date : 2022-06-30 Dan Nemet, Sigal Ben-Zaken, Roi A. Eliakim, Alon Eliakim
Purpose Attention-deficit/hyperactivity disorder (ADHD) is typically a chronic, often lifelong condition. Data suggest that ADHD itself and its treatment may be associated with dysregulated growth, including height and BMI. The reason for this association is yet unknown. The objective of this study was to examine differences in growth hormone (GH) response to exercise between children who had received
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Prolactin response to growth hormone stimulation tests Growth Horm. IGF Res. (IF 1.4) Pub Date : 2022-06-20 Avivah Silbergeld, Chen Barazani, Zvi Laron
Background Despite many similarities between the structure, receptors, proliferative and growth promoting actions, the relationship between Prolactin (PRL) and Growth Hormone (GH) in clinical conditions has received little attention. Objective To determine the PRL response to GH stimulation tests. Subjects Prepubertal and early pubertal boys (n = 581) and girls (n = 502) with idiopathic, non-syndromatic
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Expression of IGF-1 receptor and GH receptor in hepatic tissue of patients with nonalcoholic fatty liver disease and nonalcoholic steatohepatitis Growth Horm. IGF Res. (IF 1.4) Pub Date : 2022-06-19 Stephanie A. Osganian, Sonu Subudhi, Ricard Masia, Hannah K. Drescher, Lea M. Bartsch, Mark L. Chicote, Raymond T. Chung, Denise W. Gee, Elan R. Witkowski, Miriam A. Bredella, Georg M. Lauer, Kathleen E. Corey, Laura E. Dichtel
Objective The GH and IGF-1 axis is a candidate disease-modifying target in nonalcoholic fatty liver disease (NAFLD) given its lipolytic, anti-inflammatory and anti-fibrotic properties. IGF-1 receptor (IGF-1R) and GH receptor (GHR) expression in adult, human hepatic tissue is not well understood across the spectrum of NAFLD severity. Therefore, we sought to investigate hepatic IGF-1R and GHR expression
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IGF-1 knockdown inhibits phosphorylation of Akt and ERK in chicken embryonic myotubes Growth Horm. IGF Res. (IF 1.4) Pub Date : 2022-06-14 Takaoki Saneyasu, Tomonori Nakamura, Kazuhisa Honda, Hiroshi Kamisoyama
Objective We examined whether auto/paracrine insulin-like growth factor-1 (IGF-1) contributes to the phosphorylation of Akt and ERK in chicken myotubes. Methods Chicken myotubes were treated with IGF-1 siRNA, and then total RNA and protein were harvested for real-time PCR and western blot analysis. Results Treatment with IGF-1 siRNA inhibited the phosphorylation of Akt and ERK, but not of ribosomal
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In missed abortion the decrease of IGF-1 down-regulates PI3K/AKT signaling pathway reducing the secretion of progesterone and β-hCG Growth Horm. IGF Res. (IF 1.4) Pub Date : 2022-06-14 Weitao Liang, Tianyuan Zhu, Na Tan, Guangzhuang Jing, Li'ao Xie, Yuhui Dang, Zhilan Li
Objective To explore whether the reduction of IGF-1 in missed abortion down-regulates PI3K/AKT signaling pathway, thereby causing trophoblast cell apoptosis and reducing the secretion of β-hCG and progesterone. Design 12 pairs of serum and villous tissues were selected from missed abortion patients and normal early pregnant women who had terminated pregnancy by artificial abortion. The subjects in
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Time course and reaction types of serum IGF-1 and its relationship to BMI and leptin regarding inpatients with anorexia nervosa Growth Horm. IGF Res. (IF 1.4) Pub Date : 2022-05-31 Christiane Hellwig-Walter, Maik Brune, Dieter Schellberg, Magdalena Buckert, Daniela Wesche, Ulrich Cuntz, Hans-Christoph Friederich, Beate Wild
Objective Anorexia nervosa (AN) is a severe mental disorder that is characterized by restriction of energy intake, low weight, and endocrine abnormalities. One of the known endocrine changes in relation to underweight is in the GH/IGF-I axis. The aim of the study was (a) to investigate longitudinal characteristics of the IGF-I-change during therapy and weight gain in adult AN, (b) to determine relationships
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Biochemical discrepancies in the evaluation of the somatotroph axis: Elevated GH or IGF-1 levels do not always diagnose acromegaly Growth Horm. IGF Res. (IF 1.4) Pub Date : 2022-05-17 Carolina Peixe, Miriam Sánchez-García, Ashley B. Grossman, Márta Korbonits, Pedro Marques
The most frequent diagnosis underlying the finding of an elevated growth hormone (GH) and insulin-like growth factor-1 (IGF-1) is acromegaly due to a GH-secreting pituitary tumour. However, GH and IGF-1 levels can be discordant in patients with acromegaly due to early or partially treated disease, or there might be another cause of high GH or high IGF-1 unrelated to acromegaly, such as pre-analytical
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The prevalence of IGF-I axis genetic polymorphisms among decathlon athletes Growth Horm. IGF Res. (IF 1.4) Pub Date : 2022-05-18 Sigal Ben-Zaken, Yoav Meckel, Liina Remmel, Dan Nemet, Jaak Jürimäe, Alon Eliakim
Objective Decathlon is a combined track and field competition, consisting of ten, mainly anaerobic events. Insulin-like growth factor-I (IGF1) axis plays a pivotal role in athletes' structural and functional muscle adaptation to exercise training, and in their competitive performance. Based on the great demand for speed physiological characteristics among decathlon athletes, the aim of this study was
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Growth of teeth and bones in adult subjects with congenital untreated isolated growth hormone deficiency Growth Horm. IGF Res. (IF 1.4) Pub Date : 2022-05-19 Luiz A. Oliveira-Neto, Jéssica K.F. Nascimento, Roberto Salvatori, Alécia A. Oliveira-Santos, Rafaela S. Girão, Evânio V. Silva, André L.M. Santos, Matheus M. Cunha, Marcos A.V. Bittencourt, Gustavo T. Rodrigues, Bruna M.R. Andrade, Alaíde H.A. Oliveira, Eugênia H.O. Valença, Manuel H. Aguiar-Oliveira
Objective To understand the growth of teeth and mandibular and maxillary bones in subjects with isolated growth hormone deficiency (IGHD). Material and methods Mesiodistal tooth width of 28 maxillary and mandibular dental models of 14 adult IGHD subjects (9 men) were digitalized and compared to 40 models of 20 normal-statured controls (11 men). The mean SDS of the maxillary and mandibular teeth were
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Growth hormone modulates Trypanosoma cruzi infection in vitro Growth Horm. IGF Res. (IF 1.4) Pub Date : 2022-04-15 Patricia Mora-Criollo, Reetobrata Basu, Yanrong Qian, Jaime A. Costales, Jaime Guevara-Aguirre, Mario J. Grijalva, John J. Kopchick
Objective Chagas disease (CD) is caused by the protozoan parasite, Trypanosoma cruzi. It affects 7 to 8 million people worldwide and leads to approximately 50,000 deaths per year. In vitro and in vivo studies had demonstrated that Trypanosoma cruziinfection causes an imbalance in the hypothalamic-pituitary-adrenal (HPA) axis that is accompanied by a progressive decrease in growth hormone (GH) and prolactin
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Meta-analysis of MspI derived variants of growth hormone gene associated with milk yield in dairy cattle Growth Horm. IGF Res. (IF 1.4) Pub Date : 2022-03-31 Yogesh C. Bangar, Ankit Magotra, A.S. Yadav, C.S. Patil
Objective The present work aimed to obtain common effect sizes for the gene frequency and association of MspI derived variants of growth hormone (GH) gene with milk yield in dairy cows. Methods We performed a systematic review and meta-analysis of 35 published studies identified in literature search from 2000 to 2020 (n = 4164). These studies were specific to fragment size (329) for genotypes viz.
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The role of growth hormone for fertility in women with hypopituitarism Growth Horm. IGF Res. (IF 1.4) Pub Date : 2022-03-29 Julie Chen, Laurence Katznelson
Growth hormone (GH) is an important regulator of the female reproductive system. In vitro and non-human in vivo studies demonstrate a role of GH in steroidogenesis, folliculogenesis, and post-fertilization development. Given its ability to modulate the reproductive system and potentiate the effects of gonadotropins, a beneficial role of GH replacement therapy to optimize fertility has been suggested
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The true story of the “strong and gentle” Acciano's Giant Growth Horm. IGF Res. (IF 1.4) Pub Date : 2022-03-18 Maria Maddalena Sirufo, Lina Maria Magnanimi, Lia Ginaldi, Massimo De Martinis
This is the story of a giant who lived in Abruzzo 200 years ago. He became a symbol for his people and a strong resilience generator. Gigantism, in the history of humanity has always attracted attention, albeit passing over the centuries from myth, from divinity to the freak phenomenon, the freak of nature that becomes a spectacle to show off. The attraction for understanding the pathophysiological
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Liver and muscle-specific effects of phoenixin-20 on the insulin-like growth factor system mRNAs in zebrafish Growth Horm. IGF Res. (IF 1.4) Pub Date : 2022-03-10 Jithine Jayakumar Rajeswari, Emilio J. Vélez, Suraj Unniappan
Objective Phoenixin-20 (Pnx-20) is a bioactive peptide with endocrine-like actions in vertebrates. Recent studies suggest Pnx-20 promotes growth hormone/insulin-like growth factors (Gh/Igf) axis, an important endocrine regulator of growth in mammals and fish. Design In this research, we determined whether Pnx-20 affects the different members of the Igf family, its binding proteins and receptors (Igf-system)
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Effects of high-dose all-trans retinoic acid on longitudinal bone growth of young rats Growth Horm. IGF Res. (IF 1.4) Pub Date : 2022-02-05 Qin Shen, Xia Wang, Haodi Bai, Xin Tan, Xing Liu
Objective The signaling axis consisting of GH-IGF1-IGFBP3 is the primary signal taht acts prepubertally to influence height development. Growth plate thinning and even premature closure have been reported in children with tumors treated with retinoid chemotherapy, resulting in long bone dysplasia. Growth failure may occur despite received GH treatment, but the reason is unknown. This study investigate
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Hormonal, metabolic, and angiogenic responses to all-out sprint interval exercise under systemic hyperoxia Growth Horm. IGF Res. (IF 1.4) Pub Date : 2022-02-02 Michihiro Kon, Yoshiko Ebi, Kohei Nakagaki
Objective Hyperoxic gas inhalation during exercise may negatively affect all-out sprint interval exercise (SIE)-induced hormonal, metabolic, and angiogenic responses. We investigated the effects of acute all-out SIE under systemic hyperoxia on hormonal, metabolic, and angiogenic responses. Design This was a randomised-crossover trial. Ten healthy males (mean ± standard error of age = 23.1 ± 0.9 years;