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  • Retraction Note: Comparison of traditional and new generation DNA markers declares high genetic diversity and differentiated population structure of wild almond species
    Sci. Rep. (IF 3.998) Pub Date : 2020-09-22
    Karim Sorkheh; Mehrana Koohi Dehkordi; Sezai Ercisli; Attila Hegedus; Júlia Halász

    Editor's Note: this Article has been retracted; the Retraction Note is available at https://www.nature.com/articles/s41598-020-72522-x

    更新日期:2020-09-22
  • Author Correction: A thrombolytic therapy using diagnostic ultrasound combined with RGDS-targeted microbubbles and urokinase in a rabbit model
    Sci. Rep. (IF 3.998) Pub Date : 2020-09-22
    Lina Guan; Chunmei Wang; Xue Yan; Liyun Liu; Yanhong Li; Yuming Mu

    An amendment to this paper has been published and can be accessed via a link at the top of the paper.

    更新日期:2020-09-22
  • Screening participation after a false positive result in organized cervical cancer screening: a nationwide register-based cohort study
    Sci. Rep. (IF 3.998) Pub Date : 2020-09-22
    Pernille Thordal Larsen; Susanne Fogh Jørgensen; Mette Tranberg; Sisse Helle Njor

    Our aim was to investigate whether receiving a false positive (FP) cervical cytology result affected subsequent cervical cancer screening participation. This Danish nationwide register-based cohort study included 502,380 women aged 22.5–45 attending cervical cancer screening in 2012–2014 with a normal (n = 501,003) or FP (n = 1,377) cytology screening result. A FP result was defined as a cervical cytology

    更新日期:2020-09-22
  • Dorsolateral prefrontal cortex-based control with an implanted brain–computer interface
    Sci. Rep. (IF 3.998) Pub Date : 2020-09-22
    Sacha Leinders; Mariska J. Vansteensel; Mariana P. Branco; Zac V. Freudenburg; Elmar G. M. Pels; Benny Van der Vijgh; Martine J. E. Van Zandvoort; Nicolas F. Ramsey; Erik J. Aarnoutse

    The objective of this study was to test the feasibility of using the dorsolateral prefrontal cortex as a signal source for brain–computer interface control in people with severe motor impairment. We implanted two individuals with locked-in syndrome with a chronic brain–computer interface designed to restore independent communication. The implanted system (Utrecht NeuroProsthesis) included electrode

    更新日期:2020-09-22
  • Foraging postures are a potential communicative signal in female bonobos
    Sci. Rep. (IF 3.998) Pub Date : 2020-09-22
    Elisa Demuru; François Pellegrino; Dan Dediu; Florence Levréro

    Body postures are essential in animal behavioural repertoires and their communicative role has been assessed in a wide array of taxa and contexts. Some body postures function as amplifiers, a class of signals that increase the detection likelihood of other signals. While foraging on the ground, bonobos (Pan paniscus) can adopt different crouching postures exposing more or less of their genital area

    更新日期:2020-09-22
  • Hydrogen-bonded host–guest systems are stable in ionic liquids
    Sci. Rep. (IF 3.998) Pub Date : 2020-09-22
    Teresa Naranjo; Rubén Álvarez-Asencio; Patricia Pedraz; Belén Nieto-Ortega; Sara Moreno-Da Silva; Enrique Burzurí; Mark W. Rutland; Emilio M. Pérez

    We show that H-bonded host–guest systems associate in ionic liquids (ILs), pure salts with melting point below room temperature, in which dipole–dipole electrostatic interactions should be negligible in comparison with dipole-charge interactions. Binding constants (Ka) obtained from titrations of four H-bonded host–guest systems in two organic solvents and two ionic liquids yield smaller yet comparable

    更新日期:2020-09-22
  • Cross-sectional study of Staphyloccus lugdunensis prevalence in cats
    Sci. Rep. (IF 3.998) Pub Date : 2020-09-22
    Karolina Bierowiec

    Staphylococcus lugdunensis is a commensal bacterium in humans and other animals that can cause serious infections. The aim of this research was to estimate the frequency of S. lugdunensis in pet cats and to characterize the S. lugdunensis isolates obtained. The prevalence of S. lugdunensis was 0.77% (4/523) in healthy cats and 1.23% (1/81) in sick cats. The isolates (N = 5), which colonized conjunctival

    更新日期:2020-09-22
  • Stokes–Mueller method for comprehensive characterization of coherent terahertz waves
    Sci. Rep. (IF 3.998) Pub Date : 2020-09-22
    Xin Chai; Xavier Ropagnol; Luis. Sanchez Mora; S. Mohsen Raeiszadeh; Saffiedin Safavi-Naeini; François Blanchard; Tsuneyuki Ozaki

    Ideally, the full characterization of coherent terahertz (THz) pulses would provide information on the amplitude and direction of its THz electric field, in space and in time, with unlimited dynamic range. Here, we propose and demonstrate a new approach based on the Stokes–Mueller formalism. Our approach can measure the full temporal and spatial variation of coherent THz fields, as well as its polarization

    更新日期:2020-09-22
  • Soluble urokinase plasminogen activator receptor level in individuals of advanced age
    Sci. Rep. (IF 3.998) Pub Date : 2020-09-22
    Rafal N. Wlazel; Katarzyna Szwabe; Agnieszka Guligowska; Tomasz Kostka

    Soluble urokinase plasminogen activator receptor (suPAR) is a biomarker whose clinical value has been tested in various groups of patients. The aim of the present study was to determine the suPAR level in a previously uninvestigated population of 182, generally healthy, community-dwelling seniors aged 74–89 years. In addition to suPAR level, selected laboratory parameters of heart and kidney function

    更新日期:2020-09-22
  • Dynamic and subtype-specific interactions between tumour burden and prognosis in breast cancer
    Sci. Rep. (IF 3.998) Pub Date : 2020-09-22
    S. B. Lee; H.-K. Kim; Y. Choi; Y. W. Ju; H.-B. Lee; W. Han; D.-Y. Noh; B. H. Son; S. H. Ahn; K. S. Kim; S. J. Nam; E.‑K. Kim; H. Y. Park; W.-C. Park; J. W. Lee; H.-G. Moon

    We investigated the relationship between the prognostic importance of anatomic tumour burden and subtypes of breast cancer using data from the Korean Breast Cancer Registry Database. In HR+/HER2+ and HR−/HER2−tumours, an increase in T stage profoundly increased the hazard of death, while the presence of lymph node metastasis was more important in HR+/HER2+ and HR−/HER2+ tumours among 131,178 patients

    更新日期:2020-09-22
  • Formation of quantum dots in GaN/AlGaN FETs
    Sci. Rep. (IF 3.998) Pub Date : 2020-09-22
    Tomohiro Otsuka; Takaya Abe; Takahito Kitada; Norikazu Ito; Taketoshi Tanaka; Ken Nakahara

    GaN and the heterostructures are attractive in condensed matter science and applications for electronic devices. We measure the electron transport in GaN/AlGaN field-effect transistors (FETs) at cryogenic temperature. We observe formation of quantum dots in the conduction channel near the depletion of the 2-dimensional electron gas (2DEG). Multiple quantum dots are formed in the disordered potential

    更新日期:2020-09-22
  • Melt crystallization mechanism analyzed with dimensional reduction of high-dimensional data representing distribution function geometries
    Sci. Rep. (IF 3.998) Pub Date : 2020-09-22
    Hiroki Nada

    Melt crystallization is essential to many industrial processes, including semiconductor, ice, and food manufacturing. Nevertheless, our understanding of the melt crystallization mechanism remains poor. This is because the molecular-scale structures of melts are difficult to clarify experimentally. Computer simulations, such as molecular dynamics (MD), are often used to investigate melt structures.

    更新日期:2020-09-22
  • Prediction of age-related macular degeneration disease using a sequential deep learning approach on longitudinal SD-OCT imaging biomarkers
    Sci. Rep. (IF 3.998) Pub Date : 2020-09-22
    Imon Banerjee; Luis de Sisternes; Joelle A. Hallak; Theodore Leng; Aaron Osborne; Philip J. Rosenfeld; Giovanni Gregori; Mary Durbin; Daniel Rubin

    We propose a hybrid sequential prediction model called “Deep Sequence”, integrating radiomics-engineered imaging features, demographic, and visual factors, with a recursive neural network (RNN) model in the same platform to predict the risk of exudation within a future time-frame in non-exudative AMD eyes. The proposed model provides scores associated with risk of exudation in the short term (within

    更新日期:2020-09-22
  • Digestive activity and organic compounds of Nezara viridula watery saliva induce defensive soybean seed responses
    Sci. Rep. (IF 3.998) Pub Date : 2020-09-22
    Romina Giacometti; Vanesa Jacobi; Florencia Kronberg; Charalampos Panagos; Arthur S. Edison; Jorge A. Zavala

    The stink bug Nezara viridula is one of the most threatening pests for agriculture in North and South America, and its oral secretion may be responsible for the damage it causes in soybean (Glycine max) crop. The high level of injury to seeds caused by pentatomids is related to their feeding behavior, morphology of mouth parts, and saliva, though information on the specific composition of the oral

    更新日期:2020-09-22
  • The distinctive geographic patterns of common pigmentation variants at the OCA2 gene
    Sci. Rep. (IF 3.998) Pub Date : 2020-09-22
    Kenneth K. Kidd; Andrew J. Pakstis; Michael P. Donnelly; Ozlem Bulbul; Lotfi Cherni; Cemal Gurkan; Longli Kang; Hui Li; Libing Yun; Peristera Paschou; Kelly A. Meiklejohn; Eva Haigh; William C. Speed

    Oculocutaneous Albinism type 2 (OCA2) is a gene of great interest because of genetic variation affecting normal pigmentation variation in humans. The diverse geographic patterns for variant frequencies at OCA2 have been evident but have not been systematically investigated, especially outside of Europe. Here we examine population genetic variation in and near the OCA2 gene from a worldwide perspective

    更新日期:2020-09-22
  • Assessing magnetic and inductive thermal properties of various surfactants functionalised Fe 3 O 4 nanoparticles for hyperthermia
    Sci. Rep. (IF 3.998) Pub Date : 2020-09-22
    Arunima Rajan; Madhulika Sharma; Niroj Kumar Sahu

    This work reports the fabrication of magnetite (Fe3O4) nanoparticles (NPs) coated with various biocompatible surfactants such as glutamic acid (GA), citric acid (CA), polyethylene glycol (PEG), polyvinylpyrrolidine (PVP), ethylene diamine (EDA) and cetyl-trimethyl ammonium bromide (CTAB) via co-precipitation method and their comparative inductive heating ability for hyperthermia (HT) applications.

    更新日期:2020-09-22
  • Alternative splicing of MR1 regulates antigen presentation to MAIT cells
    Sci. Rep. (IF 3.998) Pub Date : 2020-09-22
    Gitanjali A. Narayanan; Abhinav Nellore; Jessica Tran; Aneta H. Worley; Erin W. Meermeier; Elham Karamooz; Megan E. Huber; Regina Kurapova; Fikadu G. Tafesse; Melanie J. Harriff; David M. Lewinsohn

    Mucosal Associated Invariant T (MAIT) cells can sense intracellular infection by a broad array of pathogens. These cells are activated upon encountering microbial antigen(s) displayed by MR1 on the surface of an infected cell. Human MR1 undergoes alternative splicing. The full-length isoform, MR1A, can activate MAIT cells, while the function of the isoforms, MR1B and MR1C, are incompletely understood

    更新日期:2020-09-22
  • Regulation of degenerative spheroids after injury
    Sci. Rep. (IF 3.998) Pub Date : 2020-09-22
    Yu Yong; Kanchana Gamage; Courtny Cushman; Anthony Spano; Christopher Deppmann

    Neuronal injury leads to rapid, programmed disintegration of axons distal to the site of lesion. Much like other forms of axon degeneration (e.g. developmental pruning, toxic insult from neurodegenerative disorder), Wallerian degeneration associated with injury is preceded by spheroid formation along axons. The mechanisms by which injury leads to formation of spheroids and whether these spheroids have

    更新日期:2020-09-22
  • Hyperspectral evaluation of hepatic oxygenation in a model of total vs. arterial liver ischaemia
    Sci. Rep. (IF 3.998) Pub Date : 2020-09-22
    Eric Felli; Mahdi Al-Taher; Toby Collins; Andrea Baiocchini; Emanuele Felli; Manuel Barberio; Giuseppe Maria Ettorre; Didier Mutter; Veronique Lindner; Alexandre Hostettler; Sylvain Gioux; Catherine Schuster; Jacques Marescaux; Michele Diana

    Liver ischaemia reperfusion injury (IRI) is a dreaded pathophysiological complication which may lead to an impaired liver function. The level of oxygen hypoperfusion affects the level of cellular damage during the reperfusion phase. Consequently, intraoperative localisation and quantification of oxygen impairment would help in the early detection of liver ischaemia. To date, there is no real-time,

    更新日期:2020-09-22
  • Magneto-mechanically actuated microstructures to efficiently prevent bacterial biofilm formation
    Sci. Rep. (IF 3.998) Pub Date : 2020-09-22
    S. Leulmi Pichot; H. Joisten; A. J. Grant; B. Dieny; R. P. Cowburn

    Biofilm colonisation of surfaces is of critical importance in various areas ranging from indwelling medical devices to industrial setups. Of particular importance is the reduced susceptibility of bacteria embedded in a biofilm to existing antimicrobial agents. In this paper, we demonstrate that remotely actuated magnetic cantilevers grafted on a substrate act efficiently in preventing bacterial biofilm

    更新日期:2020-09-22
  • Isotopic systematics point to wild origin of mummified birds in Ancient Egypt
    Sci. Rep. (IF 3.998) Pub Date : 2020-09-22
    Marie Linglin; Romain Amiot; Pascale Richardin; Stéphanie Porcier; Ingrid Antheaume; Didier Berthet; Vincent Grossi; François Fourel; Jean-Pierre Flandrois; Antoine Louchart; Jeremy E. Martin; Christophe Lécuyer

    Millions of mummified birds serving for religious purpose have been discovered from archeological sites along the Nile Valley of Egypt, in majority ibises. Whether these birds were industrially raised or massively hunted is a matter of heavy debate as it would have a significant impact on the economy related to their supply and cult, and if hunted it would have represented an ecological burden on the

    更新日期:2020-09-22
  • Binary symbolic dynamics analysis to detect stress-associated changes of nonstationary heart rate variability
    Sci. Rep. (IF 3.998) Pub Date : 2020-09-22
    Conrad Spellenberg; Peter Heusser; Arndt Büssing; Andreas Savelsbergh; Dirk Cysarz

    Psychological stress may have harmful physiological effects and result in deteriorating health. Acute psychological stress acts also on cardiac autonomic regulation and may lead to nonstationarities in the interbeat interval series. We address the requirement of stationary RR interval series to calculate frequency domain parameters of heart rate variability (HRV) and use binary symbolic dynamics derived

    更新日期:2020-09-22
  • Detecting differential ground displacements of civil structures in fast-subsiding metropolises with interferometric SAR and band-pass filtering
    Sci. Rep. (IF 3.998) Pub Date : 2020-09-22
    Darío Solano-Rojas; Shimon Wdowinski; Enrique Cabral-Cano; Batuhan Osmanoğlu

    Ground displacements due to changes in soil conditions represent a threat to the stability of civil structures in many urban areas, worldwide. In fast-subsiding areas, regional subsidence (wavelength ~ 1,000’s m) can be dominantly high and, consequently, mask other signals at local scales (wavelength ~ 10–100’s m). Still, engineering and construction applications require a comprehensive knowledge of

    更新日期:2020-09-22
  • Next-generation visitation models using social media to estimate recreation on public lands
    Sci. Rep. (IF 3.998) Pub Date : 2020-09-22
    Spencer A. Wood; Samantha G. Winder; Emilia H. Lia; Eric M. White; Christian S. L. Crowley; Adam A. Milnor

    Outdoor and nature-based recreation provides countless social benefits, yet public land managers often lack information on the spatial and temporal extent of recreation activities. Social media is a promising source of data to fill information gaps because the amount of recreational use is positively correlated with social media activity. However, despite the implication that these correlations could

    更新日期:2020-09-22
  • Maternal exercise conveys protection against NAFLD in the offspring via hepatic metabolic programming
    Sci. Rep. (IF 3.998) Pub Date : 2020-09-22
    Inga Bae-Gartz; Philipp Kasper; Nora Großmann; Saida Breuer; Ruth Janoschek; Tobias Kretschmer; Sarah Appel; Lisa Schmitz; Christina Vohlen; Alexander Quaas; Michal R. Schweiger; Christina Grimm; Axel Fischer; Nina Ferrari; Christine Graf; Christian K. Frese; Sonja Lang; Münevver Demir; Christoph Schramm; Gregor Fink; Tobias Goeser; Jörg Dötsch; Eva Hucklenbruch-Rother

    Maternal exercise (ME) during pregnancy has been shown to improve metabolic health in offspring and confers protection against the development of non-alcoholic fatty liver disease (NAFLD). However, its underlying mechanism are still poorly understood, and it remains unclear whether protective effects on hepatic metabolism are already seen in the offspring early life. This study aimed at determining

    更新日期:2020-09-22
  • Differential experiences of embodiment between body-powered and myoelectric prosthesis users
    Sci. Rep. (IF 3.998) Pub Date : 2020-09-22
    Susannah M. Engdahl; Sean K. Meehan; Deanna H. Gates

    Prosthesis embodiment, the perception of a prosthesis as part of one’s body, may be an important component of functional recovery for individuals with upper limb absence. This work determined whether embodiment differs between body-powered and myoelectric prosthesis users. In a sample of nine individuals with transradial limb absence, embodiment was quantified using a survey regarding prosthesis ownership

    更新日期:2020-09-22
  • Pancreatic β-cells respond to fuel pressure with an early metabolic switch
    Sci. Rep. (IF 3.998) Pub Date : 2020-09-22
    Ronja M. Malinowski; Seyed M. Ghiasi; Thomas Mandrup-Poulsen; Sebastian Meier; Mathilde H. Lerche; Jan H. Ardenkjær-Larsen; Pernille R. Jensen

    Pancreatic β-cells become irreversibly damaged by long-term exposure to excessive glucose concentrations and lose their ability to carry out glucose stimulated insulin secretion (GSIS) upon damage. The β-cells are not able to control glucose uptake and they are therefore left vulnerable for endogenous toxicity from metabolites produced in excess amounts upon increased glucose availability. In order

    更新日期:2020-09-22
  • Magma chamber evolution during the 1650 AD Kolumbo eruption provides clues about past and future volcanic activity
    Sci. Rep. (IF 3.998) Pub Date : 2020-09-22
    K. I. Konstantinou

    Kolumbo submarine volcano lies 7 km NE of Santorini caldera and its last eruption which occurred in 1650 AD, caused damage and casualties to the nearby islands. Here a simple model of a chamber, containing silicic magma underlain by a smaller quantity of mafic magma, is utilised in order to understand the chamber behaviour during the 1650 AD eruption. Results show that in order to reproduce the duration

    更新日期:2020-09-22
  • Mortality and risk of tuberculosis among people living with HIV in whom TB was initially ruled out
    Sci. Rep. (IF 3.998) Pub Date : 2020-09-22
    Juan Ignacio García; Edson Mambuque; Dinis Nguenha; Faustino Vilanculo; Charfudin Sacoor; Victor Guillermo Sequera; Manuel Fernández-Quevedo; Maxime Leroux-La Pierre; Helio Chiconela; Luis A. Faife; Durval Respeito; Belén Saavedra; Tacilta Nhampossa; Elisa López-Varela; Alberto L. Garcia-Basteiro

    Tuberculosis (TB) misdiagnosis remains a public health concern, especially among people living with HIV (PLHIV), given the high mortality associated with missed TB diagnoses. The main objective of this study was to describe the all-cause mortality, TB incidence rates and their associated risk factors in a cohort of PLHIV with presumptive TB in whom TB was initially ruled out. We retrospectively followed

    更新日期:2020-09-22
  • Potential of aquatic weeds to improve water quality in natural waterways of the Zambezi catchment
    Sci. Rep. (IF 3.998) Pub Date : 2020-09-22
    R. Scott Winton; Fritz Kleinschroth; Elisa Calamita; Martina Botter; Cristian R. Teodoru; Imasiku Nyambe; Bernhard Wehrli

    One prominent effect of nutrient pollution of surface waters is the mass invasion of floating plants, which can clog waterways, disrupting human use of aquatic systems. These plants are widely vilified and motivate expensive control campaigns, but their presence may be providing a poorly recognized function in the cycling of excess nutrients. The capacity for floating plants to absorb nutrients from

    更新日期:2020-09-22
  • Calcaneus height is a key morphological factor of sprint performance in sprinters
    Sci. Rep. (IF 3.998) Pub Date : 2020-09-22
    Tadashi Suga; Msafumi Terada; Takahiro Tanaka; Yuto Miyake; Hiromasa Ueno; Mitsuo Otsuka; Akinori Nagano; Tadao Isaka

    This study examined the relationships between the foot bone morphologies and sprint performance in sprinters. Foot images in 56 male sprinters obtained using magnetic resonance imaging. The relative lengths of the forefoot bones of the big and second toes, which were calculated as total lengths of the forefoot bones for each toe normalized to the foot length, correlated significantly with personal

    更新日期:2020-09-22
  • Population genetic structure of the great star coral, Montastraea cavernosa, across the Cuban archipelago with comparisons between microsatellite and SNP markers
    Sci. Rep. (IF 3.998) Pub Date : 2020-09-22
    Alexis B. Sturm; Ryan J. Eckert; Juliett González Méndez; Patricia González-Díaz; Joshua D. Voss

    Coral reef habitats surrounding Cuba include relatively healthy, well-developed shallow and mesophotic (30–150 m) scleractinian communities at the cross-currents of the Tropical Western Atlantic (TWA). However, Cuba’s coral communities are not immune to the declines observed throughout the TWA, and there is limited information available regarding genetic connectivity, diversity, and structure among

    更新日期:2020-09-22
  • Neuroprotective effect of indomethacin in normal perfusion pressure breakthrough phenomenon
    Sci. Rep. (IF 3.998) Pub Date : 2020-09-22
    Manuel Revuelta; Alvaro Zamarrón; Jose Fortes; Gregorio Rodríguez-Boto; Raquel Gutiérrez-González

    Loss of cerebral autoregulation in normal perfusion pressure breakthrough (NPPB) phenomenon has been reported in other Central Nervous System diseases such as neonatal intraventricular haemorrhage. Several studies have demonstrated that low-dose indomethacin prevents this latter condition. A previous rat model was used to resemble NPPB phenomenon. Study animals were distributed in 4 groups that received

    更新日期:2020-09-22
  • Photoperiodic effects on monoamine signaling and gene expression throughout development in the serotonin and dopamine systems
    Sci. Rep. (IF 3.998) Pub Date : 2020-09-22
    Justin K. Siemann; Piper Williams; Turnee N. Malik; Chad R. Jackson; Noah H. Green; Ronald B. Emeson; Pat Levitt; Douglas G. McMahon

    Photoperiod or the duration of daylight has been implicated as a risk factor in the development of mood disorders. The dopamine and serotonin systems are impacted by photoperiod and are consistently associated with affective disorders. Hence, we evaluated, at multiple stages of postnatal development, the expression of key dopaminergic (TH) and serotonergic (Tph2, SERT, and Pet-1) genes, and midbrain

    更新日期:2020-09-22
  • Early-stage knee OA induced by MIA and MMT compared in the murine model via histological and topographical approaches
    Sci. Rep. (IF 3.998) Pub Date : 2020-09-22
    Gaetan Aüllo-Rasser; Erick Dousset; Sandrine Roffino; Hassan Zahouani; Roger Lecurieux-Clerville; Jean-Noël Argenson; Patrick Chabrand

    Osteoarthritis (OA) is a common degenerative disease whose early management includes promising mechanical treatments. New treatments are initially validated using an animal model in which OA is induced. The MMT (mechanical induction) and MIA (chemical induction) models of OA induction are widespread, but their use to generate early OA is poorly documented. We analyzed and compared early-stage knee

    更新日期:2020-09-22
  • Chloroplast development and genomes uncoupled signaling are independent of the RNA-directed DNA methylation pathway
    Sci. Rep. (IF 3.998) Pub Date : 2020-09-22
    Liangsheng Wang; Dario Leister; Tatjana Kleine

    The Arabidopsis genome is methylated in CG and non-CG (CHG, and CHH in which H stands for A, T, or C) sequence contexts. DNA methylation has been suggested to be critical for seed development, and CHH methylation patterns change during stratification and germination. In plants, CHH methylation occurs mainly through the RNA-directed DNA methylation (RdDM) pathway. To test for an involvement of the RdDM

    更新日期:2020-09-22
  • Parallel model-based and model-free reinforcement learning for card sorting performance
    Sci. Rep. (IF 3.998) Pub Date : 2020-09-22
    Alexander Steinke; Florian Lange; Bruno Kopp

    The Wisconsin Card Sorting Test (WCST) is considered a gold standard for the assessment of cognitive flexibility. On the WCST, repeating a sorting category following negative feedback is typically treated as indicating reduced cognitive flexibility. Therefore such responses are referred to as ‘perseveration’ errors. Recent research suggests that the propensity for perseveration errors is modulated

    更新日期:2020-09-22
  • A neurobehavioral study on the efficacy of price interventions in promoting healthy food choices among low socioeconomic families
    Sci. Rep. (IF 3.998) Pub Date : 2020-09-22
    Tannista Banerjee; Veena Chattaraman; Hao Zou; Gopikrishna Deshpande

    Given the healthcare costs associated with obesity (especially in childhood), governments have tried several fiscal and policy interventions such as lowering tax and giving rebates to encourage parents to choose healthier food for their family. The efficacy of such fiscal policies is currently being debated. Here we address this issue by investigating how behavioral and brain-based responses in parents

    更新日期:2020-09-22
  • Correlation between δ 18 Ow and δ 18 Οen for estimating human mobility and paleomobility patterns
    Sci. Rep. (IF 3.998) Pub Date : 2020-09-22
    Elissavet Dotsika

    In this study a methodology for identifying the geographic origin of unidentified persons, their residence and moving patterns while providing information on lifestyle, diet and socio-economic status by combining stable isotopic data, with the biological information (isotopic composition of the skeleton), is presented. This is accomplished by comparing the oxygen isotopic composition of the spring

    更新日期:2020-09-22
  • Comparison of ultrasmall IONPs and Fe salts biocompatibility and activity in multi-cellular in vitro models
    Sci. Rep. (IF 3.998) Pub Date : 2020-09-22
    Natalia Janik-Olchawa; Agnieszka Drozdz; Damian Ryszawy; Maciej Pudełek; Karolina Planeta; Zuzanna Setkowicz; Maciej Śniegocki; Andrzej Żądło; Beata Ostachowicz; Joanna Chwiej

    In the paper, the results of the first regular studies of ultra-small iron oxide nanoparticles (IONPs) toxicity in vitro were presented. The influence of PEG-coated NPs with 5 nm magnetite core on six different cell lines was examined. These were: human bronchial fibroblasts, human embryonic kidney cells (HEK293T), two glioblastoma multiforme (GBM) cell lines as well as GBM cells isolated from a brain

    更新日期:2020-09-22
  • Removal of anionic dye Congo red from aqueous environment using polyvinyl alcohol/sodium alginate/ZSM-5 zeolite membrane
    Sci. Rep. (IF 3.998) Pub Date : 2020-09-22
    Sabarish Radoor; Jasila Karayil; Jyotishkumar Parameswaranpillai; Suchart Siengchin

    In this study, a novel PVA/SA/ZSM-5 zeolite membrane with good regeneration capacity was successfully prepared by solvent casting technique. The properties of the membranes were assessed by employing different characterization techniques such as X-ray diffraction (XRD), Fourier-transform infrared spectroscopy (FT-IR), scanning electron microscope (SEM), optical microscopy (OP), thermogravimetric analysis

    更新日期:2020-09-22
  • Effects of optogenetic stimulation of basal forebrain parvalbumin neurons on Alzheimer’s disease pathology
    Sci. Rep. (IF 3.998) Pub Date : 2020-09-22
    Caroline A. Wilson; Sarah Fouda; Shuzo Sakata

    Neuronal activity can modify Alzheimer’s disease pathology. Overexcitation of neurons can facilitate disease progression whereas the induction of cortical gamma oscillations can reduce amyloid load and improve cognitive functions in mouse models. Although previous studies have induced cortical gamma oscillations by either optogenetic activation of cortical parvalbumin-positive (PV+) neurons or sensory

    更新日期:2020-09-22
  • Regulation of Ras homolog family member G by microRNA-124 regulates proliferation and migration of human retinal pigment epithelial cells
    Sci. Rep. (IF 3.998) Pub Date : 2020-09-22
    Jong Hwa Jun; Myeong-Jin Son; Hyun-Gyo Lee; Kyu Young Shim; Won-Ki Baek; Jae-Young Kim; Choun-Ki Joo

    Uncontrolled retinal pigment epithelial (RPE) cell proliferation/migration contribute to the pathological tractional membrane development in proliferative vitreoretinopathy. Recent studies reported that microRNA (miR)-124 controls various cellular functions via the direct targeting of small Ras homolog family member G (RHOG). Therefore, we investigated the role of the neuron-specific miR-124 and RHOG

    更新日期:2020-09-22
  • Omega-3 index and blood pressure responses to eating foods naturally enriched with omega-3 polyunsaturated fatty acids: a randomized controlled trial
    Sci. Rep. (IF 3.998) Pub Date : 2020-09-22
    Alice V. Stanton; Kirstyn James; Margaret M. Brennan; Fiona O’Donovan; Fahad Buskandar; Kathleen Shortall; Thora El-Sayed; Jean Kennedy; Heather Hayes; Alan G. Fahey; Niall Pender; Simon A. M. Thom; Niamh Moran; David J. Williams; Eamon Dolan

    Diets low in seafood omega-3 polyunsaturated fatty acids (PUFAs) are very prevalent. Such diets have recently been ranked as the sixth most important dietary risk factor—1.5 million deaths and 33 million disability-adjusted life-years worldwide are attributable to this deficiency. Wild oily fish stocks are insufficient to feed the world’s population, and levels of eicosapentaenoic acid and docosahexaenoic

    更新日期:2020-09-22
  • Rhizobacterial species richness improves sorghum growth and soil nutrient synergism in a nutrient-poor greenhouse soil
    Sci. Rep. (IF 3.998) Pub Date : 2020-09-22
    Mohammad Radhi Sahib; Zahida H. Pervaiz; Mark A. Williams; Muhammad Saleem; Seth DeBolt

    Although microbes influence plant growth, little is known about the impact of microbial diversity on plant fitness trade-offs, intraspecific-interactions, and soil nutrient dynamics in the context of biodiversity-ecosystem functioning (BEF) research. The BEF theory states that higher species richness can enhance ecosystem functioning. Thus, we hypothesize that rhizobacterial species richness will alter

    更新日期:2020-09-22
  • Fueling of a marine-terrestrial ecosystem by a major seabird colony
    Sci. Rep. (IF 3.998) Pub Date : 2020-09-22
    J. Hentati-Sundberg; C. Raymond; M. Sköld; O. Svensson; B. Gustafsson; S. Bonaglia

    Seabirds redistribute nutrients between different ecosystem compartments and over vast geographical areas. This nutrient transfer may impact both local ecosystems on seabird breeding islands and regional biogeochemical cycling, but these processes are seldom considered in local conservation plans or biogeochemical models. The island of Stora Karlsö in the Baltic Sea hosts the largest concentration

    更新日期:2020-09-22
  • A high throughput screening system for studying the effects of applied mechanical forces on reprogramming factor expression
    Sci. Rep. (IF 3.998) Pub Date : 2020-09-22
    Jason Lee; Miguel Armenta Ochoa; Pablo Maceda; Eun Yoon; Lara Samarneh; Mitchell Wong; Aaron B. Baker

    Mechanical forces are important in the regulation of physiological homeostasis and the development of disease. The application of mechanical forces to cultured cells is often performed using specialized systems that lack the flexibility and throughput of other biological techniques. In this study, we developed a high throughput platform for applying complex dynamic mechanical forces to cultured cells

    更新日期:2020-09-22
  • Forensic tracers of exposure to produced water in freshwater mussels: a preliminary assessment of Ba, Sr, and cyclic hydrocarbons
    Sci. Rep. (IF 3.998) Pub Date : 2020-09-22
    Paulina K. Piotrowski; Travis L. Tasker; Thomas J. Geeza; Bonnie McDevitt; David P. Gillikin; Nathaniel R. Warner; Frank L. Dorman

    Hydraulic fracturing is often criticized due in part to the potential degradation of ground and surface water quality by high-salinity produced water generated during well stimulation and production. This preliminary study evaluated the response of the freshwater mussel, Elliptio complanata, after exposure to produced water. A limited number of adult mussels were grown over an 8-week period in tanks

    更新日期:2020-09-22
  • Identification and validation of novel and more effective choline kinase inhibitors against Streptococcus pneumoniae
    Sci. Rep. (IF 3.998) Pub Date : 2020-09-22
    Tahl Zimmerman; Valerie Chasten; Juan Carlos Lacal; Salam A. Ibrahim

    Streptococcus pneumoniae choline kinase (sChoK) has previously been proposed as a drug target, yet the effectiveness of the first and only known inhibitor of sChoK, HC-3, is in the millimolar range. The aim of this study was thus to further validate sChoK as a potential therapeutic target by discovering more powerful sChoK inhibitors. LDH/PK and colorimetric enzymatic assays revealed two promising

    更新日期:2020-09-22
  • Divalent cation-induced conformational changes of influenza virus hemagglutinin
    Sci. Rep. (IF 3.998) Pub Date : 2020-09-22
    Jong Hyeon Seok; Hyojin Kim; Dan Bi Lee; Jeong Suk An; Eun Jeong Kim; Ji-Hye Lee; Mi Sook Chung; Kyung Hyun Kim

    Divalent cations Cu2+ and Zn2+ can prevent the viral growth in mammalian cells during influenza infection, and viral titers decrease significantly on a copper surface. The underlying mechanisms include DNA damage by radicals, modulation of viral protease, M1 or neuraminidase, and morphological changes in viral particles. However, the molecular mechanisms underlying divalent cation-mediated antiviral

    更新日期:2020-09-22
  • Hyperactive and impulsive behaviors of LMTK1 knockout mice
    Sci. Rep. (IF 3.998) Pub Date : 2020-09-22
    Miyuki Takahashi; Arika Sugiyama; Ran Wei; Shizuka Kobayashi; Kimiko Fukuda; Hironori Nishino; Roka Takahashi; Koji Tsutsumi; Ichiro Kita; Kanae Ando; Toshiya Manabe; Hiroyuki Kamiguchi; Mineko Tomomura; Shin-ichi Hisanaga

    Lemur tail kinase 1 (LMTK1), previously called Apoptosis-Associated Tyrosine Kinase (AATYK), remains an uncharacterized Ser/Thr protein kinase that is predominantly expressed in the brain. It is recently reported that LMTK1A, an isoform of LMTK1, binds to recycling endosomes through its palmitoylation and regulates endosomal trafficking by suppressing the activity of Rab11 small GTPase. In neurons

    更新日期:2020-09-22
  • Neural sources of letter and Vernier acuity
    Sci. Rep. (IF 3.998) Pub Date : 2020-09-22
    Elham Barzegaran; Anthony M. Norcia

    Visual acuity can be measured in many different ways, including with letters and Vernier offsets. Prior psychophysical work has suggested that the two acuities are strongly linked given that they both depend strongly on retinal eccentricity and both are similarly affected in amblyopia. Here we used high-density EEG recordings to ask whether the underlying neural sources are common as suggested by the

    更新日期:2020-09-22
  • Serum fatty acid chain length associates with prevalent symptomatic end-stage osteoarthritis, independent of BMI
    Sci. Rep. (IF 3.998) Pub Date : 2020-09-22
    J. M. T. A. Meessen; F. Saberi-Hosnijeh; N. Bomer; W. den Hollander; J. G. van der Bom; J. A. van Hilten; W. E. van Spil; C. So-Osman; A. G. Uitterlinden; M. Kloppenburg; R. G. H. H. Nelissen; C. M. van Duijn; P. E. Slagboom; J. B. J. van Meurs; I. Meulenbelt

    Higher body mass index (BMI) is associated with osteoarthritis (OA) in both weight-bearing and non-weight-bearing joints, suggesting a link between OA and poor metabolic health beyond mechanical loading. This risk may be influenced by systemic factors accompanying BMI. Fluctuations in concentrations of metabolites may mark or even contribute to development of OA. This study explores the association

    更新日期:2020-09-22
  • Fine-scale landscape genetics unveiling contemporary asymmetric movement of red panda ( Ailurus fulgens ) in Kangchenjunga landscape, India
    Sci. Rep. (IF 3.998) Pub Date : 2020-09-22
    Supriyo Dalui; Hiren Khatri; Sujeet Kumar Singh; Shambadeb Basu; Avijit Ghosh; Tanoy Mukherjee; Lalit Kumar Sharma; Randeep Singh; Kailash Chandra; Mukesh Thakur

    Wildlife management in rapid changing landscapes requires critical planning through cross cutting networks, and understanding of landscape features, often affected by the anthropogenic activities. The present study demonstrates fine-scale spatial patterns of genetic variation and contemporary gene flow of red panda (Ailurus fulgens) populations with respect to landscape connectivity in Kangchenjunga

    更新日期:2020-09-22
  • Lifespan risks of growing up in a family with mental illness or substance abuse
    Sci. Rep. (IF 3.998) Pub Date : 2020-09-22
    Vera Clemens; Oliver Berthold; Andreas Witt; Cedric Sachser; Elmar Brähler; Paul L. Plener; Bernhard Strauß; Jörg M. Fegert

    Growing up in a family with one member being affected by mental health problems or substance abuse is an adverse childhood experience which can lead to socioeconomic and health-related impairments in later life. Furthermore, the risk of child maltreatment is increased in affected families, which often adds to the individual risk factors. However, the interdependence between the particular risk factors

    更新日期:2020-09-22
  • Sharing and caring: Testosterone, fathering, and generosity among BaYaka foragers of the Congo Basin
    Sci. Rep. (IF 3.998) Pub Date : 2020-09-22
    Lee T. Gettler; Sheina Lew-Levy; Mallika S. Sarma; Valchy Miegakanda; Adam H. Boyette

    Humans are rare among mammals in exhibiting paternal care and the capacity for broad hyper-cooperation, which were likely critical to the evolutionary emergence of human life history. In humans and other species, testosterone is often a mediator of life history trade-offs between mating/competition and parenting. There is also evidence that lower testosterone men may often engage in greater prosocial

    更新日期:2020-09-22
  • Assessment of non-inferiority with meta-analysis: example of hypofractionated radiation therapy in breast and prostate cancer
    Sci. Rep. (IF 3.998) Pub Date : 2020-09-22
    Jane-Chloé Trone; Edouard Ollier; Céline Chapelle; Patrick Mismetti; Michel Cucherat; Nicolas Magné; Paul Jacques Zuffrey; Silvy Laporte

    The aim of this study was to propose a methodology for the assessment of non-inferiority with meta-analysis. Assessment of hypofractionated RT in prostate and breast cancers is used as an illustrative example. Non-inferiority assessment of an experimental treatment versus an active comparator should rely on two elements: (1) an estimation of experimental treatment’s effect versus the active comparator

    更新日期:2020-09-22
  • Local anaesthesia decreases nerve growth factor induced masseter hyperalgesia
    Sci. Rep. (IF 3.998) Pub Date : 2020-09-22
    Yuri M. Costa; Fernando G. Exposto; Eduardo E. Castrillon; Paulo César R. Conti; Leonardo R. Bonjardim; Peter Svensson

    The aim of this investigation was to evaluate the effects of local anaesthesia on nerve growth factor (NGF) induced masseter hyperalgesia. Healthy participants randomly received an injection into the right masseter muscle of either isotonic saline (IS) given as a single injection (n = 15) or an injection of NGF (n = 30) followed by a second injection of lidocaine (NGF + lidocaine; n = 15) or IS (NGF + IS;

    更新日期:2020-09-22
  • Unique repertoire of anti-carbohydrate antibodies in individual human serum
    Sci. Rep. (IF 3.998) Pub Date : 2020-09-22
    Ralph N. D. Luetscher; Tanya R. McKitrick; Chao Gao; Akul Y. Mehta; Alyssa M. McQuillan; Robert Kardish; Kayluz Frias Boligan; Xuezheng Song; Lenette Lu; Jamie Heimburg-Molinaro; Stephan von Gunten; Galit Alter; Richard D. Cummings

    Humoral immunity to pathogens and other environmental challenges is paramount to maintain normal health, and individuals lacking or unable to make antibodies are at risk. Recent studies indicate that many human protective antibodies are against carbohydrate antigens; however, little is known about repertoires and individual variation of anti-carbohydrate antibodies in healthy individuals. Here we analyzed

    更新日期:2020-09-22
  • Mechanistic study of attenuation of monosodium glutamate mixed high lipid diet induced systemic damage in rats by Coccinia grandis
    Sci. Rep. (IF 3.998) Pub Date : 2020-09-22
    Arnab Banerjee; Debasmita Das; Rajarshi Paul; Sandipan Roy; Ujjal Das; Samrat Saha; Sanjit Dey; Arghya Adhikary; Sandip Mukherjee; Bithin Kumar Maji

    In the context of failure of treatment for non alcoholic fatty liver disease (NAFLD)-mediated systemic damages, recognition of novel and successful characteristic drug to combat these anomalous situations is earnestly required. The present study is aimed to evaluate protective value of ethanol extract of Coccinia grandis leaves (EECGL), naturally occurring medicinal plant, on NAFLD-mediated systemic

    更新日期:2020-09-22
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