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Exploring the application of poly(1,2-ethanediol citrate)/polylactide nonwovens in cell culturing Front. Bioeng. Biotech. (IF 5.7) Pub Date : 2024-03-15 Aleksandra Bandzerewicz, Joanna Howis, Kamil Wierzchowski, Miroslav Slouf, Jiri Hodan, Piotr Denis, Tomasz Gołofit, Maciej Pilarek, Agnieszka Gadomska-Gajadhur
Biomaterials containing citric acid as a building unit show potential for use as blood vessel and skin tissue substitutes. The success in commercializing implants containing a polymer matrix of poly(1,8-octanediol citrate) provides a rationale for exploring polycitrates based on other diols. Changing the aliphatic chain length of the diol allows functional design strategies to control the implant’s
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Orbital shaking conditions augment human nasoseptal cartilage formation in 3D culture Front. Bioeng. Biotech. (IF 5.7) Pub Date : 2024-03-15 Thomas Harry Jovic, Feihu Zhao, Henry Jia, Shareen Heather Doak, Iain Stuart Whitaker
Introduction: This study aimed to determine whether a dynamic orbital shaking culture system could enhance the cartilage production and viability of bioengineered nasoseptal cartilage.Methods: Human nasal chondrocytes were seeded onto nanocellulose-alginate biomaterials and cultured in static or dynamic conditions for 14 days. Quantitative polymerase chain reaction for chondrogenic gene expression
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Ethical implications of developing RNA-based therapies for cardiovascular disorders Front. Bioeng. Biotech. (IF 5.7) Pub Date : 2024-03-15 Mihaela Hostiuc, Alexandru Scafa, Bogdan Iancu, Daniela Iancu, Oana-Maria Isailă, Oana Mihaela Ion, Ana Stroe, Camelia Diaconu, Dragos Epistatu, Sorin Hostiuc
The awareness concerning RNA-based therapies was boosted significantly after the successful development of COVID-19 vaccines. However, they can potentially lead to significant advances in other areas of medicine, such as oncology or chronic diseases. In recent years, there has been an exponential increase in the number of RNA-based therapies that were evaluated as potential treatments for cardiovascular
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Targeted drug delivery of engineered mesenchymal stem/stromal-cell-derived exosomes in cardiovascular disease: recent trends and future perspectives Front. Bioeng. Biotech. (IF 5.7) Pub Date : 2024-03-15 Jian-Liang Pang, Hong Shao, Xiao-Gang Xu, Zhi-Wei Lin, Xiao-Yi Chen, Jin-Yang Chen, Xiao-Zhou Mou, Pei-Yang Hu
In recent years, stem cells and their secretomes, notably exosomes, have received considerable attention in biomedical applications. Exosomes are cellular secretomes used for intercellular communication. They perform the function of intercellular messengers by facilitating the transport of proteins, lipids, nucleic acids, and therapeutic substances. Their biocompatibility, minimal immunogenicity, targetability
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The influence of internal pressure and neuromuscular agents on C. elegans biomechanics: an empirical and multi-compartmental in silico modelling study Front. Bioeng. Biotech. (IF 5.7) Pub Date : 2024-03-15 Clara L. Essmann, Muna Elmi, Christoforos Rekatsinas, Nikolaos Chrysochoidis, Michael Shaw, Vijay Pawar, Mandayam A. Srinivasan, Vasileios Vavourakis
The function of a specific tissue and its biomechanics are interdependent, with pathologies or ageing often being intertwined with structural decline. The biomechanics of Caenorhabditis elegans, a model organism widely used in pharmacological and ageing research, has been established as biomarker for healthy ageing. However, the properties of the constituent tissues, and their contribution to the overall
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Effect of corneal cross-linking on biomechanical changes following transepithelial photorefractive keratectomy and femtosecond laser-assisted LASIK Front. Bioeng. Biotech. (IF 5.7) Pub Date : 2024-03-15 Wen Chen, FangJun Bao, Cynthia J. Roberts, Jia Zhang, Chong Wang, XueFei Li, JunJie Wang, Anas Ziad Masoud Abu Said, Kevin Nguelemo Mayopa, YaNi Chen, XiaoBo Zheng, Ashkan Eliasy, Ahmed Elsheikh, ShiHao Chen
Purpose: To evaluate the change in corneal biomechanics in patients with postoperative ectasia risk when combining two common laser vision correction procedures (tPRK and FS-LASIK) with cross-linking (in tPRK Xtra and FS-LASIK Xtra).Methods: The study included 143 eyes of 143 myopic, astigmatic patients that were divided into non-cross-linked refractive surgery groups (non-Xtra groups, tPRK and FS-LASIK)
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Applied insight: studying reducing the carbon footprint of the drying process and its environmental impact and financial return Front. Bioeng. Biotech. (IF 5.7) Pub Date : 2024-03-14 Ayman Ibrahim, Alia Amer, Islam Elsebaee, Amr Sabahe, Mariam A. Amer
Harnessing solar energy is one of the most important practical insights highlighted to mitigate the severe climate change (CC) phenomenon. Therefore, this study aims to focus on the use of hybrid solar dryers (HSDs) within an environmentally friendly framework, which is one of the promising applications of solar thermal technology to replace traditional thermal technology that contributes to increasing
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Engineering tumor-oxygenated nanomaterials: advancing photodynamic therapy for cancer treatment Front. Bioeng. Biotech. (IF 5.7) Pub Date : 2024-03-13 Tingting Zuo, Xiaodie Li, Xuan Ma, Ye Zhang, Xueru Li, Xuehai Fan, Mingze Gao, Donglin Xia, Huijun Cheng
Photodynamic therapy (PDT), a promising treatment modality, employs photosensitizers to generate cytotoxic reactive oxygen species (ROS) within localized tumor regions. This technique involves administering a photosensitizer followed by light activation in the presence of oxygen (O2), resulting in cytotoxic ROS production. PDT’s spatiotemporal selectivity, minimally invasive nature, and compatibility
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Genetic identification and expression optimization of a novel protease HapR from Bacillus velezensis Front. Bioeng. Biotech. (IF 5.7) Pub Date : 2024-03-13 Zhenying Han, Changwen Ye, Xinyu Dong, Chenchen Chen, Dian Zou, Kuo Huang, Xuetuan Wei
Due to the broad application and substantial market demand for proteases, it was vital to explore the novel and efficient protease resources. The aim of this study was to identify the novel protease for tobacco protein degradation and optimize the expression levels. Firstly, the tobacco protein was used as the sole nitrogen resource for isolation of protease-producing strains, and a strain with high
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Exploring biosurfactant from Halobacterium jilantaiense as drug against HIV and zika virus: fabrication, characterization, cytosafety property, molecular docking, and molecular dynamics simulation Front. Bioeng. Biotech. (IF 5.7) Pub Date : 2024-03-13 Mohammed S. Almuhayawi, Naglaa Elshafey, Nashwa Hagagy, Samy Selim, Soad K. Al Jaouni, Ahmed R. Sofy, Mennatalla Samy, Hattan S. Gattan, Mohammed H. Alruhaili, Mohanned Talal Alharbi, Mohammed K. Nagshabandi, Muyassar K. Tarabulsi, Mohamed E. Elnosary
Biosurfactants are surface-active molecules with unique qualities and various uses. Many microorganisms produce secondary metabolites with surface-active characteristics that serve various antiviral functions. The HIV and Zika viruses were chosen for this study because they can spread from mother to child and result in potentially fatal infections in infants. Halophilic bacteria from the Red Sea solar
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A review of antibody, aptamer, and nanomaterials synergistic systems for an amplified electrochemical signal Front. Bioeng. Biotech. (IF 5.7) Pub Date : 2024-03-13 Resmond L. Reaño, Erwin C. Escobar
The synergy between biomolecules with inorganic nanomaterials and nanoparticles has been investigated over the past years, primarily to improve biomarker reception, generate signals, and amplify the signals generated. In this paper, several articles on aptamer-based and antibody-based electrochemical biosensors that target antigens were examined. Among the key characteristics identified were the electrochemical
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Bioprinting of gelatin-based materials for orthopedic application Front. Bioeng. Biotech. (IF 5.7) Pub Date : 2024-03-13 Yusuf Olatunji Waidi, Ishaq Kariim, Sudipto Datta
Bio-printed hydrogels have evolved as one of the best regenerative medicine and tissue engineering platforms due to their outstanding cell-friendly microenvironment. A correct hydrogel ink formulation is critical for creating desired scaffolds that have better fidelity after printing. Gelatin and its derivatives have sparked intense interest in various biomedical sectors because of their biocompatibility
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In vitro and in silico biopotentials of phytochemical compositions and antistaphylococcal and antipseudomonal activities of volatile compounds of Argania spinosa (L.) seed oil Front. Bioeng. Biotech. (IF 5.7) Pub Date : 2024-03-13 Mohammed S. Almuhayawi, Mohammed H. Alruhaili, Hattan S. Gattan, Mohanned Talal Alharbi, Mohammed K. Nagshabandi, Nashwa Hagagy, Saad M. Almuhayawi, Soad K. Al Jaouni, Samy Selim, Ehab M. Mostafa, Mohamed E. Elnosary
Active components in medicinal plants provide unlimited useful and traditional medicines. Antimicrobial activities are found in secondary metabolites in plant extracts such as argan oil. This experimental investigation aims to determine argan oil’s volatile compounds and examine their in vitro antimicrobial properties. In silico simulations, molecular docking, pharmacokinetics, and drug-likeness prediction
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A GMR enzymatic assay for quantifying nuclease and peptidase activity Front. Bioeng. Biotech. (IF 5.7) Pub Date : 2024-03-13 Michael Sveiven, Ana K. Serrano, Joshua Rosenberg, Douglas J. Conrad, Drew A. Hall, Anthony J. O’Donoghue
Hydrolytic enzymes play crucial roles in cellular processes, and dysregulation of their activities is implicated in various physiological and pathological conditions. These enzymes cleave substrates such as peptide bonds, phosphodiester bonds, glycosidic bonds, and other esters. Detecting aberrant hydrolase activity is vital for understanding disease mechanisms and developing targeted therapeutic interventions
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Spent brewer’s yeast as a selective biosorbent for metal recovery from polymetallic waste streams Front. Bioeng. Biotech. (IF 5.7) Pub Date : 2024-03-13 Anna Sieber, Leon Robert Jelic, Klemens Kremser, Georg M. Guebitz
Graphical AbstractThe graphical abstract was created with BioRender.com.
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HyCas9-12aGEP: an efficient genome editing platform for Corynebacterium glutamicum Front. Bioeng. Biotech. (IF 5.7) Pub Date : 2024-03-12 Feng Zhang, Jin-Yu Wang, Chang-Lon Li, Wei-Guo Zhang
Corynebacterium glutamicum plays a crucial role as a significant industrial producer of metabolites. Despite the successful development of CRISPR-Cas9 and CRISPR-Cas12a-assisted genome editing technologies in C. glutamicum, their editing resolution and efficiency are hampered by the diverse on-target activities of guide RNAs (gRNAs). To address this problem, a hybrid CRISPR-Cas9-Cas12a genome editing
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Comparison of kinematics and joint moments calculations for lower limbs during gait using markerless and marker-based motion capture Front. Bioeng. Biotech. (IF 5.7) Pub Date : 2024-03-12 Tianchen Huang, Mianfang Ruan, Shangjun Huang, Linlin Fan, Xie Wu
Objective: This study aimed at quantifying the difference in kinematic and joint moments calculation for lower limbs during gait utilizing a markerless motion system (TsingVA Technology, Beijing, China) in comparison to values estimated using a marker-based motion capture system (Nokov Motion Capture System, Beijing, China).Methods: Sixteen healthy participants were recruited for the study. The kinematic
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Bioglass/ceria nanoparticle hybrids for the treatment of seroma: a comparative long-term study in rats Front. Bioeng. Biotech. (IF 5.7) Pub Date : 2024-03-12 Michael-Alexander Pais, Athanasios Papanikolaou, Isabel Arenas Hoyos, Robert Nißler, Simone De Brot, Alexander Gogos, Robert Rieben, Mihai A. Constantinescu, Martin T. Matter, Inge K. Herrmann, Ioana Lese
Background: Seroma formation is a common postoperative complication. Fibrin-based glues are typically employed in an attempt to seal the cavity. Recently, the first nanoparticle (NP)-based treatment approaches have emerged. Nanoparticle dispersions can be used as tissue glues, capitalizing on a phenomenon known as ‘nanobridging’. In this process, macromolecules such as proteins physically adsorb onto
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Kinematic analysis of an unrestrained passenger in an autonomous vehicle during emergency braking Front. Bioeng. Biotech. (IF 5.7) Pub Date : 2024-03-12 Silvia Santos-Cuadros, Álvaro Page del Pozo, Carolina Álvarez-Caldas, José Luis San Román García
Analyzing human body movement is a critical aspect of biomechanical studies in road safety. While most studies have traditionally focused on assessing the head-neck system due to the restraint provided by seat belts, it is essential to examine the entire pelvis-thorax-head kinematic chain when these body regions are free to move. The absence of restraint systems is prevalent in public transport and
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Evaluation of controllers for augmentative hip exoskeletons and their effects on metabolic cost of walking: explicit versus implicit synchronization Front. Bioeng. Biotech. (IF 5.7) Pub Date : 2024-03-12 Ali Reza Manzoori, Davide Malatesta, Julia Primavesi, Auke Ijspeert, Mohamed Bouri
Background: Efficient gait assistance by augmentative exoskeletons depends on reliable control strategies. While numerous control methods and their effects on the metabolic cost of walking have been explored in the literature, the use of different exoskeletons and dissimilar protocols limit direct comparisons. In this article, we present and compare two controllers for hip exoskeletons with different
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PIV-MyoMonitor: an accessible particle image velocimetry-based software tool for advanced contractility assessment of cardiac organoids Front. Bioeng. Biotech. (IF 5.7) Pub Date : 2024-03-12 Hoyeon Lee, Boyoung Kim, Jiyue Yun, Jinseung Bae, Sungsu Park, Junseok Jeon, Hye Ryoun Jang, Jaecheol Lee, Soah Lee
Induced pluripotent stem cell (iPSC)-derived cardiac organoids offer a versatile platform for personalized cardiac toxicity assessment, drug screening, disease modeling, and regenerative therapies. While previous image-based contractility analysis techniques allowed the assessment of contractility of two-dimensional cardiac models, they face limitations, including encountering high noise levels when
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Plantar pressure gradient and pressure gradient angle are affected by inner pressure of air insole Front. Bioeng. Biotech. (IF 5.7) Pub Date : 2024-03-11 Fahni Haris, Yih-Kuen Jan, Ben-Yi Liau, Chang-Wei Hsieh, Wei-Cheng Shen, Chien-Cheng Tai, Yin-Hwa Shih, Chi-Wen Lung
Clinically, air insoles may be applied to shoes to decrease plantar pressure gradient (PPG) and increase plantar gradient angle (PGA) to reduce foot ulcers. PPG and PGA may cause skin breakdown. The effects of different inner pressures of inflatable air insoles on dynamic PPG and PGA distributions are largely unknown in non-diabetics and people with diabetes. This study aimed to explore the impact
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Superior performance of biocomposite nanoparticles PLGA-RES in protecting oocytes against vitrification stimuli Front. Bioeng. Biotech. (IF 5.7) Pub Date : 2024-03-11 Guiping Hai, Jiachen Bai, Yucheng Liu, Jun Li, Aiju Liu, Jingjing Wang, Qian Liu, Weijun Liu, Pengcheng Wan, Xiangwei Fu
Irreversible cryogenic damage caused by oocyte vitrification limits its widespread use in female fertility preservation. In recent years, nanoparticles (NPs) have gained great attention as potential alternatives in protecting oocytes against cryoinjuries. In this paper, a novel composite nanoparticle, poly (lactic-co-glycolic acid)-resveratrol (PLGA-RES) was designed to improve the biocompatibility
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Knowledge and attitude toward transcranial magnetic stimulation among rehabilitation specialists in Saudi Arabia Front. Bioeng. Biotech. (IF 5.7) Pub Date : 2024-03-08 Alaa M. Albishi, Saja A. Alhadlaq, Rahaf T. Altowairqi, Mohammed F. Alharbi, Abdulrahman M. Alsubiheen, Manal H. Alosaimi, Shahid Bashir, Ahmad O. Alokaily
Research has demonstrated the benefits of transcranial magnetic stimulation (TMS) in rehabilitation. TMS has been widely used in clinical and research settings for individuals with and without neurological dysfunctions. Therefore, understanding the knowledge and attitudes of rehabilitation specialists regarding TMS is crucial for its application. To our knowledge, no such studies have previously been
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Site-selective fatty acid chain conjugation of the N-terminus of the recombinant human granulocyte colony-stimulating factor Front. Bioeng. Biotech. (IF 5.7) Pub Date : 2024-03-08 Xu-Dong Wang, Zhi-Hao Su, Jie Du, Wei-Jia Yu, Wen-Long Sun
The clinical application of the recombinant human granulocyte colony-stimulating factor (rhG-CSF) is restricted by its short serum half-life. Herein, site-selective modification of the N-terminus of rhG-CSF with PAL-PEG3-Ph-CHO was used to develop a long-acting rhG-CSF. The optimized conditions for rhG-CSF modification with PAL-PEG3-Ph-CHO were: reaction solvent system of 3% (w/v) Tween 20 and 30 mM
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Design and characterisation of a cell exposure system with high magnetic field homogeneity: RILZ coils Front. Bioeng. Biotech. (IF 5.7) Pub Date : 2024-03-08 Marco-Xavier Rivera González, Isabel López de Mingo, Alexandra Amuneke Ramírez, Ceferino Maestú Unturbe
In vitro studies requiring controlled exposure to low-frequency electromagnetic fields employ exposure systems with different geometries and configurations, the Helmholtz configuration being one of the most widely used. This configuration has limitations in the homogeneity of the spatial distribution of the magnetic field intensity values. We present the design, manufacturing, and characterisation
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A dual RPA-LFD assay for the simultaneous detection of Salmonella typhimurium and Salmonella enteritidis Front. Bioeng. Biotech. (IF 5.7) Pub Date : 2024-03-08 Chuan Liao, Lele Pan, Meiying Tan, Zihan Zhou, Shaoping Long, Xueli Yi, Xuebin Li, Guijiang Wei, Lina Liang
Introduction:Salmonella was one of the most common bacteria that caused foodborne illness, with S. typhimurium (Salmonella typhimurium) and S. enteritidis (Salmonella enteritidis) infections accounting for more than 75% of human salmonella infections.Methods: In this study, we developed a method of dual recombinase polymerase amplification (RPA) combined with a lateral flow dipstick for the rapid detection
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Experimental and virtual testing of bone-implant systems equipped with the AO Fracture Monitor with regard to interfragmentary movement Front. Bioeng. Biotech. (IF 5.7) Pub Date : 2024-03-08 Kerstin Wickert, Michael Roland, Annchristin Andres, Stefan Diebels, Bergita Ganse, Dorothea Kerner, Felix Frenzel, Thomas Tschernig, Manuela Ernst, Markus Windolf, Max Müller, Tim Pohlemann, Marcel Orth
Introduction: The management of fractured bones is a key domain within orthopedic trauma surgery, with the prevention of delayed healing and non-unions forming a core challenge. This study evaluates the efficacy of the AO Fracture Monitor in conjunction with biomechanical simulations to better understand the local mechanics of fracture gaps, which is crucial for comprehending mechanotransduction, a
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Load transfer in bone after partial, multi-compartmental, and total knee arthroplasty Front. Bioeng. Biotech. (IF 5.7) Pub Date : 2024-03-07 Jennifer C. Stoddart, Amy Garner, Mahmut Tuncer, Andrew A. Amis, Justin Cobb, Richard J. van Arkel
Introduction: Arthroplasty-associated bone loss remains a clinical problem: stiff metallic implants disrupt load transfer to bone and, hence, its remodeling stimulus. The aim of this research was to analyze how load transfer to bone is affected by different forms of knee arthroplasty: isolated partial knee arthroplasty (PKA), compartmental arthroplasty [combined partial knee arthroplasty (CPKA), two
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Prototype isochoric preservation device for large organs Front. Bioeng. Biotech. (IF 5.7) Pub Date : 2024-03-07 Alexandru Șerban, Gabriel Năstase, George-Andrei Beșchea, Ștefan-Ioan Câmpean, Cătălin Fetecău, Irinel Popescu, Florin Botea, Ion Neacșu
This paper presents the design and prototype of a constant volume (isochoric) vessel that can be used for the preservation of large organs in a supercooled state. This prototype is a preliminary version of a more advanced design. The device consists of a cooling bath operated by a mechanical vapor compression refrigeration unit and an isochoric chamber made of stainless steel. The preservation of organs
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Application of pectin hydrolyzing bacteria in tobacco to improve flue-cured tobacco quality Front. Bioeng. Biotech. (IF 5.7) Pub Date : 2024-03-07 Shuning Weng, Meizhong Deng, Shanyi Chen, Renqiang Yang, Jingjing Li, Xianbo Zhao, Shunhua Ji, Lixiang Wu, Li Ni, Enren Zhang, Chaochao Wang, Lingfeng Qi, Kuanqi Liao, Yiqiang Chen, Wen Zhang
To study the relationship between the diversity of the surface microbial community and tobacco flavor, and to improve tobacco quality using microorganisms. The microbial community composition and diversity of 14 samples of flue-cured tobacco from tobacco-producing areas in Yunnan with varying grades were analyzed by high-throughput sequencing. PICRUSt was used for predicting microbial functions. A
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Tension band high-strength suture combined with absorbable cannulated screws for treating transverse patellar fractures: finite element analysis and clinical study Front. Bioeng. Biotech. (IF 5.7) Pub Date : 2024-03-07 Feifan Xiang, Yukun Xiao, Dige Li, Wenzhe Ma, Yue Chen, Yunkang Yang
Objective: Few reports exist on the treatment of transverse patellar fractures (TPFs) using absorbable cannulated screws and high-strength sutures, and most screws and sutures lack good biomechanics and clinical trials. Therefore, this study aimed to demonstrate the biomechanical stability and clinical efficacy of tension-band high-strength sutures combined with absorbable cannulated screws (TBSAS)
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Research progress in cell therapy for oral diseases: focus on cell sources and strategies to optimize cell function Front. Bioeng. Biotech. (IF 5.7) Pub Date : 2024-03-07 Jing Wang, Zeqing Zhao, Kai Yang, Yuxing Bai
In recent years, cell therapy has come to play an important therapeutic role in oral diseases. This paper reviews the active role of mesenchymal stem cells, immune cell sources, and other cells in oral disorders, and presents data supporting the role of cell therapy in oral disorders, including bone and tooth regeneration, oral mucosal disorders, oral soft tissue defects, salivary gland dysfunction
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Chronic lateral ankle instability using anterior tibiofibular ligament distal fascicle transfer augmentation repair: an anatomical, biomechanical, and histological study Front. Bioeng. Biotech. (IF 5.7) Pub Date : 2024-03-07 Ruihan Wang, Yingqiu Yang, Guixuan You, Lei Huang, Xin Zhou, Songtao Jiang, Houyin Shi, Guoyou Wang, Lei Zhang
Background: The transfer of the anterior tibiofibular ligament distal fascicle (ATiFL-DF) for the augmentation repair of the anterior talofibular ligament (ATFL) shows potential as a surgical technique. However, evidences on the benefits and disadvantages of this method in relation to ankle joint function are lacking.Purpose: This study aimed to provide comprehensive experimental data to validate the
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Quantitative evaluation of motion compensation in post-stroke rehabilitation training based on muscle synergy Front. Bioeng. Biotech. (IF 5.7) Pub Date : 2024-03-07 Yanhong Liu, Yaowei Li, Zan Zhang, Benyan Huo, Anqin Dong
Introduction: Stroke is the second leading cause of death globally and a primary factor contributing to disability. Unilateral limb motor impairment caused by stroke is the most common scenario. The bilateral movement pattern plays a crucial role in assisting stroke survivors on the affected side to relearn lost skills. However, motion compensation often lead to decreased coordination between the limbs
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Quantifying walking speeds in relation to ankle biomechanics on a real-time interactive gait platform: a musculoskeletal modeling approach in healthy adults Front. Bioeng. Biotech. (IF 5.7) Pub Date : 2024-03-07 M. Peiffer, K. Duquesne, M. Delanghe, A. Van Oevelen, S. De Mits, E. Audenaert, A. Burssens
Background: Given the inherent variability in walking speeds encountered in day-to-day activities, understanding the corresponding alterations in ankle biomechanics would provide valuable clinical insights. Therefore, the objective of this study was to examine the influence of different walking speeds on biomechanical parameters, utilizing gait analysis and musculoskeletal modelling.Methods: Twenty
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A photoelectrochemical aptasensor based on double Z-scheme α-Fe2O3/MoS2/Bi2S3 ternary heterojunction for sensitive detection of circulating tumor cells Front. Bioeng. Biotech. (IF 5.7) Pub Date : 2024-03-07 Kai Feng, Ya Di, Meng Han, Weitao Yan, Yulin Guo, Xiangqian Huai, Yimin Wang
A novel photoelectrochemical (PEC) aptasensor based on a dual Z-scheme α-Fe2O3/MoS2/Bi2S3 ternary heterojunction for the ultrasensitive detection of circulating tumor cells (CTCs) was developed. The α-Fe2O3/MoS2/Bi2S3 nanocomposite was prepared via a step-by-step route, and the photoproduced electron/hole transfer path was speculated by conducting trapping experiments of reactive species. α-Fe2O3/MoS2/Bi2S3-modified
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Machine learning method for the classification of the state of living organisms’ oscillations Front. Bioeng. Biotech. (IF 5.7) Pub Date : 2024-03-07 David Kweku, Maria I. Villalba, Ronnie G. Willaert, Osvaldo M. Yantorno, Maria E. Vela, Anna K. Panorska, Sandor Kasas
The World Health Organization highlights the urgent need to address the global threat posed by antibiotic-resistant bacteria. Efficient and rapid detection of bacterial response to antibiotics and their virulence state is crucial for the effective treatment of bacterial infections. However, current methods for investigating bacterial antibiotic response and metabolic state are time-consuming and lack
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Therapeutic role of neural stem cells in neurological diseases Front. Bioeng. Biotech. (IF 5.7) Pub Date : 2024-03-07 Ling Yang, Si-Cheng Liu, Yi-Yi Liu, Fu-Qi Zhu, Mei-Juan Xiong, Dong-Xia Hu, Wen-Jun Zhang
The failure of endogenous repair is the main feature of neurological diseases that cannot recover the damaged tissue and the resulting dysfunction. Currently, the range of treatment options for neurological diseases is limited, and the approved drugs are used to treat neurological diseases, but the therapeutic effect is still not ideal. In recent years, different studies have revealed that neural stem
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Exploring the allelopathic autotoxicity mechanism of ginsenosides accumulation under ginseng decomposition based on integrated analysis of transcriptomics and metabolomics Front. Bioeng. Biotech. (IF 5.7) Pub Date : 2024-03-07 Rui Wang, Tingting Zhou, Yikai Wang, Jinxu Dong, Yutao Bai, Xin Huang, Changbao Chen
Continuous cropping obstacles seriously constrained the sustainable development of the ginseng industry. The allelopathic autotoxicity of ginsenosides is the key “trigger” of continuous cropping obstacles in ginseng. During harvest, the ginseng plants could be broken and remain in the soil. The decomposition of ginseng residue in soil is one of the important release ways of ginsenosides. Therefore
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Successive tendon injury in an in vivo rat overload model induces early damage and acute healing responses Front. Bioeng. Biotech. (IF 5.7) Pub Date : 2024-03-07 Pooja H. Chainani, Maria Buzo Mena, Diana Yeritsyan, Daniela Caro, Kaveh Momenzadeh, Jenna L. Galloway, Joseph P. DeAngelis, Arun J. Ramappa, Ara Nazarian
Introduction: Tendinopathy is a degenerative condition resulting from tendons experiencing abnormal levels of multi-scale damage over time, impairing their ability to repair. However, the damage markers associated with the initiation of tendinopathy are poorly understood, as the disease is largely characterized by end-stage clinical phenotypes. Thus, this study aimed to evaluate the acute tendon responses
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Nanotechnological advances in cancer: therapy a comprehensive review of carbon nanotube applications Front. Bioeng. Biotech. (IF 5.7) Pub Date : 2024-03-07 Siyang Gao, Binhan Xu, Jianwei Sun, Zhihui Zhang
Nanotechnology is revolutionising different areas from manufacturing to therapeutics in the health field. Carbon nanotubes (CNTs), a promising drug candidate in nanomedicine, have attracted attention due to their excellent and unique mechanical, electronic, and physicochemical properties. This emerging nanomaterial has attracted a wide range of scientific interest in the last decade. Carbon nanotubes
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Simulation and analysis of chest loads on crews during Lunar-Earth re-entry returns Front. Bioeng. Biotech. (IF 5.7) Pub Date : 2024-03-06 Jiatao Wang, Zhiyong Peng, Yongjie Yao, Qianxiang Zhou, Pan Guo
The safety of crews is the primary concern in the manned lunar landing project, particularly during re-entry as the manned spacecraft returns from a direct Lunar-Earth trajectory. This paper analyzed the crew’s chest biomechanical response to assess potential injuries caused by acceleration loads during the re-entry phase. Initially, a sophisticated finite element model of the chest was constructed
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DoE-based medium optimization for improved biosurfactant production with Aureobasidium pullulans Front. Bioeng. Biotech. (IF 5.7) Pub Date : 2024-03-06 Frederick Haala, Marie R. E. Dielentheis-Frenken, Friedrich M. Brandt, Tobias Karmainski, Lars M. Blank, Till Tiso
Polyol lipids (a.k.a. liamocins) produced by the polyextremotolerant, yeast-like fungus Aureobasidium pullulans are amphiphilic molecules with high potential to serve as biosurfactants. So far, cultivations of A. pullulans have been performed in media with complex components, which complicates further process optimization due to their undefined composition. In this study, we developed and optimized
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Three-dimensional model of normal human dermal tissue using serial tissue sections Front. Bioeng. Biotech. (IF 5.7) Pub Date : 2024-03-06 Peng Liu, Tao Zhang, Yihui Huang
Background: This study aims to construct a three-dimensional model of skin dermis utilizing continuous tissue sections, with the primary objective of obtaining anatomical structure data for normal human dermal tissues.Methods: Normal skin tissue specimens were acquired, paraffin-embedded, and subjected to HE staining. Panoramic images of skin sections were captured using a microscope. Tissue section
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Implications of O-glycan modifications in the hinge region of a plant-produced SARS-CoV-2-IgA antibody on functionality Front. Bioeng. Biotech. (IF 5.7) Pub Date : 2024-03-06 Pia Uetz, Kathrin Göritzer, Emil Vergara, Stanislav Melnik, Clemens Grünwald-Gruber, Rudolf Figl, Ala-Eddine Deghmane, Elisabetta Groppelli, Rajko Reljic, Julian K.-C. Ma, Eva Stöger, Richard Strasser
Introduction: Prolyl-4-hydroxylases (P4H) catalyse the irreversible conversion of proline to hydroxyproline, constituting a common posttranslational modification of proteins found in humans, plants, and microbes. Hydroxyproline residues can be further modified in plants to yield glycoproteins containing characteristic O-glycans. It is currently unknown how these plant endogenous modifications impact
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Robotic-assisted anatomic anterior cruciate ligament reconstruction: a comparative analysis of modified transtibial and anteromedial portal techniques in cadaveric knees Front. Bioeng. Biotech. (IF 5.7) Pub Date : 2024-03-06 Ling Zhang, Jinpeng Lin, Xuan Zhao, Mingwei Liu, Yao Hou, Yu Zhang, Jinzhong Zhao, Shaobai Wang
Introduction: This study employed surgical robot to perform anatomic single-bundle reconstruction using the modified transtibial (TT) technique and anteromedial (AM) portal technique. The purpose was to directly compare tunnel and graft characteristics of the two techniques.Methods: Eight cadaveric knees without ligament injury were used in the study. The modified TT and AM portal technique were both
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MicroRNA-155 mediates multiple gene regulations pertinent to the role of human adipose-derived mesenchymal stem cells in skin regeneration Front. Bioeng. Biotech. (IF 5.7) Pub Date : 2024-03-05 Hady Shahin, Luigi Belcastro, Jyotirmoy Das, Marina Perdiki Grigoriadi, Rolf B. Saager, Ingrid Steinvall, Folke Sjöberg, Pia Olofsson, Moustafa Elmasry, Ahmed T. El-Serafi
Introduction: The role of Adipose-derived mesenchymal stem cells (AD-MSCs) in skin wound healing remains to be fully characterized. This study aims to evaluate the regenerative potential of autologous AD-MSCs in a non-healing porcine wound model, in addition to elucidate key miRNA-mediated epigenetic regulations that underlie the regenerative potential of AD-MSCs in wounds. Methods: The regenerative
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Current developments and future perspectives of nanotechnology in orthopedic implants: an updated review Front. Bioeng. Biotech. (IF 5.7) Pub Date : 2024-03-04 Wenqing Liang, Chao Zhou, Juqin Bai, Hongwei Zhang, Hengguo Long, Bo Jiang, Haidong Dai, Jiangwei Wang, Hengjian Zhang, Jiayi Zhao
Orthopedic implants are the most commonly used fracture fixation devices for facilitating the growth and development of incipient bone and treating bone diseases and defects. However, most orthopedic implants suffer from various drawbacks and complications, including bacterial adhesion, poor cell proliferation, and limited resistance to corrosion. One of the major drawbacks of currently available orthopedic
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Morphology and transverse alignment of the patella have no effect on knee gait characteristics in healthy Chinese adults over the age of 40 years Front. Bioeng. Biotech. (IF 5.7) Pub Date : 2024-03-01 Zhengming Wang, Jiehang Lu, Haiya Ge, Zhengyan Li, Min Zhang, Fuwei Pan, Rui Wang, Hengkai Jin, Guangyue Yang, Zhibi Shen, Guoqing Du, Hongsheng Zhan
Background: The influence of patella morphology and horizontal alignment on knee joint kinematics and kinetics remains uncertain. This study aimed to assess patella morphology and transverse alignment in relation to knee kinetics and kinematics in individuals without knee conditions. A secondary objective was to investigate the impact of femur and tibia alignment and shape on knee gait within this
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Long-term continuous instrumented insole-based gait analyses in daily life have advantages over longitudinal gait analyses in the lab to monitor healing of tibial fractures Front. Bioeng. Biotech. (IF 5.7) Pub Date : 2024-03-01 Elke Warmerdam, Christian Wolff, Marcel Orth, Tim Pohlemann, Bergita Ganse
Introduction: Monitoring changes in gait during rehabilitation allows early detection of complications. Laboratory-based gait analyses proved valuable for longitudinal monitoring of lower leg fracture healing. However, continuous gait data recorded in the daily life may be superior due to a higher temporal resolution and differences in behavior. In this study, ground reaction force-based gait data
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Coupling dairy wastewaters for nutritional balancing and water recycling: sustainable heterologous 2-phenylethanol production by engineered cyanobacteria Front. Bioeng. Biotech. (IF 5.7) Pub Date : 2024-03-01 Giulia Usai, Alessandro Cordara, Elena Mazzocchi, Angela Re, Debora Fino, Candido Fabrizio Pirri, Barbara Menin
Microalgae biotechnology is hampered by the high production costs and the massive usage of water during large-volume cultivations. These drawbacks can be softened by the production of high-value compounds and by adopting metabolic engineering strategies to improve their performances and productivity. Today, the most sustainable approach is the exploitation of industrial wastewaters for microalgae cultivation
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Cancer diagnosis and treatment platform based on manganese-based nanomaterials Front. Bioeng. Biotech. (IF 5.7) Pub Date : 2024-03-01 Jia Fei, Yanyan Liu, Ya Zeng, Mingqi Yang, Shanshan Chen, Xiaobing Duan, Ligong Lu, Muhe Chen
Cancer is a leading cause of death worldwide, and the development of new diagnostic and treatment methods is crucial. Manganese-based nanomaterials (MnNMs) have emerged as a focal point in the field of cancer diagnosis and treatment due to their multifunctional properties. These nanomaterials have been extensively explored as contrast agents for various imaging technologies such as magnetic resonance
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How to make full use of dental pulp stem cells: an optimized cell culture method based on explant technology Front. Bioeng. Biotech. (IF 5.7) Pub Date : 2024-02-29 You Wu, Jiangling Sun, Wang Wang, Yao Wang, Reinhard E. Friedrich
Introduction: Dental pulp stem cells from humans possess self-renewal and versatile differentiation abilities. These cells, known as DPSC, are promising for tissue engineering due to their outstanding biological characteristics and ease of access without significant donor site trauma. Existing methods for isolating DPSC mainly include enzyme digestion and explant techniques. Compared with the enzymatic
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Evaluation of nanoparticle albumin-bound paclitaxel loaded macrophages for glioblastoma treatment based on a microfluidic chip Front. Bioeng. Biotech. (IF 5.7) Pub Date : 2024-02-29 Zuorun Xie, Junyi Ye, Xinghua Gao, Hang Chen, Maosong Chen, Jiangfang Lian, Jingyun Ma, Hongcai Wang
Introduction: Glioblastoma (GBM) is a primary brain malignancy with a dismal prognosis and remains incurable at present. In this study, macrophages (MΦ) were developed to carry nanoparticle albumin-bound paclitaxel (nab-PTX) to form nab-PTX/MΦ. The aim of this study is to use a GBM-on-a-chip to evaluate the anti-GBM effects of nab-PTX/MΦ. Methods: In this study, we constructed nab-PTX/MΦ by incubating
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The role of macrophage polarization in tendon healing and therapeutic strategies: Insights from animal models Front. Bioeng. Biotech. (IF 5.7) Pub Date : 2024-02-29 Yicheng Wang, Xiao Lu, Jianxi Lu, Philippe Hernigou, Fangchun Jin
Tendon injuries, a common musculoskeletal issue, usually result in adhesions to the surrounding tissue, that will impact functional recovery. Macrophages, particularly through their M1 and M2 polarizations, play a pivotal role in the inflammatory and healing phases of tendon repair. In this review, we explore the role of macrophage polarization in tendon healing, focusing on insights from animal models
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Variability of intervertebral joint stiffness between specimens and spine levels Front. Bioeng. Biotech. (IF 5.7) Pub Date : 2024-02-29 Samuele L. Gould, Giorgio Davico, Christian Liebsch, Hans-Joachim Wilke, Luca Cristofolini, Marco Viceconti
Introduction: Musculoskeletal multibody models of the spine can be used to investigate the biomechanical behaviour of the spine. In this context, a correct characterisation of the passive mechanical properties of the intervertebral joint is crucial. The intervertebral joint stiffness, in particular, is typically derived from the literature, and the differences between individuals and spine levels are
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Effectiveness of strontium/silver-based titanium surface coatings in improving antibacterial and osteogenic implant characteristics: a systematic review of in-vitro studies Front. Bioeng. Biotech. (IF 5.7) Pub Date : 2024-02-29 Marjan Kheirmand-Parizi, Katharina Doll-Nikutta, Amit Gaikwad, Hannah Denis, Meike Stiesch
Introduction: Due to the high incidence of implant failures, dual functionalization of titanium surfaces with antibacterial and osteogenic agents, like silver (Ag) and strontium (Sr), has gained significant attention in recent years. However, so far, the combined antibacterial and osteoinductive effectiveness of Ag/Sr-based titanium surface coatings has only been analyzed in individual studies.Methods:
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Distinguish different sensorimotor performance of the hand between the individuals with diabetes mellitus and chronic kidney disease through deep learning models Front. Bioeng. Biotech. (IF 5.7) Pub Date : 2024-02-29 Pu-Chun Mo, Hsiu-Yun Hsu, Cheng-Feng Lin, Yu-Shiuan Cheng, I-Te Tu, Li-Chieh Kuo, Fong-Chin Su
Diabetes mellitus and chronic kidney disease represent escalating global epidemics with comorbidities akin to neuropathies, resulting in various neuromuscular symptoms that impede daily performance. Interestingly, previous studies indicated differing sensorimotor functions within these conditions. If assessing sensorimotor features can effectively distinguish between diabetes mellitus and chronic kidney
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Inactivation of SARS CoV-2 on porous and nonporous surfaces by compact portable plasma reactor Front. Bioeng. Biotech. (IF 5.7) Pub Date : 2024-02-29 Bhaswati Choudhury, John A. Lednicky, Julia C. Loeb, Sherlie Portugal, Subrata Roy
We report the inactivation of SARS CoV-2 and its surrogate—Human coronavirus OC43 (HCoV-OC43), on representative porous (KN95 mask material) and nonporous materials (aluminum and polycarbonate) using a Compact Portable Plasma Reactor (CPPR). The CPPR is a compact (48 cm3), lightweight, portable and scalable device that forms Dielectric Barrier Discharge which generates ozone using surrounding atmosphere