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The effect of plasma cytokines on the expression of adiponectin and its receptors in the synovial membrane of joints and the infrapatellar fat pad in patients with rheumatoid arthritis and osteoarthritis Prostag. Other Lipid Mediat. (IF 2.9) Pub Date : 2024-03-02 Michał Czerewaty, Małgorzata Łączna, Kajetan Kiełbowski, Estera Bakinowska, Paweł Dec, Andrzej Modrzejewski, Daniel Kotrych, Piotr Burszewski, Krzysztof Safranow, Andrzej Pawlik
Rheumatoid arthritis (RA) is an autoimmune inflammatory disease that leads to joint destruction. Numerous pro-inflammatory mediators, including adipokines, play an important role in the pathogenesis of RA. The aim of the study was to investigate the relationships between selected plasma cytokines and expression of adiponectin and its receptors in the synovium and the infrapatellar fat pad in patients
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Biochemical Evaluation of Possible Protective Effect of Purslane Extract in Experimentally Induced Arthritis Associated with Obesity Prostag. Other Lipid Mediat. (IF 2.9) Pub Date : 2024-02-24 Mohamed G. Elharrif, H.A. Abdel Maksoud, M.H Abdullah, Alaa S. Abd Elmohsen
Arthritis, a prevalent inflammatory condition, is often linked to obesity as a contributing factor. This study aimed to assess the potential protective effects of purslane extract in male albino rats with induced arthritis and obesity. Fifty rats were randomly assigned to five groups: a control group, an induced arthritis-high-fat diet group, a high-dose purslane extract-supplemented group (300 mg/kg
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High-fat and carbohydrate diet caused chronic kidney damage by disrupting kidney function, caspase-3, oxidative stress and inflammation Prostag. Other Lipid Mediat. (IF 2.9) Pub Date : 2024-02-22 Zeynep Erdemli, Mehmet Gul, Elif Kayhan, Nurcan Gokturk, Harika Gozukara Bag, Mehmet Erman Erdemli
The study aimed to compare the effects of a diet rich in fat, carbohydrates and protein on rat kidneys. The study was conducted on 40 rats bred at İnönü University Faculty of Medicine after the approval of the ethics committee. Rats were randomly divided into 4 groups: Control group, and the groups where the animals were fed with high carbohydrate, fat and protein rich feed. After the applications
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Sevoflurane alleviates inflammation, apoptosis and permeability damage of human umbilical vein endothelial cells induced by lipopolysaccharide by inhibiting endoplasmic reticulum stress via upregulating RORα Prostag. Other Lipid Mediat. (IF 2.9) Pub Date : 2024-02-17 Weiwei Ni, Zhiwei Zou, Ping Jiang, Shuo Wang
Endothelial dysfunction often accompanies sepsis. Sevoflurane (Sev) is a widely used inhaled anesthetic that has a protective effect on sepsis-associated damage. We aimed to elucidate the role of Sev in endothelial dysfunction by using a model of LPS induced HUVECs. Sev increased the viability and decreased the apoptosis of HUVECs exposed to LPS. Inflammation and endothelial cell adhesion were improved
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2-iodohexadecanal induces autophagy during goiter involution Prostag. Other Lipid Mediat. (IF 2.9) Pub Date : 2024-02-11 Leonardo Salvarredi, Romina A. Oglio, Carla Rodriguez, Daniela Navarro, Marina Perona, María A. Dagrosa, Guillermo J. Juvenal, Lisa Thomasz
Iodine plays an important role in thyroid physiology and biochemistry. The thyroid is capable of producing different iodolipids such as 2-iodohexadecanal (2-IHDA). Data from different laboratories have shown that 2-IHDA inhibits several thyroid parameters and it has been postulated as intermediary on the action of iodide function. To explore different mechanisms involved during the involution of the
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Effect of platelet-activating factor on food intake, cloacal temperature, voluntary activity and crop emptying rate in chicks Prostag. Other Lipid Mediat. (IF 2.9) Pub Date : 2024-02-08 Tetsuya Tachibana, Chisato One, Sakirul Khan, Mark A. Cline
Platelet-activating factor (PAF) plays a significant role in several leucocyte functions, including platelet aggregation and inflammation. Additionally, PAF has a role in the behavioral and physiological changes in mammals. However, the effect of PAF has not been well studied in birds. Therefore, the study aimed to determine if PAF affects feeding behavior, voluntary activity, cloacal temperature,
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Overexpression of CuZn superoxide dismutase improves high-density lipoprotein function in swine Prostag. Other Lipid Mediat. (IF 2.9) Pub Date : 2024-02-06 Lichun Zhang, Tianliang Zhang, Xiaofeng Chen, Fengjiao Wang, Li Liu, Yanmei Yang, Yongqing Zeng, Yanhong Si, Nana Yang
Cardiovascular disease (CVD) has been the leading cause of death worldwide. As a chronic inflammatory disease, atherosclerosis (AS) acts as the initiating factor for CVD and reactive oxygen species (ROS) play a vital role in its development. Superoxide dismutases (SOD) can alleviate the detrimental effects of ROS and serve as the first line of defense through detoxifying the products derived from oxidative
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Urine LMs quantitative analysis strategy development and LMs CWP biomarkers discovery Prostag. Other Lipid Mediat. (IF 2.9) Pub Date : 2024-01-30 Yicong Geng, Chunmin Zhang, Ping He, Yi Wang, Lingfei Kong, Zhengying Li, Bin Wei, Yufang Ma, Handong Liang, Chunguang Ding, Cai Tie
Coal workers' pneumoconiosis (CWP) is one of the most common inhalation occupational diseases. It is no effective treatment methods. Early diagnosis of CWP could reduce mortality. Lipid mediators (LMs) as key mediators in the generation and resolution of inflammation, are natural biomarkers for diagnosis inflammatory disease, such as CWP. The UHPLC-MRM technique was used to detect LMs in urine. The
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Oxylipins biosynthesis and the regulation of bovine postpartum inflammation Prostag. Other Lipid Mediat. (IF 2.9) Pub Date : 2024-01-26 Jian Gong
Uncontrolled or dysregulated inflammation has adverse effects on the reproduction, production and health of animals, and is a major pathological cause of increased incidence and severity of infectious and metabolic diseases. To achieve successful transition from a non-lactation pregnant state to a non-pregnant lactation state, drastic metabolic and endocrine alteration have taken place in dairy cows
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Lipid mediators in glaucoma: Unraveling their diverse roles and untapped therapeutic potential Prostag. Other Lipid Mediat. (IF 2.9) Pub Date : 2024-01-26 DJ Mathew, JM Sivak
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Protective effect of misoprostol against paclitaxel-induced cardiac damage in rats Prostag. Other Lipid Mediat. (IF 2.9) Pub Date : 2024-01-20 İbrahim Aktaş, Fatih Mehmet Gur, Sedat BİLGİÇ
Objective One of the most critical reasons for limiting cancer treatment is the toxic effects of anti-cancer drugs on healthy tissues and organs. This study aims to investigate the possible protective effects of misoprostol (MS) against the damage that arises from paclitaxel (PT), an anti-cancer pharmacological agent, in the rat heart using histopathological and biochemical analyses. Methods In this
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Untargeted and temporal analysis of retinal lipidome in bacterial endophthalmitis Prostag. Other Lipid Mediat. (IF 2.9) Pub Date : 2024-01-05 Zeeshan Ahmad, Sukhvinder Singh, Tae Jin Lee, Ashok Sharma, Todd A. Lydic, Shailendra Giri, Ashok Kumar
Bacterial endophthalmitis is a blinding infectious disease typically acquired during ocular surgery. We previously reported significant alterations in retinal metabolism during Staphylococcus (S) aureus endophthalmitis. However, the changes in retinal lipid composition during endophthalmitis are unknown. Here, using a mouse model of S. aureus endophthalmitis and an untargeted lipidomic approach, we
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12-HETE activates Müller glial cells: The potential role of GPR31 and miR-29 Prostag. Other Lipid Mediat. (IF 2.9) Pub Date : 2023-12-22 Mohamed Moustafa, Abraham Khalil, Noureldien H.E. Darwish, Dao-Qi Zhang, Amany Tawfik, Mohamed Al-Shabrawey
Diabetic retinopathy (DR) is a neurovascular complication of diabetes, driven by an intricate network of cellular and molecular mechanisms. This study sought to explore the mechanisms by investigating the role of 12-hydroxyeicosatetraenoic acid (12-HETE), its receptor GPR31, and microRNA (miR-29) in the context of DR, specifically focusing on their impact on Müller glial cells. We found that 12-HETE
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Pomegranate seed oil mitigates liver and kidney damage in an experimental colitis model: Modulation of NF-κB activation and apoptosis Prostag. Other Lipid Mediat. (IF 2.9) Pub Date : 2023-12-07 Açelya Gül Koyuncu, Alev Cumbul, Elvan Yilmaz Akyüz, Müge Kopuz Alvarez Noval
Pomegranate seed oil, extracted from pomegranate seeds, is a slightly fragrant yellow oil with a mild odor. Pomegranate seed oil is the main source of punicic acid (conjugated linolenic acid). Punicic acid is a long-chain omega-5 polyunsaturated fatty acid and a conjugated α-linolenic acid molecule. This acid is thought to provide many health benefits. This study evaluated the potential of pomegranate
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Resolvin and lipoxin metabolism network regulated by Hyssopus Cuspidatus Boriss extract in asthmatic mice Prostag. Other Lipid Mediat. (IF 2.9) Pub Date : 2023-11-30 Ping He, Juan Hao, Ling-Fei Kong, Ayidana Wotan, Pan Yan, Yi-Cong Geng, Yi Wang, Zheng-Ying Li, Shi-Xian Hu, Bin Ren, Xiao-Juan Rong, Cai Tie
Resolvin (Rv) and lipoxin (Lx) play important regulative roles in the development of several inflammation-related diseases. The dysregulation of their metabolic network is believed to be closely related to the occurrence and development of asthma. The Hyssopus Cuspidatus Boriss extract (SXCF) has long been used as a treatment for asthma, while the mechanism of anti-inflammatory and anti-asthma action
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A new R,R-RvD6 isomer with protective actions following corneal nerve injury Prostag. Other Lipid Mediat. (IF 2.9) Pub Date : 2023-11-29 Haydee E.P. Bazan, Thang L. Pham
The transparent cornea is the most densely innervated tissue in the body, primarily by sensory nerves originating from the trigeminal ganglia (TG). Damage to corneal nerves reduces sensitivity and tear secretion and results in dry eye. Consequently, ocular pain, for which no satisfactory therapies exist, arises in many cases. Treatment of injured corneas with pigment epithelium-derived factor (PEDF)
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Moringa oleifera leaves extract loaded gold nanoparticles offers a promising approach in protecting against experimental nephrotoxicity Prostag. Other Lipid Mediat. (IF 2.9) Pub Date : 2023-11-27 Jihan Hussein, Mona El-Bana, Yasmin Abdel-Latif, Samah El-Sayed, Sahar Shaarawy, Dalia Medhat
Cisplatin is one of the most important antitumor drugs, however; it has numerous adverse effects like nephrotoxicity which is considered one of cisplatin uses . The study was planned to evaluate the nephroprotective effect of M. oleifera leaves extract loaded gold nanoparticles (Au-NPs) against cisplatin-induced nephrotoxicity in rats. Initially, total phenolic contents (TPC) and the antioxidant activity
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Analysis on the therapeutic effect of Cangfu Daotan Decoction combined with drospirenone and ethinylestradiol tablets (II) on patients with polycystic ovary syndrome Prostag. Other Lipid Mediat. (IF 2.9) Pub Date : 2023-11-18 Yanhong Fu, Pengpeng Xie, Qingping Yang, Peng Chen, Jingwei Yu
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The role of specialized pro-resolving mediators (SPMs) in inflammatory arthritis: A therapeutic strategy Prostag. Other Lipid Mediat. (IF 2.9) Pub Date : 2023-11-17 Mohammad Natami, Seyed Mehdi Hosseini, Raghad Abdulsalam Khaleel, Tamara Shamil Addulrahman, Mehdi Zarei, Sahar Asadi, Sepideh Gholami, Amir Mehrvar
Rheumatoid arthritis (RA) is classified as a persistent inflammatory autoimmune disorder leading to the subsequent erosion of articular cartilage and bone tissue originating from the synovium. The fundamental objective of therapeutic interventions in RA has been the suppression of inflammation. Nevertheless, conventional medicines that lack target specificity may exhibit unpredictable effects on cell
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Omega Fatty Acid Ratios and Neurodegeneration in a Healthy Environment Prostag. Other Lipid Mediat. (IF 2.9) Pub Date : 2023-11-15 H. Dere Yelken, M.P. Elci, P.F. Turker, S. Demirkaya
Neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, Multiple Sclerosis pose substantial public health challenges. While genetics play a primary role, recent research emphasizes the impact of environmental factors, particularly diet and lifestyle. This study investigates the initiating effects of Omega (ω)-3 and Omega (ω)-6 fatty acids on neuroinflammation, potentially contributing
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Oxylipin profiling by LC-ESI-MS/MS in canine serum and plasma to investigate ovulation-specific changes Prostag. Other Lipid Mediat. (IF 2.9) Pub Date : 2023-10-31 Margareta Ramström, Bodil S. Holst, Richard Lindberg, Malin L. Nording
New biomarkers that are directly associated with canine ovulation would be of value to ensure mating on optimal days of heat. In this study, canine plasma and serum were analyzed with liquid chromatography electrospray ionization tandem mass spectrometry (LC-ESI-MS/MS) to quantify a broad range of oxylipins for the purpose of developing a method for biomarker discovery studies in canine reproduction
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The synergistic effect of nanocurcumin and donepezil on Alzheimer's via PI3K/AKT/GSK-3β pathway modulating Prostag. Other Lipid Mediat. (IF 2.9) Pub Date : 2023-10-31 Doha M. Beltagy, Nagat F. Nawar, Tarek M. Mohamed, Ehab Tousson, Mai M. El-Keey
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A single extraction 96-well method for LC-MS/MS quantification of urinary eicosanoids, steroids and drugs Prostag. Other Lipid Mediat. (IF 2.9) Pub Date : 2023-10-23 Julia Sieminska, Johan Kolmert, Javier Zurita, Kurt Benkestock, Johanna Revol-Cavalier, Jacek Niklinski, Joanna Reszec, Sven-Erik Dahlén, Michal Ciborowski, Craig E. Wheelock
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Plasma oxylipin profiles reflect Parkinson's disease stage Prostag. Other Lipid Mediat. (IF 2.9) Pub Date : 2023-10-20 Dmitry V. Chistyakov, Nadezhda V. Azbukina, Alexander V. Lopachev, Sergei V. Goriainov, Alina A. Astakhova, Elena V. Ptitsyna, Anna S. Klimenko, Vsevolod V. Poleshuk, Rogneda B. Kazanskaya, Tatiana N. Fedorova, Marina G. Sergeeva
Derivatives of polyunsaturated fatty acids (PUFAs), also known as oxylipins, are key participants in regulating inflammation. Neuroinflammation is involved in many neurodegenerative diseases, including Parkinson's disease. The development of ultra-high-performance liquid chromatography-mass spectrometry (UPLC-MS/MS) facilitated the study of oxylipins on a system level, i.e., the analysis of oxylipin
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Effect of specialized pro-resolving lipid mediators in the regulation of vascular tone and inflammation in human saphenous vein Prostag. Other Lipid Mediat. (IF 2.9) Pub Date : 2023-10-06 Zeynep Celik, Gulsev Ozen, Seynur Sunar, Saygın Turkyilmaz, Gulsum Turkyilmaz, Ali Aycan Kavala, Onder Teskin, B.Sonmez Uydes Dogan, Gokce Topal
Specialized pro-resolving lipid mediators (SPMs), derived from polyunsaturated fatty acids are important mediators in the resolution of inflammation. Recent studies have focused on the effects of SPMs in cardiovascular health and diseases. However, little is known about the effect SPMs on human vascular tone. Therefore, in this study it is aimed to investigate the effect of various SPMs including resolvin
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The biosynthetic pathways of the protectins Prostag. Other Lipid Mediat. (IF 2.9) Pub Date : 2023-10-06 Åsmund Stenvik Haatveit, Trond Vidar Hansen
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Cilostazol induces vasorelaxation through the activation of the eNOS/NO/cGMP pathway, prostanoids, AMPK, PKC, potassium channels, and calcium channels Prostag. Other Lipid Mediat. (IF 2.9) Pub Date : 2023-09-21 Serdar Sahinturk
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Follistatin and follistatin-like 3 in metabolic disorders Prostag. Other Lipid Mediat. (IF 2.9) Pub Date : 2023-09-20 Weronika Bielka, Agnieszka Przezak, Andrzej Pawlik
Follistatin (FST) is a glycoprotein which main role is antagonizing activity of transforming growth factor β superfamily members. Folistatin-related proteins such as follistatin-like 3 (FSTL3) also reveal these properties. The exact function of them has still not been established, but it can be bound to the pathogenesis of metabolic disorders. So far, there were performed a few studies about their
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Uterodilation effect of unripe fruit extract of Crataegus azarolus var. aronia L. on rat uterine smooth muscles Prostag. Other Lipid Mediat. (IF 2.9) Pub Date : 2023-09-17 Aveen Abdullah Mohammed Ameen
Crataegus azarolus var. aronia L. (C. aronia) is one of the most important medicinal plants used widely in folk medicine for the prevention of several diseases due to its content of several bioactive compounds like phenolic acid, aromatic amines, proanthocyanidins and flavonoids. This study investigated the uterodilation effect of methanol extract (ME) of C. aronia unripe fruit on the uterine smooth
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Co-administration of curcumin and polyamines in high-fat diet induced obese rats: Assessment of changes in serum polyamine levels and some tissue parameters Prostag. Other Lipid Mediat. (IF 2.9) Pub Date : 2023-09-17 Gözde Dumlu Bilgin, Nihal Büyükuslu, Ozan Emre Eyüpoğlu, Alev Cumbul
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Imbalanced serum levels of resolvin E1 (RvE1) and leukotriene B4 (LTB4) may contribute to the pathogenesis of atherosclerosis Prostag. Other Lipid Mediat. (IF 2.9) Pub Date : 2023-09-11 Mohsen Molaie, Ramin Lotfi, Reza Heidari Moghadam, Alireza Rezaiemanesh, Ali Gorgin Karaji, Farhad Salari
Persistent and chronic unresolved inflammation exerts a critical role in developing atherosclerosis; however, mechanisms that prevent the resolution of inflammation in atherosclerosis are poorly delineated. This study aims to evaluate the serum levels of inflammatory high-sensitivity C-reactive protein (hsCRP), pro-inflammatory leukotriene B4 (LTB4), besides anti-inflammatory compounds, including eicosapentaenoic
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Bioinformatics analysis identifies the protective targets of omentin in mice with focal cerebral ischemia injury Prostag. Other Lipid Mediat. (IF 2.9) Pub Date : 2023-09-11 Wu Li, Jie Liu, Qi Zhang, Xiaojuan Ma, Jinwei Duan, Jiachen Wang, Ye Tian, Wenzhen Shi
Omentin is known to play a protective role in ischemic stroke. However, its regulatory networks and downstream targets in the pathogenesis of IS are incompletely revealed now. In this study, the model of photochemical brain ischemia was constructed after omentin over-expression. 8 key differentially expressed genes (DEGs) were obtained and analyzed by transcriptome analysis. These DEGs were mainly
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Prostaglandin D2 regulates Escherichia coli-induced inflammatory responses through TLR2, TLR4, and NLRP3 in macrophages Prostag. Other Lipid Mediat. (IF 2.9) Pub Date : 2023-09-03 Zhiguo Gong, Wei Mao, Feng Jin, Shuangyi Zhang, Jiamin Zhao, Peipei Ren, Zhuoya Yu, Yunjie Bai, Chao Wang, Jinshan Cao, Bo Liu
Prostaglandin D2 (PGD2) synthesis is closely associated with the innate immune response mediated by pattern recognition receptors (PPRs). We determined PGD2 synthesis whether mediated by Toll-like receptor 2 (TLR2), TLR4 and Nod-like receptor pyrin domain-containing protein 3 (NLRP3) in Escherichia coli (E. coli)-, lipopolysaccharide (LPS)- and Braun lipoprotein (BLP)-stimulated macrophages. Our data
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Binding interactions of fatty acyl lipid mediators within the vanilloid pocket of TRPV1: A molecular dynamics study Prostag. Other Lipid Mediat. (IF 2.9) Pub Date : 2023-08-30 Nada Birkic, David Visentin, Željko Svedružić, Christian A. Reynolds
The transient receptor potential vanilloid 1 (TRPV1) channel is a ligand-gated, nonselective cation channel expressed in primary sensory neurons, which has a role in nociception. The channel is activated by noxious heat, pH, capsaicin and other endogenous vanilloids, including lipid mediators (LMs) enzymatically derived from polyunsaturated fatty acids (PUFA). Although capsaicin binding to TRPV1 has
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The effect of SARS-CoV-2 variants on the plasma oxylipins and PUFAs of COVID-19 patients Prostag. Other Lipid Mediat. (IF 2.9) Pub Date : 2023-08-24 Denise Biagini, Paolo Oliveri, Andreina Baj, Daniela Dalla Gasperina, Francesca Drago Ferrante, Tommaso Lomonaco, Silvia Ghimenti, Alessio Lenzi, Andrea Bonini, Federico Vivaldi, Camille Oger, Jean-Marie Galano, Laurence Balas, Thierry Durand, Fabrizio Maggi, Fabio Di Francesco
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A novel HSPB1S139F mouse model of Charcot-Marie-Tooth Disease Prostag. Other Lipid Mediat. (IF 2.9) Pub Date : 2023-08-23 Keila S. Espinoza, Kyra N. Hermanson, Cameron A. Beard, Nicholas U. Schwartz, Justin M. Snider, Benjamin E. Low, Michael V. Wiles, Yusuf A. Hannun, Lina M. Obeid, Ashley J. Snider
Charcot-Marie-Tooth Disease (CMT) is a commonly inherited peripheral polyneuropathy. Clinical manifestations for this disease include symmetrical distal polyneuropathy, altered deep tendon reflexes, distal sensory loss, foot deformities, and gait abnormalities. Genetic mutations in heat shock proteins have been linked to CMT2. Specifically, mutations in the heat shock protein B1 (HSPB1) gene encoding
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Tartary buckwheat protein-derived peptide AFYRW alleviates H2O2-induced vascular injury via the PI3K/AKT/NF-κB pathway Prostag. Other Lipid Mediat. (IF 2.9) Pub Date : 2023-08-18 Yi Xiao, Jiajun Yang, Yan Deng, Lilin Zhang, Qingzhong Xu, Hongmei Li
Tartary buckwheat protein-derived peptide (Ala-Phe-Tyr-Arg-Trp, AFYRW) is a natural active peptide that hampers the atherosclerosis process, but the underlying role of AFYRW in angiogenesis remains unknown. Here, we present a system-based study to evaluate the effects of AFYRW on H2O2-induced vascular injury in human umbilical vein endothelial cells (HUVECs). HUVECs were co-incubated with H2O2 for
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Therapeutic effect of cannabidiol on myocardial arachidonic acid content in various lipid fractions in a rat model of obesity Prostag. Other Lipid Mediat. (IF 2.9) Pub Date : 2023-08-02 Klaudia Sztolsztener, Wiktor Bzdęga, Karolina Konstantynowicz-Nowicka, Adrian Chabowski, Ewa Harasim-Symbor
The study explored the potential protective influence of cannabidiol (CBD) on myocardial inflammation state, with a special focus on arachidonic acid (AA), and oxidative balance in lipid overload conditions. The 7-week experiment was conducted on male Wistar rats receiving standard or high-fat diet (HFD) with intraperitoneal CBD injections for the last 14 days. The n-3 and n-6 polyunsaturated fatty
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The role of platelets in non-alcoholic fatty liver disease: From pathophysiology to therapeutics Prostag. Other Lipid Mediat. (IF 2.9) Pub Date : 2023-07-20 Navya Malladi, Md Jahangir Alam, Subir K. Maulik, Sanjay K. Banerjee
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The analysis of fatty acids and their derivatives in the liver of C57BL/6 mice with long-term caloric restrictions. Prostag. Other Lipid Mediat. (IF 2.9) Pub Date : 2023-07-17 J. Palma, D. Maciejewska-Markiewicz, K. Zgutka, K. d Piotrowska, K. Skonieczna-Żydecka, E. Stachowska
Caloric restriction (CR) is a dietetic intervention based on the reduction of daily calorie intake by 10–30 %. When subjected to CR, the organism adjusts its metabolism to the changing availability of key nutrients. However, fatty acids’ content in organisms subjected to long-term CR has not been evaluated. The aim of the research was to analyze the influence of long-term CR on the contents of medium-
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Changes in the level of cytokines in the saliva of hypertensive patients with chronic periodontitis after scaling and root planning Prostag. Other Lipid Mediat. (IF 2.9) Pub Date : 2023-07-13 Ahed Najimelddin Abdullah, Omar Abdul Majeed Al-Habib, Saeed Ali Mohammed
Introduction Cytokines have a key role in the pathogenesis of both hypertension and periodontitis. Salivary diagnosis is a promising field with numerous clinical applications. Since limited studies have been carried out on how salivary inflammatory cytokines can be determined and how well periodontal disease and hypertension might react to scaling and root planning (SRP). The goal of this study was
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Set up and validation of a sensitive method to quantify prostaglandins, prostaglandin-glycerol esters and prostaglandin-ethanolamides, as well as their respective precursors Prostag. Other Lipid Mediat. (IF 2.9) Pub Date : 2023-06-29 Adrien Paquot, Juan Bestard-Escalas, Giulio G. Muccioli
Arachidonic acid-derived prostaglandins are widely studied for their role in inflammation. However, besides arachidonic acid, other arachidonic moiety-containing lipids can be metabolized by COX-2. Indeed, the endocannabinoids 2-arachidonoylglycerol (2-AG) and N-arachidonoylethanolamine (anandamide, AEA) can follow the same biochemical pathways than arachidonic acid leading to the formation of prostaglandin-glycerol
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Specialized pro-resolving lipid mediators and resolution of viral diseases Prostag. Other Lipid Mediat. (IF 2.9) Pub Date : 2023-06-22 Giulia Ferri, Matteo Mucci, Domenico Mattoscio, Antonio Recchiuti
The COVID-19 pandemics has made sparkly evident the importance of acute inflammation and its timely resolution to protect humans from pathogenic viruses while sparing them from collateral damages due to an uncontrolled immune response. It is clear now that resolution of inflammation is an active process regulated by endogenous specialized proresolving lipid mediators (SPM) biosynthesized from essential
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Defining the contractile prostanoid component in hyperosmolar-induced bronchoconstriction in human small airways Prostag. Other Lipid Mediat. (IF 2.9) Pub Date : 2023-06-17 Maria Belikova, Mamdoh Al-Ameri, Ann-Charlotte Orre, Jesper Säfholm
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Cross-talk between bioactive lipid mediators and the unfolded protein response in ischemic stroke Prostag. Other Lipid Mediat. (IF 2.9) Pub Date : 2023-06-17 Tarvi Teder, Jesper Z. Haeggström, Mikko Airavaara, Helike Lõhelaid
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Individual resolvin E family members work distinctly and in a coordinated manner in the resolution of inflammation Prostag. Other Lipid Mediat. (IF 2.9) Pub Date : 2023-06-14 Ayaka Hamaguchi, Hayato Fukuda, Koichi Fujiwara, Tomofumi Harada, Keijo Fukushima, Satoshi Shuto, Hiromichi Fujino
Three main E-type resolvins (RvEs): RvE1, RvE2, and RvE3, have roles in the resolution of inflammation as anti-inflammatory activities. To investigate the roles of each RvE in the resolution of inflammation, timing of interleukin (IL)− 10 release and IL-10 receptor expressions, and phagocytosis evoked by each RvE in differentiated human monocytes, macrophage-like U937 cells were examined. Here, we
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Sphingolipidoses in Morocco: Chemical profiling for an affordable and rapid diagnosis strategy Prostag. Other Lipid Mediat. (IF 2.9) Pub Date : 2023-06-07 M. Hammoud, A.M.S. Rodrigues, I. Assiri, Es Sabir, K. Lafhal, S. Najeh, M. Jakani, N. Imad, A. Bourrahouat, I. Ait Sab, R. Elqadiry, H. Nassih, A. Outzourit, M. Elamiri, F. Maoulainine, N. Slitine Elidrissi, F. Bennaoui, M. Bourous, S. Mrhar, L. Essaadouni, N. Fdil
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17-(R/S)-hydroxyeicosatetraenoic acid (HETE) induces cardiac hypertrophy through the CYP1B1 in enantioselective manners Prostag. Other Lipid Mediat. (IF 2.9) Pub Date : 2023-05-25 Fadumo Ahmed Isse, Ahmad H. Alammari, Ahmed A. El-Sherbeni, Ayman O.S. El-Kadi
Cardiac cellular hypertrophy is the increase in the size of individual cardiac cells. Cytochrome P450 1B1 (CYP1B1) is an extrahepatic inducible enzyme that is associated with toxicity, including cardiotoxicity. We previously reported that 19-hydroxyeicosatetraenoic acid (19-HETE) inhibited CYP1B1 and prevented cardiac hypertrophy in enantioselective manner. Therefore, our aim is to investigate the
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Cisplatin and progesterone separate and combined action on rat brain nuclear phospholipids content Prostag. Other Lipid Mediat. (IF 2.9) Pub Date : 2023-05-27 N.R. Hakobyan, ZH.V. Yavroyan, A.G. Hovhannisyan, E.S. Gevorgyan
The antitumor agent cisplatin and steroid hormone progesterone separate and combined action on content of total phospholipids and their individual classes in nuclei from rat brain cells were investigated. Cisplatin and progesterone exhibit their own characteristic properties, when used separately. Cisplatin reduces, and progesterone, on the contrary, increases the content of total phospholipids. When
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Altered mucosal and plasma polyunsaturated fatty acids, oxylipins, and endocannabinoids profiles in Crohn’s disease Prostag. Other Lipid Mediat. (IF 2.9) Pub Date : 2023-05-04 Yamina Ben-Mustapha, Mohamed Kacem Ben-Fradj, Sameh Hadj-Taieb, Meriem Serghini, Melika Ben Ahmed, Jalel Boubaker, Moncef Feki
Selected mucosal and plasma polyunsaturated fatty acids (PUFAs) and related oxylipins and endocannabinoids were determined in 28 Crohn’s disease (CD) patients and 39 controls. Fasting blood and colonic biopsies were collected in all participants, during a disease flare for the patients. Thirty-two lipid mediators including PUFAs, oxylipins, and endocannabinoids were assessed by LC-MS/MS. The pattern
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11,12-EET suppressed LPS induced TF expression and thrombus formation by accelerating mRNA degradation rate via strengthening PI3K-Akt signaling pathway and inhibiting p38-TTP pathway Prostag. Other Lipid Mediat. (IF 2.9) Pub Date : 2023-04-28 Liman Luo, Yan Yang, Menglu Fu, Jinlan Luo, Wenhua Li, Ling Tu, Ruolan Dong
Epoxyeicosatrienoic acids (EETs), which are synthesized from arachidonic acid by cytochrome P450 epoxygenases, function primarily as autocrine and paracrine effectors in the cardiovascular system. So far, most research has focused on the vasodilatory, anti-inflammatory, anti-apoptotic and mitogenic properties of EETs in the systemic circulation. However, whether EETs could suppress tissue factor (TF)
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Exploring the role of polyunsaturated fatty acid ratios in modulating neuroinflammation in LPS-induced microglia: A comprehensive in vitro analysis Prostag. Other Lipid Mediat. (IF 2.9) Pub Date : 2023-04-25 H. Dere Yelken, M.P. Elci, P.F. Turker, S. Demirkaya
The study investigated the effect of different omega (ω)− 3 and omega (ω)− 6 polyunsaturated fatty acid (PUFA) ratios on cytokine secretion, cell viability, and microglial cell shape in lipopolysaccharide (LPS)-induced microglia. The addition of PUFAs at different ratios, especially ω-3 and ratios of 7/1 and 2/1 ω-6/ω-3, resulted in a significant increase in the ameboid form of microglial cells, as
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Microsomal prostaglandin E synthase-1 inhibition promotes shunting in arachidonic acid metabolism during inflammatory responses in vitro Prostag. Other Lipid Mediat. (IF 2.9) Pub Date : 2023-04-23 Jianyang Liu, Bing Peng, Julia Steinmetz-Späh, Helena Idborg, Marina Korotkova, Per-Johan Jakobsson
Microsomal Prostaglandin E Synthase 1 (mPGES-1) is the key enzyme for the generation of the pro-inflammatory lipid mediator prostaglandin E2 (PGE2), which contributes to several pathological features of many diseases. Inhibition of mPGES-1 has been shown to be a safe and effective therapeutic strategy in various pre-clinical studies. In addition to reduced PGE2 formation, it is also suggested that
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Lipid mediated brain disorders: A perspective Prostag. Other Lipid Mediat. (IF 2.9) Pub Date : 2023-04-20 Anju Singh, Samiksha Kukal, Neha Kanojia, Mahak Singh, Luciano Saso, Shrikant Kukreti, Ritushree Kukreti
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TXA2 mediates LPA1-stimulated uterine contraction in late pregnant mouse Prostag. Other Lipid Mediat. (IF 2.9) Pub Date : 2023-04-14 E. Prakash, S. Pavithra, DG Kishor Kumar, Manjit Panigrahi, Thakur Uttam Singh, Dinesh Kumar, Subhashree Parida
Lysophosphatidic acid (LPA) is known to increase uterine contraction in the estrus cycle and early pregnancy, however, the effect of LPA in late pregnant uterus and its mechanisms are not clear. In the present study, we show the LPA receptor subtypes expressed and the mechanism of LPA-induced contractions in late pregnant mouse uterus. We determined the relative mRNA expression of LPA receptor genes
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Comprehensive analysis of the roles of fatty acid transport related proteins in clear cell renal cell carcinoma Prostag. Other Lipid Mediat. (IF 2.9) Pub Date : 2023-04-11 Jing Zheng, Yan-zhi Li, Wei-jie Ni, Shi-mei Hou, Ke-qi Lu, Yu Yan, Li-qun Ren, Bi-Cheng Liu, Bin Wang
Objective This study aimed to explore the clinical significance of fatty acid transport-related protein (FATRP) in patients with clear cell renal cell carcinoma(ccRCC). Methods RNA-seq data and corresponding clinical data of ccRCC were obtained from TCGA data portal. Seventeen key FATRP genes were comprehensively investigated using bioinformatics approaches to systematically investigate their expression
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Elabela relaxes rat pulmonary artery and trachea via BKCa, KV, and KATP channels Prostag. Other Lipid Mediat. (IF 2.9) Pub Date : 2023-04-12 Serdar Sahinturk
Objective Elabela is a newly discovered peptide hormone. This study aimed to determine the functional effects and mechanisms of action of elabela in rat pulmonary artery and trachea. Materials and methods Vascular rings isolated from the pulmonary arteries of male Wistar Albino rats were placed in chambers in the isolated tissue bath system. The resting tension was set to 1 g. After the equilibration
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Docosahexaenoic acid inhibits ischemic stroke to reduce vascular dementia and Alzheimer’s disease Prostag. Other Lipid Mediat. (IF 2.9) Pub Date : 2023-04-05 Kazuo Yamagata
Stroke and dementia are global leading causes of neurological disability and death. The pathology of these diseases is interrelated and they share common, modifiable risk factors. It is suggested that docosahexaenoic acid (DHA) prevents neurological and vascular disorders induced by ischemic stroke and also prevent dementia. The purpose of this study was to review the potential preventative role of
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COX Isozymes and Non-Uniform Neoangiogenesis: What is their role in Endometriosis? Prostag. Other Lipid Mediat. (IF 2.9) Pub Date : 2023-04-05 Andrea Caruana, Charles Savona-Ventura, Jean Calleja-Agius
This literature review compared the efficacy in of NSAIDs with a placebo in pain relief and disease regression of endometriosis. Despite the poor evidence found, the results showed that NSAIDs were more effective in pain relief with regressive effects on the endometriotic lesions compared to placebo. We postulate herein that COX-2 is chiefly responsible for pain whilst COX-1 is responsible mainly for