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The anti-atherosclerotic effect of Paeonol against the lipid accumulation in macrophage-derived foam cells by inhibiting ferroptosis via the SIRT1/NRF2/GPX4 signaling pathway Biochem. Biophys. Res. Commun. (IF 3.1) Pub Date : 2024-03-14 Menglong Gao, Lishun Dong, Yulong Yang, Jinjin Yan, Yuning Liang, Xiaolin Ma, Min Zhou, Hongfei Wu, Yarong Liu, Min Dai
Atherosclerosis (AS) is the underlying cause of many severe vascular diseases and is primarily characterized by abnormal lipid metabolism. Paeonol (Pae), a bioactive compound derived from Paeonia Suffruticosa Andr., is recognized for its significant role in reducing lipid accumulation. Our research objective is to explore the link between lipid buildup in foam cells originating from macrophages and
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Henlea earthworm bioluminescence comprises violet-blue BRET from tryptophan 2-carboxylate to deazaflavin cofactor Biochem. Biophys. Res. Commun. (IF 3.1) Pub Date : 2024-03-13 Valentin N. Petushkov, Matvey V. Vavilov, Anastasia N. Khokhlova, Renata I. Zagitova, Olga A. Belozerova, Aleksandr S. Shcheglov, Sergey I. Kovalchuk, Aleksandra S. Tsarkova, Natalia S. Rodionova, Ilia V. Yampolsky, Maxim A. Dubinnyi
We recently identified the deazaflavin cofactor as a light emitter in novel bioluminescence (BL) system from Siberian earthworms sp. (Petushkov et al., 2023, Org. Biomol. Chem. 21:415–427). In the present communication we compared BL spectra in the absence and in the presence of the cofactor and found a wavelength shift from 420 to 476 nm. This violet-blue BRET to deazaflavin cofactor (acceptor of
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6-Gingerol alleviates ectopic lipid deposition in skeletal muscle by regulating CD36 translocation and mitochondrial function Biochem. Biophys. Res. Commun. (IF 3.1) Pub Date : 2024-03-13 Ze Peng, Yan Zeng, Qi Tan, Qifeng He, Shang Wang, Jianwei Wang
Ectopic lipid deposition (ELD) and mitochondrial dysfunction are common causes of metabolic disorders in humans. Consuming too much fructose can result in mitochondrial dysfunction and metabolic disorders. 6-Gingerol, the main component of ginger ( Roscoe), has been proven to alleviate metabolic disorders. This study seeks to examine the effects of 6-gingerol on metabolic disorders caused by fructose
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Tyrosinase regulates the motility of human melanoma cell line A375 through its hydroxylase enzymatic activity Biochem. Biophys. Res. Commun. (IF 3.1) Pub Date : 2024-03-13 Sachie Honda, Tadashi Matsuda, Masahiro Fujimuro, Yuichi Sekine
Melanoma, originating from melanocytes, is a highly aggressive tumor. Tyrosinase is involved in melanin production in melanocytes, and its overexpression is noted in malignant melanomas. However, the role of tyrosinase in melanomas remains unclear. Therefore, this study aimed to evaluate the potential functions of tyrosinase in the human melanoma cell line A375. The expression level of tyrosinase in
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Structure of a phosphodiesterase from Streptomyces sanglieri with a novel C-terminal domain Biochem. Biophys. Res. Commun. (IF 3.1) Pub Date : 2024-03-13 Murayama Kazutaka, Toshiaki Hosaka, Mikako Shirouzu, Daisuke Sugimori
A glycerophosphoethanolamine ethanolaminephosphodiesterase (GPE-EP) from hydrolyzes glycerophosphoethanolamine to phosphoethanolamine and glycerol. The structure of GPE-EP was determined by the molecular replacement method using a search model generated with AlphaFold2. This structure includes the entire length of the mature protein and it is composed of an -terminal domain and a novel -terminal domain
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Gingipain-carrying outer membrane vesicles from Porphyromonas gingivalis cause barrier dysfunction of Caco-2 cells by releasing gingipain into the cytosol Biochem. Biophys. Res. Commun. (IF 3.1) Pub Date : 2024-03-13 Saori Nonaka, Rin Okamoto, Yui Katsuta, Shiori Kanetsuki, Hiroshi Nakanishi
Ingestion of , a periodontal pathogen, disrupts the intestinal barrier in mice. However, the involvement of outer membrane vesicles (OMVs) secreted from in the destruction of the intestinal barrier remains unclear. In this study, we tested the hypothesis that OMVs carrying gingipains, the major cysteine proteases produced by , affects the intestinal barrier function. OMVs increased the permeability
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Rbm46 inhibits reactive oxygen species in mouse embryonic stem cells through modulating BNIP3-mediated mitophagy Biochem. Biophys. Res. Commun. (IF 3.1) Pub Date : 2024-03-13 Jinchen Zhong, Jing Xu, Xiaoyang Chen, Na Li, Sha Li, Zhiwen Deng, Huimin Feng, Xiaohan Ling, Chenchen Wang, Zhi Zhou, Lingsong Li
Embryonic stem cells (ESCs) exhibit a metabolic preference for glycolysis over oxidative phosphorylation to meet their substantial adenosine triphosphate (ATP) demands during self-renewal. This metabolic choice inherently maintains low mitochondrial activity and minimal reactive oxygen species (ROS) generation. Nonetheless, the intricate molecular mechanisms governing the restraint of ROS production
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DT-13 attenuates inflammation by inhibiting NLRP3-inflammasome related genes in RAW264.7 macrophages Biochem. Biophys. Res. Commun. (IF 3.1) Pub Date : 2024-03-13 Shikha Raina, Emely Hübner, Esther Samuel, Gregor Nagel, Hendrik Fuchs
Plant derived saponins or other glycosides are widely used for their anti-inflammatory, antioxidant, and anti-viral properties in therapeutic medicine. In this study, we focus on understanding the function of the less known steroidal saponin from the roots of – saponin C (also known as DT-13) in lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages in comparison to the well-known saponin ginsenoside
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5Mesencephalic astrocyte-derived neurotrophic factor ameliorates inflammatory response in polycystic ovary syndrome via inhibiting TLR4-nf-κb-nlrp3 pathway Biochem. Biophys. Res. Commun. (IF 3.1) Pub Date : 2024-03-12 Shujun Yu, Chao Hou, Xinru Zhang, Zhaolian Wei
Polycystic ovary syndrome (PCOS) is a common reproductive endocrine disorder in women of reproductive age, which often leads to female infertility. Chronic inflammation is a significant factor in the development of PCOS. Our study aimed to explore the impact of mesencephalic astrocyte-derived neurotrophic factor (MANF), a scientifically validated anti-inflammatory factor, on 99 diagnosed PCOS patients
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Systemic loss of CD36 aggravates NAFLD-related HCC through MEK1/2-ERK1/2 signaling pathway Biochem. Biophys. Res. Commun. (IF 3.1) Pub Date : 2024-03-12 Enze Zheng, Qianqian Chen, Anhua Xiao, Xiaoqing Luo, Qiannan Lu, Chuan Tian, Huan Liu, Jinqing Zhao, Li Wei, Ping Yang, Yaxi Chen
CD36, a membrane protein widely present in various tissues, is crucial role in regulating energy metabolism. The rise of HCC as a notable outcome of NAFLD is becoming more apparent. Patients with hereditary CD36 deficiency are at increased risk of NAFLD. However, the impact of CD36 deficiency on NAFLD-HCC remains unclear. Global CD36 knockout mice (CD36KO) and wild type mice (WT) were induced to establish
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Exploring the potential of structural modeling and molecular docking for efficient siRNA screening: A promising approach to Combat viral mutants, with a focus on HIV-1 Biochem. Biophys. Res. Commun. (IF 3.1) Pub Date : 2024-03-11 Mohammad Nematian, Zahra Noormohammadi, Pooneh Rahimi, Shiva Irani, Ehsan Arefian
RNA interference (RNAi) holds immense potential for sequence-specific downregulation of disease-related genes. Small interfering RNA (siRNA) therapy has made remarkable strides, with FDA approval for treating specific human diseases, showcasing its promising future in disease treatment. Designing highly efficient siRNAs is a critical step in this process. Previous studies have introduced various algorithms
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Influence of storage solution, temperature, assay time and concentration on RT-qPCR nucleic acid detection for SARS-CoV-2 detection of SARS-CoV-2 by the RT-qPCR Biochem. Biophys. Res. Commun. (IF 3.1) Pub Date : 2024-03-11 Lingxuan Su, Yihan Lou, Jiaxuan Li, Haiyan Mao, Jianhua Li, Yi Sun, Biaofeng Zhou, Guangshang Wu, Chen Huang, Yanjun Zhang, Keda Chen
Real-time reverse transcriptase quantitative polymerase chain reaction (RT-qPCR) is an important method for the early diagnosis of coronavirus disease 2019 (COVID-19). This study investigated the effects of storage solution, temperature and detection time on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) nucleic acid detection by RT-qPCR. Various concentrations of SARS-CoV-2 were added
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Mismatch repair enzymes regulate telomere recombination in Saccharomycescerevisiae Biochem. Biophys. Res. Commun. (IF 3.1) Pub Date : 2024-03-11 Chia-Chun Liu, Mathilde M.M. Capart, Jing-Jer Lin
DNA mismatch repair (MMR) is a crucial mechanism that ensures chromosome stability and prevents the development of various human cancers. Apart from its role in correcting mismatches during DNA replication, MMR also plays a significant role in regulating recombination between non-identical sequences, a process known as homeologous recombination. Telomeres, the protective ends of eukaryotic chromosomes
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Mild hypothermia reduces lipopolysaccharide-induced microglial activation via down-regulation of Tent5c Biochem. Biophys. Res. Commun. (IF 3.1) Pub Date : 2024-03-11 Wen-xian Ma, Shao-wen Wang, Qian-wen Fan, Yue-yue Wang, Chao-qun Chu, Dong Liu, Zhen Guo, Ji-hui Tang, Jia-gen Wen
Microglial activation is a critical factor in the pathogenesis and progression of neuroinflammatory diseases. Mild hypothermia, known for its neuroprotective properties, has been shown to alleviate microglial activation. In this study, we explore the differentially expressed (DE) mRNAs and long non-coding RNAs (lncRNAs) in BV-2 microglial cells under different conditions: normal temperature (CN), mild
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Identification of HK3 as a promising immunomodulatory and prognostic target in sepsis-induced acute lung injury Biochem. Biophys. Res. Commun. (IF 3.1) Pub Date : 2024-03-11 Mingyu Zhu, Xiaokai Tang, Jingjing Xu, Yuanqi Gong
Sepsis is a life-threatening global disease with a significant impact on human health. Acute lung injury (ALI) has been identified as one of the primary causes of mortality in septic patients. This study aimed to identify candidate genes involved in sepsis-induced ALI through a comprehensive approach combining bioinformatics analysis and experimental validation. The datasets GSE65682 and GSE32707 obtained
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Role of transcriptional cofactors in cardiovascular diseases Biochem. Biophys. Res. Commun. (IF 3.1) Pub Date : 2024-03-11 Shuqing Mao, Chao Song, Hong Huang, Yali Nie, Kai Ding, Jian Cui, Jinwei Tian, Huifang Tang
Cardiovascular disease is a main cause of mortality in the world and the highest incidence of all diseases. However, the mechanism of the pathogenesis of cardiovascular disease is still unclear, and we need to continue to explore its mechanism of action. The occurrence and development of cardiovascular disease is significantly associated with genetic abnormalities, and gene expression is affected by
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Is myeloid-derived growth factor a ligand of the sphingosine-1-phosphate receptor 2? Biochem. Biophys. Res. Commun. (IF 3.1) Pub Date : 2024-03-10 Yong-Shan Zheng, Ya-Li Liu, Zeng-Guang Xu, Cheng He, Zhan-Yun Guo
Secretory myeloid-derived growth factor (MYDGF) exerts beneficial effects on organ repair, probably via a plasma membrane receptor; however, the identity of the expected receptor has remained elusive. In a recent study, MYDGF was reported as an agonist of the sphingosine-1-phosphate receptor 2 (S1PR2), an A-class G protein-coupled receptor that mediates the functions of the signaling lipid, sphingosine-1-phosphate
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The ligand binding domain of a type IV pilus chemoreceptor PilJ has a different fold from that of another PilJ-type receptor McpN Biochem. Biophys. Res. Commun. (IF 3.1) Pub Date : 2024-03-10 Rui Cui, Qi-An Wang, Lu Guo, De-Feng Li
Bacterial chemoreceptors sense the extracellular signals and regulate bacterial motilities, biofilm formation, etc. The periplasmic ligand binding domains of chemoreceptors occur as different structural folds and recognize a diversity of chemical molecules. In (PAO1), two bacterial chemoreceptors, McpN (PA2788) and PilJ (PA0411), are proposed to both contain a PilJ-like ligand-binding domain (LBD)
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Light-dependent expression and accumulation of miR408-encoded peptide, miPEP408, is regulated by HY5 in Arabidopsis Biochem. Biophys. Res. Commun. (IF 3.1) Pub Date : 2024-03-08 Ravi Shankar Kumar, Tapasya Datta, Hiteshwari Sinha, Prabodh Kumar Trivedi
Recent studies propose that primary transcripts of miRNAs (pri-miRNAs) contain small Open Reading Frames (ORFs) capable of encoding miRNA-encoded peptides (miPEPs). These miPEPs can function as transcriptional regulators for their corresponding pri-miRNAs, ultimately enhancing mature miRNA accumulation. Notably, pri-miR408 encodes the functional peptide miPEP408, regulating expression of miR408 and
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Glucose stockpile in the intestinal apical brush border in C. elegans Biochem. Biophys. Res. Commun. (IF 3.1) Pub Date : 2024-03-07 Takumi Saito, Kenji Kikuchi, Takuji Ishikawa
Revealing the mechanisms of glucose transport is crucial for studying pathological diseases caused by glucose toxicities. Numerous studies have revealed molecular functions involved in glucose transport in the nematode , a commonly used model organism. However, the behavior of glucose in the intestinal lumen-to-cell remains elusive. To address that, we evaluated the diffusion coefficient of glucose
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Role of tubulin C-terminal tail on mechanical properties of microtubule Biochem. Biophys. Res. Commun. (IF 3.1) Pub Date : 2024-03-07 Senjuti Nowroz, Syeda Rubaiya Nasrin, Arif Md Rashedul Kabir, Takefumi Yamashita, Tomoichiro Kusumoto, Junichi Taira, Marie Tani, Masatoshi Ichikawa, Kazuki Sada, Akira Kakugo
Tubulin C-terminal tail (CTT) is a disordered segment extended from each tubulin monomer of αβ tubulin heterodimers, the building blocks of microtubules. The tubulin CTT contributes to the cellular function of microtubules such as intracellular transportation by regulating their interaction with other proteins and cell shape regulation by controlling microtubule polymerization dynamics. Although the
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Cellular senescence in acute kidney injury: Target and opportunity Biochem. Biophys. Res. Commun. (IF 3.1) Pub Date : 2024-03-07 Ting Li, Kexin Yang, Wei Gao, Fujun Peng, Xiangyu Zou
Acute kidney injury (AKI) is a common clinical disease with a high incidence and mortality rate. It typically arises from hemodynamic alterations, sepsis, contrast agents, and toxic drugs, instigating a series of events that culminate in tissue and renal damage. This sequence of processes often leads to acute renal impairment, prompting the initiation of a repair response. Cellular senescence is an
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In vitro functional analysis and in silico structural modelling of pathogen-secreted polyglycine hydrolases Biochem. Biophys. Res. Commun. (IF 3.1) Pub Date : 2024-03-06 Todd A. Naumann, Nicole V. Dowling, Neil P.J. Price, David R. Rose
Polyglycine hydrolases are fungal effectors composed of an -domain with unique sequence and structure and a C-domain that resembles β-lactamases, with serine protease activity. These secreted fungal proteins cleave Gly-Gly bonds within a polyglycine sequence in corn ChitA chitinase. The polyglycine hydrolase -domain (PND) function is unknown. In this manuscript we provide evidence that the PND does
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The noncanonical function of borealin, a component of chromosome passenger complex, promotes glycolysis via stabilization of survivin in squamous cell carcinoma cells Biochem. Biophys. Res. Commun. (IF 3.1) Pub Date : 2024-03-06 Hiroaki Tawara, Takaaki Tsunematsu, Shojiro Kitajima, Ruka Nagao, Shigefumi Matsuzawa, Kunihiro Otsuka, Aya Ushio, Naozumi Ishimaru
The chromosome passenger complex (CPC) is a kinase complex formed by Aurora B, borealin, survivin and inner centromere protein (INCENP). The CPC is active during mitosis and contributes to proper chromosome segregation via the phosphorylation of various substrates. Overexpression of each CPC component has been reported in most cancers. However, its significance remains unclear, as only survivin is
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‘Nunchuck’ proteins: Short flexible linkers resist proteolysis by facilitating motions in flanking domains to inhibit the approach of proteases Biochem. Biophys. Res. Commun. (IF 3.1) Pub Date : 2024-03-06 Snehal Waghmare, Purnananda Guptasarma
Peptides linking well-folded and non-interacting domains in fusion proteins can undergo proteolytic degradation. This leads to physical separation of the domains that were originally sought to be joined. In order to identify characteristics that determine linker degradation propensity, we selected a pair of thermostable, proteolytically-resistant domains, and joined them using five different linkers
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Natural compound Byakangelicin suppresses breast tumor growth and motility by regulating SHP-1/JAK2/STAT3 signal pathway Biochem. Biophys. Res. Commun. (IF 3.1) Pub Date : 2024-03-05 Xiuzhen Shi, Yuexing Lai, Wenjing Liu, Xi Zhang, Yanqin Cang
Byakangelicin mostly obtained from the root of Angelica dahurica and has protective effect on liver injury and fibrosis. In addition, Byakangelicin, as a traditional medicine, is also used to treat colds, headache and toothache. Recent studies have shown that Byakangelicin exhibits anti-tumor function; however, the role of Byakangelicin in breast tumor progression and related mechanism has not yet
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Nobiletin enhances mitochondrial function by regulating SIRT1/PGC-1α signaling in porcine oocytes during in vitro maturation Biochem. Biophys. Res. Commun. (IF 3.1) Pub Date : 2024-03-05 Song-Hee Lee, Xiao-Han Li, Qin-Yue Lu, Cheng-Lin Zhan, Ji-Dam Kim, Gyu-Hyun Lee, Jae-Min Sim, Xiang-Shun Cui
Nobiletin is a natural flavonoid found in citrus fruits with beneficial effects, including anti-inflammatory, anti-cancer and anti-oxidation effects. The aim of this study was to investigate whether nobiletin improves mitochondrial function in porcine oocytes and examine the underlying mechanism. Oocytes enclosed by cumulus cells were cultured in TCM-199 for 44 h with 0.1% dimethyl sulfoxide (control)
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Cryo-EM structure of Influenza A virus NS1 and antiviral protein kinase PKR complex Biochem. Biophys. Res. Commun. (IF 3.1) Pub Date : 2024-03-05 Hyeon Jin Kim, Chang Woo Han, Mi Suk Jeong, Se Bok Jang
Influenza A virus is the cause of a widespread human disease with high morbidity and mortality rates. The influenza virus encodes non-structural protein 1 (NS1), an exceedingly multifunctional virulence component. NS1 plays essential roles in viral replication and evasion of the cellular innate immune system. Protein kinase RNA-activated also known as protein kinase R (PKR) phosphorylates translation
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Antiangiogenic properties of BthMP, a P–I metalloproteinase from Bothrops moojeni snake venom by VEGF pathway in endothelial cells Biochem. Biophys. Res. Commun. (IF 3.1) Pub Date : 2024-03-05 Vinícius Queiroz Oliveira, Luísa Carregosa Santos, Samuel Cota Teixeira, Thiago Macedo Lopes Correia, Leonardo Oliveira Silva Bastos Andrade, Sarah Natalie Cirilo Gimenes, Mônica Colombini, Lucas Miranda Marques, Eliécer Jiménez-Charris, Luciana Aparecida Freitas-de-Sousa, Marcelo José Barbosa Silva, Amélia Cristina Mendes de Magalhães Gusmão, Eloisa Amália Vieira Ferro, Patricia Bianca Clissa, Veridiana
Angiogenesis is a process that is controlled by a delicate combination of proangiogenic and antiangiogenic molecules and can be disrupted in various illnesses, including cancer. Non-cancerous diseases can also have an abnormal or insufficient vascular growth, inflammation and hypoxia, which exacerbate angiogenesis. These conditions include atherosclerosis, psoriasis, endometriosis, asthma, obesity
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Amelioration of endothelial integrity by 3,5,4′-trihydroxy-trans-stilbene against high-fat-diet-induced obesity and -associated vasculopathy and myocardial infarction in rats, targeting TLR4/MyD88/NF-κB/iNOS signaling cascade Biochem. Biophys. Res. Commun. (IF 3.1) Pub Date : 2024-03-05 Jitender Singh, Priyanka Bisht, Srishti Srivastav, Yash Kumar, Vikash Sharma, Ashish Kumar, Md Sayeed Akhtar, Mohd Faiyaz Khan, Saad A. Aldosari, Snehlata Yadav, Nirmala K. Yadav, Monalisa Mukherjee, Arun K. Sharma
Exacerbated expression of TLR4 protein (foremost pattern recognition receptor) during obesity could trigger NF-κB/iNOS signaling through linker protein (MyD88), predisposed to an indispensable inflammatory response. The induction of this detrimental cascade leads to myocardial and vascular abnormalities. Molecular docking was studied for protein-ligand interaction between these potential targets and
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Epidermal loss of Bcl6 exacerbates MC903-induced atopic dermatitis-like skin inflammation Biochem. Biophys. Res. Commun. (IF 3.1) Pub Date : 2024-03-01 Kaori Kanemaru, Kento Nagasawa, Yuta Kunugi, Asahi Tanaka, Shunsuke Ikeoku, Yuki Tai, Yohsuke Harada, Yoshikazu Nakamura
Atopic dermatitis (AD) is a chronic inflammatory skin disease where Th2-type immune responses are dominant. In the lesional skin of AD, keratinocytes show differentiation defects and secrete proinflammatory cytokines and chemokines, amplifying Th2-type responses in AD. We previously reported that inducible loss of B-cell lymphoma 6 (Bcl6), a transcription repressor and a master transcriptional regulator
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The anti-apoptotic role of Ginkgolide B via mitochondrial permeability transition pore inhibition in retinal ischemia-reperfusion Biochem. Biophys. Res. Commun. (IF 3.1) Pub Date : 2024-03-01 Xiou Wang, Baoqi Hu, Hanyue Zhang, Sijia Zhou, Wenfei Wu, Zizhu Tan, Meiqi Sun, Qianyan Kang
This research delves into the effectiveness of Ginkgolide B (GB), a compound from Ginkgo biloba, in combating cell death caused by glaucoma, with a focus on mitochondrial impairment and the mitochondrial permeability transition pore (mPTP). Utilizing models of high intraocular pressure and in vitro glaucoma simulations, the study investigates GB's impact on retinal progenitor cells (RPCs) under oxygen-glucose
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Biophysical library screening using a Thermo-FMN assay to identify and characterize Clostridioides difficile FabK inhibitors Biochem. Biophys. Res. Commun. (IF 3.1) Pub Date : 2024-02-29 Fahad Bin Aziz Pavel, Glen E. Palmer, Kirk E. Hevener
a gram-positive anaerobic bacterium, is one of the most frequent causes of nosocomial infections. infection (CDI) results in almost a half a million infections and approximately 30,000 deaths in the U.S. each year. Broad-spectrum antibacterial use is a strong risk factor for development of recurring CDI. There is a critical need for narrow-spectrum antibacterials with activity limited to . The enoyl-acyl
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Neutrophil extracellular traps inhibit osteoclastogenesis Biochem. Biophys. Res. Commun. (IF 3.1) Pub Date : 2024-02-29 Kento Numazaki, Hiroyuki Tada, Takashi Nishioka, Eiji Nemoto, Kenji Matsushita, Itaru Mizoguchi, Shunji Sugawara
Neutrophil extracellular traps (NETs) released by neutrophils upon inflammation or infection, act as an innate immune defense against pathogens. NETs also influence inflammatory responses and cell differentiation in host cells. Osteoclasts, which are derived from myeloid stem cells, are critical for the bone remodeling by destroying bone. In the present study, we explores the impact of NETs, induced
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l-norleucine on high glucose-induced insulin sensitivity and mitochondrial function in skeletal muscle cells Biochem. Biophys. Res. Commun. (IF 3.1) Pub Date : 2024-02-29 Bingqian Ding, Yalei Fan, Tingting Zhu, Guirong Bai, Bingbing Liang, Xinyi Tian, Xiaomin Xie
-norleucine, an isomer of leucine, stimulates the anabolic process of insulin. However, it is not known if and how it improves insulin sensitivity and insulin resistance. This experiment describes the generation of an insulin resistance model using high glucose-induced cells and the administration of 1.0 mmol/L -norleucine for 48 h, to observe the effects on metabolism and gene expression in skeletal
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Co-targeting ASK1 and THRβ synergistically improves steatohepatitis and fibrosis in a MASH animal model Biochem. Biophys. Res. Commun. (IF 3.1) Pub Date : 2024-02-29 Shu Shang, Qin Wan, Faxiu Chen, Jian Hu
Metabolic dysfunction-associated steatohepatitis (MASH) is a liver disease that has gained widespread attention globally. Unfortunately, there is no approved treatment for this condition yet. However, recent research has identified Apoptosis signal-regulating kinase 1 (ASK1) and thyroid hormone receptor-β (THR-β) as potential targets for treating MASH. Although the individual effects of these two targets
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Mechanisms of chondrocyte regulated cell death in osteoarthritis: Focus on ROS-triggered ferroptosis, parthanatos, and oxeiptosis Biochem. Biophys. Res. Commun. (IF 3.1) Pub Date : 2024-02-28 Fangyang Fan, Cheng Yang, Enran Piao, Jia Shi, Juntao Zhang
Osteoarthritis (OA) is a common chronic inflammatory degenerative disease. Since chondrocytes are the only type of cells in cartilage, their survival is critical for maintaining cartilage morphology. This review offers a comprehensive analysis of how reactive oxygen species (ROS), including superoxide anions, hydrogen peroxide, hydroxyl radicals, nitric oxide, and their derivatives, affect cartilage
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Soybean RVE8a confers salt and drought tolerance in Arabidopsis Biochem. Biophys. Res. Commun. (IF 3.1) Pub Date : 2024-02-28 Guohua Bao, Guoqing Sun, Jingying Wang, Tianran Shi, Xiao Xu, Lulu Zhai, Shaomin Bian, Xuyan Li
Soybean is an economically important crop, which often suffers various abiotic stresses. () genes have been generally considered as circadian oscillators to mediate diverse developmental processes and plant response to environmental stresses. Addressing their roles is of significance for utilizing them to enhance agronomic traits in crops. However, our understanding of soybean s is extremely limited
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Orosomucoid 2 as a biomarker of carotid artery atherosclerosis plaque vulnerability through its generation of reactive oxygen species and lipid accumulation in vascular smooth muscle cells Biochem. Biophys. Res. Commun. (IF 3.1) Pub Date : 2024-02-28 Yuan Che, Jinrui Ren, Haoyang Zhao, Yaoguo Yang, Zhong Chen
Orosomucoid (ORM) has been reported as a biomarker of carotid atherosclerosis, but the role of ORM 2, a subtype of ORM, in carotid atherosclerotic plaque formation and the underlying mechanism have not been established. Plasma was collected from patients with carotid artery stenosis (CAS) and healthy participants and assessed using mass spectrometry coupled with isobaric tags for relative and absolute
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Glycolytic enzyme Enolase-1 regulates insulin gene expression in pancreatic β-cell Biochem. Biophys. Res. Commun. (IF 3.1) Pub Date : 2024-02-28 Xiumei Luo, Cheng Luan, Jingqi Zhou, Yingying Ye, Wei Zhang, Ruchi Jain, Enming Zhang, Ning Chen
Enolase-1 (Eno1) plays a critical role in regulating glucose metabolism; however, its specific impact on pancreatic islet β-cells remains elusive. This study aimed to provide a preliminary exploration of Eno1 function in pancreatic islet β-cells. The findings revealed that the expression of ENO1 mRNA in type 2 diabetes donors was significantly increased and positively correlated with HbA1C and negatively
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Metabolomics and miRNA profiling reveals feature of gallbladder cancer-derived biliary extracellular vesicles Biochem. Biophys. Res. Commun. (IF 3.1) Pub Date : 2024-02-28 Mingyu Kong, Da Hee Hong, Sanjita Paudel, Na Eun Yoon, Byung Hwa Jung, Myounghoi Kim, Tae Hun Kim, Jaemin Jeong, Dongho Choi, Hyunbeom Lee
Although there are several studies in the development of various human cancers, the role of exosomes is poorly understood in the progression of gallbladder cancer. This study aims to characterize the metabolic changes occurring in exosomes obtained from patients with gallbladder cancer compared with those from other gallbladder disease groups. Biliary exosomes were isolated from healthy donors (n = 3)
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TSHR signaling promotes hippocampal dependent memory formation through modulating Wnt5a/β-catenin mediated neurogenesis Biochem. Biophys. Res. Commun. (IF 3.1) Pub Date : 2024-02-28 Yuchen Li, Sisi Luan, Cairong Ruan, Weihao Li, Xinyu Zhang, Zijing Ran, Wenkai Bi, Yuelin Tong, Ling Gao, Jiajun Zhao, Yuan Li, Zhao He
Subclinical hyperthyroidism is defined biochemically as a low or undetectable thyroid-stimulating hormone (TSH) with normal thyroid hormone levels. Low TSHR signaling is considered to associate with cognitive impairment. However, the underlying molecular mechanism by which TSHR signaling modulates memory is poorly understood. In this study, we found that -deficient in the hippocampal neurons impairs
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SOX4 regulates proliferation and apoptosis of human ovarian granulosa-like tumor cell line KGN through the Hippo pathway Biochem. Biophys. Res. Commun. (IF 3.1) Pub Date : 2024-02-27 Qiang Hong, Mengmeng Fan, Rui Cai, Wenhui Shi, Fenfen Xie, Yuanhua Chen, Cong Li
The proliferation and apoptosis of ovarian granulosa cells are important for folliculogenesis. As a transcription factor, SRY-box transcription factor 4 (SOX4) has important roles in regulating cellular proliferation and apoptosis. Nonetheless, the regulatory mechanisms of SOX4 on proliferation and apoptosis of granulosa cells remain elusive. Therefore, a stably overexpressed SOX4 ovarian granulosa
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Miro-mediated mitochondrial transport: A new dimension for disease-related abnormal cell metabolism? Biochem. Biophys. Res. Commun. (IF 3.1) Pub Date : 2024-02-27 Yanxing Li, Zhen Yang, Shumei Zhang, Jianjun Li
Mitochondria are versatile and highly dynamic organelles found in eukaryotic cells that play important roles in a variety of cellular processes. The importance of mitochondrial transport in cell metabolism, including variations in mitochondrial distribution within cells and intercellular transfer, has grown in recent years. Several studies have demonstrated that abnormal mitochondrial transport represents
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CD38 deficient mice are not protected from atherosclerosis Biochem. Biophys. Res. Commun. (IF 3.1) Pub Date : 2024-02-27 Xiang Yi Kong, Knut H. Lauritzen, Tuva Børresdatter Dahl, Sverre Holm, Maria Belland Olsen, Mona Skjelland, Christopher Nielsen, Annika E. Michelsen, Thor Ueland, Pål Aukrust, Bente Halvorsen, Øystein Sandanger
CD38 is a multifunctional enzyme implicated in chemotaxis of myeloid cells and lymphocyte activation, but also expressed by resident cells such as endothelial and smooth muscle cells. CD38 is important for host defense against microbes. However, CD38's role in the pathogenesis of atherosclerosis is controversial with seemingly conflicting results reported so far. To clarify the discrepancy of current
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Synergistic anticancer effects of co-delivery of linc-RoR siRNA and curcumin using polyamidoamine dendrimers against breast cancer Biochem. Biophys. Res. Commun. (IF 3.1) Pub Date : 2024-02-27 Farzaneh Vahedi, Bita Javan, Mahrokh Sharbatkhari, Alireza Soltani, Mohammad Shafiee, Ali Memarian, Vahid Erfani-Moghadam
Breast cancer resistance to chemotherapy necessitates novel combination therapeutic approaches. Linc-RoR is a long intergenic noncoding RNA that regulates stem cell differentiation and promotes metastasis and invasion in breast cancer. Herein, we report a dual delivery system employing polyamidoamine dendrimers to co-administer the natural compound curcumin and linc-RoR siRNA for breast cancer treatment
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LncRNA MIR497HG inhibits cervical cancer by upregulating BCL6B to block PI3K/AKT signaling Biochem. Biophys. Res. Commun. (IF 3.1) Pub Date : 2024-02-27 Qian Li, Yi Chen, Jie Xu, Xiaoyan Zhu
Long noncoding RNAs (lncRNAs) play key roles in cancer development. The lncRNA miR-497 host gene (MIR497HG) has been identified to slow tumor progression in several cancers. This study aims to identify the effect of MIR497HG on cervical cancer (CC) progression and explore the underlying mechanism. The effect of MIR497HG on CC cell growth, apoptosis, migration, and invasion were examined by CCK-8, colony
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Reexamining the diverse functions of arginine in biochemistry Biochem. Biophys. Res. Commun. (IF 3.1) Pub Date : 2024-02-27 Munishwar Nath Gupta, Vladimir N. Uversky
Arginine in a free-state and as part of peptides and proteins shows distinct tendency to form clusters. In free-form, it has been found useful in cryoprotection, as a drug excipient for both solid and liquid formulations, as an aggregation suppressor, and an eluent in protein chromatography. In many cases, the mechanisms by which arginine acts in all these applications is either debatable or at least
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Investigating the role of phenylalanine residues for amyloid formation of the neuropeptide neurokinin B Biochem. Biophys. Res. Commun. (IF 3.1) Pub Date : 2024-02-27 Bhawantha M. Jayawardena, Annabelle Azzi, Christopher E. Jones
Neurokinin B (NKB) is a tachykinin peptide that has diverse roles in biology, including in human reproductive development. Cellular processing of this peptide is thought to involve formation of a dense core vesicle during transit through the regulated secretory pathway. The ability of NKB to rapidly form an amyloid can contribute to formation of the secretory granule but features that support amyloid
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Corrigendum to “ANXA2 and Rac1 negatively regulates autophagy and osteogenic differentiation in osteosarcoma cells to confer CDDP resistance” [Biochem. Biophys. Res. Commun. 676 (2023) 198–206] Biochem. Biophys. Res. Commun. (IF 3.1) Pub Date : 2024-02-24 Baolong Pan, Yanyu Pan, Shuangneng Wang, Yingying Bai, Xuemei Hu, Yang Yang, Ling Wu, Jianping Liu
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Synthesis of urolithin derivatives and their anti-inflammatory activity Biochem. Biophys. Res. Commun. (IF 3.1) Pub Date : 2024-02-23 Xintong Li, Zhengzheng Zhang, Guangsen Xu, Zhiying Li, Chunhua Lu, Yuemao Shen
Two series of urolithin derivatives, totally 38 compounds, were synthesized. Their anti-inflammatory activity was investigated by detecting the inhibitory effects on the expression of TNF-α in bone marrow-derived macrophages (BMDMs), showing that 24 of 38 ones reduced the expression of TNF-α. Compound , the ring C opened derivative of urolithin B with a butoxycarbonyl substitution in ring A, showed
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Chrysophanol accelerates astrocytic mitochondria transfer to neurons and attenuates the cerebral ischemia-reperfusion injury in rats Biochem. Biophys. Res. Commun. (IF 3.1) Pub Date : 2024-02-23 Xiao-mei Su, Dan-shen Zhang, Nan Zhang
Astrocytes transfer extracellular functional mitochondria into neurons to rescue injured neurons after a stroke. However, there are no reports on drugs that interfere with intercellular mitochondrial transfer. Chrysophanol (CHR) was an effective drug for the treatment of cerebral ischemia-reperfusion injury (CIRI) and was selected as the test drug. The oxygen-glucose deprivation/reoxygenation (OGD/R)
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Podocyte Ercc1 is indispensable for glomerular integrity Biochem. Biophys. Res. Commun. (IF 3.1) Pub Date : 2024-02-23 Eriko Yoshida Hama, Ran Nakamichi, Akihito Hishikawa, Miho Kihara, Takaya Abe, Norifumi Yoshimoto, Erina Sugita Nishimura, Hiroshi Itoh, Kaori Hayashi
As life expectancy continues to increase, age-related kidney diseases are becoming more prevalent. Chronic kidney disease (CKD) is not only a consequence of aging but also a potential accelerator of aging process. Here we report the pivotal role of podocyte ERCC1, a DNA repair factor, in maintaining glomerular integrity and a potential effect on multiple organs. Podocyte-specific ERCC1-knockout mice
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Structure and function of the pyridoxal 5′-phosphate-dependent (PLP) threonine deaminase IlvA1 from Pseudomonas aeruginosa PAO1 Biochem. Biophys. Res. Commun. (IF 3.1) Pub Date : 2024-02-22 Haizhu Jia, Yujing Chen, Yuan Chen, Ruihua Liu, Qionglin Zhang, Mark Bartlam
IlvA1, a pyridoxal phosphate-dependent (PLP) enzyme, catalyzes the deamination of -threonine and -serine to yield 2-ketobutyric acid or pyruvate. To gain insights into the function of IlvA1, we determined its crystal structure from to 2.3 Å. Density for a 2-ketobutyric acid product was identified in the active site and a putative allosteric site. Activity and substrate binding assays confirmed that
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Glioma induces atypical depression-like behaviors in mice through the 5-HT and glutamatergic synapse pathways Biochem. Biophys. Res. Commun. (IF 3.1) Pub Date : 2024-02-22 Boyang Li, Kunnian Ran, Zefan Jing, Wei Han, Xiaozhong Peng
Glioma patients often undertake psychiatric disorders such as depression and anxiety. There are several clinical epidemiological studies on glioma-associated depression, but basic research and corresponding animal experiments are still lacking. Here, we observed that glioma-bearing mice exhibited atypical depression-like behaviors in orthotopic glioma mouse models. The concentrations of monoamine neurotransmitters
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The Trissin/TrissinR signaling pathway in the circadian network regulates evening activity in Drosophila melanogaster under constant dark conditions Biochem. Biophys. Res. Commun. (IF 3.1) Pub Date : 2024-02-22 Manabu Sekiguchi, Shun Katoh, Tatsuya Yokosako, Aika Saito, Momoka Sakai, Ayumi Fukuda, Taichi Q. Itoh, Taishi Yoshii
The circadian clock in Drosophila is governed by a neural network comprising approximately 150 neurons, known as clock neurons, which are intricately interconnected by various neurotransmitters. The neuropeptides that play functional roles in these clock neurons have been identified; however, the roles of some neuropeptides, such as Trissin, remain unclear. Trissin is expressed in lateral dorsal clock
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Distinct binding modes of a benzothiazole derivative confer structural bases for increasing ERK2 or p38α MAPK selectivity Biochem. Biophys. Res. Commun. (IF 3.1) Pub Date : 2024-02-22 Seisuke Hasegawa, Mayu Yoshida, Haruna Nagao, Hajime Sugiyama, Masaaki Sawa, Takayoshi Kinoshita
Mitogen-activated protein kinases (MAPKs), including extracellular signal-regulated kinase 2 (ERK2) and p38α MAP kinase (p38α MAPK), regulate various cellular responses. ERK2 is a drug target for treating many diseases, such as cancer, whereas p38α has attracted much attention as a promising drug target for treating inflammatory disorders. ERK2 is a critical off-target for p38α MAPK and vice versa
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High glucose levels accelerate atherosclerosis via NLRP3-IL/ MAPK/NF-κB-related inflammation pathways Biochem. Biophys. Res. Commun. (IF 3.1) Pub Date : 2024-02-22 Hui Sun, Xiaotian Ma, Hong Ma, Shuen Li, Yan Xia, Lijie Yao, Yingcui Wang, Xuelian Pang, Jingquan Zhong, Guihua Yao, Xiaoling Liu, Mei Zhang
As a chronic inflammatory disease, diabetes mellitus (DM) contributes to the development of atherosclerosis (AS). However, how the NLRP3 inflammasome participates in diabetes-related AS remains unclear. Therefore, this study aimed to elucidate the mechanism through which NLRP3 uses high glucose (HG) levels to promote AS. Serum and coronary artery tissues were collected from coronary artery disease
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Renoprotective effects of laxative linaclotide: Inhibition of acute kidney injury and fibrosis in a rat model of renal ischemia-reperfusion Biochem. Biophys. Res. Commun. (IF 3.1) Pub Date : 2024-02-22 Yukihiro Hitaka, Naohito Isoyama, Shunya Tsuji, Takeshi Honda, Yuki Nakayama, Mitsuhiro Yamaguchi, Kimihiko Nakamura, Hiroshi Hirata, Koji Shiraishi, Masataka Asagiri
Ischemia-reperfusion (I/R) leads to tissue damage in transplanted kidneys, resulting in acute kidney injury (AKI) and chronic graft dysfunction, which critically compromises transplant outcomes, such as graft loss. Linaclotide, a guanylate cyclase C agonist clinically approved as a laxative, has recently been identified to exhibit renoprotective effects in a chronic kidney disease (CKD) model. This
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Thyroid hormone controls the timing of cochlear ribbon synapse maturation Biochem. Biophys. Res. Commun. (IF 3.1) Pub Date : 2024-02-21 Chaorong Yu, Yihan He, Qing Liu, Xiaoyun Qian, Xia Gao, Deye Yang, Ye Yang, Guoqiang Wan
Ribbon synapses in the cochlear hair cells are subject to extensive pruning and maturation processes before hearing onset. Previous studies have highlighted the pivotal role of thyroid hormone (TH) in this developmental process, yet the detailed mechanisms are largely unknown. In this study, we found that the thyroid hormone receptor α (Thrα) is expressed in both sensory epithelium and spiral ganglion