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Trifluoperazine mitigates cyclophosphamide-induced hepatic oxidative stress, inflammation, and apoptosis in mice by modulating the AKT/mTOR-driven autophagy and Nrf2/HO-1 signaling cascades Life Sci. (IF 6.1) Pub Date : 2024-03-17 Ahmed K. Saleh, Nageh A. El-Mahdy, Thanaa A. El-Masry, Aya H. El-Kadem
This study aims to investigate the hepatoprotective effect of the antipsychotic drug trifluoperazine (TFP) against cyclophosphamide (CPA)-induced hepatic injury by exploring its effect on autophagy and the Nrf2/HO-1 signaling pathway. The hepatotoxicity of CPA was assessed by biochemical analysis of the serum hepatotoxicity markers (ALT, AST, and direct bilirubin), histopathological examination, and
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Effects of aerobic exercise on the regulation of mitochondrial carrier homolog-2 and its influence on the catabolic and anabolic activity of lipids in the mesenteric adipose tissue of obese mice Life Sci. (IF 6.1) Pub Date : 2024-03-16 Diego Gomes de Melo, Vivian Cristina da Cruz Rodrigues, Gustavo José de Sá Pereira, Thais Dantis Pereira de Campos, Raphael dos Santos Canciglieri, José Rodrigo Pauli, Adelino Sanchez Ramos da Silva, Célio Junior da Costa Fernandes, Leandro Pereira de Moura
The aim was to understand the direct impact of aerobic short-term exercise on lipid metabolism, specifically in regulating the mitochondrial carrier homolog 2 (MTCH2) and how it interferes with lipid metabolism in mesenteric adipose tissue. Swiss mice were divided into three groups: control, sedentary obese, and exercised obese. The obese groups were induced into obesity for fourteen weeks of a high-fat
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Future perspectives on the roles of mitochondrial dynamics in the heart in obesity and aging Life Sci. (IF 6.1) Pub Date : 2024-03-14 Chayodom Maneechote, Siriporn C. Chattipakorn, Nipon Chattipakorn
Increasing global obesity rates and an aging population are independently linked to cardiac complications. Consequently, it is crucial to comprehensively understand the mechanisms behind these conditions to advance innovative therapies for age-related diseases. Mitochondrial dysfunction, specifically defects in mitochondrial fission/fusion processes, has emerged as a central regulator of cardiac complications
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Polyglutamine disorders: Pathogenesis and potential drug interventions Life Sci. (IF 6.1) Pub Date : 2024-03-14 Shweta Tandon, Prerna Aggarwal, Surajit Sarkar
Polyglutamine/poly(Q) diseases are a group nine hereditary neurodegenerative disorders caused due to abnormally expanded stretches of CAG trinucleotide in functionally distinct genes. All human poly(Q) diseases are characterized by the formation of microscopically discernable poly(Q) positive aggregates, the inclusion bodies. These toxic inclusion bodies are responsible for the impairment of several
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The tale of SOX2: Focusing on lncRNA regulation in cancer progression and therapy Life Sci. (IF 6.1) Pub Date : 2024-03-14 Peng Huang, Feng Wen, YiShan Li, Qiu Li
Long non-coding RNAs (lncRNAs) have emerged as influential contributors to diverse cellular processes, which regulate gene function and expression via multiple mechanistic pathways. Therefore, it is essential to exploit the structures and interactions of lncRNAs to comprehend their mechanistic functions within cells. A growing body of evidence has revealed that deregulated lncRNAs are involved in multiple
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Zebrafish mutants in egln1 display a hypoxic response and develop polycythemia Life Sci. (IF 6.1) Pub Date : 2024-03-14 Xuehan Dou, Zhongyuan Chen, Yunzhang Liu, Yun Li, Junli Ye, Ling Lu
Prolyl hydroxylase domain 2 (PHD2), encoded by the gene, serves as a pivotal regulator of the hypoxia-inducible factor (HIF) pathway and acts as a cellular oxygen sensor. Somatic inactivation of in mice results in polycythemia and congestive heart failure. However, due to the embryonic lethality of deficiency, its role in development remains elusive. Here, we investigated the function of two paralogous
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Alpha-glycosyl isoquercitrin alleviates subchronic social defeat stress-induced depression symptoms by modulating the microbiota-gut-brain axis in mice Life Sci. (IF 6.1) Pub Date : 2024-03-13 Hong Liu, Junjie Li, Shogo Takahashi, Atsushi Toyoda, Ryo Inoue, Mihoko Koyanagi, Shim-mo Hayashi, Meiyu Xu, Yuki Yamamoto, Kentaro Nagaoka
Increasing evidence suggests a link between gut microbial dysbiosis and the pathogenesis of depression. Alpha-glycosyl isoquercitrin (AGIQ), consisting of isoquercitrin and its glycosylated quercetin, has beneficial effects on the gut microbiome and brain function. Here, we detected the potential antidepressant impact of a four-week administration of AGIQ and its underlying mechanisms using a mouse
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Ursodeoxycholic acid alleviates atopic dermatitis-associated inflammatory responses in HaCaT and RBL-2H3 cells and DNCB/DFE-treated mice Life Sci. (IF 6.1) Pub Date : 2024-03-13 Eom Ji Kim, Hoyeon Park, Eun-Young Kim, Do Kyung Kim, Hyuk-sang Jung, Youngjoo Sohn
Ursodeoxycholic acid (UDCA) is a hydrophilic dihydroxy bile acid used for cholestatic liver disease and exhibits antioxidant, antitumor, and anti-inflammatory effects. However, its potential effects on atopic dermatitis (AD) have not been elucidated. This study aimed to evaluate the efficacy of UDCA in inhibiting the inflammatory response and alleviating lesions in AD-like mice. To investigate the
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The role of gut microbiota and probiotics in preventing, treating, and boosting the immune system in colorectal cancer Life Sci. (IF 6.1) Pub Date : 2024-03-13 Forough Masheghati, Mohammad Reza Asgharzadeh, Abbas Jafari, Naser Masoudi, Hadi Maleki-Kakelar
The gut microbiome plays a significant role in developing colorectal cancer (CRC). The gut microbiome usually acts as a protective barrier against harmful pathogens and infections in the intestine, while also regulating inflammation by affecting the human immune system. The gut microbiota and probiotics play a role not only in intestinal inflammation associated with tumor formation but also in regulating
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Cinnamaldehyde/lactulose combination therapy alleviates thioacetamide-induced hepatic encephalopathy via targeting P2X7R-mediated NLRP3 inflammasome signaling Life Sci. (IF 6.1) Pub Date : 2024-03-11 Al Shaima G. Abd El Salam, Nesma A. Abd Elrazik
Cinnamaldehyde (CA), the main active constituent of cinnamon oil, is reported to have neuroprotective effects. However, the potential benefits of CA for brain protection in hepatic encephalopathy (HE) are still not understood. Thus, the present study investigates the possible ameliorative effect of CA (70 mg/kg/day, I.P.) either alone or in combination with lactulose (Lac) (5.3 g/kg/day, oral) against
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Melatonin: Current evidence on protective and therapeutic roles in gynecological diseases Life Sci. (IF 6.1) Pub Date : 2024-03-11 Azam Hosseinzadeh, Nazila Alinaghian, Mohammad Sheibani, Farnoosh Seirafianpour, Ali Jamshidi Naeini, Saeed Mehrzadi
Melatonin, a potent antioxidant and free radical scavenger, has been demonstrated to be effective in gynecological conditions and female reproductive cancers. This review consolidates the accumulating evidence on melatonin's multifaceted protective effects in different pathological contexts. In gynecological conditions such as endometriosis, polycystic ovary syndrome (PCOS), and uterine leiomyoma,
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Plasma membrane calcium ATPase powered by glycolysis is the main mechanism for calcium clearance in the hippocampal pyramidal neuron Life Sci. (IF 6.1) Pub Date : 2024-03-08 Vitor S. Alves, Fernando A. Oliveira
This study sought to elucidate the primary ATP-dependent mechanisms involved in clearing cytosolic Ca in neurons and determine the predominant ATP-generating pathway—glycolysis or tricarboxylic acid cycle/oxidative phosphorylation (TCA/OxPhos)—associated with these mechanisms in hippocampal pyramidal neurons. Our investigation involved evaluating basal Ca levels and analyzing the kinetic characteristics
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Lipid nanoparticles of quercetin (QU-Lip) alleviated pancreatic microenvironment in diabetic male rats: The interplay between oxidative stress – unfolded protein response (UPR) – autophagy, and their regulatory miRNA Life Sci. (IF 6.1) Pub Date : 2024-03-08 Safaa I. Khater, Mahran Mohamed Abd El-Emam, Hussein Abdellatif, Mahmoud Mostafa, Tarek Khamis, Rania Hassan Mohamed Soliman, Heba S. Ahmed, Sahar K. Ali, Heba Mohammed Refat M. Selim, Leena S. Alqahtani, Doaa Habib, Mohamed M.M. Metwally, Anwar M. Alnakhli, Asmaa Saleh, Amira Mohammed Abdelfattah, Hanim M. Abdelnour, Mohamed F. Dowidar
Autophagy is a well-preserved mechanism essential in minimizing endoplasmic reticulum stress (ER)-related cell death. Defects in β-cell autophagy have been linked to type 1 diabetes, particularly deficits in the secretion of insulin, boosting ER stress sensitivity and possibly promoting pancreatic β-cell death. Quercetin (QU) is a potent antioxidant and anti-diabetic flavonoid with low bioavailability
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The intestinal epithelial-macrophage-crypt stem cell axis plays a crucial role in regulating and maintaining intestinal homeostasis Life Sci. (IF 6.1) Pub Date : 2024-03-08 Xiaohui Hu, Xinyi Yuan, Guokun Zhang, Haoyun Song, Pengfei Ji, Yanan Guo, Zihua Liu, Yixiao Tian, Rong Shen, Degui Wang
The intestinal tract plays a vital role in both digestion and immunity, making its equilibrium crucial for overall health. This equilibrium relies on the dynamic interplay among intestinal epithelial cells, macrophages, and crypt stem cells. Intestinal epithelial cells play a pivotal role in protecting and regulating the gut. They form vital barriers, modulate immune responses, and engage in pathogen
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The evidence-based multifaceted roles of hepatic stellate cells in liver diseases: A concise review Life Sci. (IF 6.1) Pub Date : 2024-03-07 Jong-Won Kim, Yu Ji Kim
Hepatic stellate cells (HSCs) play central roles in liver disease pathogenesis, spanning steatosis to cirrhosis and hepatocellular carcinoma. These cells, located in the liver's sinusoidal space of Disse, transition from a quiescent, vitamin A-rich state to an activated, myofibroblast-like phenotype in response to liver injury. This activation results from a complex interplay of cytokines, growth factors
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Nox2 inhibition reduces trophoblast ferroptosis in preeclampsia via the STAT3/GPX4 pathway Life Sci. (IF 6.1) Pub Date : 2024-03-07 Xia Xu, Mengwei Zhu, Yizheng Zu, Guiying Wang, Xiuli Li, Jianying Yan
Ferroptosis, a novel mode of cell death characterized by lipid peroxidation and oxidative stress, plays an important role in the pathogenesis of preeclampsia (PE). The aim of this study is to determine the role of Nox2 in the ferroptosis of trophoblast cells, along with the underlying mechanisms. The mRNA and protein levels of Nox2, STAT3, and GPX4 in placental tissues and trophoblast cells were respectively
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Comparative analysis of effects of conditioned mediums obtained from 2D or 3D cultured mesenchymal stem cells on kidney functions of diabetic rats: Early intervention could potentiate transdifferentiation of parietal epithelial cell into podocyte precursors Life Sci. (IF 6.1) Pub Date : 2024-03-07 Serbay Ozkan, Basak Isildar, Hakan Sahin, Halil Ibrahim Saygi, Dildar Konukoglu, Meral Koyuturk
The secretome of mesenchymal stem cells (MSCs) could be a potential therapeutic intervention for diabetes and associated complications like nephropathy. This study aims to evaluate the effects of conditioned mediums (CMs) collected from umbilical cord-derived MSCs incubated under 2-dimensional (2D) or 3D culture conditions on kidney functions of rats with type-I diabetes (T1D). Sprague-Dawley rats
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Revolutionizing pancreatic islet organoid transplants: Improving engraftment and exploring future frontiers Life Sci. (IF 6.1) Pub Date : 2024-03-06 Noella Abraham, Tejaswini Kolipaka, Giriraj Pandey, Mansi Negi, Dadi A. Srinivasarao, Saurabh Srivastava
Type-1 Diabetes Mellitus (T1DM) manifests due to pancreatic beta cell destruction, causing insulin deficiency and hyperglycaemia. Current therapies are inadequate for brittle diabetics, necessitating pancreatic islet transplants, which however, introduces its own set of challenges such as paucity of donors, rigorous immunosuppression and autoimmune rejection. Organoid technology represents a significant
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Multifaced roles of the long non-coding RNA DRAIC in cancer progression Life Sci. (IF 6.1) Pub Date : 2024-03-06 Kouhei Sakurai, Hiroyasu Ito
Long non-coding RNAs (lncRNA) are functional RNAs, with over 200 nucleotides in length and lacking protein-coding potential. Studies have indicated that lncRNAs are important gene regulators under physiological conditions. Aberrant lncRNA expression is associated with the initiation and progression of various diseases, including cancers. High-throughput transcriptome analyses have revealed thousands
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Corrigendum to “Maresin1 ameliorates acute lung injury induced by sepsis through regulating Th17/Treg balance” [Life Sci. 254 (2020) 117773] Life Sci. (IF 6.1) Pub Date : 2024-03-01 Haifa Xia, Fuquan Wang, Min Wang, Jingxu Wang, Shujun Sun, Ming Chen, Shiqian Huang, Xiangdong Chen, Shanglong Yao
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Hesperetin regulates the intestinal flora and inhibits the TLR4/NF-κB signaling axis to protect the blood-milk barrier and prevent mastitis Life Sci. (IF 6.1) Pub Date : 2024-02-29 Xin Ran, Guiqiu Hu, Weiwei Guo, Kefei Li, Xiaoxuan Wang, Juxiong Liu, Shoupeng Fu
The World Health Organization recommends breastfeeding for 6 months, but mastitis, a common disease during lactation, presents a major obstacle to fulfilling this recommendation. Maternal nutrient intake during lactation has been shown to be related to mastitis. Therefore, this study aimed to explore the effect of hesperetin, a phytonutrient, on mastitis. The oral administration of hesperetin to lipopolysaccharide
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Sirtuin dysregulation in Parkinson's disease: Implications of acetylation and deacetylation processes Life Sci. (IF 6.1) Pub Date : 2024-02-29 Sonia Dhiman, Ashi Mannan, Ayushi Taneja, Maneesh Mohan, Thakur Gurjeet Singh
Parkinson's disease (PD) is a progressive neurodegenerative condition that primarily affects motor function and is caused by a gradual decline of dopaminergic neurons in the brain's substantia pars compacta (Snpc) region. Multiple molecular pathways are involved in the pathogenesis, which results in impaired cellular functions and neuronal degeneration. However, the role of sirtuins, a type of NAD-dependent
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Molecular mechanisms of TACE refractoriness: Directions for improvement of the TACE procedure Life Sci. (IF 6.1) Pub Date : 2024-02-29 Jiahao Li, Yingnan Liu, Ruipeng Zheng, Chao Qu, Jiarui Li
Transcatheter arterial chemoembolisation (TACE) is the standard of care for intermediate-stage hepatocellular carcinoma and selected patients with advanced hepatocellular carcinoma. However, TACE does not achieve a satisfactory objective response rate, and the concept of TACE refractoriness has been proposed to identify patients who do not fully benefit from TACE. Moreover, repeated TACE is necessary
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Vascular dysfunction programmed in male rats by topiramate during peripubertal period Life Sci. (IF 6.1) Pub Date : 2024-02-28 Kawane F. Moura, Deborah Gomes da Silva, Camila Borecki Vidigal, Gabriel Smolak Sobieski e Silva, Ingrid Caroline Pinto, Andréa Name Colado Simão, Bruno V.D. Marques, Fábio Goulart de Andrade, Rúbia Casagrande, Daniela C.C. Gerardin, Eliana H. Akamine, Maria do Carmo P. Franco, Graziela S. Ceravolo
The present study evaluated whether topiramate (TPM) treatment during the peripubertal period affects vascular parameters of male rats and whether oxidative stress plays a role in these changes. Rats were treated with TPM (41 mg/kg/day, gavage) or vehicle (CTR group) from the postnatal day (PND) 28 to 50. At PND 51 and 120 the rats were evaluated for: thoracic aorta reactivity to phenylephrine, in
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ATM deficiency differentially affects expression of proteins related to fatty acid oxidation and oxidative stress in a sex-specific manner in response to Western-type diet prior to and following myocardial infarction Life Sci. (IF 6.1) Pub Date : 2024-02-28 Hui Wang-Heaton, Mary C. Wingard, Suman Dalal, Paige L. Shook, Barbara A. Connelly, Patrick Johnson, Phillip L. Nichols, Mahipal Singh, Krishna Singh
Published work has shown that ataxia-telangiectasia mutated kinase (ATM) deficiency is associated with cardioprotective effects in Western-type diet (WD)-fed female mice. This study assessed the expression of proteins related to fatty acid oxidation (FAO) and oxidative stress in WD-fed male and female mouse hearts, and investigated if sex-specific cardioprotective effects in WD-fed female ATM-deficient
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Mesenchymal stem cell-derived exosomes: Characteristics and applications in disease pathology and management Life Sci. (IF 6.1) Pub Date : 2024-02-28 Hafiza Padinharayil, Jinsu Varghese, Cornelia Wilson, Alex George
Mesenchymal stem cells (MSCs) possess a role in tissue regeneration and homeostasis because of inherent immunomodulatory capacity and the production of factors that encourage healing. There is substantial evidence that MSCs' therapeutic efficacy is primarily determined by their paracrine function including in cancers. Extracellular vesicles (EVs) are basic paracrine effectors of MSCs that reside in
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Liquiritin reduces chondrocyte apoptosis through P53/PUMA signaling pathway to alleviate osteoarthritis Life Sci. (IF 6.1) Pub Date : 2024-02-28 Min Qiu, Liangyan Cheng, Jianbo Xu, Minwei Jin, Wenhua Yuan, Qinwen Ge, Kaiao Zou, Jiali Chen, Yuliang Huang, Ju Li, Liming Zhu, Bing Xu, Chunchun Zhang, Hongting Jin, Pinger Wang
The main pathological features of osteoarthritis (OA) include the degeneration of articular cartilage and a decrease in matrix synthesis. Chondrocytes, which contribute to matrix synthesis, play a crucial role in the development of OA. Liquiritin, an effective ingredient extracted from Glycyrrhiza uralensis Fisch., has been used for over 1000 years to treat OA. This study aims to investigate the impact
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Targeting type I PRMTs as promising targets for the treatment of pulmonary disorders: Asthma, COPD, lung cancer, PF, and PH Life Sci. (IF 6.1) Pub Date : 2024-02-28 Shuyan Zhou, Qiangsheng Zhang, Honglin Yang, Yongxia Zhu, Xiang Hu, Guoquan Wan, Luoting Yu
Pulmonary disorders, including asthma, chronic obstructive pulmonary disease (COPD), pulmonary fibrosis (PF), pulmonary hypertension (PH), and lung cancer, seriously impair the quality of lives of patients. A deeper understanding of the occurrence and development of the above diseases may inspire new strategies to remedy the scarcity of treatments. Type I protein arginine methyltransferases (PRMTs)
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Development of a rectally administrable Dnase1 to treat septic shock by targeting NETs Life Sci. (IF 6.1) Pub Date : 2024-02-27 Su-Bin Kwak, Sang-Jin Kim, Yeon Jun Kang, Won-Woo Lee, June Huh, Jong-Wan Park
Neutrophil extracellular trap (NET), which is formed by DNA threads, induces septic shock by aggravating systemic inflammation. An intravenous administration of deoxyribonuclease is regarded as a compelling modality for treating septic shock. However, alternative routes should be chosen when cutaneous veins are all collapsed due to hypotension. In this study, we genetically engineered this enzyme to
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Decoding cell death signalling: Impact on the response of breast cancer cells to approved therapies Life Sci. (IF 6.1) Pub Date : 2024-02-27 Lama Lozon, Wafaa S. Ramadan, Rawan R. Kawaf, Aya M. Al-Shihabi, Raafat El-Awady
Breast cancer is a principal cause of cancer-related mortality in female worldwide. While many approved therapies have shown promising outcomes in treating breast cancer, understanding the intricate signalling pathways controlling cell death is crucial for optimizing the treatment outcome. A growing body of evidence has unveiled the aberrations in multiple cell death pathways across diverse cancer
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Comprehensive pan-cancer analysis identifies the RNA-binding protein LRPPRC as a novel prognostic and immune biomarker Life Sci. (IF 6.1) Pub Date : 2024-02-27 Zheng Wu, Xinyue Liu, Fang Xie, Chao Ma, Eric W.-F. Lam, Ning Kang, Di Jin, Jinsong Yan, Bilian Jin
RNA-binding proteins (RBPs) play pivotal roles in carcinogenesis and immunotherapy. Leucine-rich pentapeptide repeat-containing protein (LRPPRC) is crucial for RNA polyadenylation, transport, and stability. Although recent studies have suggested LRPPRC's potential role in tumor progression, its significance in tumor prognosis, diagnosis, and immunology remains unclear. We comprehensively analyzed LRPPRC
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Exploring the multifaceted effects of Interleukin-1 in lung cancer: From tumor development to immune modulation Life Sci. (IF 6.1) Pub Date : 2024-02-27 Mingbo Tang, Yipeng Yin, Wei Wang, Kejian Gong, Junxue Dong, Xinliang Gao, Jialin Li, Linan Fang, Jianzun Ma, Yang Hong, Zhiqin Li, Taiyu Bi, Wenyu Zhang, Wei Liu
Lung cancer, acknowledged as one of the most fatal cancers globally, faces limited treatment options on an international scale. The success of clinical treatment is impeded by challenges such as late diagnosis, restricted treatment alternatives, relapse, and the emergence of drug resistance. This predicament has led to a saturation point in lung cancer treatment, prompting a rapid shift in focus towards
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The effect of microbiome therapy on COVID-19-induced gut dysbiosis: A narrative and systematic review Life Sci. (IF 6.1) Pub Date : 2024-02-24 Mahmoud Yousef, Mlaak Rob, Sanish Varghese, Shrinidhi Rao, Fahad Zamir, Pradipta Paul, Ali Chaari
Emerging evidence highlights the role of COVID-19 in instigating gut dysbiosis, with repercussions on disease severity and bidirectional gut-organ communication involving the lung, heart, brain, and liver. This study aims to evaluate the efficacy of probiotics, prebiotics, synbiotics, and fecal microbiota transplantation (FMT) in addressing gut dysbiosis associated with COVID-19, as well as their impact
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Cell-mediated barriers in cancer immunosurveillance Life Sci. (IF 6.1) Pub Date : 2024-02-24 Jafar Rezaie, Leila Chodari, Shadi Mohammadpour-Asl, Abbas Jafari, Zahra Niknam
The immune cells within the tumor microenvironment (TME) exert multifaceted functions ranging from tumor-antagonizing or tumor-promoting activities. During the initial phases of tumor development, the tumor-antagonizing immune cells in the TME combat cancer cells in an immune surveillance process. However, with time, cancer cells can evade detection and impede the immune cells' effectiveness through
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GT-11 impairs insulin signaling through modulation of sphingolipid metabolism in C2C12 myotubes Life Sci. (IF 6.1) Pub Date : 2024-02-24 Javokhir Rustamov, Yoon-Seok Roh, Jin Tae Hong, Hwan-Soo Yoo
Sphingolipids are involved in the regulation of insulin signaling, which is linked to the development of insulin resistance, leading to diabetes mellitus. We aimed to study whether modulation of sphingolipid levels by GT-11 may regulate insulin signaling in C2C12 myotubes. We investigated the effects of sphingolipid metabolism on Akt phosphorylation and glucose uptake using C2C12 myotubes. Either GT-11
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The mechanism by which SIRT1 regulates autophagy and EMT in drug-resistant oesophageal cancer cells Life Sci. (IF 6.1) Pub Date : 2024-02-23 Xueyan Zhang, Yalong Dong, Wenbo Li, Mingjing He, Yangyang Shi, Shuhua Han, Linlin Li, Jinzhu Zhao, Leilei Li, Junfeng Huo, Xiaojie Liu, Yanting Ji, Qi Liu, Cong Wang
Cancer cell resistance presents a significant clinical challenge. The mechanisms underlying drug resistance in cancer cells are intricate and remain incompletely understood. Notably, tumor cell resistance often coincides with the epithelial-mesenchymal transition (EMT).
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Retraction notice to “Lycium barbarum polysaccharides attenuate kidney injury in septic rats by regulating Keap1-Nrf2/ARE pathway” [Life Sci. 242 (2020) 117240] Life Sci. (IF 6.1) Pub Date : 2024-02-23 Qi Wu, Lan-tao Liu, Xue-yong Wang, Zhi-fang Lang, Xiang-hui Meng, Su-fen Guo, Bin Yan, Tao Zhan, Hui-zhe Zheng, Hong-wei Wang
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Ablation of histone methyltransferase Suv39h2 in hepatocytes attenuates NASH in mice Life Sci. (IF 6.1) Pub Date : 2024-02-23 Shiqiang Wu, Wenjing Ren, Jiameng Hong, Yuyu Yang, Yunjie Lu
Non-alcoholic steatohepatitis (NASH) is characterized by aberrant lipid metabolism in hepatocytes. We investigated the involvement of a histone H3K9 methyltransferase Suv39h2 in the pathogenesis of NASH. NASH is induced by feeding the mice with a high-fat high-carbohydrate (HFHC) diet or a high-fat choline-deficient amino acid defined (HFD-CDAA) diet. The mice were crossbred with the -Cre mice to specifically
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Significance of LncRNAs in AKI-to-CKD transition: A therapeutic and diagnostic viewpoint Life Sci. (IF 6.1) Pub Date : 2024-02-22 Bhupendra Puri, Syamantak Majumder, Anil Bhanudas Gaikwad
Acute kidney injury to chronic kidney disease (AKI-to-CKD) transition is a complex intermingling of characteristics of both AKI and CKD. Pathophysiologically, the transition lasts seven days after the AKI episode and thereafter silently progresses towards CKD. Growing reports confirm that the AKI-to-CKD transition is heavily regulated by epigenetic modifiers. Long non-coding RNAs (lncRNAs) share a
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The potential mechanisms underlying the modulating effect of perirenal adipose tissue on hypertension: Physical compression, paracrine, and neurogenic regulation Life Sci. (IF 6.1) Pub Date : 2024-02-22 Jin-Yu Sun, Zhenyang Su, Jiaming Yang, Wei Sun, Xiangqing Kong
Hypertension, a prevalent global cardiovascular disease, affects approximately 45.4 % of adults worldwide. Despite advances in therapy, hypertension continues to pose a significant health risk due to inadequate management. It has been established that excessive adiposity contributes majorly to hypertension, accounting for 65 to 75 % of primary cases. Fat depots can be categorised into subcutaneous
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Related cellular signaling and consequent pathophysiological outcomes of ubiquitin specific protease 24 Life Sci. (IF 6.1) Pub Date : 2024-02-22 Xiaoyang Song, Boyu Xia, Xinrong Gao, Xinying Liu, Hongyuan Lv, Shiwei Wang, Qinpei Xiao, Hao Luo
Ubiquitin-specific protease 24 (USP24) is an essential member of the deubiquitinating protease family found in eukaryotes. It engages in interactions with multiple proteins, including p53, MCL-1, E2F4, and FTH1, among others. Through these interactions, USP24 plays a critical role in regulating vital cellular processes such as cell cycle control, DNA damage response, cellular iron autophagy, and apoptosis
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Retraction notice to "Corrigendum to “Smooth muscle 22 alpha maintains the differentiated phenotype of vascular smooth muscle cells by inducing filamentous actin bundling” [Life Sci. 295 (2022) 120407] Life Sci. (IF 6.1) Pub Date : 2024-02-22 Mei Han, Li-Hua Dong, Bin Zheng, Jian-Hong Shi, Jin-Kun Wen, Yunhui Cheng
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Exercise and insulin glargine administration in mothers with diabetes during pregnancy ameliorate function of testis in offspring: Consequences on apelin-13 and its receptor Life Sci. (IF 6.1) Pub Date : 2024-02-22 Keyvan Mehri, Gholamreza Hamidian, Shirin Babri, Fereshteh Farajdokht, Zohreh Zavvari Oskuye
Despite the evidence exhibited that diabetes during gestation (DDG) is linked with reproductive dysfunction in offspring, the underlying cellular mechanisms involved are not precisely defined. This study was designed to assess the impact of voluntary exercise and insulin glargine on DDG-induced metabolic and reproductive disorders in male offspring. Fifty female Wistar rats (three weeks old) received
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Human gestational diabetes mellitus–derived exosomes impair glucose homeostasis in pregnant mice and stimulate functional maturation of offspring-islets Life Sci. (IF 6.1) Pub Date : 2024-02-22 Linhai Zou, Chunxue Xu, Li Wang, Xiangju Cao, Xinyu Jia, Zhihong Yang, Guohui Jiang, Lixia Ji
Pancreatic islets undergo critical development and functional maturation during the perinatal period when they are highly sensitive to microenvironment. We aim to determine the effects and mechanisms of gestational diabetes mellitus (GDM) hypermetabolic stress on glucose homeostasis in pregnant mice and functional maturation of the islets of their offspring. Exosomes were extracted from the umbilical
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Melatonin restores DNFB-induced dysbiosis of skin microbiota in a mouse model of atopic dermatitis Life Sci. (IF 6.1) Pub Date : 2024-02-21 Kun Yang, Jiang-yan Yong, Yan He, Lu Yu, Gui-ning Luo, Jilan Chen, Yi-Man Ge, You-jun Yang, Wei-jun Ding, Yi-mei Hu
The epidermic microbiota plays crucial roles in the pathogenesis of atopic dermatitis (AD), a common inflammatory skin disease. Melatonin (MLT) has been shown to ameliorate skin damage in AD patients, yet the underlying mechanism is unclear. Using 2,4-dinitrofluorobenzene (DNFB) to induce an AD model, MLT intervention was applied for 14 days to observe its pharmaceutical effect. Skin lesions were observed
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Implication of Rac1 GTPase in molecular and cellular mitochondrial functions Life Sci. (IF 6.1) Pub Date : 2024-02-20 Christian Bailly, Claire Degand, William Laine, Vincent Sauzeau, Jérôme Kluza
Rac1 is a member of the Rho GTPase family which plays major roles in cell mobility, polarity and migration, as a fundamental regulator of actin cytoskeleton. Signal transduction by Rac1 occurs through interaction with multiple effector proteins, and its activity is regulated by guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs). The small protein is mainly anchored to
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Elevated levels of alcohol dehydrogenase aggravate ethanol-evoked cardiac remodeling and contractile anomalies through FKBP5-yap-mediated regulation of ferroptosis and ER stress Life Sci. (IF 6.1) Pub Date : 2024-02-20 Qi Lu, Xing Qin, Chu Chen, Wei Yu, Jie Lin, Xiaoyu Liu, Rui Guo, Russel J. Reiter, Milad Ashrafizadeh, Ming Yuan, Jun Ren
Alcohol intake provokes severe organ injuries including alcoholic cardiomyopathy with hallmarks of cardiac remodeling and contractile defects. This study examined the toxicity of facilitated ethanol metabolism in alcoholism-evoked changes in myocardial morphology and contractile function, insulin signaling and various cell death domains using cardiac-selective overexpression of alcohol dehydrogenase
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Progress in the relationship between GDF11 and depression Life Sci. (IF 6.1) Pub Date : 2024-02-18 Xiang Jin, Wei Guan
Annually, the frequency of morbidity in depression has increased progressively in response to life stressors, and there is an increasing trend toward younger morbidity.
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The role of viruses in cancer progression versus cancer treatment: A dual paradigm Life Sci. (IF 6.1) Pub Date : 2024-02-17 Somya Ranjan Dash, Anushka Kundu, Chanakya Nath Kundu
Most human malignancies are attributed to exposure to infectious organisms such as viruses. Certain infections that can induce cancer can evade the immune system, leading to persistent inflammation that facilitates uncontrolled cell growth. Moreover, these pathogens can increase the likelihood of oncogenic transformation, leading to cancer development. Despite significant advancements in medicine,
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Dimethyl fumarate restores Ca2+ dyshomeostasis through activation of the SIRT1 signal to treat nonalcoholic fatty liver disease Life Sci. (IF 6.1) Pub Date : 2024-02-14 Rui Zhang, Quanwei Zhang, ZiYi Cui, BenZeng Huang, Haitian Ma
Nonalcoholic fatty liver disease (NAFLD) is characterized by an excessive lipid accumulation in the liver, with a global prevalence of approximately 25 %. While early-stage steatosis is reversible and can be intervened upon, it has the potential to progress to some serious complications, including cirrhosis and even liver cancer. Dimethyl fumarate (DMF), a derivative of fumaric acid shows promise in
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Cingulin family: Structure, function and clinical significance Life Sci. (IF 6.1) Pub Date : 2024-02-13 Yuling Su, You Long, Keping Xie
Cingulin and its paralog paracingulin are vital components of the apical junctional complex in vertebrate epithelial and endothelial cells. They are both found in tight junctions (TJ), and paracingulin is also detectable in adherens junctions (AJ) as TJ cytoplasmic plaque proteins. Cingulin and paracingulin interact with other proteins to perform functions. They interact with cytoskeletal proteins
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A treadmill exercise reduced cardiac fibrosis, inflammation and vulnerability to ischemia-reperfusion in rat pristane-induced arthritis Life Sci. (IF 6.1) Pub Date : 2024-02-13 C. Peyronnel, J. Kessler, S. Bobillier-Chaumont Devaux, C. Houdayer, M. Tournier, M. Chouk, D. Wendling, H. Martin, P. Totoson, C. Demougeot
To explore cardiac structural and functional parameters and myocardial sensitivity to ischemia in a rat model of chronic arthritis, pristane-induced arthritis (PIA), and to investigate the effects of a running exercise protocol on cardiac disorders related to rheumatoid arthritis (RA). 3 groups of male Dark Agouti rats were formed: Controls, PIA and PIA-Exercise. The PIA-Exercise group was subjected
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Dysbiosis of gut microbiota and metabolites is associated with radiation-induced colorectal fibrosis and is restored by adipose-derived mesenchymal stem cell therapy Life Sci. (IF 6.1) Pub Date : 2024-02-12 Mya Thandar, Xiaojie Yang, Yuanchang Zhu, Xueying Zhang, Zhifen Chen, Shenghui Huang, Pan Chi
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Synergistic therapeutic strategies and engineered nanoparticles for anti-vascular endothelial growth factor therapy in cancer Life Sci. (IF 6.1) Pub Date : 2024-02-10 Asmaa F. Khafaga, Mohamed M.S. Gaballa, Reham Karam, Salma A. Shoulah, Rehab N. Shamma, Norhan E. Khalifa, Nehal E. Farrag, Ahmed E. Noreldin
Angiogenesis is one of the defining characteristics of cancer. Vascular endothelial growth factor (VEGF) is crucial for the development of angiogenesis. A growing interest in cancer therapy is being caused by the widespread use of antiangiogenic drugs in treating several types of human cancer. However, this therapeutic approach can worsen resistance, invasion, and overall survival. As we proceed, refining
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Suv39h1 contributes to activation of hepatic stellate cells in non-alcoholic fatty liver disease by enabling anaerobic glycolysis Life Sci. (IF 6.1) Pub Date : 2024-02-08 Xiaoyan Wu, Yuzhou Shen, Yufei Meng, Jinsi Chen, Yongchen Zhang, Sheng Zeng, Huihui Xu
Non-alcoholic fatty liver disease (NAFLD) has become a global epidemic. Excessive fibrogenesis, characterized by activation of hepatic stellate cells (HSCs), is a hallmark event in late stages of NAFLD. HSC activation is metabolically programmed by anaerobic glycolysis. In the present study we investigated the involvement of suppressor of variegation 3–9 homolog 1 (Suv39h1), a lysine methyltransferase
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The structure and function of lamin A/C: Special focus on cardiomyopathy and therapeutic interventions Life Sci. (IF 6.1) Pub Date : 2024-02-08 Vikas Tiwari, Md Jahangir Alam, Madhavi Bhatia, Malladi Navya, Sanjay K. Banerjee
Lamins are inner nuclear membrane proteins that belong to the intermediate filament family. Lamin A/C lie adjacent to the heterochromatin structure in polymer form, providing skeletal to the nucleus. Based on the localization, lamin A/C provides nuclear stability and cytoskeleton to the nucleus and modulates chromatin organization and gene expression. Besides being the structural protein making the
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Identification and validation of KIF23 as a hypoxia-regulated lactate metabolism-related oncogene in uterine corpus endometrial carcinoma Life Sci. (IF 6.1) Pub Date : 2024-02-07 Tao Wang, Xiaotong Peng, Wenwen Liu, Mei Ji, Jing Sun
The “Warburg effect” has been developed from the discovery that hypoxia-inducible factor 1α (HIF-1α) could promote the conversion of pyruvate to lactate. However, no studies have linked hypoxia and lactate metabolism to uterine corpus endometrial carcinoma (UCEC). Sequencing and clinical data of patients with UCEC were extracted from The Cancer Genome Atlas (TCGA) database. Hypoxia-related lactate
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Role of hydrogen sulfide in the regulation of lipid metabolism: Implications on cardiovascular health Life Sci. (IF 6.1) Pub Date : 2024-02-07 Lorenzo Flori, Eugenia Piragine, Vincenzo Calderone, Lara Testai
The World Health Organization (WHO) defines obesity as an urgency for health and a social emergency. Today around 39 % of people is overweight, of these over 13 % is obese.
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Empagliflozin attenuates radiation-induced hematopoietic damage via NOX-4/ROS/p38 pathway Life Sci. (IF 6.1) Pub Date : 2024-02-06 Qidong Huo, Tongpeng Yue, Wenxuan Li, Xinyue Wang, Yinping Dong, Deguan Li
Damage to the hematopoietic system and functional inhibition are severe consequences of radiation exposure. In this study, we have investigated the effect of empagliflozin on radiation-induced hematopoietic damage, with the aim of providing new preventive approach to such injuries. Mice were given 4 Gy total body irradiation (TBI) 1 h after the oral administration of empagliflozin, followed by the