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The complete mitogenome sequence of the coral lily (Lilium pumilum) and the Lanzhou lily (Lilium davidii) in China Open Life Sci. (IF 0.69) Pub Date : 2020-12-31 Xiangying Qi; Kaiqi Wang; Liping Yang; Zhenshan Deng; Zhihong Sun
The mitogenomes of higher plants are conserved. This study was performed to complete the mitogenome of two China Lilium species (Lilium pumilum Redouté and Lilium davidii var. unicolor (Hoog) cotton).
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Effects of center pivot sprinkler fertigation on the yield of continuously cropped soybean Open Life Sci. (IF 0.69) Pub Date : 2020-12-31 Hua Cao; Yongshen Fan; Zhen Chen; Xiuqiao Huang
Continuous cropping is a common agricultural practice in Northeast China. Focusing on soybeans cropped continuously for two consecutive years, this article fully explores the effects of the amount of water, fertilizing rate, and fertilizing method on the growth and yield of soybean. Specifically, an orthogonal experimental plan was designed involving these three factors. Each factor was divided into
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Testosterone aggravates cerebral vascular injury by reducing plasma HDL levels Open Life Sci. (IF 0.69) Pub Date : 2020-12-31 Tao Jin; Lu Wang; Dongbo Li; Tao Yang; Yuefei Zhou
Testosterone is often used to improve the physiological function. But increased testosterone levels affect blood lipids and cause inflammation and oxidative stress, which are risk factors for vascular diseases. This study aimed at investigating the effects of testosterone on cerebral vascular injury using an established intracranial aneurysm (IA) model. Sixteen-week-old female C57Bl/6 mice were subcutaneously
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Effects of Bacillus megaterium on growth performance, serum biochemical parameters, antioxidant capacity, and immune function in suckling calves Open Life Sci. (IF 0.69) Pub Date : 2020-12-31 Jun Yao; Lili Wang; Wenju Zhang; Mengjian Liu; Junli Niu
This study was conducted to investigate the effects of Bacillus megaterium on growth performance, serum biochemical parameters, antioxidant capacity, and immune function in suckling calves.
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CD11b is involved in coxsackievirus B3-induced viral myocarditis in mice by inducing Th17 cells Open Life Sci. (IF 0.69) Pub Date : 2020-12-31 Heng Wei; Chong-Kai Lin; Sheng-Jian Lu; Yu-Xin Wen; Shuai Yuan; Yan-Li Liu
Viral myocarditis (VMC) caused by coxsackievirus B3 (CVB3) infection is a life-threatening disease. The cardiac damage during VMC is not mainly due to the direct cytotoxic effect of the virus on cardiomyocytes but mostly involves the induction of immune responses. Integrin CD11b plays an important role in immune response, for instance, in the induction of Th17 cells. However, the role of CD11b in the
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Decitabine shows anti-acute myeloid leukemia potential via regulating the miR-212-5p/CCNT2 axis Open Life Sci. (IF 0.69) Pub Date : 2020-12-31 Lina Xing; Jinhai Ren; Xiaonan Guo; Shukai Qiao; Tian Tian
Previous research has revealed the involvement of microRNA-212-5p (miR-212-5p) and cyclin T2 (CCNT2) in acute myeloid leukemia (AML). However, whether the miR-212-5p/CCNT2 axis is required for the function of decitabine in AML has not been well elucidated. Quantitative reverse transcription-polymerase chain reaction was used to examine enrichment of miR-212-5p. The relationship between CCNT2 and miR-212-5p
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Ropivacaine inhibits proliferation, migration, and invasion while inducing apoptosis of glioma cells by regulating the SNHG16/miR-424-5p axis Open Life Sci. (IF 0.69) Pub Date : 2020-12-31 Rong Liu; Min Wu; Guiju Xu; Lu Ju; Jinhui Xiao; Wei Zhong; Xiao He; Yan Yang
Regional anesthesia has anti-proliferative and pro-apoptotic effects in various cancers. Therefore, the purpose of this study was to investigate the effects of ropivacaine on the proliferation, migration, invasion, and apoptosis of glioma cells in vitro.
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Long noncoding RNA FTX ameliorates hydrogen peroxide-induced cardiomyocyte injury by regulating the miR-150/KLF13 axis Open Life Sci. (IF 0.69) Pub Date : 2020-12-31 Yamin Zhang; Xiaoying Fan; Hua Yang
Myocardial reperfusion is an effective therapy for acute myocardial infarction (AMI). However, ischemia/reperfusion (I/R) injury following myocardial reperfusion is a significant limitation for AMI treatment. Five prime to Xist (FTX) was recognized as a biomarker of multiple diseases, including heart disease. However, the molecular mechanism of FTX in I/R injury is unclear.
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Relationship between hemodynamic parameters and portal venous pressure in cirrhosis patients with portal hypertension Open Life Sci. (IF 0.69) Pub Date : 2020-12-31 Hongjuan Yao; Yongliang Wang
Cirrhosis caused by viral and alcoholic hepatitis is an essential cause of portal hypertension (PHT). The incidence of PHT complication is directly proportional to portal venous pressure (PVP), and the clinical research of PVP and its hemodynamic indexes is of great significance for deciding the treatment strategy of PHT. Various techniques are currently being developed to decrease portal pressure
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Rapid visual detection of FecB gene expression in sheep Open Life Sci. (IF 0.69) Pub Date : 2020-12-24 Li Liu; Ruirui Hu; Cunyuan Li; Xiaoyue Li; Wei Ni; Rui Yao; Mengdan Zhang; Huixiang Li; Yueren Xu; Yaseen Ullah; Shengwei Hu
Sheep play an important role in agricultural production and people’s lives, and fecundity is one of the most important economic traits of sheep for sheep breeders. The Booroola fecundity (FecB) gene has a certain correlation with litter size in sheep. Therefore, this study aims to detect FecB expression quickly, accurately and visually. Here, we used the nucleic acid dye SYBR Green I to detect FecB
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MiR-203-3p inhibits the oxidative stress, inflammatory responses and apoptosis of mice podocytes induced by high glucose through regulating Sema3A expression Open Life Sci. (IF 0.69) Pub Date : 2020-12-22 Jingfu Chen; Qing Xu; Wei Zhang; YuLan Zhen; Fei Cheng; Guo Hua; Jun Lan; Chang Tu
Diabetic nephropathy (DN) is the most serious long-term microvascular complication of diabetes, which mainly causes podocyte injury. Many studies have shown that microRNAs play a vital role in the development of DN. Studies have shown that miR-203-3p is involved in mesangial cell proliferation and apoptosis of DN mice. Therefore, we speculated that miR-203-3p might be related to the development of
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CTRP9 protects against MIA-induced inflammation and knee cartilage damage by deactivating the MAPK/NF-κB pathway in rats with osteoarthritis Open Life Sci. (IF 0.69) Pub Date : 2020-12-23 Shicheng Zheng; Jing Ren; Sihai Gong; Feng Qiao; Jinlong He
C1q/TNF-related protein 9 (CTRP9), the closest paralog of adiponectin, has been reported to protect against inflammation-related diseases. However, its role in regulating osteoarthritis (OA) has not been fully elucidated. First, a rat model of OA was generated. Furthermore, rats with OA were injected with different doses of recombinant CTRP9 protein (rCTRP9), and the knee cartilage damage was evaluated
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MiR-30c-5p/ROCK2 axis regulates cell proliferation, apoptosis and EMT via the PI3K/AKT signaling pathway in HG-induced HK-2 cells Open Life Sci. (IF 0.69) Pub Date : 2020-12-23 Lianshun Cui; Meiyan Yu; Xinglei Cui
Diabetic nephropathy (DN) is one of the most common complications of diabetes mellitus. Increasing evidence suggests that microRNA-30c-5p (miR-30c-5p) participates in the pathogenesis of DN, but the mechanism has not been clearly understood. Therefore, this study aimed to investigate the biological role of miR-30c-5p in human DN progression in vitro. Compared with the controls, DN tissues and high
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LncRNA RP1-85F18.6 affects osteoblast cells by regulating the cell cycle Open Life Sci. (IF 0.69) Pub Date : 2020-12-22 Jiangtao Song; Wenrong Song; Lei Zhang
A lncRNA RP1-85F18.6 was reported to affect cell growth by regulating the cell cycle. Here we tested whether it affects the proliferation of osteoblast cells by regulating the cell cycle. We determined the expression of RP1-85F18.6 in two osteoblast cell lines hFOB and HOB by qPCR. Then we knocked down or overexpressed RP1-85F18.6 in hFOB and tested the alteration of viability, cell cycle, and cell
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miR-339-3p regulated acute pancreatitis induced by caerulein through targeting TNF receptor-associated factor 3 in AR42J cells Open Life Sci. (IF 0.69) Pub Date : 2020-12-19 Qi Wang; Shaofeng Liu; Zhen Han
Acute pancreatitis (AP) is an inflammatory disease with high morbidity and mortality. The regulation mechanism of miRNA is involved in the production and development of various diseases, but the regulation mechanism of miRNA in AP is still not fully elucidated. The expression of miR-339-3p was detected using quantitative real-time PCR. The levels of TNF-α, IL-1β, and IL-6 were detected using enzyme-linked
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Natural variation in stress response induced by low CO2 in Arabidopsis thaliana Open Life Sci. (IF 0.69) Pub Date : 2020-12-21 Chunxia Wu; Yulou Sun; Guang Yang; Li Li; Wei Sun; Zenglan Wang; Hui Zhang; Yuanyuan Li
Variation in atmospheric carbon dioxide (CO2) concentration can dictate plant growth and development and shape plant evolution. For paired populations of 31 Arabidopsis accessions, respectively, grown under 100 or 380 ppm CO2, we compared phenotypic traits related to vegetative growth and flowering time. Four accessions showed the least variation in measured growth traits between 100 ppm CO2 and 380 ppm
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Study on the optimal antagonistic effect of a bacterial complex against Monilinia fructicola in peach Open Life Sci. (IF 0.69) Pub Date : 2020-12-15 Haotian Chang; Haiqing Yang; Tao Han; Fang Wang; Yueping Liu
Peach brown rot caused by Monilinia fructicola is one of the most economically destructive diseases of peach (Prunus persica L.) in some orchards of China. Biocontrol is a significant strategy that exhibits strong levels of control and ecologically sound concepts in disease management. The purpose of this study was to investigate the combined suppressive effects of three endophytic bacterial strains
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CRISPR/Cas9 or prime editing? – It depends on… Open Life Sci. (IF 0.69) Pub Date : 2020-12-03 Dirk Schenke
Journal Name: Open Life Sciences Volume: 15 Issue: 1 Pages: 868-870
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The prognostic and predictive value of platelet parameters in diabetic and nondiabetic patients with sudden sensorineural hearing loss Open Life Sci. (IF 0.69) Pub Date : 2020-12-04 İbrahim Özcan; İbrahim Hira; Altan Kaya; Mehmet Yaşar; Murat Doğan; Cemil Mutlu
We aimed to evaluate the association between mean platelet volume, platelet distribution width (PDW), platelet count (PC) and plateletcrit (PCT), and the presence of sudden sensorineural hearing loss (SSNHL) and treatment response. In the literature, there is no study that investigates the platelet functions in diabetic patients with SSNHL.
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LncRNA SNHG15 contributes to doxorubicin resistance of osteosarcoma cells through targeting the miR-381-3p/GFRA1 axis Open Life Sci. (IF 0.69) Pub Date : 2020-12-06 Jinshan Zhang; Dan Rao; Haibo Ma; Defeng Kong; Xiaoming Xu; Hougen Lu
Osteosarcoma is a common primary malignant bone cancer. Long noncoding RNA small nucleolar RNA host gene 15 (SNHG15) has been reported to play an oncogenic role in many cancers. Nevertheless, the role of SNHG15 in the doxorubicin (DXR) resistance of osteosarcoma cells has not been fully addressed.
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Relationship of FTO gene variations with NAFLD risk in Chinese men Open Life Sci. (IF 0.69) Pub Date : 2020-11-30 Xuefen Chen; Yong Gao; Xiaobo Yang; Haiying Zhang; Zengnan Mo; Aihua Tan
Fat mass and obesity-associated (FTO) gene is an obesity susceptibility gene and its relationship with the nonalcoholic fatty liver disease (NAFLD) remains unclear. This study aims to investigate the relationships of FTO gene variations with NAFLD risk in a Chinese male population.
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CircSAMD4A contributes to cell doxorubicin resistance in osteosarcoma by regulating the miR-218-5p/KLF8 axis Open Life Sci. (IF 0.69) Pub Date : 2020-11-24 Wei Wei; Liefeng Ji; Wanli Duan; Jiang Zhu
Circular RNA sterile alpha motif domain containing 4A (circSAMD4A) was found to be differentially expressed in osteosarcoma and contributed to the tumorigenesis of osteosarcoma. However, the role of circSAMD4A in doxorubicin (DXR) resistance of osteosarcoma is yet to be elucidated. Levels of circSAMD4A, microRNA (miR)-218-5p and Krüppel-like factor 8 (KLF8) were detected using quantitative reverse
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In vitro induction and characterisation of tetraploid drumstick tree (Moringa oleifera Lam.) Open Life Sci. (IF 0.69) Pub Date : 2020-11-18 Junjie Zhang; Ruiqi Pian; Endian Yang; Wei Zhou; Qian He; Xiaoyang Chen
Artificial induction of polyploidy is widely used in breeding programmes to improve the agronomic traits. The drumstick tree (Moringa oleifera Lam.) has a range of potential commercial uses, as the vegetative organs have high nutritional, medicinal, and feed values. In the present study, in vitro tetraploidisation in drumstick tree was performed by treating leaf segments with colchicine and subsequently
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Silver nanoparticles: synthesis, characterisation and biomedical applications Open Life Sci. (IF 0.69) Pub Date : 2020-11-19 Ahmad Almatroudi
Nanotechnology is a rapidly growing field due to its unique functionality and a wide range of applications. Nanomedicine explores the possibilities of applying the knowledge and tools of nanotechnology for the prevention, treatment, diagnosis and control of disease. In this regard, silver nanoparticles with diameters ranging from 1 to 100 nm are considered most important due to their unique properties
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Preparation of konjac oligoglucomannans with different molecular weights and their in vitro and in vivo antioxidant activities Open Life Sci. (IF 0.69) Pub Date : 2020-11-11 Weidong Yang
In this paper, konjac oligoglucomannan (KOGM) was obtained with a hydrolysis rate of 56.24% by controlling the hydrolysis conditions. KOGM was passed through a 0.2 kDa dialysis bag, a 3 kDa ultrafiltration tube, and a 5 kDa ultrafiltration tube, creating samples with molecular weights of 0.2–3 kDa (IV), 3–5 kDa (III), and >5 kDa (II), respectively. The in vitro antioxidant activities of the KOGM samples
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The impedance analysis of small intestine fusion by pulse source Open Life Sci. (IF 0.69) Pub Date : 2020-11-03 Yifan Wang; Kefu Liu; Xiaowei Xiang; Caihui Zhu; Hao Wang
The radiofrequency-induced intestine fusion has been widely studied as an alternative for traditional suture in surgery, but fusion quality cannot be evaluated directly. Impedance measurement can evaluate fusion quality, but the relation between impedance and the fusion quality needs optimization for best results. The present study reports the optimum resistance of small intestine fusion. As the feedback
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Erratum to “Thermostable cellulase biosynthesis from Paenibacillus alvei and its utilization in lactic acid production by simultaneous saccharification and fermentation” Open Life Sci. (IF 0.69) Pub Date : 2020-10-28 Yasser S. Mostafa; Saad A. Alamri; Mohamed Hashem; Nivien A. Nafady; Kamal A. M. Abo-Elyousr; Zakaria A. Mohamed
Journal Name: Open Life Sciences Volume: 15 Issue: 1 Pages: 798-798
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Erratum to “MYL6B drives the capabilities of proliferation, invasion, and migration in rectal adenocarcinoma through the EMT process” Open Life Sci. (IF 0.69) Pub Date : 2020-10-28 Zai-Qiu Wang; Xiao-Li Sun; Jin-Liang Li
Journal Name: Open Life Sciences Volume: 15 Issue: 1 Pages: 797-797
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The effects of yam gruel on lowering fasted blood glucose in T2DM rats Open Life Sci. (IF 0.69) Pub Date : 2020-10-14 Xinjun Lin; Zongting Luo; Shuqin Pang; Carol Chunfeng Wang; Li Ge; Yanling Dai; Jian Zhou; Fang Chen; Xuepei Hong; Jiahui Zhang
There is increasing evidence of the linkage between type 2 diabetes mellitus (T2DM) and gut microbiota. Based on our previous studies, we investigated the hypoglycemic mechanisms of yam gruel to provide a scientific basis for its popularization and application. Wistar rats were randomly divided into control and T2DM model groups. Rats in the model group were stimulated by a high-sugar/high-fat diet
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Studying of the promotion mechanism of Bacillus subtilis QM3 on wheat seed germination based on β-amylase Open Life Sci. (IF 0.69) Pub Date : 2020-10-14 Ya-Jing Li; Qing-Ping Hu
The response of β-amylase in early stage germination of wheat seeds to Bacillus subtilis QM3 was mainly focused on to elucidate the promotion mechanism of B. subtilis QM3. The results showed that the changes in apparent activity of amylase and endosperm liquefaction after the strain QM3 treatment were much more obvious than that of the control group; the activity of β-amylase treated with the different
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Therapeutic effects of coronary granulocyte colony-stimulating factor on rats with chronic ischemic heart disease Open Life Sci. (IF 0.69) Pub Date : 2020-10-20 Pengcheng Ren; Ming Zhang; Shuren Dai
The aim of this study was to evaluate the therapeutic effects of coronary granulocyte colony-stimulating factor (G-CSF) on rats with chronic ischemic heart disease (CIHD).
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The aspects of microbial biomass use in the utilization of selected waste from the agro-food industry Open Life Sci. (IF 0.69) Pub Date : 2020-10-22 Marek Kieliszek; Kamil Piwowarek; Anna M. Kot; Katarzyna Pobiega
Cellular biomass of microorganisms can be effectively used in the treatment of waste from various branches of the agro-food industry. Urbanization processes and economic development, which have been intensifying in recent decades, lead to the degradation of the natural environment. In the first half of the 20th century, problems related to waste management were not as serious and challenging as they
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Circ_0084043 promotes cell proliferation and glycolysis but blocks cell apoptosis in melanoma via circ_0084043-miR-31-KLF3 axis Open Life Sci. (IF 0.69) Pub Date : 2020-10-22 Songjiang Wu; Yuhan Tang; Wenli Liu
Melanoma is an aggressive malignant tumor. The crucial role of circular RNAs has been documented in many types of cancer, including melanoma. The objective of this study was to uncover the function of circ_0084043 in the biological process of melanoma and associated mechanism of action. The expression of circ_0084043, miR-31, and Krüppel-like factor 3 (KLF3) was determined by qRT-PCR. Cell proliferation
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In silico identification of Capsicum type III polyketide synthase genes and expression patterns in Capsicum annuum Open Life Sci. (IF 0.69) Pub Date : 2020-10-12 Delong Kan; Di Zhao; Pengfei Duan
Studies have shown that abundant and various flavonoids accumulate in chili pepper (Capsicum), but there are few reports on the genes that govern chili pepper flavonoid biosynthesis. Here, we report the comprehensive identification of genes encoding type III polyketide synthase (PKS), an important enzyme catalyzing the generation of flavonoid backbones. In total, 13, 14 and 13 type III PKS genes were
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Effect of addition of dried potato pulp on selected quality characteristics of shortcrust pastry cookies Open Life Sci. (IF 0.69) Pub Date : 2020-10-07 Hanna Boruczkowska; Tomasz Boruczkowski; Danuta Figurska-Ciura; Wioletta Drożdż
Potato pulp is a nuisance waste from the production of potato starch, containing large amounts of dietary fiber; therefore, addition of the pulp to food may have a positive effect on the nutritional value of food products. To increase the amount of dietary fiber, shortcrust pastry cookies were baked by replacing some of the flour (20–100%) with an equivalent amount of dried potato pulp. In all the
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In-field screening for host plant resistance to Delia radicum and Brevicoryne brassicae within selected rapeseed cultivars and new interspecific hybrids Open Life Sci. (IF 0.69) Pub Date : 2020-09-22 Janetta Niemann; Justyna Szwarc; Jan Bocianowski; Dorota Weigt; Marek Mrówczyński
Rapeseed (Brassica napus) can be attacked by a wide range of pests, for example, cabbage root fly (Delia radicum) and cabbage aphid (Brevicoryne brassicae). One of the best methods of pest management is breeding for insect resistance in rapeseed. Wild genotypes of Brassicaceae and rapeseed cultivars can be used as a source of resistance. In 2017, 2018, and 2019, field trials were performed to assess
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Distribution and density of Lutraria rhynchaena Jonas, 1844 relate to sediment while reproduction shows multiple peaks per year in Cat Ba-Ha Long Bay, Vietnam Open Life Sci. (IF 0.69) Pub Date : 2020-09-21 Do Manh Hao; Do Trung Sy; Dao Thi Anh Tuyet; Le Minh Hiep; Nguyen Tien Dat; Do Thi Thu Huong; Do Cong Thung; Dang Hoai Nhon; Tran Dinh Lan; Nguyen Van Quan
Lutraria rhynchaena Jonas, 1844 is of great commercial interest, but its reserves have dramatically declined over recent decades. Therefore, there is an urgent need of scientific basis to propose effective fishery management measures and improve artificial aquaculture of the clam. In this study, we investigated the distribution and density of L. rhynchaena, sediment characteristics, and established
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Reversine and herbal Xiang–Sha–Liu–Jun–Zi decoction ameliorate thioacetamide-induced hepatic injury by regulating the RelA/NF-κB/caspase signaling pathway Open Life Sci. (IF 0.69) Pub Date : 2020-09-15 Zhen-Hao Mai; Yu Huang; Di Huang; Zi-Sheng Huang; Zhi-Xiang He; Pei-Lin Li; Shuai Zhang; Jie-Feng Weng; Wei-Li Gu
This study investigated the anti-fibrotic effects of reversine and Chinese medicine Xiang–Sha–Liu–Jun–Zi decoction (XSLJZD) on thioacetamide (TAA)-induced hepatic injury. Sprague-Dawley rats were intraperitoneally administered with TAA, then injected with reversine intraperitoneally, and/or orally provided with XSLJZD. TAA resulted in liver injury with increases in the liver index and levels of serum
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Long non-coding RNA SNHG3 accelerates progression in glioma by modulating miR-384/HDGF axis Open Life Sci. (IF 0.69) Pub Date : 2020-09-05 Xiaofeng Zhang; Weixin Zheng; Wenting Jiang; Ruisheng Lin; Chunyang Xing
Glioma is a malignant primary brain tumor that occurs in the central nervous system and has threatened the well-being of millions of patients. It is well acknowledged that long non-coding RNA (lncRNA) SNHG3 participates in the regulation of proliferation, inflation, differentiation, and metastasis in many cancers. However, the regulatory effect of SNHG3 on glioma progression is still controversial
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CircHIPK3/miR-381-3p axis modulates proliferation, migration, and glycolysis of lung cancer cells by regulating the AKT/mTOR signaling pathway Open Life Sci. (IF 0.69) Pub Date : 2020-09-06 Feng Gu; Junhan Zhang; Lin Yan; Dong Li
Lung cancer is a lethal malignancy. Plenty of circular RNAs (circRNAs) have been identified to be the vital regulators in lung cancer development. Here, we intended to clarify the functional role of circRNA HIPK3 (circHIPK3, also called hsa_circ_0021593) and its underlying mechanism of action. Quantitative reverse transcription-polymerase chain reaction (qRT-PCR) was employed to evaluate the levels
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PCR-detectable Candida DNA exists a short period in the blood of systemic candidiasis murine model Open Life Sci. (IF 0.69) Pub Date : 2020-09-06 Zheng-Xin He; Hui-Hai Zhao; Fu-Kun Wang
Invasive candidiasis is a major challenge to clinical medicine today. However, traditional fungal diagnostic techniques and empirical treatments have shown great limitations. Although efforts are necessarily needed in methodology standardization and multicenter validation, polymerase chain reaction (PCR) is a very promising assay in detecting fungal pathogens. Using a “heat-shock” DNA preparation method
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Long non-coding RNA NEAT1 mediates MPTP/MPP+-induced apoptosis via regulating the miR-124/KLF4 axis in Parkinson’s disease Open Life Sci. (IF 0.69) Pub Date : 2020-09-06 Jiyao Liu; Defang Liu; Bo Zhao; Cunwei Jia; Yunli Lv; Jun Liao; Kai Li
Accumulating evidence suggests that dysregulation of long non-coding RNAs is closely associated with various human diseases, including Parkinson’s disease (PD). However, the role of nuclear-enriched abundant transcript 1 (NEAT1) in the PD process remains unclear. The number of TH+ cells was reduced, and the expression levels of NEAT1 and Krüppel-like factor 4 (KLF4) were increased in the midbrain of
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MiR-4328 inhibits proliferation, metastasis and induces apoptosis in keloid fibroblasts by targeting BCL2 expression Open Life Sci. (IF 0.69) Pub Date : 2020-09-01 Hongmei Tang; Qi Chen; Wenyuan Yu; Tianlan Zhao
Keloids are considered to be a type of benign tumor. MicroRNAs have been reported to be involved in the formation and growth of keloids. MicroRNA-4328 (miR-4328) was found to be abnormally expressed in keloids, while the role and the detailed molecular mechanism of miR-4328 in keloids remain unclear. The expression of miR-4328 and B-cell lymphoma 2 (BCL2) mRNA was detected by qRT-PCR. The proliferation
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Biosurfactant production by a Bacillus megaterium strain Open Life Sci. (IF 0.69) Pub Date : 2020-09-01 Mihaela Marilena Stancu
The aim of the present study was to investigate the ability of Bacillus megaterium IBBPo17 (GenBank KX499518) cells to produce biosurfactant when the growth was done in the presence of long-chain n-alkane n-hexadecane on medium supplemented with yeast extract, proteose peptone, starch, or cellulose. B. megaterium IBBPo17 revealed a higher growth in the presence of n-hexadecane when the medium was supplemented
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Aberrant expression of microRNA-132-3p and microRNA-146a-5p in Parkinson’s disease patients Open Life Sci. (IF 0.69) Pub Date : 2020-09-02 Yu Shu; Jinjun Qian; Chunyan Wang
Parkinson’s disease (PD) is an age-related neurodegenerative disorder which is assessed based on the motor symptoms. A number of microRNAs (miRNAs) are dysregulated and involved in the pathogenesis or development of PD. However, no confirmed markers are used for the early detection of PD. The present study aimed to elucidate the potential two miRNAs (miR-132-3p and miR-146-5p) as novel markers for
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Influences of advanced glycosylation end products on the inner blood–retinal barrier in a co-culture cell model in vitro Open Life Sci. (IF 0.69) Pub Date : 2020-08-24 Chen Yuan; Ya Mo; Jie Yang; Mei Zhang; Xuejun Xie
Advanced glycosylation end products (AGEs) are harmful factors that can damage the inner blood–retinal barrier (iBRB). Rat retinal microvascular endothelial cells (RMECs) were isolated and cultured, and identified by anti-CD31 and von Willebrand factor polyclonal antibodies. Similarly, rat retinal Müller glial cells (RMGCs) were identified by H&E staining and with antibodies of glial fibrillary acidic
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Modeling the effect of heat treatment on fatty acid composition in home-made olive oil preparations Open Life Sci. (IF 0.69) Pub Date : 2020-08-24 Dani Dordevic; Ivan Kushkevych; Simona Jancikova; Sanja Cavar Zeljkovic; Michal Zdarsky; Lucia Hodulova
The aim of this study was to simulate olive oil use and to monitor changes in the profile of fatty acids in home-made preparations using olive oil, which involve repeated heat treatment cycles. The material used in the experiment consisted of extra virgin and refined olive oil samples. Fatty acid profiles of olive oil samples were monitored after each heating cycle (10 min). The outcomes showed that
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Erratum to “Diagnostic performance of serum CK-MB, TNF-α and hs-CRP in children with viral myocarditis” Open Life Sci. (IF 0.69) Pub Date : 2020-08-18 Jia Chen; Yuanying Deng
Journal Name: Open Life Sciences Volume: 15 Issue: 1 Pages: 597-597
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Lipopolysaccharides promote pulmonary fibrosis in silicosis through the aggravation of apoptosis and inflammation in alveolar macrophages Open Life Sci. (IF 0.69) Pub Date : 2020-08-18 Shiyi Tan; Shang Yang; Mingke Chen; Yurun Wang; Li Zhu; Zhiqian Sun; Shi Chen
Alveolar macrophages (AMs) play an important defensive role by removing dust and bacteria from alveoli. Apoptosis of AMs is associated with lung fibrosis; however, the relationship between this apoptotic event and environmental factors, such as the presence of lipopolysaccharides (LPSs) in the workplace, has not yet been addressed. To investigate whether exposure to LPS can exacerbate fibrosis, we
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Neuroanatomy of melanocortin-4 receptor pathway in the mouse brain Open Life Sci. (IF 0.69) Pub Date : 2020-08-13 Kun Wang; Wei Mao; Xiaoyu Zhang; Yufei Zhao; Kuikui Fan; Deng Pan; Haodong Liu; Penghui Li; Rihan Hai; Chenguang Du
Melanocortin-4 receptors (MC4Rs) are key regulators of energy homeostasis and adipose deposition in the central nervous system. Considering that MC4R expression regions and function-related research mainly focus on the paraventricular nucleus (PVN), little is known about their distribution throughout the mouse brain, although its messenger RNA distribution has been analyzed in the rat. Therefore, MC4R
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Application of extrusion-cooking technology in hatchery waste management Open Life Sci. (IF 0.69) Pub Date : 2020-08-13 Aldona Sobota; Piotr Zarzycki; Anna Wirkijowska; Zbigniew Rzedzicki; Agnieszka Pawlas
The purpose of the present study was to examine the extrusion-cooking process of cereal blends with addition of hatchery waste (HW). The effect of HW addition on the physical properties and chemical composition of the extrudates was examined. The share of the HW in blends with corn meal was variable in the range of 5–30%. The study was conducted using a counter-rotating twin-screw extruder (L:D ratio
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Automatic detection and segmentation of adenomatous colorectal polyps during colonoscopy using Mask R-CNN Open Life Sci. (IF 0.69) Pub Date : 2020-08-14 Jie Meng; Linyan Xue; Ying Chang; Jianguang Zhang; Shilong Chang; Kun Liu; Shuang Liu; Bangmao Wang; Kun Yang
Colorectal cancer (CRC) is one of the main alimentary tract system malignancies affecting people worldwide. Adenomatous polyps are precursors of CRC, and therefore, preventing the development of these lesions may also prevent subsequent malignancy. However, the adenoma detection rate (ADR), a measure of the ability of a colonoscopist to identify and remove precancerous colorectal polyps, varies significantly
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Long non-coding RNA LINC00704 promotes cell proliferation, migration, and invasion in papillary thyroid carcinoma via miR-204-5p/HMGB1 axis Open Life Sci. (IF 0.69) Pub Date : 2020-08-12 Yihui Lin; Jianjia Jiang
Papillary thyroid carcinoma (PTC) is a common malignancy worldwide. LncRNA LINC00704 (mitotically associated long non-coding RNA) was reported as a crucial regulator in PTC. However, the biological mechanism of LINC00704 action remains unclear in PTC. The mRNA levels of LINC00704, miR-204-5p, and high-mobility group box 1 (HMGB1) were measured by quantitative reverse transcription-polymerase chain
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MYL6B drives the capabilities of proliferation, invasion, and migration in rectal adenocarcinoma through the EMT process Open Life Sci. (IF 0.69) Pub Date : 2020-08-03 Jin-Liang Li; Zai-Qiu Wang; Xiao-Li Sun
This study was designed to explore the biological significance of myosin light chain 6B (MYL6B) in rectal adenocarcinoma.
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Inhibition of lncRNA LINC00461/miR-216a/aquaporin 4 pathway suppresses cell proliferation, migration, invasion, and chemoresistance in glioma Open Life Sci. (IF 0.69) Pub Date : 2020-07-27 Yanguo Peng; Wangchun Wu; Zhanfang Shang; Wei Li; Shuiyu Chen
Long noncoding RNA (lncRNA) LINC00461 (LINC00461) is reported to be related to glioma progression. However, the mechanism of LINC00461 in glioma remains unclear. Expression of LINC00461, miRNA (miR)-216a, and aquaporin 4 (AQP4) was detected using real-time quantitative PCR (RT-qPCR) and western blotting. Proliferation, temozolomide (TMZ) resistance, migration, and invasion were assessed by MTT, colony
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Upregulation of miR-150-5p alleviates LPS-induced inflammatory response and apoptosis of RAW264.7 macrophages by targeting Notch1 Open Life Sci. (IF 0.69) Pub Date : 2020-07-28 Xiaoyan Deng; Zhixing Lin; Chao Zuo; Yanjie Fu
Circulating miR-150-5p has been identified as a prognostic marker in patients with critical illness and sepsis. Herein, we aimed to further explore the role and underlying mechanism of miR-150-5p in sepsis. Quantitative real-time-PCR assay was performed to detect the expression of miR-150-5p upon stimulation with lipopolysaccharide (LPS) in RAW264.7 cells. The levels of tumor necrosis factor-α, interleukin
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Antifungal activity of selected volatile essential oils against Penicillium sp. Open Life Sci. (IF 0.69) Pub Date : 2020-07-19 Soňa Felšöciová; Nenad Vukovic; Paweł Jeżowski; Miroslava Kačániová
Phytopathogenic fungi have been responsible for considerable economic losses in vineyards, and therefore, more attention should be paid to the development and implementation of preventative treatment that is environmentally friendly. The aim of this study was to evaluate the antifungal activity of ten essential oils (EOs) (viz. Lavandula angustifolia Mill., Carum carvi L., Pinus mugo var. pumilio,
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BRCA1 subcellular localization regulated by PI3K signaling pathway in triple-negative breast cancer MDA-MB-231 cells and hormone-sensitive T47D cells Open Life Sci. (IF 0.69) Pub Date : 2020-07-10 Bin Ma; Wenjia Guo; Meihui Shan; Nan Zhang; Binlin Ma; Gang Sun
This study is to investigate the effect of the PI3K/Akt signaling pathway on the regulation of BRCA1 subcellular localization in triple-negative breast cancer (TNBC) MDA-MB-231 cells and hormone-sensitive T47D cells. We found that heregulin-activated T47D cells showed more nuclear localization of BRCA1, but BRCA1 nuclear localization decreased after the inhibition of the PI3K signaling pathway. In
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Lnc-PICSAR contributes to cisplatin resistance by miR-485-5p/REV3L axis in cutaneous squamous cell carcinoma Open Life Sci. (IF 0.69) Pub Date : 2020-07-10 Dan Wang; Xiaoqiang Zhou; Jing Yin; Yang Zhou
Dysregulation of long noncoding RNAs (lncRNAs) is associated with drug resistance in multiple cancers. We explored the roles of lncRNA p38 inhibited cutaneous squamous cell carcinoma-associated lincRNA (PICSAR) in cisplatin (DDP) resistance of cutaneous squamous cell carcinoma (CSCC).
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Circ_001569 regulates FLOT2 expression to promote the proliferation, migration, invasion and EMT of osteosarcoma cells through sponging miR-185-5p Open Life Sci. (IF 0.69) Pub Date : 2020-07-10 Bin Xiao; Xusheng Zhang; Xiaojuan Li; Zhipeng Zhao
Osteosarcoma (OS) is a common malignant tumor in the world. Circular RNAs are endogenous non-coding RNAs that have been linked to the development of cancer. However, the role of circ_001569 in OS progression is still unclear. Quantitative real-time polymerase chain reaction (qRT-PCR) was used to detect the expression of circ_001569, microRNA-185-5p (miR-185-5p) and flotillin-2 (FLOT2). The abilities
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