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Sirtuin 5 regulates acute myeloid leukemia cell viability and apoptosis by succinylation modification of glycine decarboxylase Open Life Sci. (IF 2.2) Pub Date : 2024-03-16 Jun Zhang, Cheng Luo, Haiying Long
Acute myeloid leukemia (AML) is a blood system malignancy where sirtuin 5 (SIRT5) is abnormally expressed in AML cell lines. This study aimed to investigate the SIRT5 effects on the viability and apoptosis of AML cell lines. The mRNA and protein expression levels of succinylation regulatory enzyme in clinical samples and AML cell lines were detected by real-time quantitative polymerase chain reaction
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Evaluation of the impact of two citrus plants on the variation of Panonychus citri (Acari: Tetranychidae) and beneficial phytoseiid mites Open Life Sci. (IF 2.2) Pub Date : 2024-03-16 Amine Assouguem, Abdelmalek Boutaleb Joutei, Rachid Lahlali, Mohammed Kara, Ahmed Bari, Essam A. Ali, Hafize Fidan, Hajar Zine Laabidine, Younouss El Ouati, Abdellah Farah, Abderrahim Lazraq
The abundance of Panonychus citri McGregor 1916 (Acari: Tetranychidae) and its associated enemies (Euseius stipulatus Athias-Henriot, 1960; Typhlodromus sp.; Phytoseiulus persimilis Athias-Henriot, 1957) was studied on two 12-year-old citrus cultivars, specifically Clementine “Nules” (Citrus Clementina) and Valencia (Citrus sinensis), in the Gharb region of Morocco. Throughout the entire monitoring
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Knockdown of ANP32E inhibits colorectal cancer cell growth and glycolysis by regulating the AKT/mTOR pathway Open Life Sci. (IF 2.2) Pub Date : 2024-03-10 Jiaojiao Liu, Yanchao Liu, Qi Zhao
Colorectal cancer (CRC) is the third most common tumor, with an increasing number of deaths worldwide each year. Tremendous advances in the diagnosis and treatment of CRC have significantly improved the outcomes for CRC patients. Additionally, accumulating evidence has hinted the relationship between acidic nuclear phosphoprotein 32 family member E (ANP32E) and cancer progression. But the role of ANP32E
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Kaempferol regulates apoptosis and migration of neural stem cells to attenuate cerebral infarction by O‐GlcNAcylation of β-catenin Open Life Sci. (IF 2.2) Pub Date : 2024-03-10 Song Zhang, Honglei Jiao
Ischemic stroke remains a major cause of disability and death. Kaempferol (Kae) is a neuroprotective flavonoid compound. Thus, this study aimed to explore the impact of Kae on cerebral infarction. We generated the middle cerebral artery occlusion (MCAO) mouse model to study the effects of Kae on infarction volume and neurological function. The oxygen and glucose deprivation (OGD)/reoxygenation (R)
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Photosynthetic physiological characteristics, growth performance, and element concentrations reveal the calcicole–calcifuge behaviors of three Camellia species Open Life Sci. (IF 2.2) Pub Date : 2024-03-10 Shengfeng Chai, Haidu Jiang, Yishan Yang, Xinfeng Pan, Rong Zou, Jianmin Tang, Zongyou Chen, Danjuan Zeng, Xiao Wei
We grew three yellow Camellia species (the calcifuge C. nitidissima and C. tunghinensis, and the calcicole C. pubipetala) in acidic and calcareous soils for 7 months and assessed their photosynthetic physiological characteristics, growth performance, and element concentrations in this developmental context. The calcifuge C. nitidissima and C. tunghinensis species exhibited poor growth with leaf chlorosis
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Detection of serum interleukin-18 level and neutrophil/lymphocyte ratio in patients with antineutrophil cytoplasmic antibody-associated vasculitis and its clinical significance Open Life Sci. (IF 2.2) Pub Date : 2024-03-06 Changning Liu
Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a group of autoimmune diseases. This study aimed to investigate the clinical significance of changes in interleukin-18 (IL-18) and neutrophil/lymphocyte ratio (NLR) in the pathogenesis of AAV and the impact of NLR on the prognosis of patients. The clinical data of 52 AAV patients (AAV group) who met the conditions of hospitalization
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Application of the integrated airway humidification device enhances the humidification effect of the rabbit tracheotomy model Open Life Sci. (IF 2.2) Pub Date : 2024-03-06 Honglan Sheng, Jie Ni, Feng Zhao, Mi Tian, Yuhang Zhao, Longmei Dai, Ting Li, Yun Xue, Zongze Song, Qiong Yu
Long-term mechanical ventilation after tracheotomy is a common treatment in intensive care unit patients. This study investigated the differences among the effects of different wetting states on the airway, lung, and serum inflammatory factors. New Zealand rabbits (n = 36) were selected to construct tracheotomy models and then divided into four groups: Model, Mask, YTH, and Sham groups. Lung tissue
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Degradation of a mixture of 13 polycyclic aromatic hydrocarbons by commercial effective microorganisms Open Life Sci. (IF 2.2) Pub Date : 2024-03-06 Paulina Książek-Trela, Damian Figura, Dominika Węzka, Ewa Szpyrka
The study focused on the contribution of effective microorganisms (EM) and their consortia, used in commercial biological preparations and formulations for soil revitalization, to the degradation of a mixture of 13 polycyclic aromatic hydrocarbons (PAHs) commonly found in the soil environment. PAHs, diverse forms of which are present in the environment, never occur individually but always as a part
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Gut microbiota changes associated with low-carbohydrate diet intervention for obesity Open Life Sci. (IF 2.2) Pub Date : 2024-03-06 Li Li, Xiaoguo Zhao, Rashidin Abdugheni, Feng Yu, Yunyun Zhao, Ba-Fang Ma, Zhifang Yang, Rongrong Li, Yue Li, Yasen Maimaitiyiming, Mayila Maimaiti
Low-carbohydrate diets (LCDs) are frequently recommended for alleviating obesity, and the gut microbiota plays key roles in energy metabolism and weight loss. However, there is limited in-human research on how LCD changes gut microbiota. In this before–after study, 43 participants were assigned to the LCD intervention for 4 weeks. The main objective was to investigate the specific changes that occur
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Pheochromocytoma-induced myocardial infarction: A case report Open Life Sci. (IF 2.2) Pub Date : 2024-02-24 Haixia Tang, Jichun Liu, Bangsheng Hu, Yuwen Yang, Xiangrong Xie, Youquan Wei
The pheochromocytoma is an uncommon endocrine neoplasm that originates from chromaffin cells and causes significant cardiovascular effects through the intermittent or sustained release of catecholamines. In this report, we present a rare case of myocardial infarction (MI) induced by pheochromocytoma. A 53-year-old female presented to the emergency department with a history of intermittent palpitations
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Transplantation of human neural stem cell prevents symptomatic motor behavior disability in a rat model of Parkinson’s disease Open Life Sci. (IF 2.2) Pub Date : 2024-02-24 Fen Wang, Xiao-Yu Cheng, Yu-Ting Zhang, Qing-Ran Bai, Xiao-Qi Zhang, Xi-Cai Sun, Quan-Hong Ma, Xiong-Fei Zhao, Chun-Feng Liu
Parkinson’s disease (PD) is a ubiquitous brain cell degeneration disease and presents a significant therapeutic challenge. By injecting 6-hydroxydopamine (6-OHDA) into the left medial forebrain bundle, rats were made to exhibit PD-like symptoms and treated by intranasal administration of a low-dose (2 × 105) or high-dose (1 × 106) human neural stem cells (hNSCs). Apomorphine-induced rotation test,
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Single-nucleotide polymorphism rs2910829 in PDE4D is related to stroke susceptibility in Chinese populations: The results of a meta-analysis Open Life Sci. (IF 2.2) Pub Date : 2024-02-23 Guiying Zhang, Xuelei Tang, Qifu Li, Rong Lin
Stroke is a debilitating condition that often leads to disability and death. The increasing prevalence of stroke has drawn worldwide attention. Extensive evidence indicates a crucial role of genetic determinants in the occurrence and perpetuation of stroke. An Icelandic study identified a significant correlation of the phosphodiesterase 4D (PDE4D) single-nucleotide polymorphism (SNP) rs2910829 with
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Current research and evidence gaps on placental development in iron deficiency anemia Open Life Sci. (IF 2.2) Pub Date : 2024-02-21 Shaoyang Lai, Weiwei Yu, Ying Liu, Yuxin Yang, Xueqin Zhang
Studying the effects of maternal iron deficiency anemia (IDA) is complex owing to its diverse causes, each independently impacting the placenta and fetus. Simple treatment with iron supplements does not always resolve the anemia. Therefore, delving into how IDA alters placental development at a molecular level is crucial to further optimize treatment. This review addresses the effects of IDA on placental
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Aquaporin-8 promotes human dermal fibroblasts to counteract hydrogen peroxide-induced oxidative damage: A novel target for management of skin aging Open Life Sci. (IF 2.2) Pub Date : 2024-02-16 Shu-Hsiang Liu, Wei-Chun Lin, En-Chih Liao, Yung-Feng Lin, Ching-Shuen Wang, Sheng-Yang Lee, Dee Pei, Chun-Hsien Hsu
The skin is subjected to various external factors that contribute to aging including oxidative stress from hydrogen peroxide (H2O2). This study investigated the distribution of aquaporin-8 (AQP8), a protein that transports H2O2 across biological membranes, in skin cells, and its effects in mitigating H2O2-induced oxidative damage. Human dermal fibroblasts were treated with increasing concentrations
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Ang-1, Ang-2, and Tie2 are diagnostic biomarkers for Henoch-Schönlein purpura and pediatric-onset systemic lupus erythematous Open Life Sci. (IF 2.2) Pub Date : 2024-02-08 Lishan Jia, Xiaozhong Li, Jiayun Shen, Yan Teng, Baoqin Zhang, Min Zhang, Yueqin Gu, Hong Xu
Henoch-Schönlein purpura (HSP) and pediatric-onset systemic lupus erythematosus (pSLE) are closely associated with vasculitis and vascular diseases. This study aimed to investigate the clinical diagnostic values of Ang-1, Ang-2, and Tie2 for HSP and pSLE. We surveyed 82 HSP patients, 34 pSLE patients, and 10 healthy children. The expression levels of Ang-1, Ang-2, and Tie2 in the serum and urine were
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Preparation of Cu2+/TA/HAP composite coating with anti-bacterial and osteogenic potential on 3D-printed porous Ti alloy scaffolds for orthopedic applications Open Life Sci. (IF 2.2) Pub Date : 2024-02-08 Xu Haitao, Li Siyuan, Guo Sutong, Guo Yu, Xu Peirong, Wang Ling, Ding Yujian, Feng Dehong
Because of stress shielding effects, traditional titanium (Ti) alloy scaffolds have a high elastic modulus, which might promote looseness and bone disintegration surrounding the implant, increasing the likelihood of a second surgery. In contrast, 3D-printed porous Ti alloy scaffolds can reduce the scaffold weight while enhancing biocompatibility. Further, these scaffolds’ porous nature allows bone
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Effectiveness and safety of a mumps containing vaccine in preventing laboratory-confirmed mumps cases from 2002 to 2017: A meta-analysis Open Life Sci. (IF 2.2) Pub Date : 2024-02-08 Bu-Gang Gao, Ling-feng Huang, Ping Xie
Emerging evidence has figured that serum conversion rate of mumps is a crucial link of mumps disease. Nevertheless, a rising number of mumps outbreaks caused our attention and studies examining the serum conversion cases were conducted in small samples previously; this meta-analysis was conducted to assess the immunogenicity and safety of a mumps containing vaccine (MuCV) before 2019. We identified
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Role of serum B-cell-activating factor and interleukin-17 as biomarkers in the classification of interstitial pneumonia with autoimmune features Open Life Sci. (IF 2.2) Pub Date : 2024-02-08 Lihong Zhao, Li Liu, Yehua Liu, Hong Zheng, Ping Jiang
Interstitial pneumonia with autoimmune features (IPAF) is a type of interstitial lung disease (ILD) with immune features that do not meet the diagnostic criteria for specific connective tissue diseases (CTDs). This retrospective case–control study investigated the role of serum B-cell-activating factor of the tumor necrosis factor family (BAFF) and interleukin (IL)-17 as biomarkers for IPAF. The differences
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A case of Trousseau syndrome: Screening, detection and complication Open Life Sci. (IF 2.2) Pub Date : 2024-02-08 Hui Liu, Meng Jiang, Nan Wu, Qingxin Liu, Xueli Fan
Trousseau syndrome (TS) is a malignant tumor-mediated complication of the hypercoagulable state with an unknown etiology. Laboratory testing results in patients with TS have indicated elevated D-dimer levels. The imaging analysis in patients who had undergone stroke has shown the presence of several cerebral infarction lesions in multiple regions. Since patients have had malignant tumors for a long
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PTTG1 induces pancreatic cancer cell proliferation and promotes aerobic glycolysis by regulating c-myc Open Life Sci. (IF 2.2) Pub Date : 2024-02-08 Yong Wang, Jianping Hu, Chen Chen, Yongbo Li
This study aimed to clarify the role of pituitary tumor-transforming gene 1 (PTTG1) in proliferation, migration, invasion, and aerobic glycolysis of pancreatic cancer cells, and evaluate the potential of PTTG1 as a therapeutic target. PTTG1 expression in pancreatic cancers was analyzed using the GEPIA databank. In the Panc1 cell with the PTTG1 knockdown or Mia-PaCa2 cells with PTTG1 overexpression
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Low levels of sex hormone-binding globulin predict an increased breast cancer risk and its underlying molecular mechanisms Open Life Sci. (IF 2.2) Pub Date : 2024-02-08 Shuhang Zhao, Jiaojiao Gu, Yu Tian, Ruoyan Wang, Wentao Li
Sex hormone-binding globulin (SHBG) is a serum glycoprotein exhibiting the unique feature of binding sex steroids with high affinity and specificity. Over the past few decades, there have been significant breakthroughs in our understanding of the function and regulation of SHBG. The biological role of SHBG has expanded from being considered a simple sex hormone transporter to being associated with
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Brucella infection combined with Nocardia infection: A case report and literature review Open Life Sci. (IF 2.2) Pub Date : 2024-02-03 Yan Feng, Chun-Lei Zuo, Jia-Xin Shi
Human brucellosis is an infectious disease caused by Brucella and is often misdiagnosed for atypical manifestations including fever of unknown origin, headache, weakness, among else. Nocardiosis is a zoonotic disease caused by the genus Nocardia, which usually spreads through the respiratory tract, skin, and digestive tract. Limited research has documented cases of co-infection involving both Brucella
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The role and mechanism of esketamine in preventing and treating remifentanil-induced hyperalgesia based on the NMDA receptor–CaMKII pathway Open Life Sci. (IF 2.2) Pub Date : 2024-01-31 Jiafang Wang, Yankun Feng, Zhong Qi, Jin Li, Zhijun Chen, Jinming Zhang, Degang Zhu
Remifentanil-induced hyperalgesia (RIH) is a common clinical phenomenon that limits the use of opioids in pain management. Esketamine, a non-competitive N-methyl-d-aspartate (NMDA) receptor antagonist, has been shown to prevent and treat RIH. However, the underlying effect mechanism of esketamine on RIH remains unclear. This study aimed to investigate the role and mechanism of esketamine in preventing
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Effect of long-term in-row branch covering on soil microorganisms in pear orchards Open Life Sci. (IF 2.2) Pub Date : 2024-01-29 Minghui Ji, Jintao Xu, Lijuan Gao, Longfei Li, Huan Liu, Baofeng Hao
Branches covering (BC) is a way to reuse the pruned branches and save the cost of ground cloth. This study investigated the effects of BC and ground-cloth covering on the soil microcosm environment by measuring the chemical properties and microbial communities at different soil depths for 6 years. The results revealed that BC significantly improved soil chemical properties, increased the abundance
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Research progress on ocular complications caused by type 2 diabetes mellitus and the function of tears and blepharons Open Life Sci. (IF 2.2) Pub Date : 2024-01-27 Xiaohong Wang, Jian Fang, Lina Yang
The purpose of this study was to explore the related research progress of ocular complications (OCs) caused by type 2 diabetes mellitus (T2DM), tear and tarsal function, and the application of deep learning (DL) in the diagnosis of diabetes and OCs caused by it, to provide reference for the prevention and control of OCs in T2DM patients. This study reviewed the pathogenesis and treatment of diabetes
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Screening of different growth conditions of Bacillus subtilis isolated from membrane-less microbial fuel cell toward antimicrobial activity profiling Open Life Sci. (IF 2.2) Pub Date : 2024-01-24 Dharni Kuhan Sreedharan, Hartini Alias, Muaz Mohd Zaini Makhtar, Tan Joo Shun, Ana Masara Ahmad Mokhtar, Hafiza Shukor, Masoom Raza Siddiqui, Mahboob Alam, Riti Thapar Kapoor, Mohd Rafatullah
Bacteriocins produced by Bacillus subtilis have gained recognition for their safe use in humans. In this study, we aimed to assess the inhibitory activity of an antimicrobial peptide synthesized by the wild-type strain of B. subtilis against the notorious pathogen Pseudomonas aeruginosa. Our investigation employed the broth microdilution method to evaluate the inhibitory potential of this peptide.
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PEGylated porcine–human recombinant uricase: A novel fusion protein with improved efficacy and safety for the treatment of hyperuricemia and renal complications Open Life Sci. (IF 2.2) Pub Date : 2024-01-24 Xiangyan Wang, Hao Lu, Jun Rong, Zhongjie Sun, Yanhua Zheng, Bolin Fan, Ziming Jia
The growing prevalence of hyperuricemia necessitates the urgent development of more potent treatments. This study aimed to develop, optimize, and evaluate the safety and efficacy of porcine–human recombinant uricase (PHRU) both in vitro and in vivo. The study employed gene editing of PHRU through site-directed mutagenesis, with recombinant proteins expressed in vitro utilizing Escherichia coli. The
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LARP1 knockdown inhibits cultured gastric carcinoma cell cycle progression and metastatic behavior Open Life Sci. (IF 2.2) Pub Date : 2024-01-22 Xin Liu, Wei-Ming Zhang, Nuo Meng, Lian-Jie Lin, Guo-Du Tang
This study aimed to clarify the role of la-related protein 1 (LARP1) in cell cycle progression and metastatic behavior of cultured gastric carcinoma (GC) cells. To do that, LARP1 expression was detected in clinical GC tissues and cell lines using quantitative real-time polymerase chain reaction (qRT-PCR) and western blotting. The cell viability, apoptosis, cell cycle, migration, invasion, and cell
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Fractalkine modulates pulmonary angiogenesis and tube formation by modulating CX3CR1 and growth factors in PVECs Open Life Sci. (IF 2.2) Pub Date : 2024-01-16 Jun Liao, Xianwu Yang, Jiejie Yang, Jingjing Xiao, Xuyang Liu, Yingquan Zhuo, Jiafei Yang, Huajian Gu
This study aimed to investigate effects of pulmonary fractalkine (FKN/CX3CL1) on angiogenesis and tube formation. Tube forming capability of pulmonary vascular endothelial cells (PVECs) was evaluated. CCK-8 assay was used to evaluate proliferation of PVECs. RT-PCR assay was used to determine angiogenesis specific biomarkers. Western blot was applied to identify CX3CR1, Akt, phosphorylated Akt (p-Akt)
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Constitutive and evoked release of ATP in adult mouse olfactory epithelium Open Life Sci. (IF 2.2) Pub Date : 2024-01-16 Sébastien Hayoz, Cuihong Jia, Colleen Cosgrove Hegg
In adult olfactory epithelium (OE), ATP plays a role in constant cell turnover and post-injury neuroregeneration. We previously demonstrated that constitutive and ATP-evoked ATP release are present in neonatal mouse OE and underlie continuous cell turn-over and post-injury neuroregeneration, and that activation of purinergic P2X7 receptors is involved in the evoked release. We hypothesized that both
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Investigating the association between dietary patterns and glycemic control among children and adolescents with T1DM Open Life Sci. (IF 2.2) Pub Date : 2024-01-05 Reema Tayyem, Sara Zakarneh, Ghadir Fakhri Al-Jayyousi
Nutrition plays a critical role in managing diabetes, particularly in children with type 1 diabetes mellitus (T1DM). This study aimed to investigate the dietary patterns associated with glycemic control among Jordanian children and adolescents with T1DM. A total of 107 Jordanian children and adolescents with T1DM were enrolled (53 males and 54 females) in this cross-sectional study. Data were collected
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Plasma levels of CD36 and glutathione as biomarkers for ruptured intracranial aneurysm Open Life Sci. (IF 2.2) Pub Date : 2024-01-05 Hanbin Wang, Luxuan Wang, Yunmei Liu, Weidong Men, Wanjiao Hao, Chuan Fang, Chunhui Li, Lijian Zhang
Evidence has proved that intracranial aneurysm (IA) formation and rupture might be closely related to inflammatory response and oxidative stress. Our objective was to evaluate the potential of CD36 and glutathione (GSH) as biomarkers for IA. In this study, the enzyme-linked immunosorbent assay was used to measure the plasma levels of CD36 and GSH in 30 IA patients and 30 healthy controls. Then, correlation
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Development of a new candidate vaccine against piglet diarrhea caused by Escherichia coli Open Life Sci. (IF 2.2) Pub Date : 2024-01-04 Chongli Xu, Fengyang Fu, Yuhan She, Danni Yang, Kun Peng, Yimin Lin, ChongBo Xu
Enterotoxigenic Escherichia coli (ETEC) is an important type of pathogenic bacteria that causes diarrhea in humans and young livestock. The pathogen has a high morbidity and mortality rate, resulting in significant economic losses in the pig industry. To effectively prevent piglet diarrhea, we developed a new tetravalent genetically engineered vaccine that specifically targets ETEC. To eliminate the
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Acute lupus pneumonitis resembling miliary tuberculosis: A case-based review Open Life Sci. (IF 2.2) Pub Date : 2024-01-03 Xin Li, Yuan Wang, Baoyu Zhang, Xiaoxia Jia, Lin Mu, Jing Ke
Systemic lupus erythematosus (SLE) is an autoimmune disease involving multiple systems and organs, with pulmonary involvement known to be associated with disease prognosis and mortality. Acute lupus pneumonitis (ALP) resembling miliary tuberculosis (TB) is rare. Here, we present a case of ALP mimicking miliary TB and review the literature. A 19-year-old male student was referred to our hospital with
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Comparative transcriptomes reveal molecular mechanisms of apple blossoms of different tolerance genotypes to chilling injury Open Life Sci. (IF 2.2) Pub Date : 2023-12-28 Xiaolong Li, Haiying Yue, Yannan Chu, Yonghua Jia
Graphical abstract
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A study of forensic genetics: ITO index distribution and kinship judgment between two individuals Open Life Sci. (IF 2.2) Pub Date : 2023-12-28 Huanchang Jiang, Qinglian Jiang, Shuzhen Wu
According to Mendel’s law of genetic separation, there must be a certain blood relationship between members of the same family, and two individuals with blood relations must have the following three situations, that is, there are two homologous genes (I denotes), one homologous gene (T denotes), and no homologous genes (O denotes), which is the ITO index for calculating the blood relationship between
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Understory vegetation diversity patterns of Platycladus orientalis and Pinus elliottii communities in Central and Southern China Open Life Sci. (IF 2.2) Pub Date : 2023-12-22 Nan Deng, Liu Caixia, Fengfeng Ma, Qingan Song, Yuxin Tian
As a vital component of arbor forests, understory vegetation serves as an essential buffer zone for storing carbon due to its strong capacity for community regeneration. This study aimed to identify the diversity pattern and construction mechanism of Platycladus orientalis and Pinus elliottii understory vegetation based on large-scale sample surveys. The Bayesian Information Criterion value of species
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Advances in diagnosis and treatment of perimenopausal syndrome Open Life Sci. (IF 2.2) Pub Date : 2023-12-22 Wanying Chen, Mengjuan Chen, Huimin Tang, Weiwei Wei, Panqiu Shao, Shulan Dou, Jia Wu, Bingying Lu, Ruxia Shi, Jiming Chen
With the development and progress of society, people’s average life expectancy has increased, and relevant literature reports that the number of postmenopausal women in China continues to increase. With lifespans extended, the transition period and post-menopause period have become the longest essential period in every woman’s life. The life quality of women troubled by perimenopausal syndrome has
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Effects of plant density on alfalfa (Medicago sativa L.) seed yield in western Heilongjiang areas Open Life Sci. (IF 2.2) Pub Date : 2023-12-16 Xiaolong Wang, Peng Zhong, Zhao Yang, Yongcai Lai, Shasha Li, Hua Chai, Yanxia Xu, Yue Wu, Jianli Wang
Alfalfa (Medicago sativa L.) is known as the “king of forages”. The aim of the current study is to determine the optimum planting density as the key cultivation technique for high yield of alfalfa seed. Alfalfa variety (Longmu 801) was planted in experimental fields from 2014 to 2017. In the planting density test, the row spacing was 65, 80, and 95 cm, and the plant spacing was 30, 45, 60, 75, and
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Pathogenic bacteria and treatment resistance in older cardiovascular disease patients with lung infection and risk prediction model Open Life Sci. (IF 2.2) Pub Date : 2023-12-13 Hongbo Liu, Liyan Xie, Cong Xing
This study analyzes the distribution of pathogenic bacteria and their antimicrobial susceptibilities in elderly patients with cardiovascular diseases to identify risk factors for pulmonary infections. A risk prediction model is established, aiming to serve as a clinical tool for early prevention and management of pulmonary infections in this vulnerable population. A total of 600 patients were categorized
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The potential for the use of leghemoglobin and plant ferritin as sources of iron Open Life Sci. (IF 2.2) Pub Date : 2023-12-13 Michał Świątek, Adrianna Antosik, Dominika Kochanowska, Paweł Jeżowski, Krzysztof Smarzyński, Aneta Tomczak, Przemysław Łukasz Kowalczewski
Iron is an essential component for the body, but it is also a major cause for the development of many diseases such as cancer, cardiovascular diseases, and autoimmune diseases. It has been suggested that a diet rich in meat products, especially red meat and highly processed products, constitute a nutritional model that increases the risk of developing. In this context, it is indicated that people on
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Precisional detection of lymph node metastasis using tFCM in colorectal cancer Open Life Sci. (IF 2.2) Pub Date : 2023-12-13 Dan Yang, Jingling Tang, Yunhuan Zhen, Jindong Yuan, Pingsheng Hu, Xiaoyun Li, Hang Du, Xiaolan Zhang, Yuan Yang
The detection of colorectal cancer (CRC) lymph node (LN) metastases significantly influences treatment choices, yet identifying them in samples is time-consuming and error-prone. To enhance efficiency, we have established a LN metastasis detection method utilizing triple-parameter flow cytometry (tFCM) and have conducted a comparative assessment of its accuracy and cost-effectiveness in contrast to
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Adoption value of support vector machine algorithm-based computed tomography imaging in the diagnosis of secondary pulmonary fungal infections in patients with malignant hematological disorders Open Life Sci. (IF 2.2) Pub Date : 2023-12-13 Lieguang Chen, Pisheng Zhang, Lixia Shen, Huiling Zhu, Yi Wang, Kaihong Xu, Shanhao Tang, Yongcheng Sun, Xiao Yan, Binbin Lai, Guifang Ouyang
This study aimed to assess the feasibility of diagnosing secondary pulmonary fungal infections (PFIs) in patients with hematological malignancies (HM) using computerized tomography (CT) imaging and a support vector machine (SVM) algorithm. A total of 100 patients with HM complicated by secondary PFI underwent CT scans, and they were included in the training group. Concurrently, 80 patients with the
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From slides to insights: Harnessing deep learning for prognostic survival prediction in human colorectal cancer histology Open Life Sci. (IF 2.2) Pub Date : 2023-12-13 Jyoti Verma, Archana Sandhu, Renu Popli, Rajeev Kumar, Vikas Khullar, Isha Kansal, Ashutosh Sharma, Kanwal Garg, Neeru Kashyap, Khursheed Aurangzeb
Prognostic survival prediction in colorectal cancer (CRC) plays a crucial role in guiding treatment decisions and improving patient outcomes. In this research, we explore the application of deep learning techniques to predict survival outcomes based on histopathological images of human colorectal cancer. We present a retrospective multicenter study utilizing a dataset of 100,000 nonoverlapping image
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Clinicopathological characteristics of co-existing or mixed colorectal cancer and neuroendocrine tumor: Report of five cases Open Life Sci. (IF 2.2) Pub Date : 2023-12-12 Ling Zhang, Xiaoling Wang, Yun Wang, Yan Zeng, Li Li
Coexisting or mixed type of colorectal tumors has been rarely reported. This study was designed to investigate clinicopathological characteristics of co-existing or mixed colorectal adenocarcinoma and highly differentiated neuroendocrine tumor (NET-G1). To do that, clinicopathological characteristics of five cases of co-existing or mixed colorectal adenocarcinoma and NET-G1 admitted to our institution
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Role of menopausal hormone therapy in the prevention of postmenopausal osteoporosis Open Life Sci. (IF 2.2) Pub Date : 2023-12-12 Zhao Na, Wei Wei, Yingfang Xu, Dong Li, Beili Yin, Weiqun Gu
The use of menopausal hormone therapy (MHT) has declined due to concerns about its potential side effects. However, its pivotal role in managing postmenopausal osteoporosis is gaining increased recognition. In this article, we explore how MHT assists postmenopausal women in maintaining bone health and preventing fractures. Recent research indicates that MHT significantly reduces the risk of fractures
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Incidence of different pressure patterns of spinal cerebellar ataxia and analysis of imaging and genetic diagnosis Open Life Sci. (IF 2.2) Pub Date : 2023-12-12 Yufen Peng, Qi Tu, Yao Han, Liang Gao, Chenyi Wan
Neurologists have a difficult time identifying sporadic cerebellar ataxia. Multiple system atrophy of the cerebellar type (MSA-C), spontaneous late cortical cerebellar atrophy, and prolonged alcohol use are a few possible causes. In a group of people with sporadic cerebellar ataxia that was not MSA-C, an autosomal-dominant spinocerebellar ataxia (SCA) mutation was recently discovered. Chinese single-hospital
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Sarcoma protein kinase inhibition alleviates liver fibrosis by promoting hepatic stellate cells ferroptosis Open Life Sci. (IF 2.2) Pub Date : 2023-12-07 Zhengyuan Cheng, Xiaojuan Zhang, Pingsheng Chen, Haitao Wang, Kuangjing Wang, Yingzhou Shen
Liver fibrosis is a type of chronic pathological liver damage involving liver tissue hypoxia and abnormal extracellular matrix deposits. Hepatic stellate cells (HSCs) activation is critical for liver fibrosis. Currently, inhibiting HSCs activation or inducing HSCs ferroptosis is considered an effective strategy for the treatment of liver fibrosis. Sarcoma protein kinase (Src) is an important member
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Research progress of serum eosinophil in chronic obstructive pulmonary disease and asthma Open Life Sci. (IF 2.2) Pub Date : 2023-12-07 Congli Wu
Chronic obstructive pulmonary disease (COPD) and asthma are common airway diseases, and there are similarities and differences between them. Serum eosinophil (EOS) has potential application value in the diagnosis, treatment, and prognosis of COPD and asthma. However, the clinical application value of serum EOS in these two diseases is controversial. In this work, recent research progress on the application
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Down-regulation of COL1A1 inhibits tumor-associated fibroblast activation and mediates matrix remodeling in the tumor microenvironment of breast cancer Open Life Sci. (IF 2.2) Pub Date : 2023-11-30 Bin Ma, Fangfang Li, Binlin Ma
We investigated the effects of collagen type I alpha 1 (COL1A1) on tumor-associated fibroblast activation and matrix remodeling in the tumor microenvironment of breast cancer. Cells were divided into the blank control, negative control, and siRNA-COL1A1 groups, or HKF control, HKF + exosomes (EXO), HKF + siRNA negative control-EXO, and HKF + siRNA-COL1A1-EXO co-culture groups. Western blot and quantitative
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Optimised feature selection-driven convolutional neural network using gray level co-occurrence matrix for detection of cervical cancer Open Life Sci. (IF 2.2) Pub Date : 2023-11-30 K. Sudhakar, D. Saravanan, G. Hariharan, M. S. Sanaj, Santosh Kumar, Maznu Shaik, Jose Luis Arias Gonzales, Khursheed Aurangzeb
Cervical cancer is one of the most dangerous and widespread illnesses afflicting women throughout the globe, particularly in East Africa and South Asia. In industrialised nations, the incidence of cervical cancer has consistently decreased over the past few decades. However, in developing countries, the reduction in incidence has been considerably slower, and in some instances, the incidence has increased
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Case report of atypical undernutrition of hypoproteinemia type Open Life Sci. (IF 2.2) Pub Date : 2023-11-29 Qun-Ru Wang, Jun Long, Chen-Cheng Wang, Ji-Lei Hu, Ning Lin, Shan-Hong Tang
Albumin and prealbumin serve as vital markers reflecting hepatic synthesis activity and overall body nutrient status. Hypoproteinemia can result from various etiological factors, with reduced blood inflow into the liver due to portal vein thrombosis being one such cause. However, literature addressing this specific association remains limited. This report presents an atypical case of malnutrition involving
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Distinguish Dianthus species or varieties based on chloroplast genomes Open Life Sci. (IF 2.2) Pub Date : 2023-11-28 Dong Meng, Liu Yang, Zhao Yunlin, Yang Guiyan, Chen Shuwen, Xu Zhenggang
Most plants belonging to the widely distributed genus Dianthus are used for gardening. Interspecific hybridization of different Dianthus species leads to blurred genetic backgrounds. To obtain more genomic resources and understand the phylogenetic relationships among Dianthus species, the chloroplast genomes of 12 Dianthus species, including nine Dianthus gratianopolitanus varieties, were analyzed
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Exploring the conformational dynamics and thermodynamics of EGFR S768I and G719X + S768I mutations in non-small cell lung cancer: An in silico approaches Open Life Sci. (IF 2.2) Pub Date : 2023-11-28 Jun-Ling Wang, Ming-Sheng Liu, Yu-Dong Fu, Qiang-Bo Kan, Chun-Yan Li, Rong Ma, Zhe-Wei Fang, Hong-Xia Liu, Meng-Xian Li, Jia-Ling Lv, Peng Sang, Chao Zhang, Hong-Wei Li
Non-small cell lung cancer (NSCLC) is often driven by mutations in the epidermal growth factor receptor (EGFR) gene. However, rare mutations such as G719X and S768I lack standard anti-EGFR targeted therapies. Understanding the structural differences between wild-type EGFR and these rare mutants is crucial for developing EGFR-targeted drugs. We performed a systematic analysis using molecular dynamics
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Favorable response to surufatinib in a patient with necrolytic migratory erythema: A case report Open Life Sci. (IF 2.2) Pub Date : 2023-11-27 Zhongan Liu, Feng Hu, Shuang Guo, Peng Zhang, Guiling Li, You Qin
Necrolytic migratory erythema (NME) is usually associated with paraneoplastic syndrome caused by functional pancreatic neuroendocrine tumor (PNET). Accurate diagnosis and effective treatment of NET-related NME is challenging due to its rarity and lack of typical clinical symptoms and specific pathological manifestations. Here we report a rare case of PNET with NME as the initial manifestation. 68Ga-DOTA-TATE
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An advanced approach for fig leaf disease detection and classification: Leveraging image processing and enhanced support vector machine methodology Open Life Sci. (IF 2.2) Pub Date : 2023-11-24 Sharaf Alzoubi, Malik Jawarneh, Qusay Bsoul, Ismail Keshta, Mukesh Soni, Muhammad Attique Khan
In the rapidly evolving landscape of agricultural technology, image processing has emerged as a powerful tool for addressing critical agricultural challenges, with a particular focus on the identification and management of crop diseases. This study is motivated by the imperative need to enhance agricultural sustainability and productivity through precise plant health monitoring. Our primary objective
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Chromatographic analysis of the chemical composition and anticancer activities of Curcuma longa extract cultivated in Palestine Open Life Sci. (IF 2.2) Pub Date : 2023-11-24 Murad Abualhasan, Nidal Jaradat, Mohammed Hawash, Naser Shraim, Mohammad Asaad, Ahmed Mousa, Zain Mousa, Reem Tobeh, Balsam Mlitat
Curcuma longa (turmeric) is a plant that has been extensively utilized in traditional medicine for centuries. Turmeric has a long history of use in both food and traditional medicine for the treatment of ailments such as diarrhea, cancer, flatulence, and dyspepsia. In Palestine, this plant was cultivated for the first time. The objective of this study was to characterize the extract of C. longa and
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Comparative analysis of the rhizosphere microbiome and medicinally active ingredients of Atractylodes lancea from different geographical origins Open Life Sci. (IF 2.2) Pub Date : 2023-11-24 Junjie Tang, Yun Han, Lingfeng Pei, Wei Gu, Rongli Qiu, Sheng Wang, Qihan Ma, Yifu Gan, Min Tang
This study aimed to explore the important role of the rhizosphere microbiome in the quality of Atractylodes lancea (Thunb.) DC. (A. lancea). The rhizosphere microbial community of A. lancea at two sampling sites was studied using metagenomic technology. The results of α-diversity analysis showed that the rhizosphere microbial richness and diversity were higher in the Maoshan area. The higher abundance
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Influence of solvent-free extraction of fish oil from catfish (Clarias magur) heads using a Taguchi orthogonal array design: A qualitative and quantitative approach Open Life Sci. (IF 2.2) Pub Date : 2023-11-24 Jaydeep Dave, Ali Muhammed Moula Ali, Tanaji Kudre, Pikunthong Nukhthamna, Nishant Kumar, Marek Kieliszek, Sri Charan Bindu Bavisetty
This study aimed to efficiently utilize catfish heads, enhancing the oil extraction process while improving the cost-effectiveness of fish byproduct management. The study employed the wet rendering method, a solvent-free approach, utilizing a two-factor Taguchi orthogonal array design to identify critical parameters for optimizing oil yield and ensuring high-quality oil attributes. The extraction temperature
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Nrf3 alleviates oxidative stress and promotes the survival of colon cancer cells by activating AKT/BCL-2 signal pathway Open Life Sci. (IF 2.2) Pub Date : 2023-11-24 Bi-Qing Cai, Wan-Meng Chen, Meng-Wei Chen, Ya-Hui Chen, Jian-Cai Tang
Oxidative stress is closely linked to tumor initiation and development, conferring a survival advantage to cancer cells. Therefore, understanding cancer cells’ antioxidant molecular mechanisms is crucial to cancer therapy. In this study, we discovered that H2O2-induced oxidative stress increased Nrf3 expression in colon cancer cells. Overexpression of Nrf3 decreased H2O2-mediated cytotoxicity and apoptosis