-
From sequence to consequence: Deciphering the complex cis-regulatory landscape J. Biosci. (IF 2.9) Pub Date : 2024-03-14
Abstract Cell type-specific expression of genes plays a pivotal role in the development and evolution of multicellular organisms over millions of years. The majority of regulatory control resides within the non-coding regions of the genome, referred to as ‘dark matter’, which contains cis-regulatory modules. These cis-regulatory modules function collectively and can impact gene expression even when
-
Crosstalk between photosynthesis and respiration in microbes J. Biosci. (IF 2.9) Pub Date : 2024-03-13 Ginga Shimakawa, Yusuke Matsuda, Adrien Burlacot
-
Role of mitochondria and chloroplasts during stomatal closure: Subcellular location of superoxide and H2O2 production in guard cells of Arabidopsis thaliana J. Biosci. (IF 2.9) Pub Date : 2024-03-13 Shashibhushan Gahir, Pulimamidi Bharath, Deepak Saini, Gudipalli Padmaja, Agepati S Raghavendra
-
Cobra (Naja naja) venom L-amino acid oxidase (NNLAAO70) induces apoptosis and secondary necrosis in human lung epithelial cancer cells J. Biosci. (IF 2.9) Pub Date : 2024-03-07 Ananda Murali Rayapati, Bhadramurthy Vemulapati, Chandrasekhar Chanda
-
Finding identical sequence repeats in multiple protein sequences: An algorithm J. Biosci. (IF 2.9) Pub Date : 2024-02-28 Vikas Kumar Maurya, Madhumathi Sanjeevi, Chandrasekar Narayanan Rahul, Ajitha Mohan, Dhanalakshmi Ramachandran, Rashmi Siddalingappa, Roshan Rauniyar, Sekar Kanagaraj
-
Dynein functions in galectin-3 mediated processes of clathrin-independent endocytosis J. Biosci. (IF 2.9) Pub Date : 2024-02-28 Chaithra Mayya, A Hema Naveena, Pankhuri Sinha, Dhiraj Bhatia
-
Enhancing access to treatment for Gaucher disease in India: The need for indigenous manufacturing J. Biosci. (IF 2.9) Pub Date : 2024-02-20 Nidhi Patel, Heta Pandya, Ganesh Sangle, Mohua Chakraborty Choudhury
-
Spinal muscular atrophy: Molecular mechanism of pathogenesis, diagnosis, therapeutics, and clinical trials in the Indian context J. Biosci. (IF 2.9) Pub Date : 2024-02-20 Ashutosh Aasdev, R S Sreelekshmi, V Rajesh Iyer, Shivranjani C Moharir
-
Recent developments in gene therapy research in India J. Biosci. (IF 2.9) Pub Date : 2024-02-20 Ruchita Selot, Arkasubhra Ghosh
-
Understanding pathophysiology of GNE myopathy and current progress towards drug development J. Biosci. (IF 2.9) Pub Date : 2024-02-19 Fluencephila Mashangva, Shagun Singh, Jyoti Oswalia, Ranjana Arya
-
Are all VapC toxins of Mycobacterium tuberculosis endowed with enigmatic RNase activity? J. Biosci. (IF 2.9) Pub Date : 2024-02-19 Sheeba Zarin, Anwar Alam, Seyed Ehtesham Hasnain, Nasreen Zafar Ehtesham
Mycobacterium tuberculosis (M. tb) employs an extensive network of more than 90 toxin–antitoxin systems, and among them, VapC toxins are the most abundant. While most VapCs function as classical RNases with toxic effects, a significant number of them do not exhibit toxicity. However, these non-toxic VapCs may retain specific RNA binding abilities as seen in case of VapC16, leading to ribosome stalling
-
Orphan drug development: Challenges, regulation, and success stories J. Biosci. (IF 2.9) Pub Date : 2024-02-19 Narendra Chirmule, Huije Feng, Esha Cyril, Vihang Vivek Ghalsasi, Mohua Chakraborty Choudhury
-
mRNA biotherapeutics landscape for rare genetic disorders J. Biosci. (IF 2.9) Pub Date : 2024-02-19 V Rajesh Iyer, P Praveen, Bhagyashree D Kaduskar, Shivranjani C Moharir, Rakesh K Mishra
-
Rare genetic diseases in India: Steps toward a nationwide mission program J. Biosci. (IF 2.9) Pub Date : 2024-02-19 Anjana Kar, P Sundaravadivel, Ashwin Dalal
-
Rare genetic disorders in India: Current status, challenges, and CRISPR-based therapy J. Biosci. (IF 2.9) Pub Date : 2024-02-19 Pallabi Bhattacharyya, Kanikah Mehndiratta, Souvik Maiti, Debojyoti Chakraborty
-
Decoding the mitochondria without a code: mechanistic insights into mitochondrial DNA depletion syndromes J. Biosci. (IF 2.9) Pub Date : 2024-02-19 Ritoprova Sen, Cuckoo Teresa Jetto, Ravi Manjithaya
-
Lessons from the Rare Diseases Registry and Analytics Platform framework for development of a national rare diseases registry for India J. Biosci. (IF 2.9) Pub Date : 2024-02-19 Pragya Chaube, Avani Lankapalli, Mohua Chakraborty Choudhury
Rare diseases (RD) pose significant challenges for healthcare systems globally, necessitating the establishment of disease registries to facilitate research, diagnosis, and treatment. This article explores the development of a comprehensive national RD registry for India, informed by insights gained through interactions with experts from India and the Asia-Pacific Economic Cooperation (APEC) region
-
Non-viral delivery of nucleic acid for treatment of rare diseases of the muscle J. Biosci. (IF 2.9) Pub Date : 2024-02-16 Divya Rao, Munia Ganguli
-
Challenges and opportunities for discovering the biology of rare genetic diseases of the brain J. Biosci. (IF 2.9) Pub Date : 2024-02-15 Padinjat Raghu, Yojet Sharma, Aswathy Bhuvanendran Nair Suseela Devi, Harini Krishnan
-
Leaf and tree age-related changes in leaf ecophysiological traits, nutrient, and adaptive strategies of Alnus nepalensis in the central Himalaya J. Biosci. (IF 2.9) Pub Date : 2024-01-23
Abstract Leaf ecophysiological traits are known to change with leaf and tree age. In the present study, we measured the effect of leaf and tree age on leaf ecophysiological and morphological traits of nitrogen-fixing Alnus nepalensis (D. Don) which is a pioneer tree species in degraded lands. Three naturally occurring A. nepalensis forest stands, namely young (5–8 years old), mature (40–55 years old)
-
Screening of quinoa (Chenopodium quinoa Willd.) germplasms under high-SAR saline water on the basis of growth, yield, and multivariate analysis J. Biosci. (IF 2.9) Pub Date : 2024-01-22
Abstract Increasing soil and underground water salinization with decreasing availability of fresh water has become a potential threat to sustainable crop production in arid and semi-arid areas globally. Introduction and evaluation of salt-tolerant halophytic crops is one of the sustainable ways to preserve productivity in saline ecosystems. This study was aimed to screen quinoa germplasms under high-sodium
-
Lafora progressive myoclonus epilepsy: Disease mechanism and therapeutic attempts J. Biosci. (IF 2.9) Pub Date : 2024-01-20 Rashmi Parihar, Subramaniam Ganesh
-
Tumor immune microenvironment-based clusters in predicting prognosis and guiding immunotherapy in breast cancer J. Biosci. (IF 2.9) Pub Date : 2024-01-20
Abstract The development and progression of breast cancer (BC) depend heavily on the tumor microenvironment (TME), especially tumor infiltration leukocytes (TILs). TME-based classifications in BC remain largely unknown and need to be clarified. Using the bioinformatic analysis, we attempted to construct a prognostic nomogram based on clinical features and TME-related differentially expressed genes
-
Generation and characterization of retinal pigment epithelium from patient iPSC line to model oculocutaneous albinism (OCA)1A disease J. Biosci. (IF 2.9) Pub Date : 2024-01-20 Janavi Subramani, Niharika Patlolla, Rajani Battu, Taslimarif Saiyed, Rajarshi Pal
-
Sustainable blue economy: Opportunities and challenges J. Biosci. (IF 2.9) Pub Date : 2024-01-18 Sahil Narwal, Manpreet Kaur, Digvijay Singh Yadav, Felix Bast
-
A crazy ants’ crazy form of reproduction: Causes and consequences J. Biosci. (IF 2.9) Pub Date : 2024-01-12 Alok Bang, H A Ranganath, Raghavendra Gadagkar
-
Rare paediatric disorders in Indian healthcare settings with focus on neuromuscular disorders: Diagnostic and management challenges J. Biosci. (IF 2.9) Pub Date : 2024-01-10 Aakash Mahesan, Gautam Kamila, Sheffali Gulati
-
Proof-of-principle study using Saccharomyces cerevisiae for universal screening test for cancer through ultrasound-based size distinction of circulating tumor cell clusters J. Biosci. (IF 2.9) Pub Date : 2024-01-10 Saksham Rajan Saksena, Sandeep Kumar Rajan
-
Assessment of seed- and seedling-related traits in Santalum album (Indian sandalwood) reveals high adaptive potential J. Biosci. (IF 2.9) Pub Date : 2024-01-10 Chandramouli K Madhuvanthi, Muthulakshmi Eswaran, Thangaraj Karthick, Aiyar Balasubramanian, Modhumita Ghosh Dasgupta
-
Fatty acid metabolism-related molecular subtypes and a novel model for predicting prognosis in bladder cancer patients J. Biosci. (IF 2.9) Pub Date : 2024-01-05 Wen-Ting Su, Jia-Yin Chen, Jiang-Bo Sun, Qi Huang, Zhi-Bin Ke, Shao-Hao Chen, Yun-Zhi Lin, Xue-Yi Xue, Yong Wei, Ning Xu
-
CDF family of zinc transporters ZRC-1, MSC-2, and ZRG-17 are involved in survival at high zinc conditions, vegetative development, and cellulase utilization in Neurospora crassa J. Biosci. (IF 2.9) Pub Date : 2024-01-05 Serena Ngiimei D, Ranjan Tamuli
-
Epidemiology: Gray immunity model gives qualitatively different predictions J. Biosci. (IF 2.9) Pub Date : 2024-01-05 Milind Watve, Himanshu Bhisikar, Rohini Kharate, Srashti Bajpai
-
STING upregulation mediates ferroptosis and inflammatory response in lupus nephritis by upregulating TBK1 and activating NF-κB signal pathway J. Biosci. (IF 2.9) Pub Date : 2024-01-02 Jinshu Chen, Pihou Chen, Yijin Song, Jiaxin Wei, Fan Wu, Jing Sun, Zhiquan Xu
-
A novel search engine for proteins involved in Notch crosstalk signaling pathways J. Biosci. (IF 2.9) Pub Date : 2023-12-22 Madhumathi Sanjeevi, Santhosh Rajendran, Dhanalakshmi Ramachandran, Chandrasekar Narayanan Rahul, Jeyakanthan Jeyaraman, Sekar Kanagaraj
-
Helicobacter pylori infection and gut microbiota in adolescents: Is there a relation? J. Biosci. (IF 2.9) Pub Date : 2023-12-22 Doaa El Amrousy, Heba El Ashry, Sara Maher, Dina Abdelhai, Samir Hassan
Helicobacter pylori infection is a prevalent global infection associated with several complications such as peptic ulcer, upper gastrointestinal bleeding, and stomach cancer. An imbalance in the gut microbiota composition or the relationship between the microbiota and the host may be implicated in the infection. To investigate this, we studied the intestinal microbiota of 50 newly infected adolescents
-
Molecular transformations and self-association in anthocyanin pigment patterns J. Biosci. (IF 2.9) Pub Date : 2023-12-19 Wei-Yu Hsu, Patrick D. Shipman, Stephen Thompson
-
The first embryo, the origin of cancer and animal phylogeny. II. The neoplastic process as an evolutionary engine J. Biosci. (IF 2.9) Pub Date : 2023-12-19 Jaime Cofre
-
Identification and investigation of barley powdery mildew (Blumeria graminis f. sp. tritici) infection in winter wheat with conventional stress reactions and non-invasive biophoton emission parameters J. Biosci. (IF 2.9) Pub Date : 2023-12-19
Abstract The objective of this study was to characterize the effects of barley powdery mildew infection on wheat via the evolution and dynamics of chloroplasts and oxidative processes based on in vivo measurements of ultra-weak photon emission, parallel measurement of chlorophyll and ascorbic acid content, and molecular identification of the pathogen. The results showed the temporal dynamics of the
-
Exacerbation of drought-induced physiological and biochemical changes in leaves of Pisum sativum upon restriction of COX and AOX pathways of mitochondrial oxidative electron transport J. Biosci. (IF 2.9) Pub Date : 2023-12-19 Benedict Analin, Kavya Bakka, Dinakar Challabathula
-
Involvement of oxidative stress in localization of bacterial spot infection in pepper plants J. Biosci. (IF 2.9) Pub Date : 2023-12-16 Liliana Brankova, Elena Shopova, Sergei Ivanov, Yoana Kizheva, Zoltan Urshev, Iliyana Rasheva, Vladimir Aleksandrov, Lyudmila Dimitrova, Melani Dimitrova, Petya Hristova
-
Identification of biomarker genes from multiple studies for abiotic stress in maize through machine learning J. Biosci. (IF 2.9) Pub Date : 2023-12-15 Leyla Nazari, Zahra Zinati, Paolo Bagnaresi
-
Host-directed therapy against tuberculosis: Concept and recent developments J. Biosci. (IF 2.9) Pub Date : 2023-12-08 Sonakshi Udinia, Mrutyunjay Suar, Dhiraj Kumar
-
Early discoveries on enzyme deficiencies in lysosomal storage diseases: The Indian contribution J. Biosci. (IF 2.9) Pub Date : 2023-12-08 Shikha Gupta, Anand K Bachhawat
-
Roxburgh was right: Aponogeton microphyllus and Aponogeton undulatus are distinct species J. Biosci. (IF 2.9) Pub Date : 2023-12-08 Rupali N Chougule, Siddharthan Surveswaran, Arvind George, Shrirang R Yadav, Manoj M Lekhak
-
Global genome and transcription-coupled nucleotide excision repair pathway in prokaryotes J. Biosci. (IF 2.9) Pub Date : 2023-12-08 Manoj Thakur, Kalappa Muniyappa
-
SARS-CoV-2 testing and its role in understanding the evolving landscape of the pandemic in Bangladesh J. Biosci. (IF 2.9) Pub Date : 2023-12-08 Shafiul Azam, Mohammed Sayem, Salim Khan, Catherine Martini, Murshed Hasan Sarkar, Shahina Akter, Barna Goswami, Sylvana Q Sinha, Zaheed Husain
-
MiR-499 enhances Porphyromonas gingivalis LPS-induced inflammatory response in macrophages by targeting NRIP1 via JAK/STAT pathway J. Biosci. (IF 2.9) Pub Date : 2023-11-30 Chuanmin Wang, Xiangxin Li
-
Characterization of prolycopene-accumulated Tan406 mutant of Solanum lycopersicum J. Biosci. (IF 2.9) Pub Date : 2023-11-30 Pottipadu John Elia Prashanth, Nambi Rajesh, Mulugu Apurva Nandini, Jinka Siva Kumar, Bosetty Anjana, Osman Basha Pinjari
-
Characterization of complete mitochondrial genomes of five noctuoid moths (Lepidoptera: Noctuoidea) and their phylogenetic implications J. Biosci. (IF 2.9) Pub Date : 2023-11-25 Muzafar Riyaz, Rauf Ahmad Shah, Ignacimuthu Savarimuthu, Sivasankaran Kuppusamy
-
Pathway analysis of host responses to dengue virus serotype 2 infection and inhibition of viral envelope protein by naringenin from Ganoderma lucidum J. Biosci. (IF 2.9) Pub Date : 2023-11-25 Wui Zhuan Lim, Siow Wee Chang, Teow Chong Teoh
-
Cystinosis: Status of research and treatment in India and the world J. Biosci. (IF 2.9) Pub Date : 2023-11-25 Nikita Vashist, Anup Arunrao Deshpande, Armugham Kanakaraj, Rajan Ravichandran, Anand K Bachhawat
-
Co-evolution of the translation apparatus and eukaryotes J. Biosci. (IF 2.9) Pub Date : 2023-11-20 Umesh Varshney
-
Architecture, domain organization, and functional signatures of trypanosomatid keIF4A1s and Plasmodium peIF4A1s suggest conserved functions J. Biosci. (IF 2.9) Pub Date : 2023-11-20 Anica Dadwal, Supratik Das
-
The worldwide need for amyloid diagnosis in animals J. Biosci. (IF 2.9) Pub Date : 2023-11-20 Akansha Garg, Ashwani Kumar Thakur
Deposition of amyloid in tissues and organs leads to amyloidosis, impacting the function of vital organs and often resulting in mortality. About 42 proteins in humans and 10 in animals are known to form amyloid deposits. Amyloid research in humans has gained considerable pace in recent years but not in the case of animals. Being an essential part of the ecosystem, animals contribute significantly to
-
Characterising ATP binding activity of PilB ATPase of Shewanella oneidensis MR-1 using a molecular modeling and simulations approach J. Biosci. (IF 2.9) Pub Date : 2023-11-20 Vaishnav Varma Alluri, Mayur Mukhi, A. S. Vishwanathan
-
ESE-1 mediates lipopolysaccharide-induced BV2 cell inflammation via upregulation of HMGB1 expression J. Biosci. (IF 2.9) Pub Date : 2023-11-06 Yaojun Lu, Juan Ding, Jiaojiao Huang, Yanjun Zhao
-
Drosophila olfaction as a model system for studying human neurological disorders J. Biosci. (IF 2.9) Pub Date : 2023-10-20 Subhajit Sarkar, Abhijit Das
-
Diet–gene interactions ensure optimal life span and health J. Biosci. (IF 2.9) Pub Date : 2023-10-20 Tripti Nair, Arnab Mukhopadhyay
-
Controlling pathological activity of Parkinson basal ganglia based on excitation and inhibition optogenetic models and monophasic and biphasic electrical stimulations J. Biosci. (IF 2.9) Pub Date : 2023-10-13 Nazlar Ghasemzadeh, Fereidoun Nowshiravan Rahatabad, Siamak Haghipour, Shabnam Andalibi Miandoab, Keivan Maghooli
-
Novel regulators of mitochondrial genome integrity J. Biosci. (IF 2.9) Pub Date : 2023-10-13 Ashwin Nair, P V Shivaprasad