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Circ_0000620 acts as an oncogenic factor in gastric cancer through regulating MMP2 expression via sponging miR-671-5p J. Biol. Res. Thessalon. (IF 3.3) Pub Date : 2021-12-31 Ren, Junyu, Pan, Guoqing, Yang, Jun, Xu, Ning, Zhang, Qiong, Li, Wenliang
Gastric cancer (GC) is one of the most common cancers in the digestive system. Circular RNAs (circRNAs) have been found to function as important regulators in the pathogenesis of GC. This study focused on the biological role and molecular mechanism of circ_0000620 in GC progression. The expression levels of circ_0000620, microRNA-671-5p (miR-671-5p) and Matrix MetalloProteinase 2 (MMP2) were measured
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Circ_0000620 acts as an oncogenic factor in gastric cancer through regulating MMP2 expression via sponging miR-671-5p. J. Biol. Res. Thessalon. (IF 3.3) Pub Date : 2021-12-31 Junyu Ren,Guoqing Pan,Jun Yang,Ning Xu,Qiong Zhang,Wenliang Li
BACKGROUND Gastric cancer (GC) is one of the most common cancers in the digestive system. Circular RNAs (circRNAs) have been found to function as important regulators in the pathogenesis of GC. This study focused on the biological role and molecular mechanism of circ_0000620 in GC progression. METHODS The expression levels of circ_0000620, microRNA-671-5p (miR-671-5p) and Matrix MetalloProteinase 2
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Peroxiredoxin-6 regulates p38-mediated epithelial–mesenchymal transition in HCT116 colon cancer cells J. Biol. Res. Thessalon. (IF 3.3) Pub Date : 2021-11-23 Chae, Unbin, Kim, Bokyung, Kim, HanSeop, Park, Young-Ho, Lee, Seung Hwan, Kim, Sun-Uk, Lee, Dong-Seok
Peroxiredoxins (Prxs) are antioxidant enzymes that protect cells from oxidative stress induced by several factors. They regulate several signaling pathways, such as metabolism, immune response, and intracellular reactive oxygen species (ROS) homeostasis. Epithelial–mesenchymal transition (EMT) is a transforming process that induces the loss of epithelial features of cancer cells and the gain of the
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Nesfatin-1 protects H9c2 cardiomyocytes against cobalt chloride-induced hypoxic injury by modulating the MAPK and Notch1 signaling pathways J. Biol. Res. Thessalon. (IF 3.3) Pub Date : 2021-09-13 Li, Mingchen, Li, Kai, Ren, Yuan
This study aimed to explore the effect of nesfatin-1 on cobalt chloride (CoCl2)-induced hypoxic injury in cardiomyocyte H9c2 cells. H9c2 cardiomyocytes were induced by different concentrations of CoCl2 to mimic the hypoxia condition. Cell viability was detected by MTT assay. Cell apoptosis was detected by TUNEL staining and flow cytometry. ROS production was detected using the fluorescence probe DCFH-DA
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LncRNA FBXL19-AS1 promotes proliferation and metastasis of cervical cancer through upregulating COL1A1 as a sponge of miR-193a-5p J. Biol. Res. Thessalon. (IF 3.3) Pub Date : 2021-08-16 Huang, Xiaoyong, Shi, Haiyan, Shi, Xinghai, Jiang, Xuemei
Cervical cancer (CC) is one of the most common and malignant tumors in women. In this study, we aim to explore the role and mechanism of F-box and leucine rich repeat protein 19 antisense RNA 1 (FBXL19-AS1), a novel long-chain non coding RNA (lncRNA) with marked roles in a variety of tumors, in regulating the proliferation and metastasis of CC. The expression of FBXL19-AS1, miR-193a-5p and COL1A1 were
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CircCNIH4 inhibits gastric cancer progression via regulating DKK2 and FRZB expression and Wnt/β-catenin pathway J. Biol. Res. Thessalon. (IF 3.3) Pub Date : 2021-08-07 Shi, Qi, Zhou, Chuanwen, Xie, Rui, Li, Miaomiao, Shen, Peng, Lu, Yining, Ma, Shijie
Circular RNAs (circRNAs) have been reported to play an important role in tumor progression in various cancer types, including gastric cancer. The aim of this study was to investigate the role of circCNIH4 (hsa_circ_0000190) in gastric cancer and the underlying mechanism. The expression levels of circCNIH4 and Wnt antagonist genes were detected by quantitative real-time polymerase chain reaction (qRT-PCR)
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Predicted antiviral drugs Darunavir, Amprenavir, Rimantadine and Saquinavir can potentially bind to neutralize SARS-CoV-2 conserved proteins J. Biol. Res. Thessalon. (IF 3.3) Pub Date : 2021-08-04 Halder, Umesh C.
Novel Coronavirus disease 2019 or COVID-19 has become a threat to human society due to fast spreading and increasing mortality. It uses vertebrate hosts and presently deploys humans. Life cycle and pathogenicity of SARS-CoV-2 have already been deciphered and possible drug target trials are on the way. The present study was aimed to analyze Non-Structural Proteins that include conserved enzymes of SARS-CoV-2
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Callose: a multifunctional (1, 3)-β–d-glucan involved in morphogenesis and function of angiosperm stomata J. Biol. Res. Thessalon. (IF 3.3) Pub Date : 2021-08-03 Apostolakos, Panagiotis, Giannoutsou, Eleni, Galatis, Basil
Although the cellulose microfibril organization in guard cell (GC) walls play a crucial role in the mechanism of the stomatal function, recent work showed that matrix cell wall materials are also involved. Especially in the kidney-shaped stomata of the fern Asplenium nidus, callose actively participates in the mechanism of opening and closure of the stomatal pore. The present review briefly presents
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PTD-mediated delivery of α-globin chain into Κ-562 erythroleukemia cells and α-thalassemic (HBH) patients’ RBCs ex vivo in the frame of Protein Replacement Therapy J. Biol. Res. Thessalon. (IF 3.3) Pub Date : 2021-07-20 Androulla N. Miliotou, Dionysia Papagiannopoulou, Efthymia Vlachaki, Martina Samiotaki, Dimitra Laspa, Stamatia Theodoridou, Asterios S. Tsiftsoglou, Lefkothea C. Papadopoulou
α-Thalassemia, a congenital hemoglobinopathy, is characterized by deficiency and/or reduced levels of α-globin chains in serious forms of α-thalassemia (HbH disease/Hb Bart’s). This research work deals with a Protein Replacement Therapy approach in order to manage α-thalassemia manifestations, caused by the excess of β-globin chain into HbH RBCs. The main goal was to produce the recombinant human α-globin
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Relationship between the structure and function of the transcriptional regulator E2A J. Biol. Res. Thessalon. (IF 3.3) Pub Date : 2021-07-16 Jia-Jie Liang, Hu Peng, Jiao-Jiao Wang, Xiao-Hui Liu, Lan Ma, Yi-Ran Ni, Huai-Jie Yang, Yan-Qiong Zhang, Wen-Bing Ai, Jiang-Feng Wu
E proteins are transcriptional regulators that regulate many developmental processes in animals and lymphocytosis and leukemia in Homo sapiens. In particular, E2A, a member of the E protein family, plays a major role in the transcriptional regulatory network that promotes the differentiation and development of B and T lymphocytes. E2A-mediated transcriptional regulation usually requires the formation
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Sevoflurane inhibits malignant progression of colorectal cancer via hsa_circ_0000231-mediated miR-622 J. Biol. Res. Thessalon. (IF 3.3) Pub Date : 2021-06-28 Jingpeng Wang, Shuyuan Li, Gaofeng Zhang, Huihua Han
Sevoflurane (Sev), a commonly used volatile anesthetic, has been reported to inhibit the process of colorectal cancer (CRC). Circular RNAs (circRNAs) are revealed to participate in the pathogenesis of CRC. This study aims to reveal the mechanism of hsa_circ_0000231 in Sev-mediated CRC progression. The expression of hsa_circ_0000231 and microRNA-622 (miR-622) was detected by quantitative real-time polymerase
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Inhibition of cell expansion enhances cortical microtubule stability in the root apex of Arabidopsis thaliana J. Biol. Res. Thessalon. (IF 3.3) Pub Date : 2021-06-03 Veronica Giourieva, Emmanuel Panteris
Cortical microtubules regulate cell expansion by determining cellulose microfibril orientation in the root apex of Arabidopsis thaliana. While the regulation of cell wall properties by cortical microtubules is well studied, the data on the influence of cell wall to cortical microtubule organization and stability remain scarce. Studies on cellulose biosynthesis mutants revealed that cortical microtubules
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Evolutionary divergence of motifs in B-class MADS-box proteins of seed plants J. Biol. Res. Thessalon. (IF 3.3) Pub Date : 2021-05-28 Gangxu Shen, Yong Jia, Wei-Lung Wang
MADS-box transcription factors function as homo- or heterodimers and regulate many aspects of plant development; moreover, MADS-box genes have undergone extensive duplication and divergence. For example, the morphological diversity of floral organs is closely related to the functional divergence of the MADS-box gene family. B-class genes (such as Arabidopsis thaliana APETALA3 [AP3] and PISTILLATA [PI])
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Abundance and population characteristics of the invasive sea urchin Diadema setosum (Leske, 1778) in the south Aegean Sea (eastern Mediterranean) J. Biol. Res. Thessalon. (IF 3.3) Pub Date : 2021-05-21 Dimitris Vafidis, Chryssanthi Antoniadou, Konstantinos Voulgaris, Anastasios Varkoulis, Chrysoula Apostologamvrou
The Indo-Pacific sea urchin Diadema setosum has invaded the Mediterranean Sea and has spread along many locations in the southeastern part of the basin, where established populations exist on the shallow subtidal rocky shore. Diadema setosum is a ubiquitous species, of particular ecological importance due to the high levels of grazing pressure it imposes on benthic communities. Its biology, however
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Investigating the effects of two novel 4-MMPB analogs as potent lipoxygenase inhibitors for prostate cancer treatment J. Biol. Res. Thessalon. (IF 3.3) Pub Date : 2021-05-04 Sonia Iranpour, Aseel Kamil Mohammed Al-Mosawi, Ahmad Reza Bahrami, Hamid Sadeghian, Maryam M. Matin
Lipoxygenases are one of the critical signaling mediators which can be targeted for human prostate cancer (PC) therapy. In this study, 4-methyl-2-(4-methylpiperazinyl)pyrimido[4,5-b]benzothiazine (4-MMPB) and its two analogs, 4-propyl-2-(4-methylpiperazinyl)pyrimido[4,5-b]benzothiazine (4-PMPB) and 4-ethyl-2-(4-methylpiperazinyl)pyrimido[4,5-b]benzothiazine (4-EMPB), were proposed to have anti-tumor
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Barley somatic embryogenesis-an attempt to modify variation induced in tissue culture J. Biol. Res. Thessalon. (IF 3.3) Pub Date : 2021-03-16 Renata Orłowska
Somatic embryogenesis is a phenomenon carried out in an environment that generates abiotic stress. Thus, regenerants may differ from the source of explants at the morphological, genetic, and epigenetic levels. The DNA changes may be the outcome of induction media ingredients (i.e., copper and silver ions) and their concentrations and time of in vitro cultures. This study optimised the level of copper
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First report of detection of microcystins in farmed mediterranean mussels Mytilus galloprovincialis in Thermaikos gulf in Greece J. Biol. Res. Thessalon. (IF 3.3) Pub Date : 2021-03-10 Maria P. Kalaitzidou, Christina I. Nannou, Dimitra A. Lambropoulou, Konstantinos V. Papageorgiou, Alexandros M. Theodoridis, Vangelis K. Economou, Ioannis A. Giantsis, Panagiotis G. Angelidis, Spyridon K. Kritas, Evanthia J. Petridou
Microcystins are emerging marine biotoxins, produced by potentially toxic cyanobacteria. Their presence has been reported in aquatic animals in Greek freshwater, while data are few in marine environments. Since the climate change induces eutrophication and harmful algal blooms in coastal marine ecosystems affecting the public health, further research on microcystins’ presence in marine waters is required
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CircCTNNA1 acts as a ceRNA for miR-363-3p to facilitate the progression of colorectal cancer by promoting CXCL5 expression J. Biol. Res. Thessalon. (IF 3.3) Pub Date : 2021-02-27 Yan Zhang, Sheng Zheng, Nansheng Liao, Huifeng Huang, Wenxiao Chen, Zhenxing Wu, Deqing Wu
Circular RNAs (circRNA) have been shown to be involved in the pathogenesis of colorectal cancer (CRC). CircCTNNA1 was found to be one of the upregulated circRNAs in CRC. However, there are few studies on circCTNNA1, so it is necessary to carry out further studies. The expression of circCTNNA1, microRNA (miR)-363-3p, and chemokine C-X-C motif ligand 5 (CXCL5) was detected by quantitative real-time PCR
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Artemisinin attenuated oxidative stress and apoptosis by inhibiting autophagy in MPP+-treated SH-SY5Y cells J. Biol. Res. Thessalon. (IF 3.3) Pub Date : 2021-02-25 Junqiang Yan, Hongxia Ma, Xiaoyi Lai, Jiannan Wu, Anran Liu, Jiarui Huang, Wenjie Sun, Mengmeng Shen, Yude Zhang
Parkinson’s disease (PD) is the second most common neurodegenerative disease after Alzheimer's disease. The oxidative stress is an important component of the pathogenesis of PD. Artemisinin (ART) has antioxidant and neuroprotective effects. The purpose of this study is to explore the neuroprotective effect of ART on 1-methyl-4-phenyliodine iodide (MPP +)-treated SH-SY5Y cells and underlying mechanism
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Genome-scale meta-analysis of breast cancer datasets identifies promising targets for drug development J. Biol. Res. Thessalon. (IF 3.3) Pub Date : 2021-02-16 Reem Altaf, Humaira Nadeem, Mustafeez Mujtaba Babar, Umair Ilyas, Syed Aun Muhammad
Because of the highly heterogeneous nature of breast cancer, each subtype differs in response to several treatment regimens. This has limited the therapeutic options for metastatic breast cancer disease requiring exploration of diverse therapeutic models to target tumor specific biomarkers. Differentially expressed breast cancer genes identified through extensive data mapping were studied for their
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Long‐term monitoring of common spadefoot toad activity in a European steppe using barn owl pellets J. Biol. Res. Thessalon. (IF 3.3) Pub Date : 2021-02-12 Lukas Landler, Katharina Stefke
One third of the worldwide amphibian species are threatened, therefore, efficient monitoring efforts are needed. Amphibians which adopt a hidden lifestyle, such as the common spadefoot toad, are often missed with standard surveying efforts. Spadefoot toads can be identified in regurgitated pellets of the barn owl, which provides an effective way to estimate toad activity. In our study we analyzed frequency
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Different solutions lead to similar life history traits across the great divides of the amniote tree of life J. Biol. Res. Thessalon. (IF 3.3) Pub Date : 2021-02-08 Shai Meiri, Gopal Murali, Anna Zimin, Lior Shak, Yuval Itescu, Gabriel Caetano, Uri Roll
Amniote vertebrates share a suite of extra-embryonic membranes that distinguish them from anamniotes. Other than that, however, their reproductive characteristics could not be more different. They differ in basic ectothermic vs endothermic physiology, in that two clades evolved powered flight, and one clade evolved a protective shell. In terms of reproductive strategies, some produce eggs and others
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The histone methyltransferase inhibitor A-366 enhances hemoglobin expression in erythroleukemia cells upon co‐exposure with chemical inducers in culture J. Biol. Res. Thessalon. (IF 3.3) Pub Date : 2021-01-06 Christos I. Papagiannopoulos, Nikoleta F. Theodoroula, Konstantinos A. Kyritsis, Melpomeni G. Akrivou, Maria Kosmidou, Konstantina Tsouderou, Nikolaos Grigoriadis, Ioannis S. Vizirianakis
Erythroleukemia is caused by the uncontrolled multiplication of immature erythroid progenitor cells which fail to differentiate into erythrocytes. By directly targeting this class of malignant cells, the induction of terminal erythroid differentiation represents a vital therapeutic strategy for this disease. Erythroid differentiation involves the execution of a well-orchestrated gene expression program
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Circ_0000396 inhibits rheumatoid arthritis synovial fibroblast growth and inflammatory response via miR-203/HBP1 axis J. Biol. Res. Thessalon. (IF 3.3) Pub Date : 2021-01-06 Laifang Wang, Qing Zhao, Na Wang, Yanjie Ding, Lingli Kong, Jing Wang
Circ_0000396 was found to be down-regulated in the rheumatoid arthritis (RA) patients and had a high diagnostic value. However, the function and mechanisms underlying circ_0000396 in RA progression remain unclear. The expression of circ_0000396, microRNA (miR)-203 and HMG-box transcription factor 1 (HBP1) was detected using qRT-PCR and western blot. The proliferative and apoptotic capabilities of rheumatoid
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Prostate cancer and therapeutic challenges J. Biol. Res. Thessalon. (IF 3.3) Pub Date : 2020-12-10 Yousef MohammedRabaa Hawsawi, Samar Abdullah Zailaie, Atif Abdulwahab A. Oyouni, Othman Rashed Alzahrani, Osama Mohamed Alamer, Saad Ali S. Aljohani
Prostate cancer (PC) is the most prevalent type of cancer in men worldwide. In Saudi Arabia, the rate of PC is increasing annually. The sex steroid hormones androgens and their receptors have critical roles in PC development and progression. Additionally, apoptosis-related proteins such as heat-shock proteins are vital molecules in PC development. Steroid hormone-deprivation therapies remain the essential
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Campbell biology (edited by Lisa Urry, Michael Cain, Steven Wasserman, Peter Minorsky and Jane Reece) J. Biol. Res. Thessalon. (IF 3.3) Pub Date : 2020-12-09 Gangxu Shen
Campbell Biology is divided into eight units and 56 chapters. The organization and size of this book are appropriate and easy for first-year university students and help them to learn and digest the content. Campbell Biology is currently among the best biology books and it is listed with the best shelling textbooks. Campbell Biology is mainly for first-year university students, but it is also an important
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Cell adhesion molecules’ altered profile in benign and malignant salivary gland tumors. The paradigm of beta4-integrin, desmoglein-2, ICAM-1 and CD44s J. Biol. Res. Thessalon. (IF 3.3) Pub Date : 2020-12-07 Dimitrios Andreadis, Athanasios Poulopoulos, Apostolos Epivatianos, Alexandros Nomikos, Dimitrios Parlitsis, Konstantinos Christidis, Calypso Barbatis, Dimitrios Kavvadas, Alexandros Toskas, Theodora Papamitsou, Dimitrios Antoniades
Alterations in intercellular and cell-extracellular matrix connections contribute to tumour development. This study investigates the expression of specific cell adhesion molecules (CAMs) in salivary gland tumors (SGTs). Formalin–fixed, paraffin– embedded tissue specimens of different types of 34 benign and 31 malignant SGTs and normal salivary glands were studied using Envision/HRP immunohistochemical
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A potential hypothesis for 2019-nCoV infection therapy through delivery of recombinant ACE2 by red blood cell-hitchhiking J. Biol. Res. Thessalon. (IF 3.3) Pub Date : 2020-12-07 Zahra Sadat Aghili, Seyed Abbas Mirzaei, Mehdi Banitalebi-Dehkordi
A novel infectious disease, caused by 2019 Novel Coronavirus (2019-nCoV) is responsible for the recent outbreak of severe respiratory disease. The 2019-nCoV spread rapidly and reaching epidemic proportions in many countries of the world. ACE2 was identified as a key receptor for 2019-nCoV infections. Excessive form of soluble ACE2 rescues cellular ACE2 activity which has a protective role in acute
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LncRNA NCK1-AS1 in plasma distinguishes oral ulcer from early-stage oral squamous cell carcinoma J. Biol. Res. Thessalon. (IF 3.3) Pub Date : 2020-11-11 Fei Le, Yangqian Ou, Ping Luo, Xiaoming Zhong
Oral squamous cell carcinoma (OSCC) at early stages can be misdiagnosed as an oral ulcer (OU) due to similar symptoms, such as chronic and indurated ulcer. LncRNA NCK1-AS1 has been characterized as a key player in cervical cancer, while its role in OSCC is unknown. All participants were selected at Jiangxi Province Tumor Hospital from December 2016 to December 2018. Expression levels of NCK1-AS1 and
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The adaptive immune response in cardiac arrest resuscitation induced ischemia reperfusion renal injury J. Biol. Res. Thessalon. (IF 3.3) Pub Date : 2020-09-29 Maria Tsivilika, Eleni Doumaki, George Stavrou, Antonia Sioga, Vasilis Grosomanidis, Soultana Meditskou, Athanasios Maranginos, Despina Tsivilika, Dimitrios Stafylarakis, Katerina Kotzampassi, Theodora Papamitsou
The present study aims to investigate, immunohistochemically, the role of the adaptive immune response in cardiac arrest/resuscitation-induced ischemia–reperfusion renal injury (IRI), namely to assess the presence of lymphocytes in renal tissue samples and the connection between the extent of the damage and the concentration of the lymphocytes by comparing the kidneys of non resuscitated swine with
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Application of antibody phage display to identify potential antigenic neural precursor cell proteins. J. Biol. Res. Thessalon. (IF 3.3) Pub Date : 2020-08-02 Ioannis Paspaltsis,Evangelia Kesidou,Olga Touloumi,Roza Lagoudaki,Marina Boziki,Martina Samiotaki,Dimitra Dafou,Theodoros Sklaviadis,Nikolaos Grigoriadis
The discovery of neural precursor cells (NPCs) and the concomitant intensive research in the field offer regenerative medicine novel approaches, enabling it to tackle conditions, such as neurodegenerative diseases. Transplantation of NPCs is nowadays considered a cutting-edge treatment for these conditions and many related clinical trials have been already completed or are still ongoing. However, little
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Evaluating the effect of TLR4-overexpressing on the transcriptome profile in ovine peripheral blood mononuclear cells. J. Biol. Res. Thessalon. (IF 3.3) Pub Date : 2020-07-29 Xiaofei Guo,Jinlong Zhang,Yao Li,Jing Yang,Yihai Li,Chunxiao Dong,Guoshi Liu,Zhengxing Lian,Xiaosheng Zhang
Toll-like receptor 4 (TLR4) plays an important role in the elimination of Gram-negative bacteria infections and the initiation of antiinflammatory response. Using the technology of pronuclear microinjection, genetically modified (GM) sheep with TLR4 overexpression were generated. Previous studies have shown that these GM sheep exhibited a higher inflammatory response to Gram-negative bacteria infection
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Correction to: Genome wide meta-analysis of cDNA datasets reveals new target gene signatures of colorectal cancer based on systems biology approach. J. Biol. Res. Thessalon. (IF 3.3) Pub Date : 2020-07-06 Umair Ilyas,Shahiq Uz Zaman,Reem Altaf,Humaira Nadeem,Syed Aun Muhammad
An amendment to this paper has been published and can be accessed via the original article.
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Aberrant methylation-mediated downregulation of lncRNA CCND2 AS1 promotes cell proliferation in cervical cancer. J. Biol. Res. Thessalon. (IF 3.3) Pub Date : 2020-06-26 Chengcheng Zhao,Jian Liu,Huazhang Wu,Jiaojiao Hu,Jianquan Chen,Jie Chen,Fengchang Qiao
Long non-coding RNA (lncRNA) plays an important role in tumorigenesis. The lncRNA CCND2 AS1 has been shown to be involved in the growth of several tumors; however, its role in cervical cancer has not been elucidated. This study aimed to explore the expression, function, and underlying mechanism of action of CCND2 AS1 in cervical cancer. Expression of CCND2 AS1 was examined in cervical cancer and adjacent
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bolA gene involved in curli amyloids and fimbriae production in E. coli: exploring pathways to inhibit biofilm and amyloid formation J. Biol. Res. Thessalon. (IF 3.3) Pub Date : 2020-06-17 Mohd W. Azam, Azna Zuberi, Asad U. Khan
Biofilm formation is a complex phenomenon of bacterial cells, involved in several human infections. Its formation is regulated and controlled by several protein factors. The BolA-like proteins (bolA gene) are conserved in both prokaryotes and eukaryotes. The BolA protein is a transcription factor involved in bacterial cell motility and biofilm formation. This study was initiated to elucidate the role
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The occurrence of cancer in vertebrates: a mini review J. Biol. Res. Thessalon. (IF 3.3) Pub Date : 2020-06-08 Christos V. Kitsoulis, Athanasios D. Baxevanis, Theodore J. Abatzopoulos
Neoplasia is a multilevel condition caused by irregularities over the genome, which can lead to a fatal result. To fully understand this phenomenon, an evolutionary challenge has risen during the last decades, away from human limits, driving the scientific quest into the wild life. The study of wild vertebrate populations in their natural habitats has shown that cancer is rather prominent. Thus, the
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Genome wide meta-analysis of cDNA datasets reveals new target gene signatures of colorectal cancer based on systems biology approach J. Biol. Res. Thessalon. (IF 3.3) Pub Date : 2020-06-08 Umair Ilyas, Shahiq uz Zaman, Reem Altaf, Humaira Nadeem, Syed Aun Muhammad
Colorectal cancer is known to be the most common type of cancer worldwide with high disease-related mortality. It is the third most common cancer in men and women and is the second major cause of death globally due to cancer. It is a complicated and fatal disease comprising of a group of molecular heterogeneous disorders. This study identifies the potential biomarkers of CRC through differentially
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TRAF3 can interact with GMEB1 and modulate its anti-apoptotic function J. Biol. Res. Thessalon. (IF 3.3) Pub Date : 2020-05-29 George Kotsaris, Despoina Kerselidou, Dimitrios Koutsoubaris, Elena Constantinou, George Malamas, Dimitrios A. Garyfallos, Eudoxia G. Ηatzivassiliou
Members of Tumor Necrosis Factor (TNF) Receptor-Associated Factors (TRAFs) family interact with the cytoplasmic tails of TNF receptor family members to mediate signal transduction processes. TRAF3 has a major immunomodulatory function and TRAF3 deficiency has been linked to malignancies, such as multiple myeloma and lymphoid defects. In order to characterize the molecular mechanisms of TRAF3 signaling
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A potential prognostic model based on miRNA expression profile in The Cancer Genome Atlas for bladder cancer patients J. Biol. Res. Thessalon. (IF 3.3) Pub Date : 2020-05-19 Yan Liu, Dong Yan Zhu, Hong Jian Xing, Yi Hou, Yan Sun
This study aimed to construct prognostic model by screening prognostic miRNA signature of bladder cancer. The miRNA expression profile data of bladder cancer (BC) in The Cancer Genome Atlas (TCGA) were obtained and randomly divided into the training set and the validation set. Differentially expressed miRNAs (DEMs) between BC and normal control samples in the training set were firstly identified, and
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bolA gene involved in curli amyloids and fimbriae production in E. coli: exploring pathways to inhibit biofilm and amyloid formation. J. Biol. Res. Thessalon. (IF 3.3) Pub Date : 2020-06-17 Mohd W Azam,Azna Zuberi,Asad U Khan
BACKGROUND Biofilm formation is a complex phenomenon of bacterial cells, involved in several human infections. Its formation is regulated and controlled by several protein factors. The BolA-like proteins (bolA gene) are conserved in both prokaryotes and eukaryotes. The BolA protein is a transcription factor involved in bacterial cell motility and biofilm formation. This study was initiated to elucidate
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The occurrence of cancer in vertebrates: a mini review. J. Biol. Res. Thessalon. (IF 3.3) Pub Date : 2020-06-08 Christos V Kitsoulis,Athanasios D Baxevanis,Theodore J Abatzopoulos
Neoplasia is a multilevel condition caused by irregularities over the genome, which can lead to a fatal result. To fully understand this phenomenon, an evolutionary challenge has risen during the last decades, away from human limits, driving the scientific quest into the wild life. The study of wild vertebrate populations in their natural habitats has shown that cancer is rather prominent. Thus, the
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Genome wide meta-analysis of cDNA datasets reveals new target gene signatures of colorectal cancer based on systems biology approach. J. Biol. Res. Thessalon. (IF 3.3) Pub Date : 2020-06-08 Umair Ilyas,Shaiq Uz Zaman,Reem Altaf,Humaira Nadeem,Syed Aun Muhammad
BACKGROUND Colorectal cancer is known to be the most common type of cancer worldwide with high disease-related mortality. It is the third most common cancer in men and women and is the second major cause of death globally due to cancer. It is a complicated and fatal disease comprising of a group of molecular heterogeneous disorders. RESULTS This study identifies the potential biomarkers of CRC through
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TRAF3 can interact with GMEB1 and modulate its anti-apoptotic function. J. Biol. Res. Thessalon. (IF 3.3) Pub Date : 2020-05-29 George Kotsaris,Despoina Kerselidou,Dimitrios Koutsoubaris,Elena Constantinou,George Malamas,Dimitrios A Garyfallos,Eudoxia G Ηatzivassiliou
BACKGROUND Members of Tumor Necrosis Factor (TNF) Receptor-Associated Factors (TRAFs) family interact with the cytoplasmic tails of TNF receptor family members to mediate signal transduction processes. TRAF3 has a major immunomodulatory function and TRAF3 deficiency has been linked to malignancies, such as multiple myeloma and lymphoid defects. In order to characterize the molecular mechanisms of TRAF3
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A potential prognostic model based on miRNA expression profile in The Cancer Genome Atlas for bladder cancer patients. J. Biol. Res. Thessalon. (IF 3.3) Pub Date : 2020-05-19 Yan Liu,Dong Yan Zhu,Hong Jian Xing,Yi Hou,Yan Sun
BACKGROUND This study aimed to construct prognostic model by screening prognostic miRNA signature of bladder cancer. METHODS The miRNA expression profile data of bladder cancer (BC) in The Cancer Genome Atlas (TCGA) were obtained and randomly divided into the training set and the validation set. Differentially expressed miRNAs (DEMs) between BC and normal control samples in the training set were firstly
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A review on Zika virus outbreak, epidemiology, transmission and infection dynamics J. Biol. Res. Thessalon. (IF 3.3) Pub Date : 2020-03-04 Syeda Sidra Kazmi, Waqar Ali, Nousheen Bibi, Faisal Nouroz
Zika virus (ZIKV) is a newly emergent relative of the Flaviviridae family and linked to dengue (DENV) and Chikungunya (CHIVKV). ZIKV is one of the rising pathogens promptly surpassing geographical borders. ZIKV infection was characterized by mild disease with fever, headache, rash, arthralgia and conjunctivitis, with exceptional reports of an association with Guillain–Barre syndrome (GBS) and microcephaly
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Effect of crocin on antioxidant gene expression, fibrinolytic parameters, redox status and blood biochemistry in nicotinamide-streptozotocin-induced diabetic rats J. Biol. Res. Thessalon. (IF 3.3) Pub Date : 2020-03-02 Ioannis Margaritis, Katerina Angelopoulou, Sophia Lavrentiadou, Ilias C. Mavrovouniotis, Maria Tsantarliotou, Ioannis Taitzoglou, Alexandros Theodoridis, Aristidis Veskoukis, Efthalia Kerasioti, Dimitrios Kouretas, Ioannis Zervos
Diabetes is regarded as an epidemiological threat for the twenty-first century. Phytochemicals with known pharmaceutical properties have gained interest in the field of alleviating secondary complications of diseases. Such a substance is crocin, a basic constituent of saffron (Crocus sativus). The present study aimed at examining the beneficial effects of per os crocin administration on the antioxidant
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Editorial Announcement J. Biol. Res. Thessalon. (IF 3.3) Pub Date : 2020-02-19
We would like to thank all those listed below for taking the time to review for the Journal of Biological Research—Thessaloniki in 2019—your generosity is much appreciated and we hope your association with the journal continues in the future. Editor-in-Chief: Theodore J Abatzopoulos Aharon Oren Alessandro Chiarucci Alexandra Staikou Ana Claudia Oliveira Carreira Anargyros Moulas Andigoni Malousi Andriana
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Histologic evaluation of femoral nerve demyelinating and axonal neuropathy in Wistar rats due to alendronate intake: a randomised study J. Biol. Res. Thessalon. (IF 3.3) Pub Date : 2020-02-18 Papamitsou Theodora, Papakoulas Apostolos, Papaliagkas Vasileios, Karachrysafi Sofia, Dietrich Eva-Maria, Sioga Antonia
Bisphosphonates (BPs) are forceful inhibitors of osteoclast-mediated bone resorption. Long-term BP use is associated with multiple rare but severe adverse effects. The objective of this study was to investigate the possible effects of BPs in the structure of femoral nerve. Specimens from the femoral nerve of ten female 12-month old Wistar rats were used as control group and ten female 12-month old
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Histologic evaluation of femoral nerve demyelinating and axonal neuropathy in Wistar rats due to alendronate intake: a randomised study. J. Biol. Res. Thessalon. (IF 3.3) Pub Date : 2020-02-18 Papamitsou Theodora,Papakoulas Apostolos,Papaliagkas Vasileios,Karachrysafi Sofia,Dietrich Eva-Maria,Sioga Antonia
BACKGROUND Bisphosphonates (BPs) are forceful inhibitors of osteoclast-mediated bone resorption. Long-term BP use is associated with multiple rare but severe adverse effects. The objective of this study was to investigate the possible effects of BPs in the structure of femoral nerve. Specimens from the femoral nerve of ten female 12-month old Wistar rats were used as control group and ten female 12-month
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Metabolic engineering of Escherichia coli for the utilization of ethanol J. Biol. Res. Thessalon. (IF 3.3) Pub Date : 2020-01-21 Yujin Cao, Hui Mu, Jing Guo, Hui Liu, Rubing Zhang, Wei Liu, Mo Xian, Huizhou Liu
The fuel ethanol industry has made tremendous progress in the last decades. Ethanol can be obtained by fermentation using a variety of biomass materials as the feedstocks. However, few studies have been conducted on ethanol utilization by microorganisms. The price of petroleum-derived ethanol, easily made by the hydrolysis of ethylene, is even lower than that of bioethanol. If ethanol can be metabolized
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Metabolic engineering of Escherichia coli for the utilization of ethanol. J. Biol. Res. Thessalon. (IF 3.3) Pub Date : 2020-01-21 Yujin Cao,Hui Mu,Jing Guo,Hui Liu,Rubing Zhang,Wei Liu,Mo Xian,Huizhou Liu
BACKGROUND The fuel ethanol industry has made tremendous progress in the last decades. Ethanol can be obtained by fermentation using a variety of biomass materials as the feedstocks. However, few studies have been conducted on ethanol utilization by microorganisms. The price of petroleum-derived ethanol, easily made by the hydrolysis of ethylene, is even lower than that of bioethanol. If ethanol can
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Implications of salep collection for the conservation of the Elder-flowered orchid (Dactylorhiza sambucina) in Epirus, Greece J. Biol. Res. Thessalon. (IF 3.3) Pub Date : 2019-12-30 Martha Charitonidou, Kalliopi Stara, Konstantinos Kougioumoutzis, John M. Halley
In Epirus, Greece, orchids have been traditionally harvested for the production of salep, a beverage made from their tubers. Over-collection of orchids for salep is believed to be a growing threat to wild species, yet very little research has concentrated on orchid populations in the wild. Here, we studied the impact of salep collection on population demographic parameters and uniformity of distribution
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Saliva proteomics updates in biomedicine J. Biol. Res. Thessalon. (IF 3.3) Pub Date : 2019-12-12 Katerina R. Katsani, Dimitra Sakellari
In the years of personalized (or precision) medicine the ‘omics’ methodologies in biomedical sciences—genomics, transcriptomics, proteomics and metabolomics—are helping researchers to detect quantifiable biological characteristics, or biomarkers, that will best define the human physiology and pathologies. Proteomics use high throughput and high efficiency approaches with the support of bioinformatic
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Modulation of RECK levels in Xenopus A6 cells: effects on MT1-MMP, MMP-2 and pERK levels J. Biol. Res. Thessalon. (IF 3.3) Pub Date : 2019-11-27 Jessica A. Willson, Bradley S. Bork, Carlie A. Muir, Sashko Damjanovski
MT1-MMP is a cell-surface enzyme whose regulation of pro-MMP-2 and ERK activation position it as a key facilitator of ECM remodelling and cell migration. These processes are modulated by endogenous MMP inhibitors, such as RECK, a GPI-anchored protein which has been shown to inhibit both MT1-MMP and MMP-2 activity. Our previous studies have revealed a link between MT1-MMP levels, and pro-MMP-2 and ERK
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Tanshinone IIA attenuates Aβ-induced neurotoxicity by down-regulating COX-2 expression and PGE2 synthesis via inactivation of NF-κB pathway in SH-SY5Y cells J. Biol. Res. Thessalon. (IF 3.3) Pub Date : 2019-11-12 Lijiao Geng, Wei Liu, Yong Chen
Amyloid-β (Aβ)-induced neurotoxicity is a major pathological mechanism of Alzheimer’s disease (AD). Tanshinone IIA (Tan IIA), extracted from traditional Chinese herb Radix salvia miltiorrhiza, possesses anti-oxidant and anti-inflammatory actions, as well as neuroprotective effects. The present study aims to explore the possible mechanism by which Tan IIA attenuated Aβ-induced neurotoxicity. Exposure
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Heterozygosity fitness correlations and generation interval of the Norway lobster in the Aegean Sea, eastern Mediterranean J. Biol. Res. Thessalon. (IF 3.3) Pub Date : 2019-11-08 Georgios A. Gkafas, Marianthi Hatziioannou, Emmanouil E. Malandrakis, Costas S. Tsigenopoulos, Ioannis T. Karapanagiotidis, Elena Mente, Dimitrios Vafidis, Athanasios Exadactylos
Comprehensively detailed information on population dynamics for benthic species is crucial since potential admixture of individuals could shift the genetic subdivision and age structure during a full breeding period. The apparent genetic impact of the potential recruitment strategy of Norway lobster Nephrops norvegicus is still under research. For this reason the present study was focused on genetic
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A contribution to knowledge on the terrestrial malacofauna of the Kastellorizo (Megisti) island group (SE Greece) J. Biol. Res. Thessalon. (IF 3.3) Pub Date : 2019-11-08 Moisis Mylonas, Katerina Vardinoyannis, Nikos Poulakakis
The Kastellorizo island group (in the Dodecanese, Greece) is situated in the southeast corner of the Aegean Archipelago. It consists of twenty islets, of which the three largest (Kastellorizo, Ro and Strongyli) and seven smaller ones belong to Greece. Knowledge of the malacofauna on the islands is relatively poor. Only eight species were known prior to the present study, all from the islet of Kastellorizo
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Patterns and drivers of species richness and turnover of neo-endemic and palaeo-endemic vascular plants in a Mediterranean hotspot: the case of Crete, Greece J. Biol. Res. Thessalon. (IF 3.3) Pub Date : 2019-11-05 Maria Lazarina, Athanasios S. Kallimanis, Panayotis Dimopoulos, Maria Psaralexi, Danai-Eleni Michailidou, Stefanos P. Sgardelis
Exploring species richness and turnover patterns and their drivers can provide new insights into underlying mechanisms shaping community assembly, with significant implications for biodiversity conservation. Here, we explored diversity patterns of non-endemic, neo-endemic and palaeo-endemic vascular plants in Crete, Greece, a Mediterranean hotspot of plant richness and endemism. We evaluated the relationship
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Heterozygosity fitness correlations and generation interval of the Norway lobster in the Aegean Sea, eastern Mediterranean. J. Biol. Res. Thessalon. (IF 3.3) Pub Date : 2019-11-08 Georgios A Gkafas,Marianthi Hatziioannou,Emmanouil E Malandrakis,Costas S Tsigenopoulos,Ioannis T Karapanagiotidis,Elena Mente,Dimitrios Vafidis,Athanasios Exadactylos
BACKGROUND Comprehensively detailed information on population dynamics for benthic species is crucial since potential admixture of individuals could shift the genetic subdivision and age structure during a full breeding period. The apparent genetic impact of the potential recruitment strategy of Norway lobster Nephrops norvegicus is still under research. For this reason the present study was focused