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The histone methyltransferase inhibitor A-366 enhances hemoglobin expression in erythroleukemia cells upon co‐exposure with chemical inducers in culture J. Biol. Res. (Thessalon) (IF 2.121) Pub Date : 2021-01-06 Christos I. Papagiannopoulos; Nikoleta F. Theodoroula; Konstantinos A. Kyritsis; Melpomeni G. Akrivou; Maria Kosmidou; Konstantina Tsouderou; Nikolaos Grigoriadis; Ioannis S. Vizirianakis
Erythroleukemia is caused by the uncontrolled multiplication of immature erythroid progenitor cells which fail to differentiate into erythrocytes. By directly targeting this class of malignant cells, the induction of terminal erythroid differentiation represents a vital therapeutic strategy for this disease. Erythroid differentiation involves the execution of a well-orchestrated gene expression program
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Circ_0000396 inhibits rheumatoid arthritis synovial fibroblast growth and inflammatory response via miR-203/HBP1 axis J. Biol. Res. (Thessalon) (IF 2.121) Pub Date : 2021-01-06 Laifang Wang; Qing Zhao; Na Wang; Yanjie Ding; Lingli Kong; Jing Wang
Circ_0000396 was found to be down-regulated in the rheumatoid arthritis (RA) patients and had a high diagnostic value. However, the function and mechanisms underlying circ_0000396 in RA progression remain unclear. The expression of circ_0000396, microRNA (miR)-203 and HMG-box transcription factor 1 (HBP1) was detected using qRT-PCR and western blot. The proliferative and apoptotic capabilities of rheumatoid
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Prostate cancer and therapeutic challenges J. Biol. Res. (Thessalon) (IF 2.121) Pub Date : 2020-12-10 Yousef MohammedRabaa Hawsawi; Samar Abdullah Zailaie; Atif Abdulwahab A. Oyouni; Othman Rashed Alzahrani; Osama Mohamed Alamer; Saad Ali S. Aljohani
Prostate cancer (PC) is the most prevalent type of cancer in men worldwide. In Saudi Arabia, the rate of PC is increasing annually. The sex steroid hormones androgens and their receptors have critical roles in PC development and progression. Additionally, apoptosis-related proteins such as heat-shock proteins are vital molecules in PC development. Steroid hormone-deprivation therapies remain the essential
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Campbell biology (edited by Lisa Urry, Michael Cain, Steven Wasserman, Peter Minorsky and Jane Reece) J. Biol. Res. (Thessalon) (IF 2.121) Pub Date : 2020-12-09 Gangxu Shen
Campbell Biology is divided into eight units and 56 chapters. The organization and size of this book are appropriate and easy for first-year university students and help them to learn and digest the content. Campbell Biology is currently among the best biology books and it is listed with the best shelling textbooks. Campbell Biology is mainly for first-year university students, but it is also an important
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Cell adhesion molecules’ altered profile in benign and malignant salivary gland tumors. The paradigm of beta4-integrin, desmoglein-2, ICAM-1 and CD44s J. Biol. Res. (Thessalon) (IF 2.121) Pub Date : 2020-12-07 Dimitrios Andreadis; Athanasios Poulopoulos; Apostolos Epivatianos; Alexandros Nomikos; Dimitrios Parlitsis; Konstantinos Christidis; Calypso Barbatis; Dimitrios Kavvadas; Alexandros Toskas; Theodora Papamitsou; Dimitrios Antoniades
Alterations in intercellular and cell-extracellular matrix connections contribute to tumour development. This study investigates the expression of specific cell adhesion molecules (CAMs) in salivary gland tumors (SGTs). Formalin–fixed, paraffin– embedded tissue specimens of different types of 34 benign and 31 malignant SGTs and normal salivary glands were studied using Envision/HRP immunohistochemical
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A potential hypothesis for 2019-nCoV infection therapy through delivery of recombinant ACE2 by red blood cell-hitchhiking J. Biol. Res. (Thessalon) (IF 2.121) Pub Date : 2020-12-07 Zahra Sadat Aghili; Seyed Abbas Mirzaei; Mehdi Banitalebi-Dehkordi
A novel infectious disease, caused by 2019 Novel Coronavirus (2019-nCoV) is responsible for the recent outbreak of severe respiratory disease. The 2019-nCoV spread rapidly and reaching epidemic proportions in many countries of the world. ACE2 was identified as a key receptor for 2019-nCoV infections. Excessive form of soluble ACE2 rescues cellular ACE2 activity which has a protective role in acute
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LncRNA NCK1-AS1 in plasma distinguishes oral ulcer from early-stage oral squamous cell carcinoma J. Biol. Res. (Thessalon) (IF 2.121) Pub Date : 2020-11-11 Fei Le; Yangqian Ou; Ping Luo; Xiaoming Zhong
Oral squamous cell carcinoma (OSCC) at early stages can be misdiagnosed as an oral ulcer (OU) due to similar symptoms, such as chronic and indurated ulcer. LncRNA NCK1-AS1 has been characterized as a key player in cervical cancer, while its role in OSCC is unknown. All participants were selected at Jiangxi Province Tumor Hospital from December 2016 to December 2018. Expression levels of NCK1-AS1 and
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The adaptive immune response in cardiac arrest resuscitation induced ischemia reperfusion renal injury J. Biol. Res. (Thessalon) (IF 2.121) Pub Date : 2020-09-29 Maria Tsivilika; Eleni Doumaki; George Stavrou; Antonia Sioga; Vasilis Grosomanidis; Soultana Meditskou; Athanasios Maranginos; Despina Tsivilika; Dimitrios Stafylarakis; Katerina Kotzampassi; Theodora Papamitsou
The present study aims to investigate, immunohistochemically, the role of the adaptive immune response in cardiac arrest/resuscitation-induced ischemia–reperfusion renal injury (IRI), namely to assess the presence of lymphocytes in renal tissue samples and the connection between the extent of the damage and the concentration of the lymphocytes by comparing the kidneys of non resuscitated swine with
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Application of antibody phage display to identify potential antigenic neural precursor cell proteins. J. Biol. Res. (Thessalon) (IF 2.121) Pub Date : 2020-08-02 Ioannis Paspaltsis,Evangelia Kesidou,Olga Touloumi,Roza Lagoudaki,Marina Boziki,Martina Samiotaki,Dimitra Dafou,Theodoros Sklaviadis,Nikolaos Grigoriadis
The discovery of neural precursor cells (NPCs) and the concomitant intensive research in the field offer regenerative medicine novel approaches, enabling it to tackle conditions, such as neurodegenerative diseases. Transplantation of NPCs is nowadays considered a cutting-edge treatment for these conditions and many related clinical trials have been already completed or are still ongoing. However, little
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Evaluating the effect of TLR4-overexpressing on the transcriptome profile in ovine peripheral blood mononuclear cells. J. Biol. Res. (Thessalon) (IF 2.121) Pub Date : 2020-07-29 Xiaofei Guo,Jinlong Zhang,Yao Li,Jing Yang,Yihai Li,Chunxiao Dong,Guoshi Liu,Zhengxing Lian,Xiaosheng Zhang
Toll-like receptor 4 (TLR4) plays an important role in the elimination of Gram-negative bacteria infections and the initiation of antiinflammatory response. Using the technology of pronuclear microinjection, genetically modified (GM) sheep with TLR4 overexpression were generated. Previous studies have shown that these GM sheep exhibited a higher inflammatory response to Gram-negative bacteria infection
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Correction to: Genome wide meta-analysis of cDNA datasets reveals new target gene signatures of colorectal cancer based on systems biology approach. J. Biol. Res. (Thessalon) (IF 2.121) Pub Date : 2020-07-06 Umair Ilyas,Shahiq Uz Zaman,Reem Altaf,Humaira Nadeem,Syed Aun Muhammad
An amendment to this paper has been published and can be accessed via the original article.
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Aberrant methylation-mediated downregulation of lncRNA CCND2 AS1 promotes cell proliferation in cervical cancer. J. Biol. Res. (Thessalon) (IF 2.121) Pub Date : 2020-06-26 Chengcheng Zhao,Jian Liu,Huazhang Wu,Jiaojiao Hu,Jianquan Chen,Jie Chen,Fengchang Qiao
Long non-coding RNA (lncRNA) plays an important role in tumorigenesis. The lncRNA CCND2 AS1 has been shown to be involved in the growth of several tumors; however, its role in cervical cancer has not been elucidated. This study aimed to explore the expression, function, and underlying mechanism of action of CCND2 AS1 in cervical cancer. Expression of CCND2 AS1 was examined in cervical cancer and adjacent
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bolA gene involved in curli amyloids and fimbriae production in E. coli: exploring pathways to inhibit biofilm and amyloid formation J. Biol. Res. (Thessalon) (IF 2.121) Pub Date : 2020-06-17 Mohd W. Azam; Azna Zuberi; Asad U. Khan
Biofilm formation is a complex phenomenon of bacterial cells, involved in several human infections. Its formation is regulated and controlled by several protein factors. The BolA-like proteins (bolA gene) are conserved in both prokaryotes and eukaryotes. The BolA protein is a transcription factor involved in bacterial cell motility and biofilm formation. This study was initiated to elucidate the role
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The occurrence of cancer in vertebrates: a mini review J. Biol. Res. (Thessalon) (IF 2.121) Pub Date : 2020-06-08 Christos V. Kitsoulis; Athanasios D. Baxevanis; Theodore J. Abatzopoulos
Neoplasia is a multilevel condition caused by irregularities over the genome, which can lead to a fatal result. To fully understand this phenomenon, an evolutionary challenge has risen during the last decades, away from human limits, driving the scientific quest into the wild life. The study of wild vertebrate populations in their natural habitats has shown that cancer is rather prominent. Thus, the
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Genome wide meta-analysis of cDNA datasets reveals new target gene signatures of colorectal cancer based on systems biology approach J. Biol. Res. (Thessalon) (IF 2.121) Pub Date : 2020-06-08 Umair Ilyas; Shahiq uz Zaman; Reem Altaf; Humaira Nadeem; Syed Aun Muhammad
Colorectal cancer is known to be the most common type of cancer worldwide with high disease-related mortality. It is the third most common cancer in men and women and is the second major cause of death globally due to cancer. It is a complicated and fatal disease comprising of a group of molecular heterogeneous disorders. This study identifies the potential biomarkers of CRC through differentially
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TRAF3 can interact with GMEB1 and modulate its anti-apoptotic function J. Biol. Res. (Thessalon) (IF 2.121) Pub Date : 2020-05-29 George Kotsaris; Despoina Kerselidou; Dimitrios Koutsoubaris; Elena Constantinou; George Malamas; Dimitrios A. Garyfallos; Eudoxia G. Ηatzivassiliou
Members of Tumor Necrosis Factor (TNF) Receptor-Associated Factors (TRAFs) family interact with the cytoplasmic tails of TNF receptor family members to mediate signal transduction processes. TRAF3 has a major immunomodulatory function and TRAF3 deficiency has been linked to malignancies, such as multiple myeloma and lymphoid defects. In order to characterize the molecular mechanisms of TRAF3 signaling
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A potential prognostic model based on miRNA expression profile in The Cancer Genome Atlas for bladder cancer patients J. Biol. Res. (Thessalon) (IF 2.121) Pub Date : 2020-05-19 Yan Liu; Dong Yan Zhu; Hong Jian Xing; Yi Hou; Yan Sun
This study aimed to construct prognostic model by screening prognostic miRNA signature of bladder cancer. The miRNA expression profile data of bladder cancer (BC) in The Cancer Genome Atlas (TCGA) were obtained and randomly divided into the training set and the validation set. Differentially expressed miRNAs (DEMs) between BC and normal control samples in the training set were firstly identified, and
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A review on Zika virus outbreak, epidemiology, transmission and infection dynamics J. Biol. Res. (Thessalon) (IF 2.121) Pub Date : 2020-03-04 Syeda Sidra Kazmi; Waqar Ali; Nousheen Bibi; Faisal Nouroz
Zika virus (ZIKV) is a newly emergent relative of the Flaviviridae family and linked to dengue (DENV) and Chikungunya (CHIVKV). ZIKV is one of the rising pathogens promptly surpassing geographical borders. ZIKV infection was characterized by mild disease with fever, headache, rash, arthralgia and conjunctivitis, with exceptional reports of an association with Guillain–Barre syndrome (GBS) and microcephaly
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Effect of crocin on antioxidant gene expression, fibrinolytic parameters, redox status and blood biochemistry in nicotinamide-streptozotocin-induced diabetic rats J. Biol. Res. (Thessalon) (IF 2.121) Pub Date : 2020-03-02 Ioannis Margaritis; Katerina Angelopoulou; Sophia Lavrentiadou; Ilias C. Mavrovouniotis; Maria Tsantarliotou; Ioannis Taitzoglou; Alexandros Theodoridis; Aristidis Veskoukis; Efthalia Kerasioti; Dimitrios Kouretas; Ioannis Zervos
Diabetes is regarded as an epidemiological threat for the twenty-first century. Phytochemicals with known pharmaceutical properties have gained interest in the field of alleviating secondary complications of diseases. Such a substance is crocin, a basic constituent of saffron (Crocus sativus). The present study aimed at examining the beneficial effects of per os crocin administration on the antioxidant
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Editorial Announcement J. Biol. Res. (Thessalon) (IF 2.121) Pub Date : 2020-02-19
We would like to thank all those listed below for taking the time to review for the Journal of Biological Research—Thessaloniki in 2019—your generosity is much appreciated and we hope your association with the journal continues in the future. Editor-in-Chief: Theodore J Abatzopoulos Aharon Oren Alessandro Chiarucci Alexandra Staikou Ana Claudia Oliveira Carreira Anargyros Moulas Andigoni Malousi Andriana
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Histologic evaluation of femoral nerve demyelinating and axonal neuropathy in Wistar rats due to alendronate intake: a randomised study J. Biol. Res. (Thessalon) (IF 2.121) Pub Date : 2020-02-18 Papamitsou Theodora; Papakoulas Apostolos; Papaliagkas Vasileios; Karachrysafi Sofia; Dietrich Eva-Maria; Sioga Antonia
Bisphosphonates (BPs) are forceful inhibitors of osteoclast-mediated bone resorption. Long-term BP use is associated with multiple rare but severe adverse effects. The objective of this study was to investigate the possible effects of BPs in the structure of femoral nerve. Specimens from the femoral nerve of ten female 12-month old Wistar rats were used as control group and ten female 12-month old
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Metabolic engineering of Escherichia coli for the utilization of ethanol J. Biol. Res. (Thessalon) (IF 2.121) Pub Date : 2020-01-21 Yujin Cao; Hui Mu; Jing Guo; Hui Liu; Rubing Zhang; Wei Liu; Mo Xian; Huizhou Liu
The fuel ethanol industry has made tremendous progress in the last decades. Ethanol can be obtained by fermentation using a variety of biomass materials as the feedstocks. However, few studies have been conducted on ethanol utilization by microorganisms. The price of petroleum-derived ethanol, easily made by the hydrolysis of ethylene, is even lower than that of bioethanol. If ethanol can be metabolized
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Implications of salep collection for the conservation of the Elder-flowered orchid (Dactylorhiza sambucina) in Epirus, Greece J. Biol. Res. (Thessalon) (IF 2.121) Pub Date : 2019-12-30 Martha Charitonidou; Kalliopi Stara; Konstantinos Kougioumoutzis; John M. Halley
In Epirus, Greece, orchids have been traditionally harvested for the production of salep, a beverage made from their tubers. Over-collection of orchids for salep is believed to be a growing threat to wild species, yet very little research has concentrated on orchid populations in the wild. Here, we studied the impact of salep collection on population demographic parameters and uniformity of distribution
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Saliva proteomics updates in biomedicine J. Biol. Res. (Thessalon) (IF 2.121) Pub Date : 2019-12-12 Katerina R. Katsani; Dimitra Sakellari
In the years of personalized (or precision) medicine the ‘omics’ methodologies in biomedical sciences—genomics, transcriptomics, proteomics and metabolomics—are helping researchers to detect quantifiable biological characteristics, or biomarkers, that will best define the human physiology and pathologies. Proteomics use high throughput and high efficiency approaches with the support of bioinformatic
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Modulation of RECK levels in Xenopus A6 cells: effects on MT1-MMP, MMP-2 and pERK levels J. Biol. Res. (Thessalon) (IF 2.121) Pub Date : 2019-11-27 Jessica A. Willson; Bradley S. Bork; Carlie A. Muir; Sashko Damjanovski
MT1-MMP is a cell-surface enzyme whose regulation of pro-MMP-2 and ERK activation position it as a key facilitator of ECM remodelling and cell migration. These processes are modulated by endogenous MMP inhibitors, such as RECK, a GPI-anchored protein which has been shown to inhibit both MT1-MMP and MMP-2 activity. Our previous studies have revealed a link between MT1-MMP levels, and pro-MMP-2 and ERK
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Tanshinone IIA attenuates Aβ-induced neurotoxicity by down-regulating COX-2 expression and PGE2 synthesis via inactivation of NF-κB pathway in SH-SY5Y cells J. Biol. Res. (Thessalon) (IF 2.121) Pub Date : 2019-11-12 Lijiao Geng; Wei Liu; Yong Chen
Amyloid-β (Aβ)-induced neurotoxicity is a major pathological mechanism of Alzheimer’s disease (AD). Tanshinone IIA (Tan IIA), extracted from traditional Chinese herb Radix salvia miltiorrhiza, possesses anti-oxidant and anti-inflammatory actions, as well as neuroprotective effects. The present study aims to explore the possible mechanism by which Tan IIA attenuated Aβ-induced neurotoxicity. Exposure
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Heterozygosity fitness correlations and generation interval of the Norway lobster in the Aegean Sea, eastern Mediterranean J. Biol. Res. (Thessalon) (IF 2.121) Pub Date : 2019-11-08 Georgios A. Gkafas; Marianthi Hatziioannou; Emmanouil E. Malandrakis; Costas S. Tsigenopoulos; Ioannis T. Karapanagiotidis; Elena Mente; Dimitrios Vafidis; Athanasios Exadactylos
Comprehensively detailed information on population dynamics for benthic species is crucial since potential admixture of individuals could shift the genetic subdivision and age structure during a full breeding period. The apparent genetic impact of the potential recruitment strategy of Norway lobster Nephrops norvegicus is still under research. For this reason the present study was focused on genetic
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A contribution to knowledge on the terrestrial malacofauna of the Kastellorizo (Megisti) island group (SE Greece) J. Biol. Res. (Thessalon) (IF 2.121) Pub Date : 2019-11-08 Moisis Mylonas; Katerina Vardinoyannis; Nikos Poulakakis
The Kastellorizo island group (in the Dodecanese, Greece) is situated in the southeast corner of the Aegean Archipelago. It consists of twenty islets, of which the three largest (Kastellorizo, Ro and Strongyli) and seven smaller ones belong to Greece. Knowledge of the malacofauna on the islands is relatively poor. Only eight species were known prior to the present study, all from the islet of Kastellorizo
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Patterns and drivers of species richness and turnover of neo-endemic and palaeo-endemic vascular plants in a Mediterranean hotspot: the case of Crete, Greece J. Biol. Res. (Thessalon) (IF 2.121) Pub Date : 2019-11-05 Maria Lazarina; Athanasios S. Kallimanis; Panayotis Dimopoulos; Maria Psaralexi; Danai-Eleni Michailidou; Stefanos P. Sgardelis
Exploring species richness and turnover patterns and their drivers can provide new insights into underlying mechanisms shaping community assembly, with significant implications for biodiversity conservation. Here, we explored diversity patterns of non-endemic, neo-endemic and palaeo-endemic vascular plants in Crete, Greece, a Mediterranean hotspot of plant richness and endemism. We evaluated the relationship
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Polyphasic taxonomy of green algae strains isolated from Mediterranean freshwaters J. Biol. Res. (Thessalon) (IF 2.121) Pub Date : 2019-10-30 Urania Lortou; Spyros Gkelis
Terrestrial, freshwater and marine green algae constitute the large and morphologically diverse phylum of Chlorophyta, which gave rise to the core chlorophytes. Chlorophyta are abundant and diverse in freshwater environments where sometimes they form nuisance blooms under eutrophication conditions. The phylogenetic relationships among core chlorophyte clades (Chlorodendrophyceae, Ulvophyceae, Trebouxiophyceae
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Endemic plants of Crete in electronic trade and wildlife tourism: current patterns and implications for conservation J. Biol. Res. (Thessalon) (IF 2.121) Pub Date : 2019-10-30 Viktoria Menteli; Nikos Krigas; Manolis Avramakis; Nicholas Turland; Despoina Vokou
The island of Crete is a biodiversity hotspot having 223 endemic vascular taxa (species and subspecies) as a result of its long isolation and the wide range of habitats it includes. We explore trends and patterns in the electronic trade of these unique genetic resources and in their involvement in wildlife tourism, the ways these two activities are performed and the associated potential threats on
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The decreased SIRT1 level may account for the lipid profile in chronic kidney disease J. Biol. Res. (Thessalon) (IF 2.121) Pub Date : 2019-10-16 Gang Chen; Xuemei Li
Dysregulated lipid profile with hypertriglyceridemia and increased low-density lipoprotein (LDL) is common in chronic kidney disease (CKD) whereas the reason is unclear. A similar phenomenon is found in the elder population. Silent information regulator-1 (SIRT1) associates with many modulators regulating lipid metabolism and results in increased expression of sterol regulatory element-binding proteins
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T-Box20 inhibits osteogenic differentiation in adipose-derived human mesenchymal stem cells: the role of T-Box20 on osteogenesis J. Biol. Res. (Thessalon) (IF 2.121) Pub Date : 2019-09-18 Samaneh Mollazadeh; Bibi Sedigheh Fazly Bazzaz; Vajiheh Neshati; Antoine A. F. de Vries; Hojjat Naderi-Meshkin; Majid Mojarad; Zeinab Neshati; Mohammad Amin Kerachian
Skeletal development and its cellular function are regulated by various transcription factors. The T-box (Tbx) family of transcription factors have critical roles in cellular differentiation as well as heart and limbs organogenesis. These factors possess activator and/or repressor domains to modify the expression of target genes. Despite the obvious effects of Tbx20 on heart development, its impact
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Genetic diversity analysis in Plectranthus edulis (Vatke) Agnew populations collected from diverse geographic regions in Ethiopia using inter-simple sequence repeats (ISSRs) DNA marker system J. Biol. Res. (Thessalon) (IF 2.121) Pub Date : 2019-09-09 Medhin Gebrehiwet; Teklehaimanot Haileselassie; Fekadu Gadissa; Kassahun Tesfaye
Plectranthus edulis (Vatke) Agnew (Lamiaceae), locally known as Ethiopian potato syno. Ethiopian dinich, is one of the native Ethiopian edible tuber crops that has been significantly contributing to household food security for millions of subsistence farmers. However, its current production is declining to the extent of total extinction from several administrative regions where it used to be widely
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Promoting evolution: the brand new Hellenic Evolutionary Society (HEVOS) J. Biol. Res. (Thessalon) (IF 2.121) Pub Date : 2019-08-30 Theodore J. Abatzopoulos; Sinos Giokas; Panayiotis Pafilis; Nikos Poulakakis; Spyros Sfenthourakis; Eleftherios Zouros
Herein we present the recently founded Hellenic Evolutionary Society (HEVOS) that has been recently instituted to promote evolution and scientific thinking among the Greek-speaking public. HEVOS is a timely initiative, given the low levels of acceptance of evolution by Greek society and the almost complete lack of evolution teaching in primary and secondary education in Greece. Herein, the main aims
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Comparative transcriptional analysis of flavour-biosynthetic genes of a native Saccharomyces cerevisiae strain fermenting in its natural must environment, vs. a commercial strain and correlation of the genes’ activities with the produced flavour compounds J. Biol. Res. (Thessalon) (IF 2.121) Pub Date : 2019-08-05 Maria Parapouli; Afroditi Sfakianaki; Nikolaos Monokrousos; Angelos Perisynakis; Efstathios Hatziloukas
During alcoholic fermentation, Saccharomyces cerevisiae synthesizes more than 400 different compounds with higher alcohols, acetate esters of higher alcohols and ethyl esters of medium-chain fatty acids being the most important products of its metabolism, determining the particular flavour profile of each wine. The concentration of the metabolites produced depends to a large extent on the strain used
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Unbiased phenotypic identification of functionally distinct hematopoietic progenitors J. Biol. Res. (Thessalon) (IF 2.121) Pub Date : 2019-07-18 Grigorios Georgolopoulos; Mineo Iwata; Nikoletta Psatha; Minas Yiangou; Jeff Vierstra
Hematopoiesis is a model-system for studying cellular development and differentiation. Phenotypic and functional characterization of hematopoietic progenitors has significantly aided our understanding of the mechanisms that govern fate choice, lineage specification and maturity. Methods for progenitor isolation have historically relied on complex flow-cytometric strategies based on nested, arbitrary
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Comparative analysis of differentially expressed genes between the ovaries from pregnant and nonpregnant goats using RNA-Seq J. Biol. Res. (Thessalon) (IF 2.121) Pub Date : 2019-05-06 Qing Quan; Qi Zheng; Yinghui Ling; Fugui Fang; Mingxing Chu; Xiaorong Zhang; Yong Liu; Wenyong Li
A multitude of genes tightly regulate ovarian follicular development and hormone secretion. These complex and coordinated biological processes are altered during pregnancy. In order to further understand the regulatory role of these genes during pregnancy, it is important to screen the differentially expressed genes (DEGs) in the ovaries of pregnant and nonpregnant mammals. To detect the genes associated
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A systematic simulation-based meta-analytical framework for prediction of physiological biomarkers in alopecia J. Biol. Res. (Thessalon) (IF 2.121) Pub Date : 2019-04-04 Syed Aun Muhammad; Nighat Fatima; Rehan Zafar Paracha; Amjad Ali; Jake Y. Chen
Alopecia or hair loss is a complex polygenetic and psychologically devastating disease affecting millions of men and women globally. Since the gene annotation and environmental knowledge is limited for alopecia, a systematic analysis for the identification of candidate biomarkers is required that could provide potential therapeutic targets for hair loss therapy. We designed an interactive framework
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Intraspecific morphological variation of the sperm storing organ in two hermaphroditic land snail species J. Biol. Res. (Thessalon) (IF 2.121) Pub Date : 2019-01-30 Alexandra Staikou; Evripidis Koemtzopoulos
Postcopulatory sexual selection is very important in species with reproductive strategies that involve multiple mating and prolonged sperm storage. The sperm storage organ has been hypothesized to evolve in response to different levels of sperm competition in several species while population density has been considered as a factor that approximates sperm competition risk and intensity in the field
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Immune cell counts and signaling in body fluids of cows vaccinated against Clostridium difficile J. Biol. Res. (Thessalon) (IF 2.121) Pub Date : 2018-12-10 Christiane Schmautz; Nadine Müller; Marlene Auer; Ines Ballweg; Michael W. Pfaffl; Heike Kliem
New treatment options are needed to prevent relapses following failed antibiotic therapies of Clostridium difficile infections (CDI) in humans. The concomitant therapy with an anti-C. difficile IgA containing whey protein concentrate can support the sustainable recovery of CDI patients. For 31 weeks, nine dairy cows were continuously vaccinated with several anti-C. difficile vaccines by certain routes
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Transcriptional regulation of anthocyanin biosynthesis in a high-anthocyanin resynthesized Brassica napus cultivar J. Biol. Res. (Thessalon) (IF 2.121) Pub Date : 2018-11-26 Gayatri Goswami; Ujjal Kumar Nath; Jong-In Park; Mohammad Rashed Hossain; Manosh Kumar Biswas; Hoy-Taek Kim; Hye Ran Kim; Ill-Sup Nou
Anthocyanins are plant secondary metabolites with key roles in attracting insect pollinators and protecting against biotic and abiotic stresses. They have potential health-promoting effects as part of the human diet. Anthocyanin biosynthesis has been elucidated in many species, enabling the development of anthocyanin-enriched fruits, vegetables, and grains; however, few studies have investigated Brassica
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Developing computational biology at meridian 23° E, and a little eastwards J. Biol. Res. (Thessalon) (IF 2.121) Pub Date : 2018-11-14 Christos A. Ouzounis
Modern biology is experiencing a deep transformation by the expansion of molecular-level measurements at all scales, using omics technologies. A key element in this transformation is the field of bioinformatics, that has—in the meanwhile—permeated pretty much all of biological and biomedical research and is now emerging as a key inter-disciplinary area that connects the natural sciences, chemical and
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Combined study on clastogenic, aneugenic and apoptotic properties of doxorubicin in human cells in vitro J. Biol. Res. (Thessalon) (IF 2.121) Pub Date : 2018-10-11 Vasiliki Chondrou; Katerina Trochoutsou; Andreas Panayides; Maria Efthimiou; Georgia Stephanou; Nikos A. Demopoulos
Doxorubicin is a widely used anticancer drug due to its broad spectrum of antitumor activity. Various mechanisms have been proposed for its cytostatic activity, including DNA intercalation, topoisomerase II inhibition, generation of free radicals and apoptosis. The present study aims to further clarify the cytostatic activity of doxorubicin by its specific effect on (a) DNA damage, (b) micronucleation
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MicroRNA expression profile of urinary exosomes in Type IV lupus nephritis complicated by cellular crescent J. Biol. Res. (Thessalon) (IF 2.121) Pub Date : 2018-10-04 Yi Li; Xiaosong Xu; Xiaopeng Tang; Xiuwu Bian; Bingbing Shen; Hongwen Zhao; Shiyuan Luo; Zhiwen Chen; Keqin Zhang
Type IV lupus nephritis (LNIV) is a severe disease characterized by diffuse proliferative lesions, and its prognosis is worse with cellular crescent (LNIV-CC) involvement. Urinary exosomes have been shown to reflect the degree of kidney injury. This study was aimed to identify non-invasive diagnostic markers for LNIV-CC. We analysed the expression profile of microRNAs (miRNAs) isolated from urinary
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3D electron tomographic and biochemical analysis of ER, Golgi and trans Golgi network membrane systems in stimulated Venus flytrap (Dionaea muscipula) glandular cells J. Biol. Res. (Thessalon) (IF 2.121) Pub Date : 2018-08-08 Zachary R. Gergely; Dana E. Martinez; Bryon S. Donohoe; Soren Mogelsvang; Rachel Herder; L. Andrew Staehelin
The insect-trapping leaves of Dionaea muscipula provide a model for studying the secretory pathway of an inducible plant secretory system. The leaf glands were induced with bovine serum albumin to secrete proteases that were characterized via zymogram activity gels over a 6-day period. The accompanying morphological changes of the endoplasmic reticulum (ER) and Golgi were analyzed using 3D electron
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The family Raphitomidae (Mollusca: Gastropoda: Conoidea) in the Greek Seas with the description of two new species J. Biol. Res. (Thessalon) (IF 2.121) Pub Date : 2018-07-09 Thanasis Manousis; Constantinos Kontadakis; George Mbazios; Georgios Polyzoulis
The Raphitomidae family in the Mediterranean Sea is under revision. Accordingly, new data are of taxonomic and comparative relevance. In this study, new material from the Hellenic Seas is presented. The Raphitomidae fauna of Greece was collected and investigated during the period from October 2008 to February 2018. Thirty-five (35) species were identified and their status was compared with existing
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Differences in trophic resources and niches of two juvenile predatory species in three Pangani estuarine zones, Tanzania: stomach contents and stable isotope approaches J. Biol. Res. (Thessalon) (IF 2.121) Pub Date : 2018-07-03 Alistidia Paul Mwijage; Daniel Abel Shilla; John Ferdinand Machiwa
Estuaries are primary habitats that serve as feeding and nursery grounds for most juvenile marine fish. However, estuaries have been used as fishing grounds by the artisanal fishers in Tanzania. The slow-growing predatory fish at juvenile and sub-adult stages are among the most frequently caught species that functionally enhance multiple linkages of energy pathways within the food web. Stomach contents
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Cortical microtubule orientation in Arabidopsis thaliana root meristematic zone depends on cell division and requires severing by katanin J. Biol. Res. (Thessalon) (IF 2.121) Pub Date : 2018-06-15 Emmanuel Panteris; Barbara-Evelin Diannelidis; Ioannis-Dimosthenis S. Adamakis
Transverse cortical microtubule orientation, critical for anisotropic cell expansion, is established in the meristematic root zone. Intending to elucidate the possible prerequisites for this establishment and factors that are involved, microtubule organization was studied in roots of Arabidopsis thaliana, wild-type and the p60-katanin mutants fra2, ktn1-2 and lue1. Transverse cortical microtubule orientation
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StarSeeker: an automated tool for mature duplex microRNA sequence identification based on secondary structure modeling of precursor molecule J. Biol. Res. (Thessalon) (IF 2.121) Pub Date : 2018-06-15 Paschalis Natsidis; Ilias Kappas; Wojciech M. Karlowski
MicroRNAs (miRNAs) are small, non-coding RNA molecules that play a key role in gene regulation in both plants and animals. MicroRNA biogenesis involves the enzymatic processing of a primary RNA transcript. The final step is the production of a duplex molecule, often designated as miRNA:miRNA*, that will yield a functional miRNA by separation of the two strands. This miRNA will be incorporated into
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Correction to: Molecular, biochemical and kinetic analysis of a novel, thermostable lipase (LipSm) from Stenotrophomonas maltophilia Psi‑1, the first member of a new bacterial lipase family (XIX) J. Biol. Res. (Thessalon) (IF 2.121) Pub Date : 2018-06-14 Maria Parapouli; Athanasios Foukis; Panagiota‑Yiolanda Stergiou; Maria Koukouritaki; Panagiotis Magklaras; Olga A. Gkini; Emmanuel M. Papamichael; Amalia‑Sofia Afendra; Efstathios Hatziloukas
We have recently (8th February 2018) published our article entitled “Molecular, biochemical and kinetic analysis of a novel, thermostable lipase (LipSm) from Stenotrophomonas maltophilia Psi-1, the first member of a new bacterial lipase family (XVIII)” [1]. While our manuscript was going through the final stages of publication, an article by Samoylova et al. [2] was published (12th January 2018) in
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Spatial and temporal patterns in the diet of barn owl (Tyto alba) in Cyprus J. Biol. Res. (Thessalon) (IF 2.121) Pub Date : 2018-05-31 Michaella Moysi; Maria Christou; Vassilis Goutner; Nikos Kassinis; Savvas Iezekiel
The barn owl, a nocturnal raptor with cosmopolitan distribution, shows a great adaptability to different environments. Regarding prey, the barn owl is a rather selective species, but if changes in the abundance of the selected prey occur, it becomes an opportunistic predator and easily incorporates other prey in its diet, using a wide range of prey species and foraging habitats. Small rodents are usually
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Changes in the microstructure of compact and trabecular bone tissues of mice subchronically exposed to alcohol J. Biol. Res. (Thessalon) (IF 2.121) Pub Date : 2018-05-24 Monika Martiniakova; Anna Sarocka; Ramona Babosova; Birgit Grosskopf; Edyta Kapusta; Zofia Goc; Grzegorz Formicki; Radoslav Omelka
Alcohol is one of the most commonly consumed neurotoxins by humans. Its negative effect on bone health is known for a long time. However, its impact on qualitative and quantitative 2D characteristics of the compact bone is still unclear. Therefore, the aim of this study was to investigate in detail the effects of subchronic alcohol exposure on compact and trabecular bone tissues microstructure of laboratory
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The repeated emergence of asexuality, the hidden genomes and the role of parthenogenetic rare males in the brine shrimp Artemia J. Biol. Res. (Thessalon) (IF 2.121) Pub Date : 2018-05-18 Theodore J. Abatzopoulos
The backbone of this endeavour consists of three major components as they appear in the title. My intention is to summarise, as explicitly as possible, both existing and novel data on the occurrence of parthenogenetic rare males assessing their role in conveying sets of genetic information between asexual strains and sexual Artemia species to and fro. Additionally, an assemblage of strong indications
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New marine gastropod records for the Hellenic waters J. Biol. Res. (Thessalon) (IF 2.121) Pub Date : 2018-03-20 Thanasis Manousis; Constantinos Kontadakis; Georgios Polyzoulis; George Mbazios; Sofia Galinou-Mitsoudi
The Hellenic Seas are influenced by on-going environmental changes and the introduction of alien species, which are expected to have an impact on their biodiversity. This study contributes to the knowledge of the Hellenic marine gastropod biodiversity, expanding data over the entire Greek territory, during the period from October 2008 to March 2017. This work presents 45 species of gastropods not previously
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Cadmium uptake kinetics in parts of the seagrass Cymodocea nodosa at high exposure concentrations J. Biol. Res. (Thessalon) (IF 2.121) Pub Date : 2018-03-06 Paraskevi Malea; Theodoros Kevrekidis; Konstantina-Roxani Chatzipanagiotou; Athanasios Mogias
Seagrass species have been recommended as biomonitors of environmental condition and as tools for phytoremediation, due to their ability to concentrate anthropogenic chemicals. This study aims to provide novel information on metal accumulation in seagrasses under laboratory conditions to support their use as a tool in the evaluation and abatement of contamination in the field. We investigated the kinetics
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Molecular, biochemical and kinetic analysis of a novel, thermostable lipase (LipSm) from Stenotrophomonas maltophilia Psi-1, the first member of a new bacterial lipase family (XVIII) J. Biol. Res. (Thessalon) (IF 2.121) Pub Date : 2018-02-08 Maria Parapouli; Athanasios Foukis; Panagiota-Yiolanda Stergiou; Maria Koukouritaki; Panagiotis Magklaras; Olga A. Gkini; Emmanuel M. Papamichael; Amalia-Sofia Afendra; Efstathios Hatziloukas
Microbial lipases catalyze a broad spectrum of reactions and are enzymes of considerable biotechnological interest. The focus of this study was the isolation of new lipase genes, intending to discover novel lipases whose products bear interesting biochemical and structural features and may have a potential to act as valuable biocatalysts in industrial applications. A novel lipase gene (lipSm), from
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Bone marrow stem cells to destroy circulating HIV: a hypothetical therapeutic strategy J. Biol. Res. (Thessalon) (IF 2.121) Pub Date : 2018-02-05 Umesh Chandra Halder
Human immunodeficiency virus (HIV) still poses enigmatic threats to human life. This virus has mastered in bypassing anti retroviral therapy leading to patients’ death. Circulating viruses are phenomenal for the disease outcome. This hypothesis proposes a therapeutic strategy utilizing receptor-integrated hematopoietic, erythroid and red blood cells. Here, HIV specific receptors trap circulating viruses
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HaloDom: a new database of halophiles across all life domains J. Biol. Res. (Thessalon) (IF 2.121) Pub Date : 2018-01-15 Alexios Loukas; Ilias Kappas; Theodore J. Abatzopoulos
Halophilic organisms may thrive in or tolerate high salt concentrations. They have been studied for decades and a considerable number of papers reporting new halophilic species are being published every year. However, an extensive collection of these salt-loving organisms does not exist nowadays. Halophilic life forms have representatives from all three life domains, Archaea, Bacteria and Eukarya.