We report outcomes for a cohort of patients with multidrug-resistant tuberculosis who received high-dose isoniazid in Haiti. Patients who received high-dose isoniazid had a faster time to culture conversion and higher odds of successful outcome, despite high-level isoniazid resistance. This suggests high-dose isoniazid may have effectiveness even with phenotypic resistance.

中文翻译：

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海地耐多药结核病治疗中使用高剂量异烟肼改善结果。

我们报告了一组在海地接受高剂量异烟肼的耐多药结核病患者的结果。尽管异烟肼存在高水平耐药性，但接受高剂量异烟肼的患者培养转化时间更快，成功结果的几率更高。这表明即使具有表型耐药性，高剂量异烟肼也可能有效。