Given the increasing understanding of cancer as a heterogeneous group of diseases, detection methods should offer a sensitivity profile that ensures perfect sensitivity for biologically important cancers while screening out self-limiting pseudocancers. However, mammographic screening is biased toward detection of ductal carcinoma in situ and slowly growing cancers-and thus frequently fails to detect biologically aggressive cancers. This explains the persistently high rates of interval cancers and high rates of breast cancer mortality observed in spite of decades of mammographic screening. Magnetic resonance imaging (MRI), in contrast, has a sensitivity profile that matches clinical needs. Conventional MRI is not suitable for population-wide screening due to high cost, limited tolerability, and lack of availability. We introduced abbreviated MRI in 2014. Abbreviated MRI will change the way MRI is used in clinical medicine. This article describes the rationale to use MRI in general, and abbreviated MRI in particular, for breast cancer screening.

中文翻译：

---

用于乳腺癌筛查的缩写磁共振成像（MRI）：基本原理，概念和向临床实践的转移。

鉴于人们对癌症是一种异质性疾病的认识不断提高，因此检测方法应提供敏感性概况，以确保对生物学上重要的癌症具有完美的敏感性，同时筛选出自限性假癌。然而，乳腺X线摄影筛查偏向于原位检测导管癌和缓慢生长的癌症，因此常常无法检测到生物学上具有侵略性的癌症。这解释了尽管进行了数十年的乳腺X线摄影筛查，但观察到的间歇性癌症的发生率一直很高，乳腺癌的死亡率也很高。相反，磁共振成像（MRI）具有符合临床需求的灵敏度曲线。常规MRI由于成本高，耐受性有限和缺乏可用性而不适用于人群筛查。我们在2014年推出了缩写MRI。缩写MRI将改变MRI在临床医学中的使用方式。本文介绍了一般使用MRI（尤其是缩写MRI）进行乳腺癌筛查的基本原理。