BACKGROUND Whole-body imaging is the current standard of care for staging all patients presenting with skin lesions of B-cell lymphomas (BCLs), regardless of skin disease extent; however, supporting data are lacking. OBJECTIVE To determine the clinical utility of imaging in the detection of systemic involvement in low-grade cutaneous BCLs in the skin. METHODS Retrospective cohort analysis of patients presenting with cutaneous lesions of BCLs at Memorial Sloan Kettering Cancer Center and Stanford University during 1997-2016. RESULTS At initial staging, of the 522 patients, extracutaneous disease was noted in 3.6% and 8.8% of patients with marginal zone lymphoma (MZL, n = 306) and follicle center lymphoma (FCL, n = 216) histology, respectively. In patients with systemic involvement, imaging alone identified 81.8% (9/11) of MZL cases and 89.4% of follicular lymphoma cases. In primary cutaneous MZL, 1.7% of patients subsequently had extracutaneous involvement (median follow-up 45 months), and in primary cutaneous FCL. 3.0% subsequently had extracutaneous involvement (median follow-up 47 months). LIMITATIONS This was a retrospective study. CONCLUSION Imaging is effective at identifying patients with systemic involvement in indolent BCLs present in the skin; however, incidence is low. After negative initial staging, primary cutaneous MZL patients may be followed clinically without routine imaging.

中文翻译：

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影像学在皮肤低度皮肤 B 细胞淋巴瘤中的作用。

背景全身成像是目前对所有出现 B 细胞淋巴瘤 (BCL) 皮肤病变的患者进行分期的护理标准，无论皮肤疾病的程度如何；然而，缺乏支持数据。目的 确定影像学在检测皮肤低级别皮肤 BCL 全身受累中的临床效用。方法 对 1997 年至 2016 年在纪念斯隆·凯特琳癌症中心和斯坦福大学出现 BCL 皮肤病变的患者进行回顾性队列分析。结果 在 522 名患者的初始分期中，边缘区淋巴瘤 (MZL，n = 306) 和滤泡中心淋巴瘤 (FCL，n = 216) 组织学患者中分别有 3.6% 和 8.8% 的患者出现皮外疾病。在全身受累的患者中，仅通过影像学检查即可发现 81.8% (9/11) 的 MZL 病例和 89.4% 的滤泡性淋巴瘤病例。在原发性皮肤 MZL 中，1.7% 的患者随后出现皮外受累（中位随访 45 个月），在原发性皮肤 FCL 中也是如此。3.0% 随后出现皮外受累（中位随访时间 47 个月）。局限性这是一项回顾性研究。结论 影像学可有效识别皮肤中存在惰性 BCL 的全身受累患者；然而，发生率很低。初始分期阴性后，原发性皮肤 MZL 患者无需常规影像学检查即可进行临床随访。