Despite having been underappreciated in favor of their protein-coding counterparts for a long time, long noncoding RNAs (lncRNAs) have emerged as functional molecules, which defy the central dogma of molecular biology, with clear implications in cancer. Altered expression levels of some of these large transcripts in human body fluids have been related to different cancer conditions that turns them into potential noninvasive cancer biomarkers. In this review, a brief discussion about the importance and current challenges in the determination of lncRNAs associated to cancer is provided. Different electrochemical nucleic acid-based strategies for lncRNAs detection are critically described. Future perspectives and remaining challenges for the practical implementation of these methodologies in clinical medicine are also discussed.

尽管长期以来人们对其蛋白质编码对应物的认识不足，但长期以来，非编码RNA（lncRNA）作为功能分子出现了，这违背了分子生物学的核心教条，对癌症有着明显的影响。这些大量转录物在人体体液中表达水平的改变已与不同的癌症状况相关，从而将其转变为潜在的非侵入性癌症生物标志物。在这篇综述中，提供了有关确定与癌症相关的lncRNAs的重要性和当前挑战的简短讨论。严格描述了用于lncRNAs检测的基于电化学核酸的不同策略。还讨论了这些方法在临床医学中的实际应用的未来前景和尚存的挑战。