The catecholamines and the adrenergic receptors have been long known to be vital components in the regulation of fat cell metabolism. Whether in response to stress, cold temperature or diet, the β-adrenergic receptors (βARs) respond to epinephrine/norepinephrine to activate a signalling cascade that drives triglyceride hydrolysis to free fatty acids for use as fuel for skeletal and cardiac muscle work. The βARs also are well-established activators of brown fat for the conversion of substrate energy to generate heat from the oxidation of glucose and fatty acids. Long thought to be irrelevant to the biology of adult humans, the realization that there is indeed functional brown fat in humans has now created great interest and enthusiasm over the possibility that recruiting brown fat to target obesity and metabolic disease could represent a viable therapeutic option. Coupled with newer evidence that various stimuli independent of the βARs may also be able to increase active brown adipocytes, including the cardiac natriuretic peptides, it is an exciting time to be working in this area. This review will focus on the catecholamines and natriuretic peptides as cooperative actors in promoting fat metabolism, and will consider areas in need of further research.

众所周知，儿茶酚胺和肾上腺素受体是调节脂肪细胞代谢的重要成分。无论是应对压力、低温还是饮食，β-肾上腺素能受体 (βAR) 都会对肾上腺素/去甲肾上腺素作出反应，以激活信号级联反应，驱动甘油三酯水解为游离脂肪酸，用作骨骼和心肌工作的燃料。βARs 也是公认的棕色脂肪活化剂，用于将底物能量转化为葡萄糖和脂肪酸氧化产生的热量。长期以来被认为与成年人的生物学无关，认识到人类确实存在功能性棕色脂肪，现在已经引起了人们对招募棕色脂肪来靶向肥胖和代谢疾病可能代表一种可行的治疗选择的可能性的极大兴趣和热情。再加上新的证据表明，独立于 βAR 的各种刺激也可能能够增加活跃的棕色脂肪细胞，包括心脏利钠肽，现在是在这一领域工作的激动人心的时刻。本综述将重点关注儿茶酚胺和利钠肽作为促进脂肪代谢的协同作用，并将考虑需要进一步研究的领域。在这个领域工作是一个激动人心的时刻。本综述将重点关注儿茶酚胺和利钠肽作为促进脂肪代谢的协同作用，并将考虑需要进一步研究的领域。在这个领域工作是一个激动人心的时刻。本综述将重点关注儿茶酚胺和利钠肽作为促进脂肪代谢的协同作用，并将考虑需要进一步研究的领域。