The tauopathies constitute a group of diseases that have Tau inclusions in neurons or glia as their common denominator. In this review, we describe the biochemical and histological differences in Tau pathology that are characteristic of the spectrum of frontotemporal lobar degeneration as primary tauopathies and of Alzheimer's disease as a secondary tauopathy, as well as the commonalities and differences between the familial and sporadic forms. Furthermore, we discuss selected advances in transgenic animal models in delineating the different pathomechanisms of Tau.

中文翻译：

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Tauopathies的分子发病机制。

tauopathies构成了一组疾病，其中神经元或神经胶质中的Tau夹杂物是它们的共同特征。在这篇综述中，我们描述了Tau病理学中的生化和组织学差异，这些差异是额颞叶变性为原发性Tauopathies和Alzheimer病为继发性Tauopathy的特征，以及家族形式和散发形式之间的共性和差异。此外，我们讨论了转基因动物模型在描述Tau的不同致病机制中的某些选定进展。