当前位置:
X-MOL 学术
›
Ann. Review Paleopathol. Mech. Disease
›
论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Type I Interferons in Autoimmune Disease.
Annual Review of Pathology: Mechanisms of Disease ( IF 36.2 ) Pub Date : 2018-10-17 , DOI: 10.1146/annurev-pathol-020117-043952 Mary K Crow 1 , Mikhail Olferiev 1 , Kyriakos A Kirou 1
Annual Review of Pathology: Mechanisms of Disease ( IF 36.2 ) Pub Date : 2018-10-17 , DOI: 10.1146/annurev-pathol-020117-043952 Mary K Crow 1 , Mikhail Olferiev 1 , Kyriakos A Kirou 1
Affiliation
Type I interferons, which make up the first cytokine family to be described and are the essential mediators of antivirus host defense, have emerged as central elements in the immunopathology of systemic autoimmune diseases, with systemic lupus erythematosus as the prototype. Lessons from investigation of interferon regulation following virus infection can be applied to lupus, with the conclusion that sustained production of type I interferon shifts nearly all components of the immune system toward pathologic functions that result in tissue damage and disease. We review recent data, mainly from studies of patients with systemic lupus erythematosus, that provide new insights into the mechanisms of induction and the immunologic consequences of chronic activation of the type I interferon pathway. Current concepts implicate endogenous nucleic acids, driving both cytosolic sensors and endosomal Toll-like receptors, in interferon pathway activation and suggest targets for development of novel therapeutics that may restore the immune system to health.
中文翻译:
自身免疫性疾病中的I型干扰素。
I型干扰素构成了第一个被描述的细胞因子家族,是抗病毒宿主防御的重要介体,已成为系统性自身免疫疾病免疫病理学的核心要素,以系统性红斑狼疮为原型。病毒感染后干扰素调控研究的经验教训可以应用于狼疮,其结论是持续产生I型干扰素会使免疫系统的几乎所有成分转移到导致组织损伤和疾病的病理功能上。我们回顾了主要来自系统性红斑狼疮患者研究的最新数据,这些数据为I型干扰素途径的慢性激活的诱导机制和免疫学后果提供了新见解。当前的概念暗示了内源性核酸,
更新日期:2019-01-24
中文翻译:
自身免疫性疾病中的I型干扰素。
I型干扰素构成了第一个被描述的细胞因子家族,是抗病毒宿主防御的重要介体,已成为系统性自身免疫疾病免疫病理学的核心要素,以系统性红斑狼疮为原型。病毒感染后干扰素调控研究的经验教训可以应用于狼疮,其结论是持续产生I型干扰素会使免疫系统的几乎所有成分转移到导致组织损伤和疾病的病理功能上。我们回顾了主要来自系统性红斑狼疮患者研究的最新数据,这些数据为I型干扰素途径的慢性激活的诱导机制和免疫学后果提供了新见解。当前的概念暗示了内源性核酸,