Human induced pluripotent stem cells (iPSCs) provide a renewable supply of patient-specific and tissue-specific cells for cellular and molecular studies of disease mechanisms. Combined with advances in various omics technologies, iPSC models can be used to profile the expression of genes, transcripts, proteins, and metabolites in relevant tissues. In the past 2 years, large panels of iPSC lines have been derived from hundreds of genetically heterogeneous individuals, further enabling genome-wide mapping to identify coexpression networks and elucidate gene regulatory networks. Here, we review recent developments in omics profiling of various molecular phenotypes and the emergence of human iPSCs as a systems biology model of human diseases.

中文翻译：

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诱导性多能干细胞模型中的全系统方法。

人类诱导的多能干细胞（iPSC）为疾病机制的细胞和分子研究提供了患者特异性和组织特异性细胞的可再生供应。结合各种组学技术的进步，iPSC模型可用于分析相关组织中基因，转录本，蛋白质和代谢产物的表达。在过去的两年中，大批iPSC品系来自数百个遗传异质的个体，从而进一步实现了全基因组定位，以鉴定共表达网络并阐明基因调控网络。在这里，我们回顾了各种分子表型的组学分析的最新进展以及作为人类疾病的系统生物学模型的人iPSC的出现。