Alcohol addiction is a worldwide concern as its detrimental effects go far beyond the addicted individual and can affect the entire family as well as the community. Considerable effort is being expended in understanding the neurobiological basis of such addiction in hope of developing effective prevention and/or intervention strategies. In addition, organ damage and neurotoxicological effects of alcohol are intensely investigated. Pharmacological approaches, so far, have only provided partial success in prevention or treatment of alcohol use disorder (AUD) including the neurotoxicological consequences of heavy drinking. Pituitary adenylate cyclase-activating polypeptide (PACAP) is an endogenous 38 amino-acid neuropeptide with demonstrated protection against neuronal injury, trauma as well as various endogenous and exogenous toxic agents including alcohol. In this mini-review, following a brief presentation of alcohol addiction and its neurotoxicity, the potential of PACAP as a therapeutic intervention in toxicological consequences of this devastating disorder is discussed.

中文翻译：

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PACAP对酒精中毒的治疗潜力。

酒精成瘾已成为全球关注的问题，因为其有害影响远远超出了成瘾者的个人，并且可能影响整个家庭以及整个社区。为了理解有效的预防和/或干预策略，人们正在花费大量的努力来理解这种成瘾的神经生物学基础。另外，对酒精的器官损伤和神经毒理作用进行了深入研究。迄今为止，药理学方法仅在预防或治疗酒精使用障碍（AUD）方面取得了部分成功，其中包括大量饮酒的神经毒理学后果。垂体腺苷酸环化酶激活多肽（PACAP）是内源性的38个氨基酸的神经肽，具有抗神经元损伤的保护作用，创伤以及各种内源性和外源性毒性剂，包括酒精。在本小型回顾中，在简要介绍酒精成瘾及其神经毒性后，讨论了PACAP作为对该破坏性疾病的毒理学后果进行治疗性干预的潜力。