Low-intensity extracorporeal shock wave therapy (Li-ESWT) is a form of energy transfer that is of lower intensity (<0.2mJ/mm2) relative to traditional Extracorporeal Shock Wave Lithotripsy (ESWL) used for management of urinary stones. At this intensity and at appropriate dosing energy transfer is thought to induce beneficial effects in human tissues. The proposed therapeutic mechanisms of action for Li-ESWT include neovascularization, tissue regeneration, and reduction of inflammation. These effects are thought to be mediated by enhanced expression of vascular endothelial growth factor, endothelial nitric oxide synthase, and proliferating cell nuclear antigen. Upregulation of chemoattractant factors and recruitment/activation of stem/progenitor cells may also play a role. Li-ESWT has been studied for management of musculoskeletal disease, ischemic cardiovascular disorders, Peyronie's Disease, and more recently erectile dysfunction (ED). The underlying mechanism of Li-ESWT for treatment of ED is incompletely understood. We summarize the current evidence basis by which Li-ESWT is thought to enhance penile hemodynamics with an intention of outlining the fundamental mechanisms by which this therapy may help manage ED.

中文翻译：

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低强度体外冲击波疗法调节的细胞信号通路。

低强度体外冲击波疗法（Li-ESWT）是一种能量传递形式，相对于用于管理尿路结石的传统体外冲击波碎石术（ESWL）而言，强度较低（<0.2mJ / mm2）。在这种强度和适当的剂量下，能量转移被认为在人体组织中引起有益的作用。Li-ESWT的拟议治疗作用机制包括新血管形成，组织再生和炎症减轻。认为这些作用是通过血管内皮生长因子，内皮一氧化氮合酶和增殖细胞核抗原的表达增强来介导的。趋化因子的上调和干/祖细胞的募集/激活也可能起作用。Li-ESWT已被研究用于肌肉骨骼疾病的治疗，缺血性心血管疾病，佩罗尼氏病和最近的勃起功能障碍（ED）。Li-ESWT治疗ED的潜在机制尚不完全清楚。我们总结了目前的证据基础，据此认为Li-ESWT可增强阴茎血流动力学，以概述该疗法可帮助管理ED的基本机制。