Association of electroretinography with visual outcomes after ophthalmic artery chemosurgery for retinoblastoma in ICRb D and E eyes.,PLOS ONE

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Association of electroretinography with visual outcomes after ophthalmic artery chemosurgery for retinoblastoma in ICRb D and E eyes.
PLOS ONE ( IF 3.7 ) Pub Date : 2019-01-16 , DOI: 10.1371/journal.pone.0210647
Ariana M Levin _{1,

2} , Jasmine H Francis _{1,

3} , Molly McFadden ₂ , Scott Brodie _{1,

4} , Y Pierre Gobin ₃ , David H Abramson _{1,

3}

Affiliation

Importance

Predictions of visual outcomes are useful in clinical and family decisions regarding treatment for retinoblastoma. Very little has been published on the association of post-treatment visual acuity with pre-treatment electroretinography (ERG), which can be performed on infants too young to reliably quantify visual acuity.

Objective

To report associations of pre-treatment ERG with post-treatment visual acuity in eyes with advanced retinoblastoma treated with ophthalmic artery chemosurgery (OAC).

Design

Retrospective case-control study of eyes treated from 2006 through 2017, with mean follow-up of 51 months (range 2.3–150 months).

Setting

Single large academic center.

Participants

Group D and E eyes treated with OAC at Memorial Sloan Kettering Cancer Center with recorded visual acuity and ERG (30Hz flicker).

Main outcome and measure

Snellen visual acuity (uncorrected) compared to initial 30Hz flicker ERG.

Results

This study included 157 Group D and E eyes. Results of the Jonckheere-Terpstra test for trend were statistically significant and indicated that eyes with lower pre-treatment ERG readings tended to have more visual impairment post-treatment. Among eyes with initial ERG 75+ μV, 11 of 32 eyes (34%) had visual acuity 20/40 or better. Among eyes with ERG 0 μV, 44 of 46 (96%) had visual acuity of 20/200 or worse.

Conclusions and relevance

Eyes with advanced intraocular retinoblastoma treated with OAC can achieve excellent visual acuity, but poor ERG at initial visit is associated with poor visual acuity after treatment in the majority of eyes. Expectations regarding visual potential may influence decisions about treatment.

中文翻译：

视网膜电图与ICRb D和E眼视网膜母细胞瘤眼动脉化学外科手术后视觉结果的关联。

重要性

视觉结果的预测在有关视网膜母细胞瘤治疗的临床和家庭决策中很有用。关于治疗后视力与治疗前视网膜电图（ERG）的关联的研究很少，这可以在年龄太小而无法可靠地量化视力的婴儿身上进行。

客观的

报告在眼动脉化学外科手术（OAC）治疗的晚期视网膜母细胞瘤眼中，治疗前ERG与治疗后视敏度的关系。

设计

回顾性病例对照研究，研究对象为2006年至2017年的眼睛，平均随访时间为51个月（范围2.3-150个月）。

环境

单一的大型学术中心。

参加者

D和E组眼睛在纪念斯隆凯特琳癌症中心接受OAC治疗，并记录了视敏度和ERG（30Hz闪烁）。

主要成果和措施

与最初的30Hz闪烁ERG相比，Snellen视敏度（未校正）。

结果

这项研究包括157组D和E眼。Jonckheere-Terpstra趋势检验的结果具有统计学意义，表明治疗前ERG读数较低的眼睛在治疗后往往有更多的视力障碍。在初始ERG为75+μV的眼中，32眼中有11眼（34％）的视力为20/40或更高。在ERG 0μV的眼中，有46眼的眼中有44眼（96％）的视力为20/200或更差。