Following the Research Domain Criteria (RDoC) concept, major brain circuits are conserved in evolution and malfunctioning of a brain circuit will lead to specific behavioral symptoms. Reverse translation of patient-based findings from Alzheimer’s disease (AD), schizophrenia (SZ) and major depression (MD) patients to preclinical models accordingly can be a starting point for developing a deeper understanding of the functional circuit biology and contribute to the validation of new hypotheses for therapeutic intervention in patients. In the context of the EU funded PRISM project, a preclinical test battery of tasks has been selected and aligned with the clinical test battery. It allows for assessment of social functioning, sensory processing, attention and working memory and is designed for validation of biological substrates from human molecular landscaping of social withdrawal. This review will broadly summarize the available literature on tasks for studying social behavior in rodents and outline the development of a preclinical test battery for the PRISM project by reverse translation.

遵循研究领域标准（RDoC）的概念，主要的大脑回路在进化中得以保留，并且大脑回路的故障将导致特定的行为症状。将基于阿尔茨海默氏病（AD），精神分裂症（SZ）和重度抑郁（MD）的患者发现的结果反向翻译为临床前模型，可以成为深入了解功能回路生物学的起点，并有助于验证对患者进行治疗干预的新假设。在欧盟资助的PRISM项目的背景下，已选择了一项临床前测试任务组，并与临床测试组保持一致。它可以评估社交功能，感觉处理，注意和工作记忆，旨在验证社交退缩对人类分子的美化作用中的生物底物。这篇综述将广泛总结有关研究啮齿动物社会行为的任务的现有文献，并概述通过反向翻译为PRISM项目开发临床前测试电池的过程。