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Technologies for image-guided surgery for managing lymphatic metastases in prostate cancer.
Nature Reviews Urology ( IF 15.3 ) Pub Date : 2019-03-01 , DOI: 10.1038/s41585-018-0140-8
Fijs W B van Leeuwen 1, 2 , Alexander Winter 3 , Henk G van Der Poel 2 , Matthias Eiber 4 , Nazareno Suardi 5 , Markus Graefen 6 , Friedhelm Wawroschek 3 , Tobias Maurer 6
Affiliation  

One of the challenges for the surgical management of prostate cancer is the lymphatic spread of metastases. Lymph node metastases vary in size (micrometastases (<2 mm) or macrometastases (>2 mm)), and their interactions with the lymphatic environment differ (whether they are hypoxic or connected to blood flow). Thus, devising a universal imaging system and an image-guided surgical approach that supports the resection of all affected lymph nodes is difficult. Two complementary approaches to identifying affected lymph nodes have been described as alternatives to performing a traditional pelvic lymph node dissection: lymphatic mapping using radioguidance (the most widely applied modality), fluorescence guidance, integrated hybrid radioguidance and fluorescence guidance or magnetic guidance; and surgery guided by radiolabelled prostate-specific membrane antigen. Careful patient selection using preoperative imaging seems to be a crucial aspect in determining whether one of the individual image-guided surgery procedures alone would be optimal or whether a combination would be considered to be the most desirable course of action. The successful implementation and dissemination of both lymph-node-targeted and disease-targeted procedures are very much reliant on ongoing technical developments in the field and their standardization and interpretation. However, when these innovative surgical procedures are fully refined, evaluation of their influence on oncological outcome is imperative.

中文翻译:

用于在前列腺癌中处理淋巴转移的图像引导手术技术。

前列腺癌外科治疗的挑战之一是转移灶的淋巴扩散。淋巴结转移的大小不同(微转移(<2 mm)或巨转移(> 2 mm)),它们与淋巴环境的相互作用不同(低氧或与血流有关)。因此,难以设计出支持所有受影响的淋巴结切除的通用成像系统和图像引导的手术方法。两种识别感染淋巴结的补充方法已被描述为进行传统盆腔淋巴结清扫术的替代方法:使用放射引导(应用最广泛的方式)进行淋巴定位,荧光引导,综合性混合放射引导和荧光引导或磁引导;放射性标记的前列腺特异性膜抗原指导手术。使用术前影像进行仔细的患者选择似乎是确定单独的影像引导手术方法中的一种是否最佳或组合是否被认为是最理想的治疗方案的关键方面。淋巴结靶向和疾病靶向程序的成功实施和传播,在很大程度上取决于该领域正在进行的技术发展及其标准化和解释。但是,当这些创新的外科手术程序得到充分完善时,必须评估它们对肿瘤学结局的影响。使用术前影像进行仔细的患者选择似乎是确定单独的影像引导手术方法中的一种是否最佳或组合是否被认为是最理想的治疗方案的关键方面。淋巴结靶向和疾病靶向程序的成功实施和传播,在很大程度上取决于该领域正在进行的技术发展及其标准化和解释。但是,当这些创新的外科手术程序得到充分完善时,必须评估它们对肿瘤学结局的影响。使用术前影像进行仔细的患者选择似乎是确定单独的影像引导手术方法中的一种是否最佳或组合是否被认为是最理想的治疗方案的关键方面。淋巴结靶向和疾病靶向程序的成功实施和传播,在很大程度上取决于该领域正在进行的技术发展及其标准化和解释。但是,当这些创新的外科手术程序得到充分完善时,必须评估它们对肿瘤学结局的影响。淋巴结靶向和疾病靶向程序的成功实施和传播,在很大程度上取决于该领域正在进行的技术发展及其标准化和解释。但是,当这些创新的外科手术程序得到充分完善时,必须评估它们对肿瘤学结局的影响。淋巴结靶向和疾病靶向程序的成功实施和传播,在很大程度上取决于该领域正在进行的技术发展及其标准化和解释。但是,当这些创新的外科手术程序得到充分完善时,必须评估它们对肿瘤学结局的影响。
更新日期:2019-05-16
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