In this issue of Immunity, Britton et al. (2019) demonstrate that the colonization of germ-free mice with microbiotas from inflammatory bowel disease patients induces an altered ratio of RORγt⁺ regulatory T cells to T(h17) effector cells and recapitulates human disease severity in colitis-susceptible mice.

中文翻译：

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定义炎症性肠病中的生物功能异常

在《免疫》一期中，Britton等人。（2019）证明，来自炎症性肠病患者的微生物群在无菌小鼠中的定殖导致RORγt ⁺调节性T细胞与T（h17）效应细胞的比率发生改变，并概括了易患结肠炎的小鼠的人类疾病严重程度。