We read with great interest the paper by Wu et al 1 reporting on the development of a carnitine challenge test to facilitate the identification of trimethylamine N-oxide (TMAO)-producer phenotype and host-diet-gut dysbiosis. Such a test assumes that, according to a partial reading of the literature, TMAO plays a key role in cardiovascular disease (CVD). Accordingly, the authors assert the implied importance of the potential for adverse CVD-inducing actions of compounds generating TMAO subsequent to the action of gut microbiota on dietary carnitine. However, a more objective reading of the literature shows that the biomedical community is still debating the potential involvement of TMAO in inducing …

中文翻译：

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三甲胺 N-氧化物 (TMAO) 生产者表型的鉴定很有趣，但有帮助吗？

我们非常感兴趣地阅读了 Wu 等人 1 的论文，该论文报告了肉碱激发试验的发展，以促进三甲胺 N-氧化物 (TMAO) 生产者表型和宿主-饮食-肠道生态失调的鉴定。这样的测试假设，根据对文献的部分阅读，TMAO 在心血管疾病 (CVD) 中起着关键作用。因此，作者断言，在肠道微生物群对膳食肉碱的作用之后，产生 TMAO 的化合物具有潜在的不利 CVD 诱导作用的重要性。然而，对文献的更客观阅读表明，生物医学界仍在争论 TMAO 是否可能参与诱导……