Microalgae are potential iron supplements for improving iron deficiency through an unknown mechanism. To analyze the increase in non-heme iron absorption caused by microalgae, six different microalgal feeds were prepared from Spirulina, Chlorella and Synechococcus sp. PCC 7002 as the main source of dietary iron (25 mg kg⁻¹; denoted as H-Sp, H-Ch, and H-Sy, respectively) or as a partial source of dietary iron (5 mg kg⁻¹; denoted as L-Sp, L-Ch, and L-Sy, respectively) to suppress iron-deficiency anemia in rats. The hemoglobin regeneration efficiencies in anemic rats were in the order ferric citrate (34.7 ± 1.8%) < H-Ch (49.9 ± 4.1%) ≈ H-Sy (50.6 ± 5.3%) ≈ L-Sp (46.9 ± 6.2%) ≈ L-Ch (43.1 ± 6.9%) ≈ L-Sy (43.5 ± 2.4%) ≈ FeSO₄ (47.2 ± 4.9%) < H-Sp (54.8 ± 5.5%). The percentage content of intestinal nanosized iron in the H-Sp, H-Ch, and H-Sy treatment groups was significantly higher than that in the L-Sp, L-Ch, and L-Sy groups, and was significantly higher in the microalgal diet groups than in the ferric citrate group, providing strong evidence for nanosized iron supplementation from microalgae. Overall, microalgae, especially Spirulina, are functional iron nutritive fortifiers that can supply intestinal nanosized iron.

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微藻作为铁的补充剂对大鼠缺铁性贫血的影响

微藻是通过未知机制改善铁缺乏症的潜在铁补充剂。为了分析微藻引起的非血红素铁吸收的增加，从螺旋藻，小球藻和Synechococcus sp。制备了六种不同的微藻饲料。PCC 7002作为膳食铁的主要来源（25 mg kg ^-1；分别表示为H- Sp，H- Ch和H- Sy）或作为膳食铁的部分来源（5 mg kg ^-1；表示为L- Sp，L- Ch和L- Sy分别）抑制大鼠缺铁性贫血。贫血大鼠的血红蛋白再生效率约为柠檬酸铁（34.7±1.8％）<H- Ch（49.9±4.1％）≈H- Sy（50.6±5.3％）≈L- Sp（46.9±6.2％）≈ L- Ch（43.1±6.9％）≈L- Sy（43.5±2.4％）≈FeSO ₄（47.2±4.9％）<H- Sp（54.8±5.5％）。H- Sp，H- Ch和H- Sy治疗组中肠道纳米铁的百分比含量显着高于L- Sp，L- Ch和L- Sy治疗组组，并且微藻饮食组中的柠檬酸铁组显着高于柠檬酸铁组，这为从微藻中补充纳米级铁提供了有力的证据。总体而言，微藻，尤其是螺旋藻，是可以提供肠道纳米级铁的功能性铁营养强化剂。