Journal of the American Academy of Dermatology ( IF 13.8 ) Pub Date : 2019-01-11 , DOI: 10.1016/j.jaad.2018.12.062 Erin M. Warshaw , Amy J. Zhang , Donald V. Belsito , Joseph F. Fowler , James S. Taylor , Howard I. Maibach , Toby Mathias , Denis Sasseville , James G. Marks , Vincent A. DeLeo , Anthony F. Fransway , Kathryn A. Zug , Melanie D. Pratt , Matthew J. Zirwas , Joel G. DeKoven
Background
Little is known regarding the characteristics of patients with negative patch test (NPT) results.
Objective
To characterize patients with NPT results.
Methods
Retrospective cross-sectional analysis of 34,822 patch tested patients. NPT results were defined as negative or irritant final interpretations of all North American Contact Dermatitis Group screening allergens and no relevant allergens on supplemental series.
Results
Almost one-third of patients (n = 10,888 [31.3%]) had NPT results. Patients with NPT results were significantly more likely to be male (P < .0001), be age 40 years or younger (P = .0054), be nonwhite (P = .0005), and have dermatitis primarily having a scattered generalized distribution (P = .0007) or primarily located on the lips (P = .0214) or eyelids (P = .0364). However, the absolute differences in age, race, and site were small and may not be clinically meaningful. Patients with NPT results were significantly less likely to have occupationally related skin disease (P < .0001). Overall, 8.3% of patients with NPT results had occupationally related skin disease, with precision production worker/machine operator (28.5%), health care worker (17.0%), and mechanic/repairer (7.5%) being the most commonly related occupations. In all, 22.9% of patients with NPT results had relevant irritants and 41.6% of irritants were occupationally related; cosmetics/health care products and soaps were common sources for both occupationally related and non–occupationally related irritants.
Limitations
Retrospective cross-sectional study of tertiary referral population.
Conclusions
Patients with NPT results have distinct characteristics.
中文翻译:
斑贴试验阴性的患者:北美接触性皮炎组(NACDG)数据2001-2016年的回顾性分析
背景
关于阴性斑贴试验(NPT)结果患者的特征知之甚少。
客观的
表征具有NPT结果的患者。
方法
回顾性横断面分析34 822贴片测试的患者。NPT结果定义为所有北美接触性皮炎组筛查过敏原的阴性或刺激性最终解释,补充系列中无相关过敏原。
结果
几乎三分之一的患者(n = 10,888 [31.3%])有NPT结果。获得NPT结果的患者更有可能是男性(P <.0001),年龄在40岁或更年轻(P = .0054),非白人(P = .0005)以及主要分布在全身的皮炎(P = .0007)或主要位于嘴唇(P = .0214)或眼睑(P = .0364)上。但是,年龄,种族和地点的绝对差异很小,在临床上可能没有意义。获得NPT结果的患者患职业性皮肤病的可能性显着降低(P <.0001)。总体而言,在NPT结果中有8.3%的患者患有与职业有关的皮肤病,其中最常见的职业是精密生产工人/机器操作员(28.5%),卫生保健工作者(17.0%)和技工/修理工(7.5%)。总共有22.9%的NPT结果患者有相关刺激物,而41.6%的刺激物是职业相关的;化妆品/保健品和肥皂是与职业有关和与非职业有关的刺激物的常见来源。
局限性
第三转诊人口的回顾性横断面研究。
结论
NPT结果的患者具有鲜明的特征。