To date only small animal models have been employed to assess the effect of mesenchymal stromal cell (MSC) therapy on acute pancreatitis (AP), the most common cause of hospitalization for gastrointestinal diseases worldwide. We outline the challenges inherent in the small animal models of AP. We also point to specific benefits afforded by the adoption of larger animal models. The potential for MSC therapeutics in the treatment of AP was recognized over a decade ago. With sharper focus on the form of AP and development of new MSC delivery routes in larger animals, we believe the challenge can be engaged.

中文翻译：

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简要评论：在急性胰腺炎的治疗中采用间质基质细胞的挑战和机遇。

迄今为止，仅采用小动物模型来评估间充质基质细胞（MSC）治疗对急性胰腺炎（AP）的影响，急性胰腺炎是全球胃肠道疾病住院的最常见原因。我们概述了AP的小动物模型固有的挑战。我们还指出了采用较大动物模型所带来的特定利益。十年前，人们已经认识到了MSC治疗AP的潜力。随着人们更加关注AP的形式以及在大型动物中开发新的MSC递送途径，我们相信这一挑战将迎刃而解。