Derived from the term exposure, the exposome is an omic-scale characterization of the nongenetic drivers of health and disease. With the genome, it defines the phenome of an individual. The measurement of complex environmental factors that exert pressure on our health has not kept pace with genomics and historically has not provided a similar level of resolution. Emerging technologies make it possible to obtain detailed information on drugs, toxicants, pollutants, nutrients, and physical and psychological stressors on an omic scale. These forces can also be assessed at systems and network levels, providing a framework for advances in pharmacology and toxicology. The exposome paradigm can improve the analysis of drug interactions and detection of adverse effects of drugs and toxicants and provide data on biological responses to exposures. The comprehensive model can provide data at the individual level for precision medicine, group level for clinical trials, and population level for public health.

中文翻译：

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外来分子：人口的分子。

从术语“接触”衍生而来，该暴露体是健康和疾病的非遗传驱动因素的omic规模表征。利用基因组，它定义了一个人的现象。对我们的健康造成压力的复杂环境因素的测量与基因组学并没有保持同步，并且历史上也没有提供类似水平的解决方案。新兴技术使得有可能获得有关药物，有毒物质，污染物，营养物质以及人体和心理应激源的详细信息。这些作用力也可以在系统和网络级别进行评估，从而为药理学和毒理学的发展提供框架。暴露范例可以改善药物相互作用的分析以及药物和毒物的不良反应的检测，并提供有关暴露的生物学反应的数据。