Syrian hamsters undergo a reversible hyperphosphorylation of protein τ during hibernation, providing a unique natural model that may unveil the physiological mechanisms behind this critical process involved in the development of Alzheimer's disease and other tauopathies. The hibernation cycle of these animals fluctuates between a pair of stages: 3-4 days of torpor bouts interspersed with periods of euthermia called arousals that last several hours. In this study, we investigated for the first time the metabolic changes in brain tissue during hibernation. A total of 337 metabolites showed statistically significant differences during hibernation. Based on these metabolites, several pathways were found to be significantly regulated and, therefore, play a key role in the regulation of hibernation processes. The increase in the levels of ceramides containing more than 20 C atoms was found in torpor animals, reflecting a higher activity of CerS2 during hibernation, linked to neurofibrillary tangle generation and structural changes in the Golgi apparatus. Our results open up the debate about the possible significance of some metabolites during hibernation, which may possibly be related to τ phosphorylation and dephosphorylation events. In general, this study may provide insights into novel neuroprotective agents because the alterations described throughout the hibernation process are reversible.

中文翻译：

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冬眠叙利亚仓鼠大脑的代谢组学研究：寻找神经保护剂。

叙利亚仓鼠在冬眠期间经历了蛋白质τ的可逆超磷酸化，从而提供了独特的自然模型，该模型可能揭示了涉及阿尔茨海默氏病和其他疾病发展过程的这一关键过程背后的生理机制。这些动物的冬眠周期在两个阶段之间波动：3-4天的r回折，散布着持续数小时的被称为唤醒的正常体温。在这项研究中，我们首次研究了冬眠期间脑组织的代谢变化。共有337种代谢物在冬眠期间显示出统计学上的显着差异。基于这些代谢物，发现有几种途径被显着调节，因此，它们在冬眠过程的调节中起着关键作用。在to动物中发现了包含20个以上C原子的神经酰胺水平的增加，这反映了冬眠期间CerS2的更高活性，这与神经原纤维缠结的产生和高尔基体的结构改变有关。我们的研究结果引发了关于某些代谢物在冬眠期间可能具有的重要性的争论，这可能与τ磷酸化和去磷酸化事件有关。总的来说，由于整个冬眠过程中描述的改变是可逆的，因此本研究可以提供对新型神经保护剂的见解。我们的研究结果引发了关于某些代谢物在冬眠期间可能具有的重要性的争论，这可能与τ磷酸化和去磷酸化事件有关。总的来说，由于整个冬眠过程中描述的改变是可逆的，因此本研究可以提供对新型神经保护剂的见解。我们的研究结果引发了关于某些代谢物在冬眠期间可能具有的重要性的争论，这可能与τ磷酸化和去磷酸化事件有关。总的来说，由于整个冬眠过程中描述的改变是可逆的，因此本研究可以提供对新型神经保护剂的见解。