Chichibabin pyridine synthesis involves the reaction of three aldehydes and ammonia to form 2,3,5-trisubstituted pyridines. This study examined the synthesis of tetrasubstituted pyridinium from aldehydes and an amine hydrochloride in the presence/absence of Pr(OTf)₃. Important insights into the reaction mechanisms of Chichibabin pyridinium synthesis were proposed through the investigation of reaction intermediates along with quantitative GC–MS analysis.

中文翻译：

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chichibabin吡啶鎓的合成

chichibabin吡啶的合成涉及三种醛与氨的反应以形成2,3,5-三取代的吡啶。这项研究研究了在存在/不存在Pr（OTf）_3的情况下，由醛和胺盐酸盐合成四取代吡啶鎓的方法。通过对反应中间体的研究以及定量GC-MS分析，提出了对Chichibabin吡啶鎓合成反应机理的重要见解。