Anthocyanins have been shown to exhibit antitumor activity in several cancers in vitro and in vivo. Oxaliplatin is widely used as an anti-cancer drug. However, a large proportion of patients receiving platinum-based anti-cancer drug treatments will relapse because of metastasis and drug resistance. The aim of this study is to discover an effective anthocyanin that possesses the combinational anti-metastatic effects of oxaliplatin. Our results showed that cyanidin, one of the main constituents of anthocyanins, widely found in black rice, black bean, Hawthorn and other foods, could reverse drug resistance and enhance the effects of oxaliplatin on hepatic cellular cancer (HCC). Cyanidin inhibited migration and reversed EMT biomarker changes induced by low dose OXA. Moreover, 3-phosphoinositide-dependent protein kinase 1 (PDK1) can be considered a potential target and cyanidin significantly increased OXA sensitivity and inhibited the EMT induced by OXA via PI3K/Akt signaling in HCC.

中文翻译：

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氰胺通过靶向PDK1-PI3K / Akt信号通路 抑制奥沙利铂诱导的E​​MT

花青素已显示呈现在几种癌症的抗肿瘤活性在体外和体内。奥沙利铂广泛用作抗癌药。但是，由于转移和耐药性，接受铂类抗癌药物治疗的患者中有很大一部分会复发。这项研究的目的是发现一种有效的花色苷，它具有奥沙利铂的联合抗转移作用。我们的结果表明，花青素是花青素的主要成分之一，广泛存在于黑米，黑豆，山楂和其他食品中，可以逆转耐药性并增强奥沙利铂对肝细胞癌（HCC）的作用。Cyanidin抑制了低剂量OXA诱导的迁移并逆转了EMT生物标志物的变化。而且，通过HCC中的PI3K / Akt信令。