Lactulose synergizes with CpG-ODN to modulate epithelial and immune cells cross talk,Food & Function

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Lactulose synergizes with CpG-ODN to modulate epithelial and immune cells cross talk
Food & Function ( IF 6.1 ) Pub Date : 2019-01-04 00:00:00 , DOI: 10.1039/c8fo02376j
R. Mukherjee _{1,

2,

3,

4,

5} , M. van de. Kaa _{2,

3,

4,

5,

6} , J. Garssen _{2,

3,

4,

5,

6} , R. J. Pieters _{1,

2,

3,

4,

5} , A. D. Kraneveld _{2,

3,

4,

5,

6} , L. E. M. Willemsen _{2,

3,

4,

5,

6}

Affiliation

Lactulose, a non-digestible oligosaccharide and functional food, promotes Bifidobacteria growth. Here we show that lactulose, beyond its prebiotic action, may have direct immunomodulatory effects as well. In synergy with CpG-ODN, a bacterial DNA mimetic, lactulose enhances basolateral concentrations of IFN-γ, IL-10, and galectin-9 in the co-culture model of epithelial and immune cells.

中文翻译：

乳果糖与CpG-ODN协同调节上皮和免疫细胞的串扰

乳果糖是一种不易消化的低聚糖和功能性食品，可促进双歧杆菌的生长。在这里，我们显示乳果糖除了具有其益生元作用外，还可能具有直接的免疫调节作用。在细菌上皮模拟物CpG-ODN的协同作用下，乳果糖在上皮细胞和免疫细胞的共培养模型中提高了IFN-γ，IL-10和galectin-9的基底外侧浓度。

更新日期：2019-01-04

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