Abstract Chitosan is one of the most widely used natural biopolymers for a great variety of biomedical applications owing to its biocompatibility, biodegradability, and antibacterial activity, being generally regarded as a safe material. It can be employed as a dispersant, binder, and surface charge agent for particles in suspension. Electrophoretic deposition (EPD) of chitosan, especially in combination with other materials, is receiving increasing attention for biomedical applications. This article presents a comprehensive review of the field of EPD of chitosan-based composite coatings by highlighting their microstructural, mechanical, surface, and biological properties. Since suspension characteristics have significant influences on the deposition mechanisms, kinetics, and on the overall properties of the electrophoretically deposited coatings, suspension parameters such as concentration, viscosity, and zeta potential are discussed, including chitosan-based suspensions with hydroxyapatite, bioactive glass particles, carbonaceous materials and other inorganic and organic materials. The deposition mechanisms proposed for each composite system are highlighted. Moreover, the effects of key EPD process parameters on the microstructural homogeneity, mechanical properties as well as surface and biological characteristics of the coatings are emphasised, and specific approaches for future research are proposed based on the state-of-the-art and considering EPD produced chitosan-based coatings in applications such as tissue engineering and drug delivery systems.

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用于生物医学应用的壳聚糖基复合涂层的电泳沉积：综述

摘要 壳聚糖具有生物相容性、生物降解性和抗菌活性，是一种应用最广泛的天然生物聚合物，广泛应用于各种生物医学领域，被普遍认为是一种安全的材料。它可以用作分散剂、粘合剂和悬浮颗粒的表面电荷剂。壳聚糖的电泳沉积 (EPD)，尤其是与其他材料的结合，在生物医学应用中越来越受到关注。本文通过突出其微观结构、机械、表面和生物特性，对壳聚糖基复合涂料的 EPD 领域进行了全面回顾。由于悬浮特性对沉积机制、动力学和电泳沉积涂层的整体性能有显着影响，讨论了浓度、粘度和 zeta 电位等悬浮液参数，包括含有羟基磷灰石、生物活性玻璃颗粒、碳质材料和其他无机和有机材料的壳聚糖基悬浮液。强调了为每个复合系统提出的沉积机制。此外，还强调了关键 EPD 工艺参数对涂层微观结构均匀性、机械性能以及表面和生物学特性的影响，并基于最新技术并考虑 EPD 提出了未来研究的具体方法在组织工程和药物输送系统等应用中生产基于壳聚糖的涂层。包括含羟基磷灰石的壳聚糖悬浮液、生物活性玻璃颗粒、含碳材料和其他无机和有机材料。强调了为每个复合系统提出的沉积机制。此外，还强调了关键 EPD 工艺参数对涂层微观结构均匀性、机械性能以及表面和生物学特性的影响，并基于最新技术并考虑 EPD 提出了未来研究的具体方法在组织工程和药物输送系统等应用中生产基于壳聚糖的涂层。包括含羟基磷灰石的壳聚糖悬浮液、生物活性玻璃颗粒、含碳材料和其他无机和有机材料。强调了为每个复合系统提出的沉积机制。此外，还强调了关键 EPD 工艺参数对涂层微观结构均匀性、机械性能以及表面和生物学特性的影响，并基于最新技术并考虑 EPD 提出了未来研究的具体方法在组织工程和药物输送系统等应用中生产基于壳聚糖的涂层。