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Variation in fourteen brain structure volumes in schizophrenia: A comprehensive meta-analysis of 246 studies.
Neuroscience & Biobehavioral Reviews ( IF 8.2 ) Pub Date : 2019-01-04 , DOI: 10.1016/j.neubiorev.2018.12.030
Susan S Kuo 1 , Michael F Pogue-Geile 2
Affiliation  

Despite hundreds of structural MRI studies documenting smaller brain volumes on average in schizophrenia compared to controls, little attention has been paid to group differences in the variability of brain volumes. Examination of variability may help interpret mean group differences in brain volumes and aid in better understanding the heterogeneity of schizophrenia. Variability in 246 MRI studies was meta-analyzed for 13 structures that have shown medium to large mean effect sizes (Cohen's d≥0.4): intracranial volume, total brain volume, lateral ventricles, third ventricle, total gray matter, frontal gray matter, prefrontal gray matter, temporal gray matter, superior temporal gyrus gray matter, planum temporale, hippocampus, fusiform gyrus, insula; and a control structure, caudate nucleus. No significant differences in variability in cortical/subcortical volumes were detected in schizophrenia relative to controls. In contrast, increased variability was found in schizophrenia compared to controls for intracranial and especially lateral and third ventricle volumes. These findings highlight the need for more attention to ventricles and detailed analyses of brain volume distributions to better elucidate the pathophysiology of schizophrenia.

中文翻译:

精神分裂症中 14 个大脑结构体积的变化:对 246 项研究的综合荟萃分析。

尽管数百项结构 MRI 研究表明,与对照组相比,精神分裂症患者的平均脑容量较小,但很少有人关注脑容量变异性的群体差异。检查变异性可能有助于解释脑容量的平均群体差异,并有助于更好地理解精神分裂症的异质性。对 246 项 MRI 研究的变异性进行了 13 种结构的荟萃分析,这些结构显示出中等到较大的平均效应量(Cohen's d≥0.4):颅内容量、总脑容量、侧脑室、第三脑室、总灰质、额叶灰质、前额叶灰质、颞叶灰质、颞上回灰质、颞平面、海马、梭状回、脑岛;和一个控制结构,尾状核。与对照组相比,在精神分裂症中未检测到皮质/皮质下体积的变异性存在显着差异。相比之下,与颅内尤其是侧脑室和第三脑室容积的对照相比,精神分裂症患者的变异性增加。这些发现强调需要更多地关注脑室和详细分析脑容量分布,以更好地阐明精神分裂症的病理生理学。
更新日期:2019-01-04
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