Dietary (−)-epicatechin affects NF-κB activation and NADPH oxidases in the kidney cortex of high-fructose-fed rats,Food & Function

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Dietary (−)-epicatechin affects NF-κB activation and NADPH oxidases in the kidney cortex of high-fructose-fed rats
Food & Function ( IF 6.1 ) Pub Date : 2019-01-03 00:00:00 , DOI: 10.1039/c8fo02230e
Paula Denise Prince _{1,

2,

3,

4,

5} , Cecilia Rodríguez Lanzi _{6,

7,

8,

9,

10} , César G. Fraga _{1,

2,

3,

4,

5} , Mónica Galleano _{1,

2,

3,

4,

5}

Affiliation

Inflammation involves the activation of redox-sensitive transcription factors, e.g., nuclear factor κB (NF-κB). Administration of (−)-epicatechin to high-fructose-fed rats prevented NF-κB activation and up-regulation of the NADPH oxidase 4 (NOX4) in the kidney cortex. These results add mechanistic insights into the action of (−)-epicatechin diminishing inflammatory responses.

中文翻译：

饮食（-）-表儿茶素会影响高果糖喂养大鼠肾皮质中NF-κB活化和NADPH氧化酶

炎症涉及氧化还原敏感的转录因子，例如核因子κB（NF-κB）的激活。向高果糖喂养的大鼠施用（-）-表儿茶素可预防肾皮质中NF-κB的活化和NADPH氧化酶4（NOX4）的上调。这些结果为（-）-表儿茶素减少炎症反应的作用增加了机械学见解。

更新日期：2019-01-03

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