Organic/inorganic nanohybrids have attracted widespread interests due to their favorable properties and promising applications in biomedical areas. Great efforts have been made to design and fabricate versatile nanohybrids. Among different organic components, diverse polymers offer unique avenues for multifunctional systems with collective properties. This review focuses on the design, properties, and biomedical applications of organic/inorganic nanohybrids fabricated from inorganic nanoparticles and polymers. We begin with a brief introduction to a variety of strategies for the fabrication of functional organic/inorganic nanohybrids. Then the properties and functions of nanohybrids are discussed, including properties from organic and inorganic parts, synergistic properties, morphology-dependent properties, and self-assembly of nanohybrids. After that, current situations of nanohybrids applied for imaging, therapy, and imaging-guided therapy are demonstrated. Finally, we discuss the prospect of organic/inorganic nanohybrids and highlight the challenges and opportunities for the future investigations.

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多种类型的有机/无机纳米杂化物：从策略设计到生物医学应用

有机/无机纳米杂化物因其良好的性能和在生物医学领域的应用前景而备受关注。在设计和制造通用纳米杂合体方面已经付出了巨大的努力。在不同的有机成分中，各种聚合物为具有集体特性的多功能系统提供了独特的途径。这篇综述着重于由无机纳米颗粒和聚合物制成的有机/无机纳米杂化物的设计，性质和生物医学应用。我们首先简要介绍各种制备功能性有机/无机纳米杂化物的策略。然后讨论了纳米杂化物的性质和功能，包括来自有机和无机部分的性质，协同性质，依赖形态的性质以及纳米杂化物的自组装。之后，展示了纳米杂交技术在成像，治疗和成像指导治疗中的应用现状。最后，我们讨论了有机/无机纳米杂化物的前景，并强调了未来研究的挑战和机遇。