Collagen mimetic scaffolds play a pivotal role in regenerative medicine and tissue engineering due to their extraordinary structural and biological features. We have herein, for the first time, reported the construction of luminescent lanthanide–collagen peptide hybrid three-dimensional nanofibrous scaffolds, which well mimic the characteristic architectural structure of native collagen. Three collagen mimetic peptides, composed of repetitive central (GPO)₇ sequences and altered terminal amino acids, have been shown to consistently self-assemble to form biocompatible nanofibers under the trigger of a variety of lanthanide ions, which also functionalize the assembled materials with easily tunable photoluminescence. Furthermore, the collagen peptide–lanthanide hybrid scaffolds possess programmable pH-responsive features. The lanthanide ion-mediated assembly of all three collagen peptides are conveniently and reversibly regulated by pH, while their pH-dependent patterns are finely tuned by the identity of terminal amino acids. Using camptothecin and cefoperazone sodium as two model drugs, the drug-loading and releasing efficiency of the collagen peptide–lanthanide scaffolds are nicely modulated by pH, demonstrating the efficacy of these nanofibrous scaffolds as pH-responsive drug carriers. These novel luminescent collagen peptide–lanthanide scaffolds provide a facile system for pH-controlled drug delivery, suggesting promising applications in the development of therapies for many diseases.

中文翻译：

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发光的镧系元素-胶原蛋白肽框架，用于pH控制的药物输送

胶原蛋白模拟支架由于其非凡的结构和生物学特性，在再生医学和组织工程中起着举足轻重的作用。我们在这里首次报道了发光镧系-胶原肽杂合三维纳米纤维支架的构建，该支架很好地模仿了天然胶原蛋白的特征性结构。三种胶原蛋白模拟肽，由重复性中枢（GPO）_7组成序列和改变的末端氨基酸已显示出在各种镧系元素离子的触发下始终自组装形成生物相容性纳米纤维，这也使组装后的材料具有易于调节的光致发光功能。此外，胶原蛋白肽-镧系元素混合支架具有可编程的pH响应功能。所有三种胶原蛋白肽的镧系元素离子介导的组装均可方便地且可逆地受pH调节，而其pH依赖性模式可通过末端氨基酸的身份进行微调。使用喜树碱和头孢哌酮钠作为两种模型药物，胶原肽-镧系元素支架的载药量和释放效率可通过pH很好地调节，证明了这些纳米纤维支架作为pH响应药物载体的功效。