Cell therapy offers much promise for the treatment of ischemic diseases by augmenting tissue vasculogenesis. Matrix-assisted cell transplantation (MACT) has been proposed as a solution to enhance cell survival and integration with host tissue following transplantation. By designing semi synthetic matrices (sECM) with the correct physical and biochemical signals, encapsulated cells are directed towards a more angiogenic phenotype. In this review, we describe the choice of cells suitable for pro-angiogenic therapies, the properties that should be considered when designing sECM for transplantation and their relative importance. Pre-clinical models where MACT has been successfully applied to promote angiogenesis are reviewed to show the great potential of this strategy to treat ischemic conditions.

中文翻译：

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用于组织血管形成的基质辅助细胞移植。

细胞疗法通过增强组织血管生成为缺血性疾病的治疗提供了广阔前景。已经提出了基质辅助细胞移植（MACT）作为增强细胞存活和移植后与宿主组织整合的解决方案。通过设计具有正确物理和生化信号的半合成基质（sECM），将包囊的细胞导向更具血管生成性的表型。在这篇综述中，我们描述了适用于促血管生成疗法的细胞的选择，在设计用于移植的sECM时应考虑的特性及其相对重要性。回顾了成功应用MACT促进血管生成的临床前模型，以显示该策略治疗缺血性疾病的巨大潜力。