O-mannosyl glycan is a pivotal glycan part of α-dystroglycan, which serves as a transmembrane linker connecting the intracellular cytoskeleton and extracellular matrix, such as laminin in skeletal muscle. We synthesized β-d-Xyl-(1–4)-d-Rbo-5P (1), β-d-Xyl-(1–4)-d-Rbo (2), and β-d-Xyl-(1–4)-d-Rbo-5P1-d-Rbo (3), partial structures of O-mannosyl glycan, in regio- and stereo-controlled manners, and demonstrated compatibility with the natural product.

中文翻译：

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β-Xyl（1-4）Rbo-5P1-Rbo的区域和立体控制合成，O-甘露糖基聚糖的部分结构

O-甘露糖基聚糖是α-dystroglycan的关键聚糖部分，它充当跨膜连接体，连接细胞内细胞骨架和细胞外基质，例如骨骼肌中的层粘连蛋白。我们合成了β- d -Xyl-（1-4）-d -Rbo-5P（1），β- d -Xyl-（1-4）-d -Rbo（2）和β- d -Xyl-（（ 1–4）-d -Rbo-5P1- d -Rbo（3），O-甘露糖基聚糖的部分结构，以区域和立体方式控制，并证明了与天然产物的相容性。