Background

An overview of mortality risk associated with psoriasis is lacking.

Objective

To perform a systematic review and meta-analysis of mortality risk in psoriasis.

Methods

We included studies reporting all-cause or cause-specific mortality risk estimates in psoriasis patients compared with general population or subjects free of psoriasis. We calculated pooled relative risks (RRs) and 95% confidence intervals (CIs).

Results

We included 12 studies. The pooled RRs for all-cause mortality were 1.21 (95% CI 1.14-1.28) in psoriasis, 1.13 (95% CI 1.09-1.16) in mild psoriasis, and 1.52 (95% CI 1.35-1.71) in severe psoriasis. The pooled RRs for cardiovascular mortality were 1.15 (95% CI 1.09-1.21) in psoriasis, 1.05 (95% CI 0.92-1.20) in mild psoriasis, and 1.38 (95% CI 1.09-1.74) in severe psoriasis. For noncardiovascular causes, mortality risk from liver disease, kidney disease, and infection was significantly increased in psoriasis, regardless of disease severity. The mortality risk in liver and kidney disease was the highest. There was also a significantly increased mortality risk associated with neoplasms in severe psoriasis patients and chronic lower respiratory disease in all and mild psoriasis patients.

Limitations

Although associations were consistent, their magnitude was heterogenous.

Conclusion

Psoriasis is associated with an increased risk for mortality from all causes (in a dose-response manner with disease severity) and from several specific causes.

中文翻译：

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牛皮癣的全因病因和特定病因死亡率：系统评价和荟萃分析

背景

缺乏与牛皮癣相关的死亡风险的概述。

客观的

对牛皮癣的死亡风险进行系统的回顾和荟萃分析。

方法

我们纳入的研究报告了与普通人群或无牛皮癣的受试者相比，牛皮癣患者的全因或特定原因死亡风险估计值。我们计算了汇总相对风险（RRs）和95％置信区间（CIs）。

结果

我们纳入了12项研究。汇总的全因死亡率在牛皮癣中为1.21（95％CI 1.14-1.28），在轻度牛皮癣中为1.13（95％CI 1.09-1.16），在严重牛皮癣中为1.52（95％CI 1.35-1.71）。在牛皮癣中，心血管疾病死亡率的总RR为1.15（95％CI 1.09-1.21），在轻度牛皮癣中为1.05（95％CI 0.92-1.20），在严重牛皮癣中为1.38（95％CI 1.09-1.74）。对于非心血管原因，无论疾病的严重程度如何，牛皮癣的肝病，肾病和感染致死风险均显着增加。肝肾疾病的死亡风险最高。重症牛皮癣患者和所有轻度牛皮癣患者的慢性下呼吸道疾病的死亡率也显着增加。

局限性

尽管关联是一致的，但是它们的大小是不同的。

结论

银屑病与所有原因（以疾病严重程度的剂量反应方式）和几种特定原因引起的死亡风险增加相关。